Liver's Matrisome

Matrisome

The classical definition of the Extra Cellular Matrix (ECM) has recently been extended to include non-fibrillar proteins that either interact or are structurally affiliated with the ECM, termed the ‘matrisome.’ In addition to providing the structure and architectural support for cells and tissue, the matrisome serves as a reservoir for growth factors and cytokines, as well as a signaling hub via which cells can communicate with their environment and vice-versa.

The matrisome can act as a regulator of tissue homeostasis and organ function, which can dynamically and appropriately respond to any stress or injury. Failure to properly regulate these responses can lead to changes in the matrisome that are maladaptive.

The qualitative and quantitative alterations of the hepatic matrisome during fibrosis are reasonably more diverse than only accumulation of collagens and occur long before fibrosis is histologically detected.

The liver's matrisome, part of the extracellular matrix (ECM), is a complex and dynamic network of proteins that provides structural support and signaling pathways for liver cells and tissues. It acts as a reservoir for growth factors and cytokines, playing a crucial role in maintaining liver homeostasis and responding to injury. Dysregulation of the matrisome, particularly during liver diseases like fibrosis and cirrhosis, can lead to tissue damage and dysfunction. Dysregulation of ECM components contributes to the pathogenesis of both liver cirrhosis and cancer. Dysregulation of growth factor signals leads to growth signaling autonomy and tumor progression.HYPOTHESIS: could control of growth factor expression prevent tumor progression? Control of hepatocyte growth factor; insulin-like growth factor-1 and epidermal growth factor.

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