Hypotheses

Could acquired complexity regress??

And could the outcome be disease? Possible.

Could serum albumin level become an effective and inexpensive indicator of liver disease??

Possible.

Patients with liver cirrhosis present posttranslational modifications on albumin that compromises its function. Those modified albumin forms were proved to have prognostic value and its knowledge may change the paradigm of albumin treatment. Plus albumins binding capacity, anti-oxidant and anti-inflammatory properties, modulation of hemostasis, vasodilatation and acid base homeostasis.–1 

Could bile acids mediate the adverse effects of eating at the wrong time.??

Possibly.

Could control of Liver's ECM growth factor expression prevent tumor progression??

Possibly.

Can Growth Hormone (GH) and IGF1 activate thermogenesis??

Very likely.

Can it be of any significance of administering IGF1 together with insulin in diabetes??

Very likely.

Is there any significance in activation of STAT5 by IGF-1 in diabetes??

Very likely.

Can IGF1 alternatively promote cell apoptosis??

Possibly.

Can disturbed glucose clearing lead to breast cancer??

Possibly.

Could liver dysfunction lead to disrupted mitochondrial function in multiple organs??

Possibly.

Can (liver) endocrine Fibroblast Growth Factors (FGFs) overrule other hormones in the body??

Possibly.

Could metabolic changes cause gene mutations in humans??

Possibly.

Could an imbalance in the GH/IGF axis lead to genetic changes??

Possibly.

Can genetic expression and genetic changes be induced by diet??

Possibly.

Is there a role for DNA methylation in diabetes??

Possibly.

Could therapeutic induced DNA methylation be curative in diabetes??

Possibly.

Could dietary changes lead to specific DNA methylation??

Possibly.

Is there a relation of liver factors to methylation??

Very likely.

Are blood methylation profiles a good non invasive proxy for liver methylation status??

Very likely.

Is the reverse of epigenetic modifications (like methylation) sensible??

Very likely.

Could an overactive FGF21 expression lead to pathologies??

Very likely.

Is there a role for ghrelin in addiction??

Very likely.

Could IGF1 downregulate ghreling expression or release??

Very likely.