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In portal hypertension, a mosaic or snakeskin appearance of the gastric mucosa is frequently seen endoscopically, especially in the corpus and fundus. It may lead to silent blood loss and therapy-resistant iron-free anemia. This creates a need for regular intravenous iron administration.

Gastric dome varicose veins are caused by left-sided portal hypertension. These are venous collaterals, originating from the vena lienalis and protruding into the fundus of the stomach. In case of bleeding gastric dome varicose veins, tissue glue should be used.

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