3.3 Sinusoidal obstructive syndrome (SOS)

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In these conditions, there is impaired venous drainage from the liver, due to occlusion in the small hepatic venules, by damage to the endothelium of the sinusoids. It occurs in a graft-versus-host disease after bone marrow transplantation, or in response to certain cytostatics.

It is clinically characterized by icterus, tender hepatomegaly and ascites. It has a poor prognosis.

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