Our publications

Alcón P., Kaczmarczyk A.P., Kumar Ray K., Liolios T., Guilbaud G., Sijacki T., Shen Y., McLaughlin S.H., Sale J.E., Knipscheer P., Rueda D.S. & Passmore L.A. 

FANCD2–FANCI surveys DNA and recognizes double- to single-stranded junctions.

Nature (2024)

Saredi G., Carelli F.N., Rolland S., Furlan G., Piquet S., Appert A., Sanchez-Pulido L., Price J.L., Alcón P., Lampersberger L., Déclais A-C., Ramakrishna N.B., Toth R., Macartney T., Alabert C., Ponting C.P., Polo S.E., Miska E.A., Gartner A., Ahringer J., Rouse J. 

The histone chaperone SPT2 regulates chromatin structure and function in Metazoa.

Nature Structural & Molecular Biology (2024)

Sijacki, T., Alcón, P.*, Chen, Z.A*. McLaughlin, S.; Rappsilber, J.; Shakeel, S.; Passmore, L. A. 

* equal contribution.

The DNA-damage kinase ATR activates the FANCD2-FANCI clamp by priming it for ubiquitination.

Nature Structural & Molecular Biology (2024)

Manso, J. A., T. Marcos, V. Ruiz-Martin, J. Casas, P. Alcón, M. Sanchez Crespo, Y. Bayon, J. M. de Pereda and A. Alonso.

PSTPIP1-LYP phosphatase interaction: structural basis and implications for autoinflammatory disorders.

Cellular and Molecular Life Sciences (2022)

Alcón, P.*, S. Shakeel*, Z. A. Chen, J. Rappsilber, K. J. Patel and L. A. Passmore

* equal contribution.

FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.

Nature Structural & Molecular Biology (2020)

S. Shakeel*, E. Rajendra*, P. Alcón, F. O'Reilly, D. S. Chorev, S. Maslen, G. Degliesposti, C. J. Russo, S. D. He, C. H. Hill, J. M. Skehel, S. H. W. Scheres, K. J. Patel, J. Rappsilber, C. V. Robinson and L. A. Passmore.

* equal contribution.

Structure of the Fanconi anaemia monoubiquitin ligase complex.

Nature (2019)

Dorosz, J., L. H. Kristensen, N. G. Aduri, O. Mirza, R. Lousen, S. Bucciarelli, V. Mehta, S. Selles-Baiget, S. M. O. Solbak, A. Bach, P. Mesa, P. Alcón, G. Montoya, T. Nguyen, K. D. Rand, T. Boesen and M. Gajhede. 

Molecular architecture of the Jumonji C family histone demethylase KDM5B.

Scientific Reports (2019)

Stella, S.*, P. Mesa*, J. Thomsen, B. Paul, P. Alcón, S. B. Jensen, B. Saligram, M. E. Moses, N. S. Hatzakis and G. Montoya.

* equal contribution.

Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity.

Cell (2018)

Stella, S.*, P. Alcón* and G. Montoya.

* equal contribution.

Class 2 CRISPR-Cas RNA-guided endonucleases: Swiss Army knives of genome editing.

Nature Structural & Molecular Biology (2017)

Stella, S.*, P. Alcón* and G. Montoya.

* equal contribution.

Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage.

Nature (2017)

Alcón, P., G. Montoya and S. Stella.

Assembly of Francisella novicida Cpf1 endonuclease in complex with guide RNA and target DNA.

Acta Crystallographica F Structural Biology Communications (2017)