The Singh Lab at IITK - PRINCIPAL INVESTIGATOR

Appu Kumar Singh, Ph.D

Assistant Professor,

Department of Biological Sciences and Bioengineering,

Indian Institute of Technology

Kanpur-208016.

Phone: 91-512-259-2142 (office)

Fax: 0512-259-4010

Email: singhappu@iitk.ac.in

Biography

After obtaining an MSc in Biotechnology from IIT Roorkee, Dr. Appu Kumar Singh completed his Ph.D. in the lab of Dr. Sangaralingam Kumaran at IMTECH, Chandigarh, in 2014. Subsequently, he joined the lab of Dr. Alexander Sobolevsky as a postdoctoral fellow and was later promoted to the status of associate research scientist at Columbia University, New York. Dr. Singh joined as a faculty in the BSBE department at IIT Kanpur, in December 2019.

Education and Training

2002-2005 Bachelor of Science (Zoology Hons.), University of Delhi, India

2006-2008 Master of Science (Biotechnology), Indian Institute of Technology , Roorkee, India

2009-2014 Doctoral Research, CSIR-Institute of Microbial Technology, Chandigarh, India

2014-2019 Postdoctoral Training, Columbia University, New York, NY.

Appointments

2019-present Assistant Professor, Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur

2025-2030 Editorial Board member of Journal of Biological Chemistry (JBC)

Honors and Awards

2023 The Interstellar Beyond, Japan Agency for Medical Research and Development and the New York Academy of Sciences.

2022 The Interstellar Initiative, Japan Agency for Medical Research and Development and the New York Academy of Sciences.

2019 Har-Gobind Khorana Innovative Young Biotechnologist Award (IYBA, DBT).

2019 Awarded Ramalingaswami Re-entry Fellowship.

2018 Nominated by Columbia University for the Blavatnik Award for Young Scientist.

2015 Nominated by Columbia University for the Charles Revson Postdoctoral Fellowship.

2009 Awarded Junior Research Fellowship and Senior Research Fellowship from CSIR.

2006 Awarded National Scholarship of Joint Admission Test to M.Sc (JAM).

Key Publications

Mansi Sharma*, Dabbu K. Jaijyan*, Sristi Nanda, Montserrat Samso, Wenhui Hu, Shikha Singh#, Appu K. Singh#. Cryo-EM structures of human GPR155 elucidate its regulatory and transport mechanisms (2024). (Under revision) https://www.biorxiv.org/content/10.1101/2024.09.24.614577v1

Patil DN, Singh S, Laboute T, Strutzenberg TS, Qiu X, Wu D, Novick SJ, Robinson CV, Griffin PR, Hunt JF, Izard T, Singh, A.K#, Martemyanov KA#. Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex. Science. (2021) Nov 18;:eabl4732. [Epub ahead of print] PubMed PMID: 34793198. PUBMED (#Co-Corresponding Author)

Singh, A. K*., McGoldrick, L. L*., Twomey, E. C., and Sobolevsky, A. I. (2018) Structure and gating mechanism of the transient receptor potential channel TRPV3." Nature Structural & Molecular Biology. (Featured as NSMB cover Page, and F1000 article).

McGoldrick, L. L*., Singh, A. K*., Saotome, K., Yelshanskaya, M. V., Twomey, E. C., Grassucci, R. A., and Sobolevsky, A. I. (2018) Opening of the human epithelial calcium channel TRPV6. Nature 553, 233-237.

Saotome, K*., Singh, A. K*., Yelshanskaya, M. V., and Sobolevsky, A. I. (2016) Crystal structure of the epithelial calcium channel TRPV6. Nature 534, 506-511.

Singh, A.K., McGoldrick, L.L., Demirkhanyan, L., Leslie, M., Zakharian, E., and Sobolevsky, A.I. Structural basis of temperature sensation by the TRP channel TRPV3. Nature Structural & Molecular Biology (2019) (Featured as F1000 article).