Publications

2025

Nagai T, Takahashi A (2025) Aggression is not blind: dominance and social history modulate murine responses to social instigation. Psychopharmacology. online ahead of print. doi: 10.1007/s00213-025-06824-9
紹介記事・English

高橋阿貴 (2025) 攻撃性の個体差を生み出す神経生物学的基盤 生体の科学 76(1):56-61

2024

Mitsui K, Takahashi A (2024) Aggression modulator: Understanding the multifaceted role of the dorsal raphe nucleus. Bioessays. 46(4):e2300213. doi: 10.1002/bies.202300213. (REVIEW)

Takahashi A (2024) Associations of the immune system in aggression traits and the role of microglia as mediators. Neuropharmacology. 256:110021. (REVIEW)

2023

高橋阿貴 (2023) 攻撃行動の神経学的基盤 臨床精神医学52(6):599-605

Takahashi A, Russo SJ (2023). Link Between the Immune System and Aggression. In: Martin, C., Preedy, V.R., Patel, V.B. (eds) Handbook of Anger, Aggression, and Violence. Springer, Cham. 

2022

Takahashi A, Durand-de Cuttoli R, Flanigan ME, Hasegawa E, Tsunematsu T, Aleyasin H, Cherasse Y, Miya K, Okada T, Keino-Masu K, Mitsui K, Li L, Patel V, Blitzer RD, Lazarus M, Tanaka KF, Yamanaka A, Sakurai T, Ogawa S, Russo SJ (2022) Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice. Nature Communications. 13, 4039. 

紹介記事・ポッドキャスト・Science Portal・神経科学トピックス

2022年10月にNature IndexでResearch highlightsとして選出されました

Takahashi A (2022) The role of social isolation stress in escalated aggression in rodent models. Neuroscience Research. S0168-0102(22)00212-7 (REVIEW)

Takahashi A (2022) Social stress and aggression in murine models. Curr Top Behav Neurosci. 54:181-208. (REVIEW)

2021

Takahashi A (2021) Toward understanding the sex differences in the biological mechanism of social stress in mouse models. Frontiers in Psychiatry. 12:644161. (REVIEW)

高橋阿貴 (2021) 社会的敗北の動物モデル. 精神科. 39(1): 17-23. (REVIEW)

2020

Flanigan ME, Aleyasin H, Li L, Burnett CJ, Chan KL, LeClair KB, Lucas EK, Matikainen-Ankney B, Cuttoli RD, Takahashi A, Menard C, Pfau ML, Golden SA, Bouchard S, Calipari ES, Nestler EJ, DiLeone RJ, Yamanaka A, Huntley GW, Clem RL, Russo SJ (2020) Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice. Nature Neuroscience. 23:638–650. 

高橋阿貴 (2020) 過剰な攻撃行動の脳内メカニズム. Medical Science Digest. 46:50-51.  (REVIEW)

2018

Takahashi A, Flanigan ME, McEwen BS, Russo SJ (2018) Aggression, social stress and the immune system in humans and animal models. Frontiers in Behavioral Neuroscience. 12:56. (REVIEW) 

Aleyasin H, Flanigan ME, Golden SA, Takahashi A, Menard C, Pfau ML, Multer J, Pina J, McCabe KA, Bhatti N, Hodes GE, Heshmati M, Neve RL, Nestler EJ, Heller EA, Russo SJ (2018) Cell-type-specific role of FosB in nucleus accumbens in modulating intermale aggression. The Journal of Neuroscience. 38(26):5913-5924. 

Heshmati M, Aleyasin H, Menard C, Christoffel DJ, Flanigan ME, Pfau ML, Goff PH, Hodes GE, Lepack A, Bicks L, Takahashi A, Chandra R, Turecki G, Lobo MK, Maze I, Golden SA, Russo SJ (2018) Cell-type specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility. Proceedings of the National Academy of Sciences U S A. 115(5):1111-1116. 

Golden SA, Takahashi A. (2018) Combinatorial psycho-pharmacological approaches for the treatment of abnormal aggression. Neuropsychopharmacology. 43(2):233-234. (COMMENTARY) 

村川友哲, 高橋阿貴, 小川園子 (2018) 内側視索前野を中心とした養育行動の神経内分泌学的基盤に関わる研究の動向. 筑波大学心理学研究. 56: 1-12. (REVIEW)

2017

Takahashi A, Chung J, Zhang S, Zhang H, Grossman Y, Aleyasin H, Flanigan ME, Pfau ML, Menard C, Dumitriu D, Hodes GE, McEwen BS, Nestler EJ, Han MH, Russo SJ (2017) Establishment of a repeated social defeat stress model in female mice. Scientific Reports. 7(1):12838. 

高橋阿貴 (2017) 過剰な攻撃行動の神経生物学―動物行動神経科学の視点から. 臨床精神医学. 46(9):1077-1082. (REVIEW) 

Menard C, Pfau ML, Hodes GE, Kana V, Wang VX, Bouchard S, Takahashi A, Flanigan ME, Aleyasin H, LeClair KB, Janssen WG, Labonté B, Parise EM, Lorsch ZS, Golden SA, Heshmati M, Tamminga C, Turecki G, Campbell M, Fayad ZA, Tang CY,  Merad M, Russo SJ. (2017) Social stress induces neurovascular pathology promoting depression. Nature Neuroscience. 20:1752–1760. 

Horii Y, Nagasawa T, Sakakibara H, Takahashi A, Tanave A, Matsumoto Y, Nagayama H, Yoshimi K, Yasuda MT, Shimoi K, Koide T. (2017) Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice. Scientific Reports. 7(1):6991.

Okabe S, Tsuneoka Y, Takahashi A, Ooyama R, Watarai A, Maeda S, Honda Y, Nagasawa M, Mogi K, Nishimori K, Kuroda M, Koide T, Kikusui T. (2017) Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice. Psychoneuroendocrinology. 79:20-30. 

Golden SA, Aleyasin H, Heins R, Flanigan M, Heshmati M, Takahashi A, Russo SJ, Shaham Y. (2017) Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice. Genes Brain, & Behavior. 16(1):44-55. 

Flanigan M, Aleyasin H, Takahashi A, Golden SA, Russo SJ. (2017) An emerging role for the lateral habenula in aggressive behavior. Pharmacology Biochemistry and Behavior. 162:79-86. (REVIEW) 

Arakawa T, Tanave A, Takahashi A, Kakihara S, Koide T, Tsuchiya T. (2017) Automated estimation of mouse social behaviors based on a hidden markov model. Methods in Molecular Biology. 1552:185-197. (BOOK CHAPTER)  

2016

Hirata H, Takahashi A, Shimoda Y, Koide T. (2016) Caspr3-deficient mice exhibit low motor learning during the early phase of the accelerated rotarod task. PLOS ONE. 11(1):e0147887. 

2015

Takahashi A, Lee RX, Iwasato T, Itohara S, Arima H, Bettler B, Miczek KA, Koide T. (2015) Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice. The Journal of Neuroscience. 35(16):6452-63. 

Takahashi A, Sugimoto H, Kato S, Shiroishi T, Koide T. (2015) Mapping of genetic factors that elicit intermale aggressive behavior on mouse Chromosome 15: Intruder effects and the complex genetic basis. PLOS ONE. 21;10(9):e0137764.  

Hodes GE, Pfau ML, Purushothaman I, Ahn HF, Golden SA, Christoffel DJ, Magida J, Brancato A, Takahashi A, Flanigan ME, Ménard C, Aleyasin H, Koo JW, Lorsch ZS, Feng J, Heshmati M, Wang M, Turecki G, Neve R, Zhang B, Shen L, Nestler EJ, Russo SJ. (2015) Sex differences in nucleus accumbens transcriptome profiles associated with susceptibility versus resilience to subchronic variable stress. The Journal of Neuroscience. 35(50):16362-16376. 

Newman EL, Smith KS, Takahashi A, Chu A, Hwa LS, Chen Y, DeBold JF, Rudolph U, Miczek KA. (2015) α2-containing GABA(A) receptors: a requirement for midazolam-escalated aggression and social approach in mice. Psychopharmacology (Berl). 232(23):4359-69. 

Miczek KA, Takahashi A, Gobrogge KL, Hwa LS, de Almeida RM. (2015) Escalated aggression in animal models: Shedding new light on mesocorticolimbic circuits. Current Opinion in Behavioral Sciences. 3:90-95.  (REVIEW) 

2014

Takahashi A, Nagayasu K, Nishitani N, Kaneko S, Koide T (2014) Control of intermale aggression by medial prefrontal cortex activation in the mouse. PLOS ONE. 9(4):e94657. 

Takahashi A, Shiroishi T, Koide T (2014) Genetic mapping of escalated aggression in wild-derived mouse strain MSM/Ms: association with serotonin-related genes. Frontiers in Neuroscience. 8:156. 

Takahashi A, Miczek KA (2014) Neurogenetics of Aggressive Behavior: Studies in Rodents. Current Topics in Behavioral Neurosciences. 17:3-44. (REVIEW)

Kanno K, Kokubo H, Takahashi A, Koide T, Ishiura S (2014) Enhanced prepulse inhibition and low sensitivity to a dopamine agonist in HESR1 knockout mice. Journal of Neuroscience Research. 92(3):287-297. 

Arakawa T, Tanave A, Ikeuchi S, Takahashi A, Kakihara S, Kimura S, Sugimoto H, Asada N, Shiroishi T, Tomihara K, Tsuchiya T, Koide T (2014) A male-specific QTL for social interaction behavior in mice mapped with automated pattern detection by a hidden Markov model incorporated into newly developed freeware. Journal of Neuroscience Methods. 234:127-34. 

Sluyter F, Takahashi A, Maxson SC (2014) Pathological aggression. In, Susanna Pietropaolo, Frans Sluyter and Wim E. Crusio (Eds), Behavioral Genetics of the Mouse Vol. 2: Genetic Mouse Model of Neurobehavioral Disorders (Chapter 10). Cambridge, UK: Cambridge University Press.  (BOOK CHAPTER)

2012

Takahashi A, Schilit AN, Kim J, DeBold JF, T Koide, Miczek KA (2012) Behavioral characterization of escalated aggression induced by GABA(B) receptor activation in the dorsal raphé nucleus. Psychopharmacology (Berl). 224(1):155-156. 

Takahashi A, Quadros IM, de Almeida RM, Miczek KA. (2012) Behavioral and pharmacogenetics of aggressive behavior. In, John Cryan (Ed), Current Topics in Behavoral Neurosciences. 2012 12:73-138. (REVIEW)

高橋阿貴 (2012) 光遺伝学（オプトジェネティクス）：行動を制御する神経回路をあきらかにする試み. 動物心理学研究. 62(2), 147-162. (REVIEW)

Faccidomo S, Quadros IM, Takahashi A, Fish EW, Miczek KA (2012) Infralimbic and dorsal raphé microinjection of the 5-HT(1B) receptor agonist CP-93,129: attenuation of aggressive behavior in CFW male mice. Psychopharmacology (Berl). 222(1):117-128.

Newman EL, Chu A, Bahamón B, Takahashi A, Debold JF, Miczek KA (2012) NMDA receptor antagonism: escalation of aggressive behavior in alcohol-drinking mice. Psychopharmacology (Berl). 224(1):167-177. 

2011

Takahashi A, Quadros IM, de Almeida RM, Miczek KA. (2011) Brain serotonin receptors and transporters: initiation vs. termination of escalated aggression. Psychopharmacology (Berl). 213:183-212. (REVIEW)

Miczek KA, Nikulina EM, Takahashi A, Covington HE 3rd, Yap JJ, Boyson CO, Shimamoto A, de Almeida RM (2011) Gene expression in aminergic and peptidergic cells during aggression and defeat: Relevance to violence, depression and drug abuse. Behavior Genetics. 41(6):787-802. (REVIEW)

Ishii A, Koide T, Takahashi A, Shiroishi T, Hettinger TP, Frank ME, Savoy LD, Formaker BK, Yertutanol S, Lionikas A, Blizard DA (2011) B6-MSM consomic mouse strains reveal multiple loci for genetic variation in sucrose octaacetate aversion. Behavior Genetics. 41(5):716-723. 

Koide T, Ikeda K, Ogasawara M, Shiroishi T, Moriwaki K, Takahashi A (2011) A new twist on behavioral genetics by incorporating wild-derived mouse strains. Experimental Animals. 60: 347-354. (REVIEW)

2010

Takahashi A, Shimamoto A, Boyson C, deBold JF, Miczek KA (2010) GABA(B) receptor modulation of serotonin neurons in the dorsal raphé nucleus and escalation of aggression in mice. The Journal of Neuroscience. 30:11771-11780. 

Takahashi A, Kwa C, deBold JF, Miczek KA. (2010) GABA(A) receptors in the dorsal raphé nucleus of mice: escalation of aggression after alcohol consumption. Psychopharmacology (Berl). 211:467-477.

Takahashi A, Tomihara K, Shiroishi T, Koide T (2010) Genetic mapping of social interaction behavior in B6/MSM consomic mouse strains. Behavior Genetics. 40:366-376.

Nishi A, Ishii A, Takahashi A, Shiroishi T, Koide T (2010) QTL analysis of measures of mouse home-cage activity using B6/MSM consomic strains. Mammalian Genome. 21:477-485.

Tanaka N, Waki K, Kaneda H, Suzuki T, Yamada I, Furuse T, Kobayashi K, Motegi H, Toki H, Inoue M, Minowa O, Noda T, Takao K, Miyakawa T, Takahashi A, Koide T, Wakana S, Masuya H (2010) SDOP-DB: a comparative standardized-protocol database for mouse phenotypic analyses. Bioinformatics. 26:1133-1134.

2009

Takahashi A, Yap JJ, Bohager DZ, Faccidomo S, Clayton T, Cook JM, Miczek KA (2009) Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups. Psychopharmacology (Berl). 204(1):61-72.

Quadros IM, Takahashi A, Mickzek KA (2009) Serotonin in aggressive and violent behavior. In, Christian Muller & Barry Jacobs (Eds), Handbook of the Behavioral Neurobiology of Serotonin 18 (Chapter 10.4). Philadelphia, USA: Elsevier (BOOK CHAPTER)

2008

Takahashi A, Nishi A, Ishii A, Shiroishi T, Koide T (2008) Systematic analysis of emotionality in consomic mouse strains established from C57BL/6J and wild-derived MSM/Ms. Genes Brain and Behavior. 7:849-858.

Takahashi A, Shiroishi T, Koide T (2008) Multigenic factors associated with a hydrocephalus-like phenotype found in inter-subspecific consomic mouse strains. Mammalian Genome. 19:333-338.

高橋阿貴、小出剛 (2008)  系統について知ろう（第2章）、マウスの行動を解析しよう（第10章） 小出剛（編）「マウス実験の基礎知識」 オーム社 (BOOK CHAPTER)

2007

Blizard DA, Takahashi A, Galsworthy M, Martin B, Koide T (2007) Test standardization in behavioral neuroscience: a response to Stanford. Journal of Psychopharmacology. 21:136-139. (COMMENTARY)

2006

Takahashi A, Kato K, Makino J, Shiroishi T, Koide T (2006) Multivariate analysis of temporal descriptions of open-field behavior in wild-derived mouse strains. Behavior Genetics. 10:1-12.

Blizard DA, Wada Y, Onuki Y, Kato K, Mori T, Taniuchi T, Hosokawa H, Otobe T, Takahashi A, Shisa H, Hiai H, Makino J (2005) Use of A Standard Strain for External Calibration in Behavioral Phenotyping. Behavior Genetics. 35:323-332.

2005

Barnes SJ, Hua JM, Pinel JP, Takahashi A, Wig GS (2005) Conditioned effects of kindling three different sites in the hippocampal complex of the rat. Behavioral Neuroscience. 119:1572-1579. 

2004

高橋阿貴・加藤克紀・牧野順四郎 (2004) 高・低活動系マウスのオープンフィールド行動の時間構造：ICRおよび近交系５系統との比較. 動物心理学研究. 54:73-85.

Barnes SJ, Magyar O, Pinel JP, Takahashi A. (2004) Anticipating the attack: temporal conditioning during amygdala kindling in rats. Behavioral Neuroscience. 118:89-96.