Publications

138. Dong Joon Lee, Yu Cao, Vinayak Juvekar, Sauraj, Choong-Kyun Noh, Sung Jae Shin,,* Zhihong Liu,* and Hwan Myung Kim*  "Development of a Small Molecule-Based Two-Photon Photosensitizer for Targeting Cancer Cells" J. Mater. Chem. B 2024, 12, 12232-12238. (Invited in special issue "Materials Chemistry of Fluorescence Bioimaging"; Selected in the Journal of Materials Chemistry B 2024 "Most Popular Articles collection"; Featured in the collection "Celebrating Lunar New Year 2025") 

137. Vinayak Juvekar, Yu Cao, Chang Woo Koh, Dong Joon Lee, Sun Young Kwak, Sun Mi Kim, Tae Jun Park, Sungnam Park,* Zhihong Liu,* and Hwan Myung Kim* "Overcoming melanin interference in melanocyte photodynamic therapy with a pyrene-derived two-photon photosensitizer" Chem. Eng. J. 2024, 493, 152796.

136. Van-Nghia Nguyen, Dong Joon Lee, Dianqi Zhang, Jeongsun Ha, Kunemadihalli Mathada Kotraiah Swamy, Rui Wang,* Hwan Myung Kim,* Fabiao Yu,* and Juyoung Yoon* "Rational Design of Efficient Heavy-Atom-Free Boron-Dipyrromethene Nanophotosensitizers for Two-Photon Excited Photodynamic Therapy of Cancer" Chem. Mater. 2024, 36, 5534-5541.

135. Kim, E. S.;  Lee, J.-M.; Kwak, J.-Y.; Lee, H. W.; Lee, I.-J.*; Kim, H. M.* "Multi-Color Two-Photon Microscopy Imaging of Lipid Droplets and Liver Capsule Macrophages in Vivo" Anal. Chem. 2024, 96, 8467-8473.

134. Juvekar, V.; Lee, D. J.; Park, T. G.; Samanta, R.; Kasar, P.; Kim, C.; Rotermund, F.*; Kim, H. M.* "Two-photon excitation photosensitizers for photodynamic therapy: From small-molecules to nano-complex systems" Coord. Chem. Rev. 2024, 506, 215711. (Invited in special issue "Phototherapy")

133. Morozov, B. S.; Gargiulo, F.; Ghule, S; Lee, D. J.; Hampel, F.; Kim, H. M.*; Kataev, E. A.* "Macrocyclic Conformational Switch Coupled with Pyridinium-Induced PET for Fluorescence Detection of Adenosine Triphosphate" J. Am. Chem. Soc. 2024, 146, 7105.

132. Juvekar, V.; Kim, H. M.* "Chapter 6: Two-Photon Fluorescent Probes"; Editors: Wu, L.; Sedgwick, A. C.; He, X.-P.; James, T. D., Fluorescent Chemosensors (Royal Society of Chemistry) 2023, 106-123. (DOI: https://doi.org/10.1039/9781839167324) 

131. Lee, H. W.; Juvekar, V.; Lee, D. J.; Kim, H. M.* "Recent advances in organelle-specific two-photon small-molecule fluorescent probes for bioanalysis in live tissues" TrAC-Trends Anal. Chem. 2023, 165, 117128. (Invited in special issue "Luminescence Probes")

130. Pham, T. C.; Lee, D. J.; Kim, D. H.; Yoon, J.; Lam, T. D.; Kim, H. M.*; Lee, S* "Imidazole–carbazole conjugate for two-photon-excited photodynamic therapy and fluorescence bioimaging" Chem. Commun. 2023, 59, 4503-4506.

129. Lee, D. J.†; Kim, E. S.†; Lee, H. W.*; Kim, H. M.* "Advances in Small Molecule Two-Photon Fluorescent Trackers for Lipid Droplets in Live Sample Imaging" Front. Chem. 2022, 10, 1072143. (Invited in Themed Issue "Fluorescent Probe Technologies for Imaging Biospecies")

128. Lee, H. W.†; Tanmay, K. P.†; Lee, I.-J.†; Lee, J.-M.; Kim, B. R.; Kwak, S. Y.; Kim, H. M.* "In Vivo Simultaneous Imaging of Plasma Membrane and Lipid Droplets in Hepatic Steatosis using Red-Emissive Two-Photon Probes" Anal. Chem. 2022, 94, 15100-15107. 

127. Juvekar, V.†; Lee, H. W.†; Lee, D. J.†; Kim, H. M.* "Two-Photon Fluorescent Probes for Quantitative Bio-Imaging Analysis in Live Tissues" TrAC-Trends Anal. Chem. 2022, 157, 116787.

126. Lee, C.-G.†; Lee, S.-J.; Park, S.†; Choi, S.-E; Song, M.-W.; Lee, H. W.; Kim, H. J.; Kang, Y.; Lee, K. W.; Kim, H. M.; Kwak, J.-Y.*; Lee, I.-J.; Jeon, J. Y.* "In Vivo Two-photon Imaging Analysis of Dynamic Degradation of Hepatic Lipid Droplets in MS-275-Treated Mouse Liver" Int. J. Mol. Sci. 2022, 23, 9978. 

125. Lee, H. W.; Lee, I.-J.; Lee, S.-J.; Kim, Y. R.; Kim, H. M.* "Highly Sensitive Two-Photon Lipid Droplet Tracker for In Vivo Screening of Drug Induced Liver Injury" ACS Sens. 2022, 7, 1027-1035.

124. Kwon, N.†; Lim, C. S.†; Lee, D.; Ko, G.; Ha, J.; Cho, M.; Swamy, K. M. K.; Lee, E.-Y.; Lee, D. J.; Nam, S.-J.; Zhou, X.*; Kim, H. M.*; Yoon, J.* "A coumarin-based reversible two-photon fluorescence probe for imaging glutathione near N-methyl-D-aspartate (NMDA) receptors" Chem. Commun. 2022, 58, 3633-3636 (Themed Issue in Multimolecular Crowding in Biosystems).

123. Han, J.†; Lee, H. W.†; Chen, Y.; Li, H.*, Kim, H. M.*; Yoon, J.* "Observing Hepatic Steatosis with a Commercially Viable Two-Photon Fluorogenic Probe" Mater. Chem. Front. 2022, 6, 553-560 (HOT article). 

122. Lee, D. J.†; Juvekar, V.†; Lee, H. W.; Kim, E. S.; Noh, C.-K.; Shin, S. J.*; Kim, H. M.* "Cancer targeted azo dye for two-photon photodynamic therapy in human colon tissue" Anal. Chem. 2021, 93, 16821-16827.

121. Lee, H. W.†; Juvekar, V.†; Lee, D. J.; Kim, S. M.; Kim, H. M.* "Highly Stable Red-Emissive Ratiometric Probe for β-galactosidase Activity using Fluorescence Microscopy and Flow Cytometry" Anal. Chem. 2021, 93, 14778-14783.

120. Wu, L.†; Tian, X.†; Lee, D. J.; Yoon, J.; Lim, C. S.*; Kim, H. M.*; James, T. D.* "Two-photon ESIPT-based fluorescent probe using 4-hydroxyisoindoline-1,3-dione for the detection of peroxynitrite" Chem. Commun. 2021, 57, 11084-11087. 

119. Lopez-Alled, C. M.; Park, S. J.; Lee, D. J.; Murfin, L. C.; Kociok-Kohn, G.; Hann, J. L.; Wenk, J.*; James, T. D.*; Kim, H. M.*; Lewis, S. E.* "Azulene-based fluorescent chemosensor for adenosine diphosphate" Chem. Commun. 2021, 57, 10608-10611.

118. Cui, Y.†; Park, S. J.†; Wu, X.; Wang, R.; Qi, S.; Kim, H. M.*; Yoon, J.* "Highly selective two-photon fluorescent off–on probes for imaging tyrosinase activity in living cells and tissues" Chem. Commun. 2021, 57, 6911-6914.

117. Kwon, N.†; Lim, C. S.†; Ko, G.†; Ha, J.†; Lee, D.; Yin, J.*; Kim, H. M.*; Yoon, J.* "Fluorescence Probe for Imaging N-Methyl-d-aspartate Receptors and Monitoring GSH Selectively Using Two-Photon Microscopy" Anal. Chem. 2021, 93, 11612-11616. 

116. Noh, C. K.†; Lim, C. S.†; Lee, G. H.; Cho, M. K.; Lee, H. W.; Roh, J.; Kim, Y. B.; Lee, E.; Park, B.; Kim, H. M.*; Shin, S. J.* "A Diagnostic Method for Gastric Cancer Using Two-Photon Microscopy with Enzyme-Selective Fluorescent Probes: A Pilot Study" Front. Oncol. 2021, 11, 634219. 

115. Juvekar, V.†; Cho, M. K.†; Lee, H. W.†; Lee, D. J.; Kang, H.; Song, J. M.; Je, J. T.*; Kim, H. M.* "A red-emissive two-photon fluorescent probe for mitochondrial sodium ions in live tissue" Chem. Commun. 2021, 57, 8929-8932.

114. Pham, T. C.; Nguyen V. N.; Choi, Y.; Kim, D.; Jung, O. S.; Lee, D. J.; Kim, H. J.; Lee, M. W.; Yoon, J.; Kim, H. M.*; Lee, S* "Hypochlorite-Activated Fluorescence Emission and Antibacterial Activities of Imidazole Derivatives for Biological Applications" Front. Chem. 2021, 9, 713078.

113. Juvekar, V.; Lee, H. W.; Kim, H. M.* "Two-Photon Fluorescent Probes for Detecting Enzyme Activities in Live Tissues" ACS Appl. Bio Mater. 2021, 4, 2957-2973 (invited).

112. Juvekar, V.†; Lim, C. S.†; Lee, D. J.; Song, D. H.; Noh, C. K.; Kang, H.; Shin, S. J.*; Kim, H. M.* "Near-Infrared Ratiometric Two-Photon Probe for pH Measurement in Human Stomach Cancer Tissue" ACS Appl. Bio Mater. 2021, 4, 2135-2141 (Invited in special issue "Biospecies Sensors").

111. Park, S. J.; Cho, M. K.; Lee, D. J.; Song, D. H.; Lim, C. S.; Noh, C. K.; Lee, D. M.; Choi, K. S.*; Shin, S. J.*; Kim, H. M.* "Development of two-photon fluorescence probe for detecting cyclooxygenase-2 level in human colorectal cancer tissue" Sens. Actuator B-Chem. 2021, 330, 129329.

110. Lim, C. S.; Choi, J. W.; Kim, Y. C.*; Kim, H. M.* "Analyzing Nonmelanoma Skin Cancer Using Enzyme-Activatable Two-Photon Probes" Bull. Korean. Chem. Soc. 2021, 42, 103-106 (invited in special issue "Chemosensors and Imaging probes"). 

109. Juvekar, V.†; Lim, C. S.†; Lee, D. J.; Song, G. O.; Kang, H.; Kim, H. M.* "An azo dye for photodynamic therapy that is activated selectively by two-photon excitation" Chem. Sci. 2021, 12, 427-434.

108. Juvekar, V.†; Park, S, J,†; Yoon, J.*; Kim, H. M.* "Recent progress in the two-photon fluorescent probes for metal ions" Coord. Chem. Rev. 2021, 427, 213574 (invited in special issue "Metal as a guest or host").

107. Nguyen, V.†; Park, S. J.†; Qi, S.; Ha, J.; Heo, S.; Yim, Y.; Baek, G.; Lim C. S.; Lee, D. J.; Kim H. M.*; Yoon, J. "Design and synthesis of efficient heavy-atom-free photosensitizers for photodynamic therapy of cancer" Chem. Commun. 2020, 56, 11489-11492.

106. Cho, M. K.†; Seo, M. J.†; Juvekar, V.; Jo, J. H.; Kim, W.; Choi, K. S.*; Kim, H. M.* "Screening of Drug-Induced Steatosis and Phospholipidosis Using Lipid Droplet-Selective Two-Photon Probes" Anal. Chem. 2020, 92, 11223-11231.

105. Chung, J.†; Li, H.†; Lim, C. S.†; Kim, H. M.*; Yoon, J.* Two-photon imaging of hydrogen polysulfides in living cells and hippocampal tissues" Sens. Actuator B-Chem, 2020, 332, 128564.

104. Odyniec, M. L.; Park, S. J.; Gardiner, J. E.; Webb, E. C.; Sedgwick, A. C.; Yoon, J.; Bull, S. D.*; Kim, H. M.*; James, T. D.* "A Fluorescent ESIPT-based Benzimidazole Platform for the Ratiometric Two-Photon Imaging of ONOO- In Vitro and Ex Vivo" Chem. Sci. 2020, 11, 7329-7334.

103. Kumar, H.; Lim, C. S.; Choi, H.; Joshi, H. P.; Kim, K.-T.; Kim, Y. H.; Park, C.-K.; Kim, H. M.; Han, I.-B.* "Elevated TRPV4 Levels Contribute to Endothelial Damage and Scarring in Experimental Spinal Cord Injury" J. Neurosci. 2020, 40, 1943-1955.

102. Kim, D.; Lee, J. H.; Koo, J. Y.; Kim, H. M.; Park, S. B.* "Two-Photon and Multicolor Fluorogenic Bioorthogonal Probes Based on Tetrazine-Conjugated Naphthalene Fluorophores" Bioconjugate Chem. 2020, 31, 1545-1550.

101. Park, S. J.†; Juvekar, V.†; Jo, J. H.; Kim, H. M.* "Combining hydrophilic and hydrophobic environment sensitive dyes to detect wide range of cellular polarity" Chem. Sci. 2020, 11, 596-601.

100. Park, S. J.; Shin, B. K.; Lee, H. W.; Song, J. M.; Je, J. T.*; Kim, H. M.* "Asymmetric cyanine as a far-red fluorescence probe for mitochondrial viscosity" Dyes. Pigment. 2020, 174, 108080. 

99. Murfin, L. C.†; Weber, M.†; Park, S. J.†; Kim, W. T.†; Lopez-Alled, C. M.; McMullin, C. L.; Pradaux-Caggiano, F.; Lyall, C. L.; Kociok-Köhn, G.; Wenk, J.; Bull, S. D.; Yoon, J.; Kim, H. M.*; James, T. D.*; Lewis, S. E.* "Azulene-Derived Fluorescent Probe for Bioimaging: Detection of Reactive Oxygen and Nitrogen Species by Two-Photon Microscopy" J. Am. Chem. Soc. 2019, 141, 19389-19396.

98. Lee, H. W.; Lim, C. S.; Choi, H.; Cho, M. K.; Noh, C.-K.; Lee, K.*; Shin, S. J.*; Kim, H. M.* "Discrimination between Human Colorectal Neoplasms with a Dual-Recognitive Two-Photon Probe" Anal. Chem. 2019, 91, 14705-14711.

97. Chen, L.†; Cho, M. K.†; Wu, D.; Kim, H. M.*; Yoon, J.* "A two-photon fluorescence probe for selective monitoring of superoxide in live cells and tissues" Anal. Chem. 2019, 91, 14691-14696. 

96. Kim, Y. J.†; Park, S. J.†; Lim, C. S.; Lee, D. J.; Noh, C.; Lee, K.; Shin, S. J.*; Kim, H. M.* "Ratiometric Detection of γ-Glutamyltransferase in Human Colon Cancer Tissues using a Two-photon Probe" Anal. Chem. 2019, 91, 9246-9250.

95. Yoon, Y.; Jo, S.; Park, S. J.; Kim, H. M.; Kim, D.; Lee, T. S.* "Unusual fluorescence of o-phenylazonaphthol derivatives with aggregation-induced emission and their use in two-photon cell imaging" Chem. Commun. 2019, 55, 6747-6750.

94. Cho, M. K.†; Juvekar, V.†; Lim, C. S.; Noh, C.; Shin, S. J.*; Kim, H. M.* "A Highly Sensitive Two-Photon Ratiometric Probe for Rapid Detection of the hNQO1 Enzyme in Colon Cancer Tissue" Asian J. Org. Chem. 2019. 8, 1707-1712 (Invited in themed issue "Researchers in Korea").

93. Chen, L.†; Park, S. J.†; Wu, D.*; Kim, H. M.*; Yoon, J.* "A two-photon fluorescence probe for colorimetric and ratiometric monitoring of mercury in live cells and tissues" Chem. Commun. 2019. 55, 1766-1769.

92. Choi, H. J.; Lim, C. S.; Cho, M. K.; Kang, J. S.; Park, S. J.; Park, S. M.*; Kim, H. M.* "A Two-Photon Ratiometric Probe for Hydrogen Polysulfide (H2Sn): Increase in Mitochondrial H2Sn Production in a Parkinson's Disease Model" Sens. Actuator B-Chem. 2019, 283, 810-819. 

91. Chang, M. J.; Kim, K.; Park, K. S.; Kang, J. S.; Lim, C. S.*; Kim, H. M.*; Kang, C,*; Lee, M. H.* "High-depth fluorescence imaging using a two-photon FRET system for mitochondrial pH in live cells and tissues" Chem. Commun. 2018, 54, 13531-13534.

90. Pak, Y.†; Park, S. J.†; Song, G.; Yim, Y.; Kang, H.; Kim, H. M.*; Bouffard, J.*; Yoon, J.* "Endoplasmic Reticulum-Targeted Ratiometric N-Heterocyclic Carbene Borane Probe for Two-Photon Microscopic Imaging of Hypochlorous Acid" Anal. Chem. 2018. 90, 12937-12943.

89. Jo, A.†; Sung, J.†; Lee, S.; Nam, H.; Lee, H. W.; Park, J.; Kim, H. M.; Kim, E.*; Park, S. B.* "Near-IR Fluorescent Tracer for Glucose-Uptake Monitoring in Live Cells" Bioconjugate Chem. 2018, 29, 3394-3401. 

88. Park, S. J.; Kim, Y. J.; Kang, J. S.; Kim, I. Y.; Choi, K. S.; Kim, H. M.* "Carboxylesterase-2-Selective Two-Photon Ratiometric Probe Reveals Decreased Carboxylesterase-2 Activity in Breast Cancer Cells" Anal. Chem. 2018, 90, 9465-9471.

87. Pak, Y. L.†; Park, S. J.†; Xu, Q.; Kim, H. M.*; Yoon, J.* "A Ratiometric Two-photon Fluorescent Probe for Detecting and Imaging Hypochlorite" Anal. Chem. 2018, 90, 9510-9514.

86. Lee, D.†; Lim, C. S.†; Ko, G.†; Kim, D.; Cho, M. K.; Nam, S. J.; Kim, H. M.*; Yoon, J.* "A Two-Photon Fluorescent Probe for Imaging Endogenous ONOO- near NMDA Receptors in Neuronal Cells and Hippocampal Tissues" Anal. Chem. 2018, 90, 9347-9352.

85. Si, H. Y.†; Cho, M. K.†; Kang, J. S.; Noh, C.; Shin, S. J.; Lim, C. S.*; Kim, H. M.* "Carboxylate-containing two-photon probe for simultaneous detection of extra- and intracellular pH values in colon cancer tissue" Anal. Chem. 2018, 90, 8058-8064.

84. Cho, M. K.†; Lim, C. S.†; Sarkar, A. R.; Lee, H. W.; Choi, H. J.; Noh, C.; Shin, S. J.*; Kim, H. M.* "A Two-Photon Ratiometric Probe for Detection of hNQO1 Enzyme Activity in Human Colon Tissue" Sens. Actuator B-Chem. 2018, 272, 203-210.

83. Chen, L.†; Park, S. J.†; Wu, D.; Kim, H. M.*; Yoon, J.* "A two-photon ESIPT based fluorescence probe for specific detection of hypochlorite" Dyes. Pigment. 2018, 158, 526-532.

82. Park, S. S.; Lee, D. M.; Lim, J. H.; Lee, D.; Park, S. J.; Kim, H. M.; Sohn, S.; Yoon, G.; Eom, Y. W.; Jeong, S. Y.; Choi, E. K.*;  Choi, K. S.* "Pyrrolidine dithiocarbamate reverses Bcl-xL-mediated apoptotic resistance to doxorubicin by inducing paraptosis" Carcinogenesis 2018, 39, 458-470.

81. Pak, Y. L.†; Park, S. J.†; Wu, D.†; Cheon, B.; Kim, H. M.*; Bouffard, J.*; Yoon, J.* "N-Heterocyclic Carbene Boranes as Reactive Oxygen Species-Responsive Materials: Application to the Two-Photon Imaging of Hypochlorous Acid in Living Cells and Tissues" Angew. Chem. Int. Ed. 2018, 57, 1567-1571.

80. Li, J.†; Kwon, Y.†; Chung, K. S.†; Lim, C. S.†; Lee, D.; Yue, Y.; Yoon, J.; Kim, G.; Nam, S. J.; Chung, T. W.; Kim, H. M*; Yin, C.*;  Ryu, J. H.*;  Yoon, J* "Naphthalene-based fluorescent probes for glutathione and their applications in living cells and patients with sepsis" Theranostics 2018, 8, 1411-1420.

79. Lim, C. S.†; Cho, M. K.†; Park, M. Y.; Kim, H. M.* "A Two-Photon Ratiometric Fluorescent Probe for Imaging of Hydrogen Peroxide Levels in Rat Organ Tissues" ChemistryOpen 2018, 7, 53-56 (Invited in themed issue "Chemosensors: Recent Developments").

78. Majumdar, A.; Lim, C. S.; Kim, H. M.;* Ghosh, K.* "New Six-Membered pH-Insensitive Rhodamine Spirocycle in Selective Sensing of Cu2+ through C-C Bond Cleavage and Its Application in Cell Imaging" ACS Omega 2017, 2, 8167-8176.

77. Li, J.†; Lim, C. S.†; Kim, G.; Kim, H. M.*; Yoon, J.* "Highly Selective and Sensitive Two-Photon Fluorescence Probe for Endogenous Peroxynitrite Detection and Its Applications in Living cells and Tissues" Anal. Chem. 2017, 89, 8496-8500.

76. Kim, H. J.†; Lim, C. S.†; Lee, H. W.; Lee, H. S.; Um, Y. J.; Kumar, H.; Han, I.; Kim, H. M.* "A ratiometric two-photon probe for Ca2+ in live tissues and its application to spinal cord injury model" Biomaterials. 2017, 141, 251-259.

75. Moon, J. Y.; Choi, S. J.; Heo, C. H.; Kim, H. M.; Kim, H. S.* "α-Syntrophin stabilizes catalase to reduce endogenous reactive oxygen species levels during myoblast differentiation" FEBS J. 2017, 284, 2052-2065.

74. Lee, H. W.; Cho, M. K.; Kim, H.; Lim, C. S.; Kang, C.*; Kim, H. M.* "Visualization of Vesicular Transport from the Endoplasmic Reticulum to Lysosome using an Amidine Derived Two‐Photon Probe" Chem. Commun. 2017, 53, 6097-6100 (Invited in themed issue "Chemosensors and Molecular logic").

73. Chen, L. Y.; Wu, D.*; Lim, C. S.; Kim, D.; Nam, S. J.; Lee, W.; Kim, G.; Kim, H. M.*; Yoon, J.* "A Two-Photon Fluorescent Probe for Specific Detection of Hydrogen Sulfide Based on a Familiar ESIPT Fluorophore bearing AIE Characteristics" Chem. Commun. 2017, 53, 4791-4794.

72. Chen, X.†; Lim, C. S.†; Lee, D.†; Lee, S.; Park, S. J.; Kim, H. M.*; Yoon, J.* "Two-photon fluorescence sensors for imaging NMDA receptors and monitoring release of Zn2+ from the presynaptic terminal" Biosens. Bioelectron. 2017, 91, 770-779.

71. Agrawalla, B. K.; Lee, H. W.; Phue, W. H.; Raju, A.; Kim, J. J.; Kim, H. M.; Kang, N. Y.*; Chang, Y. T.* "Two-Photon Dye Cocktail for Dual-Color 3D Imaging of Pancreatic Beta and Alpha Cells in Live Islets" J. Am. Chem. Soc. 2017, 139, 3480-3487.

70. Kwon, N.†; Cho, M. K.†; Park, S. J.; Kim, D.; Nam, S. J.; Cui, L.; Kim, H. M.*; Yoon, J.* "Efficient Two-Photon Fluorescent Probe for Human NAD(P)H:Quinone Oxidoreductase (hNQO1) Detection and Imaging in Tumor Cells" Chem. Commun. 2017, 53, 525-528.

69. Joe, A.; Park, S. H.; Shim, K. D.; Kim, D. J.; Jhee, K. H.; Lee, H. W.; Heo, C. H.; Kim, H. M.; Jang, E. S.* "Antibacterial mechanism of ZnO nanoparticles under dark conditions" J. Ind. Eng. Chem. 2017, 45, 430-439.

68. Heo, C. H.; Cho, M. K.; Shin, S.; Yoo, T. H.*; Kim, H. M.* "Real-Time Monitoring of Vesicle pH in an Endocytic Pathway using an EGF-Conjugated Two-Photon Probe" Chem. Commun. 2016, 52, 14007-14010 (Invited in themed issue "Biological optical imaging"). 

67. Koo, J. Y.; Heo, C. H.; Shin, Y.-H.; Kim, D.; Lim, C. S.; Cho, B. R.; Kim, H. M.; Park, S. B.* "Readily Accessible and Predictable Naphthalene-Based Two-Photon Fluorophore with Full Visible-Color Coverage" Chem. Eur. J. 2016, 22, 14166-14170.

66. Baek, Y.; Park, S. J.; Zhou, X.*; Kim, G.; Kim, H. M.*; Yoon, J.* "A viscosity sensitive fluorescent dye for real-time monitoring of mitochondria transport in neurons" Biosens. Bioelectron. 2016, 86, 885-891.

65. Xu, Q.†; Heo, C. H.†; Kim, J. A.†; Lee, H. S.; Hu, Y.; Kim, D.; Swamy, K. M. K.; Kim, G.; Nam, S.; Kim, H. M.*; Yoon, J.* "A Selective Imidazoline-2-thione-Bearing Two-Photon Fluorescent Probe for Hypochlorous Acid in Mitochondria" Anal. Chem. 2016, 88, 6615-6620.

64. Heo, C. H.†; Sarkar, A. R.†; Baik, S. H.†; Jung, T. S.; Kim, J. J.; Kang, H.; Mook-J., I.*; Kim, H. M.* "A Quadrupolar Two-Photon Fluorescent Probe for In Vivo Imaging of Amyloid-β Plaques" Chem. Sci. 2016, 7, 4600-4606.

63. Park, S. J.; Lee, H. W.; Kim, H.; Kang, C.*; Kim, H. M.* "A Carboxylesterase-Selective Ratiometric Fluorescent Two-Photon Probe and Its Application to Hepatocytes and Liver Tissues" Chem. Sci. 2016, 7, 3703-3709.

62. Sarkar, A.R.†; Heo, C. H.†; Xu, L.; Lee, H. W.; Si, H. Y.; Byun, J. W.; Kim, H. M.* "A Ratiometric Two-Photon Probe for Quantitative Imaging of Mitochondrial pH Values" Chem. Sci. 2016, 7, 766-773.

61. Park, J.; Heo, C. H.; Kim, H. M.*; Hong, J. I.*, "Two-photon fluorescent probe for peroxynitrite" Tetrahedron Lett. 2016, 57, 715-718.

60. Choi, J.-A.; Jung, Y. S.; Kim, J. Y.; Kim, H. M.; Lim, I. K.* "Inhibition of breast cancer invasion by TIS21/BTG2/Pc3-Akt1-Sp1-Nox4 pathway targeting actin nucleators, mDia genes" Oncogene 2016, 35, 83-93.

59. Cha, S. H.; Choi, Y. R.; Heo, C. H.; Kang, S. J.; Joe, E. H.; Jou. I.; Kim, H. M.; Park, S. M.* "Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson's disease" Mol. Neurodegeneration 2015, 10, 63.

58. Pramanik, S.; Bhalla, V.; Kim, H. M.; Singh, H.; Lee, H. W.; Kumar, M.* "Hexaphenylbenzene Based AIEE Active Two Photon Probe for Detection of Hydrogen Sulfide with Tunable Self-assembly in Aqueous Media and Application in Live cell Imaging" Chem. Commun. 2015, 51, 15570-15573.

57. Choi, Y-M.; Kim, H-K.; Shim, W.; Anwar, M. A.; Kwon, J-W.; Kwon, H-K.; Kim, H. J.; Jeong, H.; Kim, H. M.; Hwang, D.; Kim, H. S.; Choi, S.* "Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation" PLoS ONE, 2015, 10, e0135083.

56. Singh, H.†; Lee, H. W.†; Heo, C. H.; Byun, J. W.; Sarkar, A. R.; Kim, H. M.* "A Golgi-localized two-photon probe for imaging zinc ions" Chem. Commun. 2015, 51, 12099-12102.

55. Kim, H. M.*; Cho, B. R.* "Small-Molecule Two-Photon Probes for Bioimaging Applications" Chem. Rev. 2015, 115, 5014-5055.

54. Hu, Y.; Heo, C. H.; Kim, G.; Jun, E. J.; Yin, J.; Kim, H. M.*; Yoon, J.* "One-Photon and Two-Photon Sensing of Biothiols Using a Bis-Pyrene-Cu(II) Ensemble and Its Application To Image GSH in the Cells and Tissues" Anal. Chem. 2015, 87, 3308-3313.

53. Xu, Q.†; Heo, C. H.†; Kim, G.; Lee, H. W.; Kim, H. M.*; Yoon, J.* "Development of Imidazoline-2-Thiones Based Two-Photon Fluorescence Probes for Imaging Hypochlorite Generation in a Co-Culture System" Angew. Chem. Int. Ed. 2015, 54, 4890-4894.

52. Sarkar, A. R.†; Heo, C. H.†; Kim, E.; Lee, H. W.; Singh, H.; Kim, J. J.; Kang, H.; Kang, C.*; Kim, H. M.* "A cysteamine-selective two-photon fluorescent probe for ratiometric bioimaging" Chem. Commun. 2015, 51, 2407-2410. 

51. Lee, H. W.†; Heo, C. H.†; Sen, D.; Byun, H.-O.; Kwak, I. H.; Yoon, G.*; Kim, H. M.* "Ratiometric Two-Photon Fluorescent Probe for Quantitative Detection of β Galactosidase Activity in Senescent Cells" Anal. Chem. 2014, 86, 10001-10005. 

50. Sarkar, A. R.†; Heo, C. H.†; Lee, H. W.; Park, K. H.; Suh, Y. H.; Kim, H. M.* "Red Emissive Two-Photon Probe for Real-Time Imaging of Mitochondria Trafficking" Anal. Chem. 2014, 86, 5638-5641.

49. Dong, X.†; Heo, C. H.†; Chen, S.; Kim, H. M.*; Liu, Z.* "Quinoline-Based Two-Photon Fluorescent Probe for Nitric Oxide in Live Cells and Tissues" Anal. Chem. 2014, 86, 308-311.

48. Sarkar, A. R.; Kang, D. E.; Kim, H. M.*; Cho, B. R.* "Two-photon Fluorescent Probes for Metal Ions in Live Tissues" Inorg. Chem. 2014, 53, 1794-1803 (Cover).

47. Sarkar, A. R.; Heo, C. H.; Park, M. Y.; Lee, H. W.; Kim, H. M.* "A small molecule two-photon fluorescent probe for intracellular sodium ions" Chem. Commun. 2014, 50, 1309-1312. 

46. Kim, H. J.†; Heo, C. H.†; Kim, H. M.* “Benzimidazole-Based Ratiometric Two-Photon Fluorescent Probes for Acidic pH in Live Cells and Tissues" J. Am. Chem. Soc. 2013, 135, 17969-17977.

45. Jung, H. J.; Sohn, W. Y.; Heo, C. H.; Kim, H. M.; Ishiuchi, S.; Fujii, M.; Kang, H.* “Gas-Phase Spectroscopy of Laser-Desorbed Acedan and Proline-Acedan” Bull. Korean Chem. Soc. 2013, 34, 2241-2242. 

44. Bae, S. K.†; Heo, C. H.†; Choi, D. J.†; Sen, D.; Cho, E. H.*; Cho, B. R.*; Kim, H. M.* “A Ratiometric Two-Photon Fluorescent Probe Reveals Reduction in Mitochondrial H2S Production in a Parkinson’s Disease Gene Knockout Astrocytes" J. Am. Chem. Soc. 2013, 135, 9915–9923.

43. Kim, H. M.*; Cho, B. R.* “Mitochondrial-Targeted Two-Photon Fluorescent Probes for Zinc Ions, H2O2, and Thiols in Living Tissues” Oxid. Med. Cell. Longev. 2013, 323619.

42. Heo, C. H.†; Kim, K. H.†; Kim, H. J.; Baik, S. H.; Song, H. D; Kim, Y. S.; Lee, J. W.; Mook-J., I.*; Kim, H. M.* “A two-photon fluorescent probe for amyloid-ß plaques in living mice" Chem. Commun. 2013, 49, 1303–1305.

41. Han, J. H.; Park, S. K.; Lim, C. S.; Park, M. K.; Kim, H. J.; Kim, H. M.*; Cho, B. R.* “Simultaneous Imaging of Mitochondria and Lysosomes by Using Two-Photon Fluorescent Probes" Chem. Eur. J. 2012, 18, 15246–15249.

40. Dong, X.; Han, J. H.; Heo, C. H.; Kim, H. M.*; Liu, Z.*; Cho, B. R.* “Dual-Color Imaging of Magnesium/Calcium Ion Activities with Two-Photon Fluorescent Probes" Anal. Chem. 2012, 84, 8110–8113.

39. Seo, E. W.†; Han, J. H.†; Heo, C. H.; Shin, J. H.; Kim, H. M.*; Cho, B. R.* “A Small-Molecule Two-Photon Probe for Nitric Oxide in Living Tissue" Chem. Eur. J. 2012, 18, 12388-12394.

38. Baek, N. Y.†; Heo, C. H.†; Lim, C. S.; Masanta, G.; Cho, B. R.*; Kim, H. M.* “A Highly Sensitive Two-Photon Fluorescent Probe for Mitochondrial Zinc Ions in Living Tissue" Chem. Commun. 2012, 48, 4546-4548 (Inside Cover).

37. Masanta, G.†; Heo, C. H.†; Lim, C. S.; Bae, S. K.; Cho, B. R.*; Kim, H. M.* “A Mitochondria-Localized Two-Photon Fluorescent Probe for Ratiometric Imaging of Hydrogen Peroxide in Live Tissue" Chem. Commun. 2012, 48, 3518-3520.

36. Kang, M. Y.†; Lim, C. S.†; Kim, H. S.; Seo, E. W.; Kim, H. M.*; Kwon, O. H.*; Cho, B. R.* “Detection of Nickel in Fish Organs with a Two-Photon Fluorescent Probe" Chem. Eur. J. 2012, 18, 1953-1960.

35. Lim, C. S.†; Chung, C.†; Kim, H. M.; An, M. J.; Tian, Y. S.; Chun, H. J.; Cho, B. R.* “A two-photon turn-on probe for glucose uptake" Chem. Commun. 2012, 48, 2122-2124.

34. Lim, C. S.; Masanta, G.; Kim, H. J.; Han, J. H.; Kim, H. M.*; Cho, B. R.* “Ratiometric Detection of Mitochondrial-Thiols with a Two-Photon Fluorescent Probe” J. Am. Chem. Soc. 2011, 133, 11132-11135.

33. Masanta, G.; Lim, C. S.; Kim, H. J.; Han, J. H.; Kim, H. M.*; Cho, B. R.* “A Mitochondrial-Targeted Two-Photon Probe for Zinc Ion” J. Am. Chem. Soc. 2011, 133, 5698-5700.

32. Lim, C. S.; Kim, H. J.; Lee, J. H.; Tian, Y. S.; Kim, C. H.; Kim, H. M.*; Joo, T.*; Cho, B. R.* “A Two-Photon Turn-On Probe for Lipid Rafts with Minimum Internalization” ChemBioChem 2011, 12, 392-395 (Cover). 

31. Kim, H. M.*; Cho, B. R.* "Two-Photon Fluorescent Probes for Metal Ions" Chem.-Asian J. 2011, 6, 58-69.

30. Kim, H. J.†; Han, J. H.†; Kim, M. K.; Lim, C. S.; Kim, H. M.*; Cho, B. R.* “Dual-Color Imaging of Sodium/Calcium Ion Activities with Two-Photon Fluorescent Probes” Angew. Chem. Int. Ed. 2010, 49, 6786-6789 (Hot Article).

29. Kim, M. K.†; Lim, C. S.†; Hong, J. T.; Han, J. H.; Jang, H.Y.; Kim, H. M.*; Cho, B. R.* “Sodium Ion Selective Two-Photon Fluorescent Probe for In Vivo Imaging” Angew. Chem. Int. Ed. 2010, 49, 364-367. 

28. Kim, H. M.; Seo, M. S.; Jeon, S.-J.; Cho, B. R. “Two-photon absorption properties of hexa-substituted benzene derivatives. Comparison between dipolar and octupolar molecules” Chem. Commun. 2009, 47, 7422-7424.

27. Tian, Y. S.; Lee, H. Y.; Lim, C. S.; Park, J.; Kim, H. M.; Shin, Y. N.; Kim, E. S.; Jeon, H. J.; Park, S. B.; Cho, B. R. “A Two-Photon Tracer for Glucose Uptake” Angew. Chem. Int. Ed. 2009, 48, 8027-8031.

26. Kim, H. M.; Cho, B. R. “Second-order nonlinear optical properties of octupolar molecules. Structure-property relationship” J. Mater. Chem. 2009, 19, 7402-7409.

25. Yi, J.-S.; Choo, H.-J.; Cho, B. R.; Kim, H. M.; Kim, Y.-N.; Ham, Y.-M.; Ko, Y.-G. “Ginsenoside Rh2 induces ligand-independent Fas activation via lipid raft disruption” Biochem. Biophys. Res. Commun. 2009, 385, 154-159.

24. Kim, H. M.; Cho, B. R. “Two-photon probes for intracellular free metal ions, acidic vesicles, and lipid rafts in live tissues” Acc. Chem. Res. 2009, 42, 863-872.

23. Kim, H. M.; Cho, B. R. “Two-photon materials with large two-photon cross sections. Structure-property relationship” Chem. Commun. 2009, 153-164.

22. Kim, H. M.; Kim, B. R.; Choo, H.-J.; Ko, Y.-G.; Jeon, S.-J.; Kim, C. H.; Joo, T.; Cho, B. R. “Two-photon fluorescent probes for lipid raft imaging: Effect of chain length” ChemBioChem 2008, 9, 2830-2838.

21. Kim, H. M.†; Lee, Y. O.†; Lim, C. S.; Kim, J. S.; Cho, B. R. “Two-photon absorption properties of alkynyl-conjugated pyrene derivatives” J. Org. Chem. 2008, 73, 5127-5130.

20. Kim, H. M.; Seo, M. S.; An, M. J.; Hong, J. H.; Tian, Y. S.; Choi, J. H.; Kwon, O.; Lee, K. J.; Cho, B. R. “Two-Photon Fluorescent Probes for Intracellular Free Zinc Ions in Live Tissue” Angew. Chem. Int. Ed. 2008, 47, 5167-5170.

19. Kim, H. M.; Jeong, B. H.; Hyon, J.-Y.; An, M. J.; Seo, M. S.; Hong, J. H.; Lee, K. J.; Kim, C. H.; Joo, T.; Hong, S.-C.; Cho, B. R. “Two-Photon Fluorescent Turn-On Probe for Lipid Rafts in Live Cell and Tissue” J. Am. Chem. Soc. 2008, 130, 4246-4247.

18. Kim, H. M.; An, M. J.; Hong, J. H.; Jeong, B. H.; Kwon, O.; Hyon, J.-Y.; Hong, S.-C.; Lee, K. J.; Cho, B. R. “Two-Photon Fluorescent Probes for the Acidic Vesicles in Live Cell and Tissue” Angew. Chem. Int. Ed. 2008, 47, 2231-2234.

17. Kim, H. M.; Kim, B. R.; An, M. J.; Hong, J. H.; Lee, K. J.; Cho, B. R. “Two-Photon Fluorescent Probes for Long-Term Imaging of Calcium Waves in Live Tissue” Chem. Eur. J. 2008, 14, 2075-2083.

16. Kim, H. M.; Kim, B. R.; Hong, J. H.; Park, J.-S.; Lee, K. J.; Cho, B. R. “A Two-Photon Fluorescent Probe for Calcium Waves in Live Tissue” Angew. Chem. Int. Ed. 2007, 46, 7445-7448.

15. Pyun, S. Y.; Seok, H. J.; Kim, J. C.; Kim, H. M.; Cho, B. R. “Ketene-Forming Elimination Reactions from Aryl Phenylacetates Promoted by R2NH in MeCN. Effects of Base-Solvent and beta Phenyl Group” J. Phys. Org. Chem. 2007, 20, 685-689.

14. Jeong, M.-Y.; Kim, H. M.; Jeon, S.-J.; Brasselet, S.; Cho, B. R. “Octupolar films with significant 2nd harmonic generation” Adv. Mater. 2007, 19, 2107-2111.

13. Kim, H. M.; Jung, C.; Kim, B. R.; Jung, S.-Y.; Hong, J. H.; Ko, Y.-G.; Lee, K. J.; Cho, B. R. “Environmentally Sensitive Two-Photon Probe for Intracellular Free Mg2+ Ions in Live Tissues” Angew. Chem. Int. Ed. 2007, 46, 3460-3463.

12. Kim, H. M.; Fang, X. Z.; Yang, P. R.; Yi, J.-S.; Ko, Y.-G.; Piao, M. J.; Chung, Y. D.; Park, Y. W.; Jeon, S.-J.; Cho, B. R. “Design of Molecular Two-Photon Probes for In Vivo Imaging. 2H-Benzo[h]chromene-2-one Derivatives” Tetrahedron Lett. 2007, 48, 2791-2795.

11. Kim, H. M.; Yang, P. R.; Seo, M. S.; Yi, J.-S.; Hong, J. H.; Jeon, S.-J.; Ko, Y.-G.; Lee, K. J.; Cho, B. R. “Magnesium Ion-Selective Two-Photon Fluorescent Probe Based on a Benzo[h]chromene Derivative for In vivo Imaging” J. Org. Chem. 2007, 72, 2088-2096.

10. Kim, H. M.; Choo, H.-J.; Jung, S.-Y.; Ko, Y.-G.; Park, W.-H.; Jeon, S.-J.; Kim, C. H.; Joo, T.; Cho, B. R. “A Two-Photon Fluorescent Probe for Lipid Rafts Imaging: C-Laurdan” ChemBioChem 2007, 8, 553-559.

9. Kim, J. S.; Kim, H. J.; Kim, H. M.; Kim, S. H.; Lee, J. W.; Kim, S. K.; Cho, B. R. “Metal Ion Sensing Novel Calix[4]crown Fluoroionophore with Two-Photon Absorption Property” J. Org. Chem. 2006, 71, 8016-8022.

8. Nam, J. R.; Kim, C. H.; Jeoung, S. C.; Lim, K. S.; Kim, H. M.; Jeon, S.-J.; Cho, B. R. “Measurement of two-photon absorption coefficient of dye molecules doped in polymer thin films based on ultrafast laser ablation” Chem. Phys. Lett. 2006, 427, 210-214.

7. Piao, M. J.; Chajara, K.; Yoon, S. J.; Kim, H. M.; Jeon, S.-J.; Kim, T.-H.; Song, K.; Asselberghs, I.; Persoons, A.; Clays, K.; Cho, B. R. “First hyperpolarizabilities of hexa(ethynyl)benzene derivatives: effect of conjugation length” J. Mater. Chem. 2006, 16, 2273-2281.

6. Lee, S. H.; Park, J. R.; Jeong, M.-Y.; Kim, H. M.; Li, S.; Song, J.; Ham, S.; Jeon, S.-J.; Cho, B. R. “First Hyperpolarizabilities of 1,3,5-Tricyanobenzene Derivatives: Origin of Larger β Value for the Octupoles than for the Dipoles” ChemPhysChem. 2006, 7, 206-212.

5. Kim, H. M.; Yang, W. J.; Kim, C. H.; Park, W.-H.; Jeon, S.-J.; Cho, B. R. “Two-Photon Dyes Containing Heterocyclic Rings with Enhanced Photostability” Chem. Eur. J. 2005, 11, 6386-6391. 

4. Ahn, H. C.; Yang, S. K.; Kim, H. M.; Li, S.; Jeon, S.-J.; Cho, B. R. “Molecular two-photon sensor for metal ions derived from bis(2-pyridylamine)” Chem. Phys. Lett. 2005, 410, 312-315.

3. Yang, W. J.; Kim, D. Y.; Jeong, M.-Y.; Kim, H. M.; Lee, Y. K.; Fang, X.; Jeon, S.-J.; Cho, B. R. “Two-photon absorption properties of 2,6-bis(styryl)anthracene derivatives. Effects of donor-acceptor substituents and pi-center” Chem. Eur. J. 2005, 11, 4191-4198.

2. Kim, H. M.; Jeong, M.-Y.; Ahn, H. C.; Jeon, S.-J.; Cho, B. R. “Two-photon sensor for metal ions derived from azacrown ether” J. Org. Chem. 2004, 69, 5749-5751.

1. Yang, W. J.; Kim, D. Y.; Jeong, M.-Y.; Kim, H. M.; Jeon, S.-J.; Cho, B. R. “2,6-Bis(styryl)anthracene derivatives with large two-photon cross-sections” Chem. Commun. 2003, 2618-2619.