Research publications

1. 1. Lee Y, Jo S, Lim MH, Hwang S, Jang S, Kim K, Yoon SJ, Sima J, Idda ML, Kim KM, Gorospe M, Park C, Noh JH. (2025 Aug) GRSF1 loss in THP-1 macrophages promotes senescence-associated transcription in neighboring fibroblasts. Sci Rep, 15(1):29851. doi: 10.1038/s41598-025-11385-0. 

1. 2. Koh D, Lee Y, Kim K, Jeon HB, Oh C, Hwang S, Lim M, Lee KP, Park Y, Yang YR, Kim YK, Shim D, Gorospe M, Noh JH#, Kim KM#. (2025 Jan) Reduced UPF1 levels in senescence impair nonsense-mediated mRNA decay. Commun Biol, 8(1):83. doi: 10.1038/s42003-025-07502-4. (BIOLOGY 분야 상위 7%)

1. 3.  Oh C, Mazan-Mamczarz K, Gorospe M, Noh JH#, Kim KM#. (2024 Nov) Impact of UPF2 on the levels of CD81 on extracellular vesicles. Front Cell Dev Biol, 12:1469080. doi: 10.3389/fcell.2024.1469080.

1. 4.  Kim CH, Lee WJ, Oh Y, Lee Y, Lee HK, Seong JB, Lim KS, Park SJ, Huh JW, Kim YH, Kim KM#, Hur JK#, Lee SH#. (2024 Feb) Utilization of nicking properties of CRISPR-Cas12a effector for genome editing. Sci Rep, 14(1):3352. doi: 10.1038/s41598-024-53648-2.

1. 5.  Yao Y, Ren Z, Yang R, Mei Y, Dai Y, Cheng Q, Xu C, Xu X, Wang S, Kim KM, Noh JH, Zhu J, Zhao N, Liu YU, Mao G, Sima J. (2022 Nov) Salidroside reduces neuropathology in Alzheimer's disease models by targeting NRF2/SIRT3 pathway. Cell Biosci, 12(1):180.

1. 6.   Kim KM*, Meng Q*, Perez de Acha O, Mustapic M, Cheng A, Eren E, Kundu G, Piao Y, Munk R, Wood III WH, De S, Noh JH, Delannoy M, Cheng L, Abdelmohsen K, Kapogiannis D, Gorospe M. (2020 Nov) Mitochondrial RNA in Alzheimer’s Disease Circulating Extracellular Vesicles. Front. Cell Dev. Biol, 8:581882. (*: equally contributed) (https://irp.nih.gov/blog/post/2021/02/alzheimer-s-patients-show-traces-of-cellular-batteries-in-blood)

1. 7. Pandey PR, Yang JH, Tsitsipatis D, Panda AC, Noh JH, Kim KM, Munk R, Nicholson T, Hanniford D, Argibay D, Yang X, Martindale JL, Chang MW, Jones SW, Hernando E, Sen P, De S, Abdelmohsen K, Gorospe M. (2020 Apr) circSamd4 represses myogenic transcriptional activity of PUR proteins. Nucleic Acids Res, 48(7):3789-3805.

1. 8. Casella G, Munk R, Kim KM, Piao Y, De S, Abdelmohsen K, Gorospe M. (2019 Aug) Transcriptome Signature of Cellular Senescence. Nucleic Acids Res, 47(14):7294-7305.

1. 9. Noh JH*, Kim KM*, Pandey PR, Noren Hooten N, Munk R, Kundu G, De S, Martindale JL, Yang X, Evans MK, Abdelmohsen K, Gorospe M. (2019 Mar) Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program. Nucleic Acids Res, 47(5):2472-2486. (*: equally contributed)

1. 10. Noh JH*, Kim KM*, Idda ML*, Martindale JL, Yang X, Abdelmohsen K, Gorospe M. (2018 Aug) GRSF1 suppresses cell senescence. Aging (Albany NY), 10:1856-1866. (*: equally contributed)

1. 11. Kim KM*#, Noh JH*, Bodogai M, Martindale JL, Pandey PR, Yang X, Biragyn A, Abdelmohsen K, Gorospe M. (2018 Jul) SCAMP4 enhances the senescent cell secretome. Genes and Development, 32(13-14):909-914. (*: equally contributed, #: Corresponding author).

1. 12. Kim KM*#, Noh JH*, Bodogai M, Martindale JL, Yang X, Indig FE, Basu SK, Ohnuma K, Morimoto C, Johnson PF, Biragyn A, Abdelmohsen K, Gorospe M. (2017 Sep) Identification of senescent cell surface targetable protein DPP4. Genes and Development, 31(15):1529-1534. (*: equally contributed, #: Corresponding author). 

1. 13. Park J, Park Y, Ryu I, Choi MH, Lee HJ, Oh N, Kim K, Kim KM, Choe J, Lee C, Baik JH, Kim YK. (2017 Jun) Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex. Nat Commun, 8:15730.  

1. 14. Abdelmohsen K, Panda AC, Munk R, Grammatikakis I, Dudekula DB, De S, Kim J, Noh JH, Kim KM, Martindale JL, Gorospe M. (2017 Mar) Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. RNA Biol, 14(3):361-369. 

1. 15. Panda AC, Grammatikakis I, Kim KM, De S, Martindale JL, Munk R, Yang X, Abdelmohsen K, Gorospe M. (2017 Apr) Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1. Nucleic Acids Res, 45(7):4021-4035. 

1. 16. Noh JH*, Kim KM*, Abdelmohsen K, Yoon JH, Panda AC, Munk R, Kim J, Curtis J, Moad CA, Wohler CM, Indig FE, de Paula W, Dudekula DB, De S, Piao Y, Yang X, Martindale JL, de Cabo R, Gorospe M. (2016 May) HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP. Genes and Development, 30(10):1224-39. (*: equally contributed). 

1. 17. Abdelmohsen K, Panda AC, De S, Grammatikakis I, Kim J, Ding J, Noh JH, Kim KM, Mattison JA, de Cabo R, Gorospe M. (2015 Nov) Circular RNAs in monkey muscle: age-dependent changes. Aging, 7(11):903-10. 

1. 18. Yoon JH, De S, Srikantan S, Abdelmohsen K, Grammatikakis I, Kim J, Kim KM, Noh JH, White EJ, Martindale JL, Yang X, Kang MJ, Wood WH 3rd, Noren Hooten N, Evans MK, Becker KG, Tripathi V, Prasanth KV, Wilson GM, Tuschl T, Ingolia NT, Hafner M, Gorospe M. (2014 Nov) PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity. Nat Commun, 5: 5248. 

1. 19. Cho H, Ahn SH, Kim KM, Kim YK. (2013 Jul) Non-structural protein 1 of influenza viruses inhibits rapid mRNA degradation mediated by double-stranded RNA-binding protein, staufen1. FEBS Lett, 587(14) 2118-24. 

1. 20. Choe J*, Kim KM*, Park S, Lee YK, Song OK, Kim MK, Lee BG, Song HK, Kim YK. (2013 Jan) Rapid degradation of replication-dependent histone mRNAs largely occurs on mRNAs bound by nuclear cap-binding proteins 80 and 20. Nucleic Acids Research, 41(2) 1307–1318. (*: equally contributed). 

1. 21. Kim KM*, Cho H*, Kim YK. (2012 Aug) The upstream open reading frame of cyclin-dependent kinase inhibitor 1A mRNA negatively regulates translation of the downstream main open reading frame. Biochem. Biophys. Res. Commun, 424(3) 469-475. (*: equally contributed).

1. 22. Cho H, Kim KM, Han S, Choe J, Park SG, Choi SS, Kim YK. (2012 May) Staufen1-Mediated mRNA Decay Functions in Adipogenesis. Molecular Cell, 46(4):495-506

1. 23. Kim KM*, Cho H*, Choi K*, Kim J, Kim BW, Ko YG, Jang SK, Kim YK. (2009 Sep) A new MIF4G domain-containing protein CTIF directs nuclear cap-binding protein CBP80/20-dependent translation. Genes and Development, 23:2033-2045. (*: equally contributed).

1. 24. Cho H*, Kim KM*, Kim YK. (2009 Jan) Human proline-rich nuclear receptor coregulatory protein 2 (PNRC2) mediates an interaction between mRNA surveillance machinery and decapping complex. Molecular Cell, 33(1), 75-86. (*: equally contributed).

1. 25. Oh N, Kim KM, Choe J, Kim YK. (2007 Oct) Pioneer round of translation mediated by nuclear cap-binding proteins CBP80/20 occurs during prolonged hypoxia. FEBS Lett, 581(26), 5158-5164.

1. 26. Oh N, Kim KM, Cho H, Choe J, Kim YK. (2007 Oct) Pioneer round of translation occurs during serum starvation. Biochem. Biophys. Res. Commun, 362(1), 145-151.

1. 27. Kim KM, Kwon SN, Kang JI, Lee SH, Jang SK, Ahn BY, Kim YK. (2007 May) Hepatitis C virus NS2 protein activates cellular cyclic AMP-dependent pathways. Biochem. Biophys. Res. Commun, 356(4):948-54.

1. 28. You KT, Li LS, Kim NG, Kang HJ, Koh KH, Chwae YJ, Kim KM, Kim YK, Park SM, Jang SK, Kim H. (2007 May) Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors. PLOS Biology, 5(5): e109.

1.     Koh D, Jeon HB, Oh C, Noh JH, Kim KM. (Sep 2023) RNA-binding proteins in cellular senescence. Mech Ageing Dev, 214:111853. doi: 10.1016/j.mad.2023.111853.

2.     Sung WJ, Kim D, Zhu A, Cho N, Yoo HM, Noh JH, Kim KM, Lee HS, Hong J. (Nov 2022) The lysosome as a novel therapeutic target of EGFR-mediated tumor inflammation. Front Pharmacol, 13:1050758.

3.     Oh C, Koh D, Jeon HB, Kim KM. (Sep 2022) The Role of Extracellular Vesicles in Senescence. Mol Cells, 45(9):603-609.

4.     Munk R*, Kim KM*, Gorospe M, Abdelmohsen K. (Jan 2019) Senescence lncRNAs govern cell surface components: lncRNA-OIS1 transcriptionally elevates DPP4 (Editorial). Non-coding RNA investigation, 3:6. (*: equally contributed)

5.     Noh JH, Kim KM, McClusky WG, Abdelmohsen K, Gorospe M. (Mar 2018) Cytoplasmic functions of long noncoding RNAs. Wiley Interdiscip Rev RNA, 9(3): e1471.

6.     Kim KM#, Abdelmohsen K, Mustapic M, Kapogiannis D, Gorospe M. (Jul 2017) RNA in extracellular vesicles. Wiley Interdiscip Rev RNA, 8(4): e1413. Review. (#: Corresponding author).

7.     Kim KM, Noh JH, Abdelmohsen K, Gorospe M. (Apr 2017) Mitochondrial noncoding RNA transport. BMB Rep, 50(4):164-174.

8.     Kim J, Kim KM, Noh JH, Yoon JH, Abdelmohsen K, Gorospe M. (Jan 2016) Long noncoding RNAs in diseases of aging. Biochim Biophys Acta, 1859(1):209-21.

Kim KM#, Noh J.H., Gorospe M. (2020) Senolysis and Senostasis Through the Plasma Membrane. In: Muñoz-Espin D., Demaria M. (eds) Senolytics in Disease, Ageing and Longevity. Healthy Ageing and Longevity, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-030-44903-2_7 (#: Corresponding author)