One of the effective ways to explore development is through the use of stem cell-derived cell types. However, these models still face challenges in terms of maturity, reproducibility, and accurately representing various cell types. Our objective is to address these limitations by building new models or improvising existing ones, with a particular emphasis on comprehending the role of supporting cells in the development and functionality of stem cell models. Through the application of advanced imaging techniques, organoid systems, and molecular profiling methods, this study aims to unravel the signaling pathways, paracrine factors, and physical interactions that occur between these cell types.

The process of determining a cell's fate is a complex phenomenon that entails intricate interactions among genetic factors, epigenetic modifications, and changes in genome organization. Our focus lies in comprehending the significance of chromatin regulators in governing cell fate decisions related to reprogramming, pluripotency, and differentiation. By studying these regulators, we aim to gain insights into the mechanisms underlying cellular identity and the potential for manipulating cell fate for various biomedical applications.