TEAM
PRINCIPAL INVESTIGATORS
EDWARD J. KELLY, PH.D
Dr. Kelly earned his PhD in Biochemistry from the University of Washington in the laboratory of Dr. Richard Palmiter, developing transgenic and knockout mouse models to study the function of the metal-binding protein metallothionein. Following a postdoctoral fellowship in molecular toxicology at the UW Department of Environmental Health with Dave Eaton, he ventured into Biotech, managing the Preclinical Bioanalytics group at Targeted Genetics Corporation, evaluating the safety and efficacy of gene therapies for diseases such as cystic fibrosis, rheumatoid arthritis and hemophilias. Upon his return to academia, his research interests have stayed within the realm of preclinical biology. Dr. Ed Kelly will lead the efforts for Aim 3 of the UW-TEC. His lab focuses on development of microphysiological systems as novel alternative methods to animal-based research. The focus of Aim 3 will be to characterize transporter expression in pediatric intestine utilizing a combination of primary tissues and stem cell-derived intestinal organoids.
Dr. Kelly holds the position of Associate Professor in the Department of Pharmaceutics, Adjunct Associate Professor in the Department of Environmental and Occupational Health Sciences and serves as Co-Director of the Pharmaceutical Bioengineering Extension Program.
CATHERINE YEUNG, PHARMD, PH.D
Cathy earned a PharmD from the University of Michigan, a PhD from the University of Washington (Medicinal Chemistry), and in an attempt to understand biostatistics, a MPH (Epidemiology) from the University of Washington School of Public Health. She completed postdoctoral fellowships in Pharmaceutical Chemistry and Pharmacokinetics before joining the faculty at the University of Washington School of Pharmacy. Her research is centered around making better medication choices for medically complex patients by personalizing dosing regimens and avoiding drug interactions. She has worked with the Kidney on a Chip team for the past decade and is currently funded by NASA to extend the longevity of the cells in the kidney chip with the future goal of using 3D cell models to understand and predict kidney injury associated with extended spaceflight. She enjoys running and climbing and still does not understand biostatistics.
GRADUATE STUDENTS
CHRIS ARIAN
PhD Candidate
Chris is from Cleveland, Ohio. His research involves developing and characterizing intestinal enteroids for use in drug absorption modeling. He likes to make Italian pasta sauce, bouldering, and his cat Chives.
ANISH MAHADEO
PhD Candidate
Anish earned his B.S. in biochemistry from USC in 2020. He uses kidney microphysiological systems to assess risk factors for chronic kidney disease of unknown etiology (CKDu). He loves spicy food, skiing and gaming.
BRAD HANSEN
PhD Candidate
Brad is a Toxicology PhD Student in the UW School of Public Health. He is co-advised with Dr. Elaine Faustman. He is interested in in-vitro models to study reproductive and developmental toxicity.
EIMEAR O'MAHONY
PhD Student
Eimear received her B.S. in genetics, cell biology, and development from the University of Minnesota in 2020. She spent two years as a clinical development scientist for a private pharmacogenomics company. Eimear is currently a pharmaceutics PhD student researching natural drug product interactions in the gut.
TIM TSANG
PhD Candidate
Tim graduated from University of California Los Angeles in 2019 with B.S. in chemistry. He is currently working on a PhD in Pharmaceutics The title of Tim's project is “The Regulation of Renal Transporters by Pregnancy Hormones and Pro-inflammatory Cytokine in Proximal Tubular Epithelial Cells”.
Yousif Abuhamad
Masters Student
Yousif received his B.S. in environmental and occupational health sciences and is working on his Masters in the same program with an emphasis on environmental toxicology at the University of Washington. The title of his thesis is: "Characterization of the Long-Term Toxic Response of Proximal Tubule Epithelial Cells in a Microphysiological System".
Kai Wang
Masters Student
Kai received his B.S. in biochemistry from Virginia Tech. He currently working at UW to achieve a Masters degree in pharmaceutics. His research project focuses on investigating the effect of cytokines on drug transporter regulation in human enterocytes.
RESEARCH SCIENTISTS
BROOKE CHALKER
Research Scientist
Brooke has her B.S. in cellular molecular biology from Cal Poly Humboldt. She also completed a year long internship as a stem cell researcher at the University of California Davis. Brooke now works on the kidney chip project and the intestinal organoid team.
UNDERGRADUATE STUDENTS
Mei Personius
Undergraduate Researcher
Mei is working hard to obtain a B.S. in chemical engineering, expected June 2025. Her goal in lab is to craft a collagen matrix aimed at enhancing the functionality of the kidney chips to emulate the characteristics of human kidneys.
Keemia Mohammadi
Undergraduate Researcher
Keemia is diligently working to receive a B.S. in chemical engineering. Her research project is to integrate kidney matrices into the kidney-on-a-chip to create a more biologically accurate model, while also maintaining its functional capabilities.
Ethan Zhu
Undergraduate Researcher
Ethan is tenaciously working on his B.S. in biochemistry. He work on the CNI project, which evaluates he toxicity of different calcineurin inhibitors on the human kidney using microphysiological systems (organ-on-a-chip).
Mahi Agarwal
Undergraduate Researcher
Mahi received her I.B. Diploma in 2022. She is now working towards her BS in Biology with an emphasis in Physiology, she is also minoring in Business Entrepreneurship here at UW. She is working on her research project which investigates avenues to derive M2 testicular resident macrophages in vitro.
Angela Zheng
Undergraduate Researcher
Angela is working towards her B.S. in Molecular, Cellular, and Developmental Biology. She is currently working on investigating the impact of ochratoxin-A on chronic kidney disease of unknown etiology. She is a coffee aficionado frequently spotted at local cafes.
Lab Alumni
Ying Long, Pharm.D
Undergraduate Researcher
Ying was a part of the Kelly Lab 2011-2012. After graduating from the University of Washington with her Bachelor's degree, Ying went on to earn her Pharm.D at the University of Southern California.
Brian Chapron, Pharm.D, Ph.D
Graduate Researcher
Brian earned his Ph.D in 2017. He did a pediatric clinical pharmacology fellowship at Children's Mercy Hospital in Kansas City, Missouri.
Malini Naidu
Undergraduate Researcher
Bio needed.
María Lόpez Suárez, M.S.
Graduate Researcher
Maria earned her Master's degree in 2013. Her thesis title was "Isolation, Propagation, and Characterization of Primary Human Renal Epithelial Cells.".
Kiera Sullivan
High School Volunteer
Kiera joined our lab in winter of 2015 as a junior in high school. In the fall of 2017, Kiera enrolled at UC Santa Barbara to pursue a major in Chemistry and Biochemistry with a concentration in Biochemistry. She then went to work in Dr. Thomas Weimbs lab.
Megan Corn
Undergraduate Volunteer
Megan graduated from Cal-Poly State University in San Luis Obispo where she majored in biology and minored in Spanish and biotechnology. She now attends medical school, serving as the president of the class of 2024 at University of North Dakota School of Medicine & Health Sciences.
Mariko Nakano, Ph.D
Collaborator
Mariko began collaborating with Dr. Kelly while working on her dissertation, titled “Biochemical Characterization of CYP4V2 and Its Role in the Retinal Disease Bietti’s Crystalline Dystrophy.”.
Oliver Parkinson
Graduate Researcher
Oliver Parkinson worked in collaboration with the Kelly Lab between 2007 and 2012 on the effects and metabolism of toxic furans in CYP4B1 null mice, demonstrating that CYP4B1 bioactivates ipomeanol and perilla ketone in vivo. After graduating from UW Oliver went on to become an internationally acclaimed circus performer.
Krystle Okialda-Chase, M.S.
Graduate Researcher
Krystle graduated with her Master's degree in 2012. Her thesis was titled "Screening for MicroRNA Regulators of an Orphan Cytochrome P450 4V2 (CYP4V2)." After graduating, she has worked in the biotech industry as a Manager of Talent Acquisition at AbbVie, overseeing recruitment for oncology R&D in the West Coast.
Wade Washington
GenOM-ALVA Undergraduate Researcher
Wade plans to major in physiology and minor in music as a pre-med undergraduate. Driven by his own experience in receiving a kidney transplant, he aspires to one day be a kidney transplant surgeon. Wade has also been playing the cello for 16 years.
Cate Lockhart, BFA, BS, Ph.D, PharmD, M.S.
Graduate Researcher
Cate earned her Ph.D in 2016. Her thesis title was "Function and Regulation of Cytochrome P450 4V2 and the Implications in Bietti's Crystalline Dystrophy." Following graduation, she became the Health Economics and Outcome Specialist at Omeros Corporation.
Jenna Voellinger, Ph.D
Graduate Researcher
Jenna joined the Kelly lab in 2009 as a PhD student and graduated in 2015. Her thesis is titled "Molecular and Cellular Characterization of Human Embryonic Stem Cell Derived Hepatocytes." Following graduation she took a position at Seattle Genetics as a Clinical Pharmacologist.
Elijah J. Weber, Ph.D
Graduate Researcher
Eli earned his Ph.D in 2018. His thesis was titled "Development of a Microphysiological Model of the Kidney Proximal Tubule and Application in Predictive Toxicity Testing of Polymyxin Antibiotics." Shortly after graduating, he started his position as a clinical pharmacologist at Gilead in Forest City, California.
Phoenix Chen
Undergraduate Student
Phoenix Chen graduated from the UW with a degree in Biochemistry. He is a Seattle native and loves going on runs in the summer around Green Lake. He can also solve a Rubik's cube in under a minute.
Jacelyn Bain
Undergraduate Researcher
Jacelyn Bain graduated from the University of Washington in 2021 with a degree in Bioengineering. Her favorite hobbies include reading, movie-going, and hiking.
Hadar Scharff, M.S.
Graduate Researcher
Hadar earned her Master's in Public Health in 2011. Her thesis title was "MicroRNA Regulation of Drug Metabolizing Enzymes, Including Ethical Implications for Pharmaceutical Research in Pregnant Women." She is currently a User Experience Researcher at Google.
Shirley Y. Chang, Ph.D
Research Scientist
Shirley is an international student who comes from Taiwan. She got her BS degree from Fu-Jen Catholic University, Taipei, Taiwan, and her MS degree from National Yang-Ming University, Taipei, Taiwan. Her academic background is in Biochemistry and Molecular Biology. As a student in the Toxicology PhD program, she contributes experiences related to the broad field of environmental health, including finding the etiology of environment-related diseases.
Tomoki Imaoka, Ph.D
Research Scientist
Tomoki was a visiting scientist from Japan. With an educational background in drug metabolism and pharmacokinetic research, he is exploring the applications of a microphysiological model of the human renal proximal tubule to evaluate and predict renal handling of drugs in humans. He also has strong interest in studying chemical toxicity related to environmental diseases.
Ranita S. Patel, M.D.
Pediatric Nephrologist, Research Fellow
Born and raised in Texas, Ranita completed her medical doctorate program at Texas Tech Health Sciences Center School of Medicine and residency program at the University of Texas at Austin's Dell Children's Medical Center. Upon finishing her pediatric nephrology fellowship with the University of Washington and Seattle Children's Hospital Division of Nephrology, she is continuing as a research fellow in the Kelly Lab.
Kirk P. Van Ness, Ph.D
Research Scientist
Kirk attended the University of Washington to earn both his MS in fisheries and Ph.D in toxicology. While working in the Kelly Lab, Kirk was engaged in the investigation of the implementation of microfluidic devices (organs-on-a-chip) to evaluate the toxicity and pharmacology of drugs and toxicants exposed to renal and hepatic cells growing in a 3D connective tissue matrix. Outside of lab, he is a Expert Toxicology Witness for the King County Department of Public Defense and Diplomate of the American Board of Toxicology.
Kevin A. Lidberg
Graduate Researcher
Kevin received his PhD in June of 2021. Kevin's work focused on utilizing a microphysiological model of the human renal proximal tubule to evaluate whether phosphorothioate backbone chemistry is a major determinate of antisense oligonucleotide-induced renal injury. Kevin was also interested in understanding how human serum components affect proximal tubule epithelial cell phenotype. Kevin currently holds a position at RayzeBio.
Francine Cesar, M.S.
Graduate Researcher
Francine earned her MS in 2021. Her Thesis is titled, "Development of a Cystic Fibrosis Microphysiologic Model of Glomerular Filtrate Reabsorption". Following graduation, she has taken a position as a Pharmacokinetic Scientist at Altasciences.
Virginia Vaenuku
GenOM-ALVA Undergraduate Researcher
Virginia Vaenuku graduated from Hudson’s Bay High School in Vancouver, WA in 2017. As a UW GenOM ALVA summer intern, Virginia tested the nephrotoxicity of an antibiotic, Gentamicin. As a pre-med student with interest in pediatrics, she hopes to also pursue research in drug-related nephrotoxicity in children.
Alenka Jaklic-Chapron, Ph.D
Graduate Researcher
Alenka graduated with her Ph.D in 2018. Her thesis was titled "Development and Characterization of Vascularized Proximal Tubule Microphysiological System as a Novel In Vitro Model for Renal Tubular Drug Secretion." She is currently a post-doctoral fellow at Children's Mercy Hospital in Kansas City, Missouri.
Efriem Bezabih
GenOM-ALVA Undergraduate Researcher
Bio needed.
Ria Mehrotra
Undergraduate Volunteer
Bio needed.
Sara Eyal, Ph.D
Visiting Scientist
Sara spent her post-doctoral fellowship with the Dept. of Pharmaceutics here at the University of Washington before she assumed her position at Hebrew University in Israel. She returned to Seattle in July 2018 to join the Kelly Lab for a "mini-sabbatical". During her stay, she assisted in vitamin-D related experiments with kidney-on-a-chips.
Mikias Woldetensae, B.S., B.A.
GenOM-ALVA Undergraduate Researcher
Mikias was in the Kelly Lab in 2011 as a GenOM-ALVA student. He is currently a Phlebotomist at Bloodworks Northwest.
Christina Kim
Undergraduate Volunteer
Christina is a lab technician for the Kelly Lab. She majored in Molecular, Cellular, and Developmental Biology, graduating from UW in 2018, and will be continuing her studies as a dental student at UW's School of Dentistry. Her work mainly consisted of recombinant protein expression and purification.
Pavan K. Bhatraju, M.D., MSc.
Acting Instructor, Pulmonary Fellow
Pavan is a physician in the Division of Pulmonary, Critical Care, and Sleep Medicine at the Department of Medicine; a member of the Kidney Research Institute; and acting instructor at the University of Washington.
Wei-Yang (Jeremy) Chen
Postdoctoral Researcher
Jeremy received his PhD in Pharmacology & Toxicology from University of Louisville in 2016, where he studied alcohol-induced gut-liver injury in alcoholic liver disease. He continued training as a postdoc in neuroscience and behavioral research in Center for Alcohol Research in Epigenetics (CARE) at the University of Illinois at Chicago before he joined Dr. Catherine Yeung’s lab in July 2020. Jeremy is interested in pharmacokinetic modeling and microphysiological system (MPS) in the application of drug metabolism and disposition research.
Mickey Ruiz
Undergraduate Researcher
Mickey intends to major in neurobiology and minor in global health. She hopes to become a neurosurgeon in the future. Her hobbies outside of lab and school include drawing, singing, and playing the ukulele. She is now doing a post-bac in pharmacology at the University of Washington.
Jade Yang
Research Scientist
Jade started as an Undergraduate Research Assistant and is now a Research Scientist in the Kelly lab. She graduated from the University of Washington in 2020 with a degree in Biochemistry.
Kendan Jones-Isaac
Graduate Researcher
Bio needed.
Roshni Sabhaya
Undergraduate Researcher
Mei is working hard to obtain a B.S. in chemical engineering, expected June 2025. Her goal in lab is to craft a collagen matrix aimed at enhancing the functionality of the kidney chips to emulate the characteristics of human kidneys.