PUBLICATIONS
2023
Molecular Mechanisms of OATP/ SLCO-mediated Organic Anion Clearance at the Blood-Cerebrospinal Fluid Barrier.
Sun A, Hagenbuch B, Kelly EJ & Wang J.
Molecular Pharmacology. doi: 10.1124/molpharm.123.000703. 2023. PMID: 37652713.
2022
Kidney microphysiological models for nephrotoxicity assessment.
Mahadeo, A., Yeung, C.K., Himmelfarb, J., Kelly, E.J.
Current Opinion in Toxicology. Jun:30: 100341. PMCID: 9053105.
View on NIH
Microphysiological systems in absorption, distribution, metabolism, and elimination sciences. Clinical and Translational Science.
Van Ness KP, Cesar F, Yeung CK, Himmelfarb J & Kelly EJ.
Clinical and Translational Science. 15(1): 9-42. 2022. PMID: 34378335.
Gutsy science: In vitro systems of the human intestine to model oral drug disposition.
Arian CM, Imaoka T, Yang J, Kelly EJ & Thummel KE.
Pharmacology & Therapeutics. doi: 10.3389/fphar.2021.695920. PMID: 34478775.
Serum protein exposure activates a core regulatory program driving human proximal tubule injury.
Lidberg KA, Muthusamy S, Adil M, Mahadeo A, Yang J, Patel RS, Wang L, Bammler TK, Reichel J, Yeung CK, Himmelfarb J, Kelly EJ & Akilesh S.
Journal of the American Society of Nephrology. doi: 10.1681/ASN.2021060751. 2022. PMID: 35197326
Authors' Reply: Serum Protein-induced Tubular Injury.
Lidberg KA, Himmelfarb J, Kelly EJ & Akilesh S.
Journal of the American Society of Nephrology. doi: 10.1681/ASN.2022060657. PMID: 35906085.
2021
Pharmacokinetics, metabolism and off-target effects in the rat of 8-[(1H- benzotriazol-1-yl)amino]octanoic acid, a selective inhibitor of human cytochrome P450 4Z1: β-oxidation as a potential augmenting pathway for inhibition.
Kowalski JP, Pelletier RD, McDonald MG, Kelly EJ & Rettie AE.
Xenobiotica. 51(8):901-915. 2021. PMID: 33993844.
Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease.
Lidberg, KA, Annalora, AJ, Jozic, M, Elson, DJ, Wang, L, Bammler, TK, Ramm, S, Monteiro, MB, Himmelfarb, J, Marcus, CB, Iversen, P & Kelly, EJ.
Scientific Reports. doi: 10.1038/s41598-021-84194-w. PMID: 33633318.
Kidney organoid and microphysiological kidney chip models to accelerate drug development and reduce animal testing.
Chen WY, Evangelista EA, Yang J, Kelly EJ & Yeung CK.
Frontiers in Pharmacology. doi: 10.3389/fphar.2021.695920. PMID: 34381363.
Bridging the gap between in silico and in vivo by modeling opioid disposition in a kidney proximal tubule microphysiological system.
Imaoka T, Huang W, Shum S, Hailey DW, Chang SY, Chapron A, Yeung CK, Himmelfarb J, Isoherranen N & Kelly EJ.
Scientific Reports. doi: 10.1038/s41598-021-00338-y. PMID: 34725352.
2020
Tissue Chips in Space-Challenges and Opportunities.
Yeung CK, Koenig P, Countryman S, Thummel KE, Kelly EJ.
Clinical and Translational Science, 2020, 13 (1), 31524321.
View on PubMed
Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling.
Sakolish, C, Chen, Z, Dalaijamts, C, Mitra, K, Liu, Y, Fulton, T, Wade, TL, Kelly, EJ, Rusyn, I & Chiu, WA.
Toxicology In Vitro, 2020, 63:104752, 31857146.
View on PubMed
An improved vascularized, dual-channel microphysiological system facilitates modeling of proximal tubular solute secretion.
Chapron, A, Chapron, BD, Hailey, DW, Chang, SY, Imaoka, T, Thummel, KE, Kelly, EJ, Himmelfarb, J, Shen, D & Yeung, CK.
ACS Pharmacology & Translational Science, 2020, 3 (3), 32566915.
View on PubMed
Transcriptomic profiling of PBDE-exposed HepaRG cells unveils critical lncRNA- PCG pairs involved in intermediary metabolism.
Zhang, A, Li, CY, Kelly, EJ, Sheppard, L & Cui, JY.
PLoS One, 2020, 15 (2), 32101552.
View on PubMed
Microphysiological system modeling of ochratoxin A-associated nephrotoxicity.
Imaoka, T, Yang, J, Wang, L, McDonald, MG, Afsharinejad, Z, Bammler, TK, Van Ness, K, Yeung, CK, Rettie, AE, Himmelfarb, J & Kelly, EJ.
Toxicology, 2020, 444:152582, 32905824.
View on PubMed
Characterization of differential tissue abundance of major non-CYP enzymes in human.
Basit, A, Neradugomma, NK, Wolford, C, Fan, PW, Murray, B, Takahashi, RH, Khojasteh, SC, Smith, BJ, Heyward, S, Totah, RA, Kelly, EJ & Prasad, B.
Molecular Pharmaceutics, 2020, 17 (11), 32955894.
View on PubMed
A multi compartment human kidney proximal tubule-on-a-chip replicates cell polarization-dependent cisplatin toxicity.
Nieskens, TTG, Persson, M, Kelly, EJ & Sjögren, AK.
Drug Metabolism and Disposition, 2020, doi: 10.1124/dmd.120.000098, 33020068.
View on PubMed
2019
A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda.
Patel, RC, Stalter, RM, Thomas, KK, Tamraz, B, Blue, SW, Erikson, DW, Kim, CJ, Kelly, EJ, Nanda, K, Kourtis, AP, Lingappa, JR, Mugo, N, Baeten, JM, Scarsi, KK; Partners PrEP Study Team.
AIDS, 2019, 33 (13), 31306173.
View on PubMed
Mechanisms of CYP3A Induction During Pregnancy: Studies in HepaRG Cells.
Sachar, M, Kelly, EJ & Unadkat, JD.
The AAPS Journal, 2019, 21 (3), 30919109.
View on PubMed
Translational Assessment of Drug-Induced Proximal Tubule Injury Using a Kidney Microphysiological System.
Maass, C, Sorensen, NB, Himmelfarb, J, Kelly, EJ, Stokes, CL & Cirit, M.
CPT Pharmacometrics Systems Pharmacology, 2019, 8 (5), 30869201.
View on PubMed
2018
Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity.
Weber EJ, Lidberg KA, Wang L, Bammler TK, MacDonald JW, Li MJ, Redhair M, Atkins WM, Tran C, Hines KM, Herron J, Xu L, Monteiro MB, Ramm S, Vaidya V, Vaara M, Vaara T, Himmelfarb J, Kelly EJ.
The Journal of Clinical Investigation Insight, 2018, 3 (24), e123673.
Reconstructing the human renal vascular-tubular unit in vitro.
Rayner SG, Phong KT, Xue J, Lih D, Shankland SJ, Kelly EJ, Himmelfarb J, Zheng Y.
Advanced Healthcare Materials, 2018, 7 (23), e1801120.
View on PubMed
A high-throughput screen identifies DYRK1A inhibitor ID-8 that stimulates human kidney tubular epithelial cell proliferation.
Monteiro MB, Ramm S, Chandrasekaran V, Boswell SA, Weber EJ, Lidberg KA, Kelly EJ, Vaidya VS.
Journal of the American Society of Nephrology, 2018, 29 (12), 2820-2833.
View on PubMed
Technology transfer of the microphysiological systems: A case study of the human proximal tubule tissue chip.
Sakolish C, Weber EJ, Kelly EJ, Himmelfarb J, Mouneimne R, Grimm FA, House JS, Wade T, Han A, Chiu WA, Rusyn I.
Scientific Reports, 2018, 8 (1), 14882.
View on PubMed
Emerging kidney models to investigate metabolism, transport, and toxicity of drugs and xenobiotics.
Bajaj P, Chowdhury SK, Yucha R, Kelly EJ, Xiao G.
Drug Metabolism and Disposition, 2018, 46 (11), 1692-1702.
View on PubMed
Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system.
Chapron BD, Chapron A, Phillips B, Okoli MC, Shen DD, Kelly EJ, Himmelfarb J, Thummel KE.
Alternatives to Animal Experimentation, 2018, 35 (4), 504-515.
View on PubMed
Longitudinal characterisation of function and structure of Bietti crystalline dystrophy: report on a novel homozygous mutation in CYP4V2.
Lockhart CM, Smith TB, Yang P, Naidu M, Rettie AE, Nath A, Weleber R, Kelly EJ.
British Journal of Ophthalmology, 2018, 102 (2), 187-194.
View on PubMed
2017
Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity.
Chang SY, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquiest TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL.
The Journal of Clinical Investigation Insight, 2017, 2 (22), e95978.
View on PubMed
Concise Review: Current and emerging biomarkers of nephrotoxicity.
Weber EJ, Himmelfarb J, Kelly EJ.
Current Opinion in Toxicology, 2017, 4, 16-21.
View on PubMed
Microphysiological systems to assess nonclinical toxicity.
Van Ness KP, Chang SY, Weber EJ, Zumpano D, Eaton DL, Kelly EJ.
Current Protocols in Toxicology, 2017, 73 (1), 11.23.1-22.5.22.
View on PubMed
Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity.
Chang SY, Voellinger JL, Van Ness KP, Chapron B, Shaffer RM, Neumann T, White CC, Kavanagh TJ, Kelly EJ, Eaton DL.
Toxicology In Vitro, 2017, 40, 170-183.
View on PubMed
Functional coupling of human microphysiology systems: Intestine, liver, kidney proximal tubule, blood-brain barrier and skeletal muscle.
Vernetti L, Gough A, Baetz N, Blutt S, Broughman JR, Brown JA, Foulke-Abel J, Hasan N, In J, Kelly E, Kovbasnjuk O, Repper J, Senutovitch N, Stabb J, Yeung C, Zachos NC, Donowitz M, Estes M, Himmelfarb J, Truskey G, Wikswo JP, Taylor DL.
Scientific Reports, 2017, 8 (7), 42296.
View on PubMed
2016
Abundance of drug transporters in the human kidney cortex as quantified by quantitative targeted proteomics.
Bhagwat Prasad, Katherine Johnson, Sarah Billington, Caroline Lee, Git W Chung, Colin D A Brown, Edward J Kelly, Jonathan Himmelfarb, Jashvant D Unadkat
Drug Metabolism and Disposition, 2016, 44 (12), 1920-1924.
View on PubMed
Transporter expression in liver tissue from subjects with alcoholic or hepatitis C cirrhosis quantified by targeted quantitative proteomics.
Wang L, Collins C, Kelly EJ, Chu,X, Ray AS, Salphati L, Xiao G, Lee C, Lai Y, Liao,M, Mathias A, Evers R, Humphreys G, Hop CE, Kumer SC, Unadkat JD.
Drug Metabolism and Disposition, 2016, 44 (11), 1752-1758.
View on PubMed
Development of a microphysiological model of human kidney proximal tubule function.
Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura,Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski,KA, Himmelfarb J, Kelly EJ.
Kidney International, 2016, 90 (3), 627-637. (Article featured on journal cover)
View on PubMed
Liver and kidney on chips: Microphysiological models to understand transporter function.
Chang SY, Weber EJ, Ness KV, Eaton DL, Kelly EJ.
Clinical Pharmacology and Therapeutics, 2016, 100 (5), 464-478.
View on PubMed
Pharmacokinetics of metoprolol during pregnancy and lactation.
Ryu RJ, Eyal S, Easterling,TR, Caritis SN, Venkataraman R, Hankins G, Rytting E, Thummel K, Kelly EJ, Risler L, Phillips B, Honaker MT, Shen DD, Hebert MF.
Journal of Clinical Pharmacology, 2016, 56 (5), 581-589.
View on PubMed
Species differences in microsomal oxidation and glucuronidation of 4-ipomeanol: Relationship to target organ toxicity.
Parkinson OT, Teitelbaum AM, Whittington D, Kelly EJ, Rettie AE.
Drug Metabolism and Disposition, 2016, 44 (10), 1598-1602.
View on PubMed
A quantitative approach to screen for nephrotoxic compounds in vitro.
Adler M, Ramm S, Hafner M, Muhlich JL, Gottwald EM, Weber E, Jaklic A, Ajay AK, Svoboda D, Auerbach S, Kelly EJ, Himmelfarb J, Vaidya VS.
Journal of the American Society of Nephrology, 2016, 27(4), 1015-1028.
View on PubMed
Pharmacogenetic profiling and metabolic activity of human embryonic stem cell derived hepatocytes: focus on CYP450-mediated oxidation.
Voellinger JL, Kelly EJ.
ADMET and DMPK, 2016, 4(2), 62-83.
View on IAPChem
2015
Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol.
Wiek C, Schmidt EM, Röllecke K, Nakano M, Kelly EJ, Kaisers W, Yarov-Yarovoy V, Rettie AE, Hanenberg H.
Biochemical Journal, 2015, 465 (1), 103-114. 2015.
2014
Identification of CYP3A7 for glyburide metabolism in human fetal livers.
Shuster DL, Risler LJ, Prasad B, Calamia JC, Voellinger JL, Kelly EJ, Unadkat, JD, Hebert MF, Shen,DD, Thummel KE, Mao Q.
Biochemical Pharmacology, 2014, 92 (4), 690-700. 2014.
View on PubMed
Generation and characterization of a murine model of Bietti Crystalline Dystrophy.
Lockhart CM, Nakano M, Rettie AE, Kelly EJ.
Investigative Ophthalmology & Visual Science, 2014, 55 (9), 5572-5581.
View on PubMed
Ocular cytochrome P450s and transporters: roles in disease and endobiotic and xenobiotic disposition.
Nakano M, Lockhart CM, Kelly EJ, Rettie AE.
Drug Metabolism Reviews, 2014, 46 (3), 247-260.
View on PubMed
2013
Innovations in preclinical biology: ex vivo engineering of a human kidney tissue microperfusion system.
Kelly EJ, Wang Z, Voellinger JL, Yeung CK, Shen DD, Thummel KE, Zheng Y, Ligresti G, Eaton DL, Muczynski KA, Duffield JS, Neumann T, Tourovskaia A, Fauver M, Kramer G, Asp E, Himmelfarb J.
Stem Cell Research & Therapy, 2013, 4 (1), S17.
View on PubMed
Effect of gestational age on mRNA and protein expression of polyspecific organic cation transporters during pregnancy.
Lee N, Hebert MF, Prasad B, Easterling TR, Kelly EJ, Unadkat JD, Wang J.
Drug Metabolism and Disposition, 2013, 41 (12), 2225-2232.
View on PubMed
Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of ipomeanol.
Parkinson OT, Liggitt HD, Rettie AE, Kelly EJ.
Toxicological Sciences, 2013, 134 (2), 243-250.
View on PubMed