Research

We are interested in probing and better understanding the electrode/solution interface. Toward this goal, we develop new method to study the transient behavior of single molecules and nanoparticles. We also like to design, fabricate, and test new biosensors that address interesting biological problems. For example, our microelectrodes allow us to detect and quantify neurotransmitters secreted from single neurons.

Electrochemistry of Single Nanoparticles

nanoparticle collision (Silver, platinum, gold, etc.):

We have been studying the transient collision and oxidation of Ag nanoparticles and reported an interesting multi-peak collision behavior. Our results suggest that the particles undergo repeated collision and oxidation prior to their full oxidation or departure from the electrode surface.
https://pubs.acs.org/doi/full/10.1021/jacs.6b11143

Surface nanobubbles

Single-molecule fluorescence imaging

We have been interested in probing the nucleation and growth of H2 and O2 nanobubbles on an electrode using highly sensitive fluorescence methods.
https://www.pnas.org/doi/abs/10.1073/pnas.1800945115

Biosensors

Electrochemical biosensors

We like developing new sensors that are sensitive for single entities (viruses, exosomes, proteins, etc.). Here's an example of how we use glass nanopipette and carbon-fiber microelectrode to detect single redox-containing liposomes.
https://pubs.acs.org/doi/10.1021/acs.analchem.0c01993

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