Research

In the context of human cancer biology, the intricate relationship between cell growth, function, and their impact on proliferation significantly influences disease progression. At the heart of this process lies the pivotal role of a family of genes known as Lymphocyte Antigen-6 (Ly6), whose involvement in cancer holds immense therapeutic potential. Our research delves into understanding Ly6's contributions to cancer development and  transforming growth factor-β (TGF-β) signaling, which aids in the development of innovative approaches such as antibodies, novel chimeric antigen receptor-T cells (CAR-T) and small molecule-based therapies. By elucidating the interplay between Ly6 genes and tumorigenesis, we aim to pave the way for novel therapeutic interventions. Additionally, our investigation extends to the realm of extracellular vesicles (EVs), shedding light on their role as mediators in cancer cell communication and their application in advancing cancer treatments and diagnostic capabilities.