Eleftheria Hatzimichael, MD, PhD
Associate Professor of Haematology
Faculty of Medicine, School of Health Sciences, University of Ioannina
Short CV
Eleftheria Hatzimichael, MD, PhD (born 1975) is a Haematologist, with a strong background and research activities in epigenetics and translational research. and currently an Associate Professor of Haematology, in the Faculty of Medicine, School of Health Sciences, University of Ioannina Greece. She graduated from the School of Medicine, University of Ioannina in 1998 and was trained in Haematology at St. Bartholomew’s Hospital, Barts and the London Trust, London, UK and the University Hospital of Ioannina, Ioannina, Greece. For her achievements on 2011, she was awarded a prestigious early-carrier one-year fellowship from the Hellenic Society of Haematology Foundation to work with Dr Isidore Rigoutsos as a Visiting Scientist at the Computational Medicine Centre, Jefferson Medical College, Thomas Jefferson University, US, in the field of the non-coding human genome by computational and experimental approaches. She has also received the prestigious Clinical Research Training in Haematology award 2016-2017 by the European Haematology Association, 9-month-long unique training and mentoring experience focused on clinical research in Europe, with a global scope.
She is the PI of more than 30 Phase II-IV clinical trials and has served as a subinvestigator in more than 25 phase I-III clinical trials and as a reviewer for more than 27 journals. She is a member of the Associate Editorial Board of the American Journal of Blood Research and member of the Editorial Board of Diseases (section Oncology), Associate Editor in Frontiers in Medicine (section Hematology) and a member of the Hellenic Society of Haematology, the Greek Myeloma Study Group (GMSG), The Greek (Hellenic) MDS Group, the American Society of Hematology, the European Cancer Research Association, and the European Haematology Association. She is also the Secretary of the Steering Committee of the Scientific Department of Myelodysplastic Syndromes and Marrow Failure of the Hellenic Society of Hematology, 2022-2023, 2024-2025, and a Member of the Board of Directors of the Hellenic Society of Hematology, 2022-2024.
She has more than 130 papers in peer-reviewed journals with an h-index of 32 (source Scopus).
Medical education
1992-1998 Medical School of Ioannina, University of Ioannina, Ioannina, Greece
Jul 1998 Medical License 9894/ 27-7-1998
Dec 2008 PhD, Medical School of Ioannina, University of Ioannina, Greece
Title of thesis: “Study of the expression and clinical significance of cyclins and the methylation status of cyclin inhibitors in hematological malignancies”
Education relevant to clinical research
16th ECCO-AACR-EORTC-ESMO Workshop on Methods in Clinical Cancer Research, Flims, Switzerland, 21 - 27 June 2014 (Accepted after assessment)
Clinical Research Training in Haematology 2016-2017, European Haematology Association
ICH GCP E6 (R2) The global health network 28/02/2023
Publications
Dimitriadis, S.; Dova, L.; Kotsianidis, I.; Hatzimichael, E.; Kapsali, E.; Markopoulos, G.S. Imaging Flow Cytometry: Development, Present Applications, and Future Challenges. Methods Protoc.2024,7,28. https://doi.org/ 10.3390/mps7020028
Papoudou-Bai, A.; Koumpis, E.; Karpathiou, G.; Hatzimichael, E*.; Kanavaros, P*. Expression Patterns of GATA3 in Classical Hodgkin Lymphoma: A Clinico-Pathological Study. Diseases 2024, 12, 51. https://doi.org/10.3390/diseases12030051, * equal contribution
Georgoulis V, Koumpis E, Hatzimichael E. The Role of Non-Coding RNAs in Myelodysplastic Neoplasms. Cancers (Basel). 2023 Sep 30;15(19):4810. doi: 10.3390/cancers15194810. PMID: 37835504
Vassilakopoulos TP, Piperidou A, Mellios Z, Verigou E, Katodritou E, Kalpadakis C, Papageorgiou SG, Chatzidimitriou C, Prassopoulos V, Siakantaris MP, Giatra H, Karantanis D, Papathanasiou N, Ligdi L, Kopsaftopoulou A, Leonidopoulou T, Xanthopoulos V, Karakatsanis S, Vrakidou E, Chatziioannou S, Drougkas D, Hatzimichael E, Gainaru G, Palassopoulou M, Tsirogianni M, Kotsopoulou M, Tsourouflis G, Skoura E, Mainta C, Terpos E, Poziopoulos C, Triantafyllou T, Zikos P, Koumarianou A, Liapi D, Pappa V, Verrou E, Tsirigotis P, Labropoulou V, Papadaki H, Datseris I, Symeonidis A, Bouzani M, Bakiri M, Karmiris T, Angelopoulou MK, Rondogianni P. PET for Response Assessment to R-da-EPOCH in Primary Mediastinal Large B-cell lymphoma: Who Is Worthy to be Irradiated? Hemasphere. 2023 Nov 7;7(11):e965. PMID: 38027423
Bouchla A, Papageorgiou SG, Symeonidis A, Sakellari I, Zikos P, Thomopoulos TP, Hatzimichael E, Galanopoulos A, Vyniou NA, Kotsianidis I, Pappa V. Evaluation of complete response to azacitidine according to the revised International Working Group 2023 response criteria for higher risk MDS. Does it make a difference in patients' outcome? Leukemia. 2023 Dec;37(12):2517-2519. doi: 10.1038/s41375-023-02051-3. Epub 2023 Oct 10.
Chatzikonstantinou T, Scarfò L, Karakatsoulis G, Minga E, Chamou D, Iacoboni G, Kotaskova J, Demosthenous C, Smolej L, Mulligan S, Alcoceba M, Al-Shemari S, Aurran-Schleinitz T, Bacchiarri F, Bellido M, Bijou F, Calleja A, Medina A, Khan MA, Cassin R, Chatzileontiadou S, Collado R, Christian A, Davis Z, Dimou M, Donaldson D, Santos GD, Dreta B, Efstathopoulou M, El-Ashwah S, Enrico A, Fresa A, Galimberti S, Galitzia A, García-Serra R, Gimeno E, González-Gascón-Y-Marín I, Gozzetti A, Guarente V, Guieze R, Gogia A, Gupta R, Harrop S, Hatzimichael E, Herishanu Y, Hernández-Rivas JÁ, Inchiappa L, Jaksic O, Janssen S, Kalicińska E, Kamel L, Karakus V, Kater AP, Kho B, Kislova M, Konstantinou E, Koren-Michowitz M, Kotsianidis I, Kreitman RJ, Labrador J, Lad D, Levin MD, Levy I, Longval T, Lopez-Garcia A, Marquet J, Martin-Rodríguez L, Maynadié M, Maslejova S, Mayor-Bastida C, Mihaljevic B, Milosevic I, Miras F, Moia R, Morawska M, Murru R, Nath UK, Navarro-Bailón A, Oliveira AC, Olivieri J, Oscier D, Panovska-Stavridis I, Papaioannou M, Papajík T, Kubova Z, Phumphukhieo P, Pierie C, Puiggros A, Rani L, Reda G, Rigolin GM, Ruchlemer R, Daniel de Deus Santos M, Schipani M, Schiwitz…Other malignancies in the history of CLL: an international multicenter study conducted by ERIC, the European Research Initiative on CLL, in HARMONY. EClinicalMedicine. 2023 Nov 15;65:102307. doi: 10.1016/j.eclinm.2023.102307. eCollection 2023 Nov.
Koumpis E, Kyriazopoulou L, Tigas S, Kapsali E, Hatzimichael E. (July 07, 2023) Central Diabetes Insipidus in a Patient With Lymphoma: A Case Report. Cureus 15(7): e41500. doi:10.7759/cureus.41500
Georgoulis V, Papoudou-Bai A, Makis A, Kanavaros P, Hatzimichael, Unraveling the Immune Microenvironment in Classic Hodgkin Lymphoma: Prognostic and Therapeutic Implications. Biology (Basel). 2023 Jun 15;12(6):862. doi: 10.3390/biology12060862.
Kanavos T, Birbas E, Papoudou-Bai A, Hatzimichael E, Kitsouli A, Karpathiou G, Kanavaros P. Primary Bone Lymphoma: A Review of the Literature with Emphasis on Histopathology and Histogenesis. Diseases. 2023 Mar 2;11(1):42. doi: 10.3390/diseases11010042.
Liapis K, Papadopoulos V, Pontikoglou C, Vrachiolias G, Stavroulaki E, Kourakli A, Lazaris V, Galanopoulos AG, Papoutselis M, Papageorgiou SG, Diamantopoulos PT, Pappa V, Viniou NA, Τsokanas D, Vassilakopoulos TP, Hatzimichael E, Bouronikou E, Ximeri M, Megalakaki A, Zikos P, Panayiotidis P, Dimou M, Karakatsanis S, Papaioannou M, Papadakis S, Vardi A, Kontopidou F, Harchalakis N, Adamopoulos I, Symeonidis A, Papadaki HA, Kotsianidis I. Myelodysplastic neoplasm with isolated thrombocytopenia and immune thrombocytopenic purpura in adults: insights from a comparison of two national registries. Leukemia. 2023 Mar;37(3):708-711. doi: 10.1038/s41375-023-01819-x. Epub 2023 Jan 16.
Diamantopoulos PT, Solomou E, Symeonidis A, Pappa V, Kotsianidis I, Galanopoulos A, Pontikoglou C, Anagnostopoulos A, Vassilopoulos G, Zikos P, Hatzimichael E, Papaioannou M, Megalakaki A, Vassilakopoulos T, Dimou M, Tsokanas D, Papoutselis MK, Papageorgiou S, Kourakli A, Papadaki H, Panayiotidis P, Viniou NA. The prognostic significance of macrocytosis in patients with myelodysplastic neoplasms. Am J Hematol. 2023 Feb 20. doi: 10.1002/ajh.26886. Online ahead of print.
Vassilakopoulos TP, Panitsas F, Mellios Z, Apostolidis J, Michael M, Gurion R, Ferhanoglu B, Hatzimichael E, Karakatsanis S, Dimou M, Kalpadakis C, Katodritou E, Leonidopoulou T, Kotsianidis I, Giatra H, Kanellias N, Sayyed A, Tadmor T, Akay OM, Angelopoulou MK, Horowitz N, Bakiri M, Pangalis GA, Panayiotidis P, Papageorgiou SG. Incidence and risk factors for central nervous system relapse in patients with primary mediastinal large b-cell lymphoma in the rituximab era. Hematol Oncol. 2022 Oct 31. doi: 10.1002/hon.3096
Diamantopoulos P, Charakopoulos E, Symeonidis A, Kotsianidis I, Viniou N-A, Pappa V, Pontikoglou Ch, Tsokanas D, Drakos G, Kourakli A, Solomou E, Hatzimichael E, Pouli A, Kotsopoulou M, Asmanis E, Dimou M, Panayiotidis P, Papageorgiou S, Vassilopoulos G, Anagnostopoulos A, Vassilakopoulos Th, Papadaki H, Galanopoulos G. Real world data on the prognostic significance of monocytopenia in myelodysplastic syndrome. Sci Rep. 2022 Oct 26;12(1):17914. doi: 10.1038/s41598-022-21933-7.
-----elected Associate Professor of Haematology
Georgoulis V, Haidich A-B, Bougioukas K, Hatzimichael E. Efficacy and safety of carfilzomib for the treatment of multiple myeloma: an overview of systematic reviews, Crit Rev Hematol Oncol https://doi.org/10.1016/j.critrevonc.2022.103842.
Hatzimichael E, Timotheatou D, Koumpis E, Benetatos L, Makis A. Luspatercept: A New Tool for the Treatment of Anemia Related to β-Thalassemia, Myelodysplastic Syndromes and Primary Myelofibrosis. Diseases 2022, 10, 85
Kyriazopoulou L, Karpathiou G, Hatzimichael E, Peoc'h M, Papoudou-Bai A, Kanavaros P. Autophagy and cellular senescence in classical Hodgkin lymphoma. Pathol Res Pract. 2022 Jun 1;236:153964. doi: 10.1016/j.prp.2022.153964
Karakatsanis SJ, Bouzani M, Symeonidis A, Angelopoulou MK, Papageorgiou SG, Michail M, Gainaru G, Kourti G, Sachanas S, Kalpadakis C, Katodritou E, Leonidopoulou T, Kotsianidis I, Hatzimichael E, Kotsopoulou M, Dimou M, Variamis E, Boutsis D, Kanellias N, Dimopoulou MN, Michali E, Karianakis G, Tsirkinidis P, Vadikolia C, Poziopoulos C, Pigaditou A, Vrakidou E, Economopoulos T, Kyriazopoulou L, Siakantaris MP, Kyrtsonis MC, Anargyrou K, Papaioannou M, Hatjiharissi E, Vervessou E, Tsirogianni M, Palassopoulou M, Stefanoudaki E, Zikos P, Tsirigotis P, Tsourouflis G, Assimakopoulou T, Verrou E, Papadaki H, Lampropoulou P, Dimopoulos MA, Pappa V, Konstantopoulos K, Karmiris T, Roussou P, Panayiotidis P, Pangalis GA, Vassilakopoulos TP; Hellenic Cooperative Lymphoma Group. Real-life Experience With Rituximab-CHOP Every 21 or 14 Days in Primary Mediastinal Large B-cell Lymphoma. In Vivo. 2022 May-Jun;36(3):1302-1315. doi: 10.21873/invivo.12831.
Barakos GP, Hatzimichael E. Microenvironmental Features Driving Immune Evasion in Myelodysplastic Syndromes and Acute Myeloid Leukemia. Diseases. 2022; 10(2):33. https://doi.org/10.3390/diseases10020033
Papakonstantinou I, Koumpis E, Fytsili E, Panteli A, Milionis H, Papoudou-Bai A, Kapsali E, Hatzimichael E. Leishmaniasis mimicking multiple myeloma. Int J Lab Hematol 2022 Feb;44(1):44-46. doi: 10.1111/ijlh.13667.
E. Tzavella, L. Gika, E. Hatzimichael, H. Milionis, E. Liberopoulos Severe thrombocytopenia in COVID-19: a case report. Journal of Atherosclerosis Prevention and Treatment, J Atherosclerosis Prev Treat. 2021 May-Aug;12(2):51-54 | doi:10.53590/japt.02.1023
Koumpis E, Tassi I, Malea T, Papathanasiou K, Papakonstantinou I, Serpanou A, Tsolas E, Kapsali E, Vassilakopoulos TP, Papoudou-Bai A, Hatzimichael E. CD56 expression in multiple myeloma: Correlation with poor prognostic markers but no effect on outcome. Pathol Res Pract. 2021 Jul 28;225:153567. doi: 10.1016/j.prp.2021.153567. Online ahead of print.
Makis A, Voskaridou E, Papassotiriou I, Hatzimichael E. Novel therapeutic advances in β-thalassemia. Biology (Basel) 2021 Jun 18;10(6):546
Papakonstantinou I, Kosmidou M, Papathanasiou K, Koumpis E, Kapsali E, Milionis H, Vassilakopoulos TP, Papoudou-Bai A, Hatzimichael E. Paraneoplastic Intrahepatic Cholestasis in Supradiaphragmatic Classical Hodgkin Lymphoma Successfully Treated With Brentuximab Vedotin: A Case Report and Review of the Literature. In Vivo. 2021 Jul-Aug;35(4):1951-1957. doi: 10.21873/invivo.12462.
Karakatsanis S; Hellenic Cooperative Lymphoma Group, Papageorgiou SG, Michail M, Angelopoulou MK, Kalpadakis C, Leonidopoulou T, Katodritou E, Kotsopoulou M, Kotsianidis I, Hatzimichael E, Lakiotaki E, Boutsis D, Karianakis G, Symeonidis A, Gavriatopoulou M, Panayiotidis P, Konstantopoulos K, Karmiris T, Pangalis GA, Vassilakopoulos TP. Subdiaphragmatic extranodal localizations at diagnosis of primary mediastinal large B-cell lymphoma: an impressive, rare presentation with no independent effect on prognosis. Leuk Res. 2021 Apr 24;107:106595. doi: 10.1016/j.leukres.2021.106595. Online ahead of print.
Koumpis Ε, Papathanasiou Κ, Papakonstantinou Ι, Tassi Ι, Serpanou Α, Kapsali Ε, Hatzimichael Ε. Rifampicin-induced thrombocytopenia: a case report and short review of the literature. EMJ. 2021; DOI/10.33590/emj/20-00193
Liapis K, Papadopoulos V, Vrachiolias G, Galanopoulos AG, Papoutselis M, Papageorgiou SG, Diamantopoulos PT, Pappa V, Viniou NA, Kourakli A, Τsokanas D, Vassilakopoulos TP, Hatzimichael E, Bouronikou E, Ximeri M, Pontikoglou C, Megalakaki A, Zikos P, Panayiotidis P, Dimou M, Karakatsanis S, Papaioannou M, Vardi A, Kontopidou F, Harchalakis N, Adamopoulos I, Symeonidis A, Kotsianidis I. Refinement of prognosis and the effect of azacitidine in intermediate-risk myelodysplastic syndromes. Blood Cancer J. 2021 Feb 11;11(2):30. doi: 10.1038/s41408-021-00424-4
Dimou M, Papageorgiou SG, Stavroyianni N, Katodritou E, Tsirogianni M, Kalpadakis C, Banti A, Arapaki M, Iliakis Th , Bouzani M, Verrou E, Spanoudakis E, Giannouli S, Marinakis Th, Mandala E, Mparmparousi D, Sachanas S, Dalekou-Tsolakou M, Hatzimichael E, Vadikolia Ch, Violaki V, Poziopoulos C, Tsirkinidis P, Chatzileontiadou S, Vervessou E, Ximeri M, Sioni A, Konstantinidou P, Kyrtsonis M-C, Siakantaris M, Angelopoulou MK, Pappa V, Konstantopoulos K, Panayiotidis P, Vassilakopoulos TP. Real-life experience with the combination of polatuzumab vedotin, rituximab, and bendamustine in aggressive B-cell lymphomas. Hematol Oncol 2021 Feb 13. doi: 10.1002/hon.2842. Online ahead of print.
Vassilakopoulos TP, Michail M, Papageorgiou S, Kourti G, Angelopoulou MK, Panitsas F, Sachanas S, Kalpadakis C, Katodritou E, Leonidopoulou T, Kotsianidis I, Hatzimichael E, Kotsopoulou M, Dimou M, Variamis E, Boutsis D, Terpos E, Dimopoulou MN, Karakatsanis S, Michali E, Karianakis G, Tsirkinidis P, Vadikolia C, Poziopoulos C, Pigaditou A, Vrakidou E, Economopoulos T, Kyriazopoulou L, Siakantaris MP, Kyrtsonis MC, Symeonidis A, Anargyrou K, Papaioannou M, Chatziharissi E, Vervessou E, Tsirogianni M, Palassopoulou M, Gainaru G, Stefanoudaki E, Zikos P, Tsirigotis P, Tsourouflis G, Assimakopoulou T, Konstantinidou P, Papadaki H, Megalakaki K, Dimopoulos MA, Pappa V, Karmiris T, Roussou P, Panayiotidis P, Konstantopoulos K, Pangalis GA. Identification of Very Low-Risk Subgroups of Patients with Primary Mediastinal Large B-Cell Lymphoma Treated with R-CHOP. Oncologist 2021 doi: 10.1002/onco.13789. Online ahead of print.
Vassilakopoulos TP, Papageorgiou SG, Angelopoulou MK, Chatziioannou S, Prassopoulos V, Karakatsanis S, Arapaki M, Mellios Z, Sachanas S, Kalpadakis C, Katodritou E, Leonidopoulou T, Kotsianidis I, Hatzimichael E, Kotsopoulou M, Dimou M, Variamis E, Boutsis D, Terpos E, Michali E, Karianakis G, Tsirkinidis P, Vadikolia C, Poziopoulos C, Pigaditou A, Vrakidou E, Siakantaris MP, Kyrtsonis MC, Symeonidis A, Anargyrou K, Papaioannou M, Chatziharissi E, Vervessou E, Tsirogianni M, Palassopoulou M, Gainaru G, Mainta C, Tsirigotis P, Assimakopoulou T, Konstantinidou P, Papadaki H, Dimopoulos MA, Pappa V, Karmiris T, Roussou P, Datseris I, Panayiotidis P, Konstantopoulos K, Pangalis GA, Rondogianni P. Positron emission tomography after response to rituximab-CHOP in primary mediastinal large B-cell lymphoma: impact on outcomes and radiotherapy strategies. Ann Hematol. 2021 Feb 1. doi: 10.1007/s00277-021-04421-2. Online ahead of print.
Papageorgiou S.G, Kotsianidis I., Bouchla A., Symeonidis A., Galanopoulos A., Viniou N-A, Hatzimichael E., Vassilakopoulos T.P, Gogos D., Megalakaki A., Zikos P., Diamantopoulos P., Kourakli A., Giannoulia P., Papoutselis M., Poulakidas E., Arapaki M., .Vardi A, Anagnostopoulos A., Mparmparousi D., Papaioannou M., Bouronikou E., Dimou M., Papadaki H., Panayiotidis P., Pappa V. Serum ferritin and ECOG performance status predict the response and improve the prognostic value of IPSS or IPSS-R in patients with high-risk myelodysplastic syndromes and oligoblastic acute myeloid leukemia treated with 5-azacytidine: a retrospective analysis of the Hellenic national registry of myelodysplastic and hypoplastic syndromes. Ther Adv Hematol. 2020 Dec 8;11 doi: 10.1177/2040620720966121
Vassilakopoulos TP, Piperidou A, Hadjiharissi E, Panteliadou AK, Panitsas F, Vassilopoulos I, Variamis E, Boutsis D, Michail M, Papageorgiou S, Tsourouflis G, Dimou M, Karakatsanis S, Kalpadakis C, Stavroyianni N, Katodritou E, Kotsopoulou M, Kotsianidis I, Verigou E, Hatzimichael E, Leonidopoulou T, Xanthopoulos V, Panayiotidis P, Konstantopoulos K, Dimopoulos MA, Karmiris T, Batsis I, Papaioannou M, Pangalis GA, Angelopoulou MK. Development of Classic Hodgkin Lymphoma after successful treatment of primary mediastinal large b-cell lymphoma: results from a well-defined database. Leuk Res. 2020 Nov 16;100:106479. doi: 10.1016/j.leukres.2020.106479. Online ahead of print.
Koumpis E, Florentin M, Hatzimichael E, Liamis G. Hyponatremia in Patients with Hematologic Diseases. J Clin Med. 2020 Nov 19;9(11):3721. doi: .3390/jcm9113721.PMID: 33228240
Pomoni A, Aggeli I, Loutsi E, Hatzimichael E, Chaliasos N, Makis A. Cyanosis Due to Methemoglobinemia as the Presenting Sign of Glucose-6-Phosphate Dehydrogenase Deficiency in a Child: Diagnostic and Clinical Implications. J Pediatr Hematol Oncol. 2020 Oct 7. doi: 10.1097/MPH.0000000000001967.
Hoeks M, Bagguley T, van Marrewijk C, Smith A, Bowen D, Culligan D, Kolade S, Symeonidis A, Garelius H, Spanoudakis M, Langemeijer S, Roelofs R, Wiegerinck E, Tatic A, Killick S, Panagiotidis P, Stanca O, Hellström-Lindberg E, Cermak J, van der Klauw M, Wouters H, van Kraaij M, Blijlevens N, Swinkels DW, de Witte T; EUMDS Registry Participants. Toxic iron species in lower-risk myelodysplastic syndrome patients: course of disease and effects on outcome. Leukemia. 2021 Jun;35(6):1745-1750. doi: 10.1038/s41375-020-01022-2. Epub 2020 Sep 18.
Prieto JC, Vallejo Casas JA, Hatzimichael E, Fotopoulos A, Kiortsis DN, Sioka C. The contribution of metabolic parameters of FDG PET/CT prior and during therapy of adult patients with lymphomas. Ann Nucl Med. 2020 Oct;34(10):707-717. doi: 10.1007/s12149-020-01521-3.
Diamantopoulos PT, Symeonidis A, Pappa V, Kotsianidis I, Galanopoulos A, Pontikoglou C, Anagnostopoulos A, Vassilopoulos G, Zikos P, Hatzimichael E, Papaioannou M, Megalakaki A, Repousis P, Kotsopoulou M, Dimou M, Solomou E, Dryllis G, Tsokanas D, Papoutselis MK, Papageorgiou S, Kyrtshonis MC, Kourakli A, Papadaki H, Panayiotidis P, Viniou NA. The effect of 5-azacytidine treatment delays and dose reductions on the prognosis of patients with myelodysplastic syndrome: how to optimize treatment results and outcomes. Br J Haematol. 2020 Aug 30. doi: 10.1111/bjh.17062. Online ahead of print.PMID: 3286244
Papadopoulos V, Diamantopoulos PT, Papageorgiou SG, Papoutselis M, Vrachiolias G, Pappa V, Galanopoulos AG, Vassilakopoulos TP, Hatzimichael E, Zikos P, Papadak HA, Bouchla A, Panayiotidis P, Megalakaki A, Papaioannou M, Liapis K. Dryllis G, Τsokanas D, Kourakli A, Symeonidis, A Viniou NA, Kotsianidis I. Estimated glomerular filtration rate independently predicts outcome of azacitidine therapy in higher-risk Myelodysplastic syndromes. Results from 536 patients of the Hellenic National Registry of Myelodysplastic and Hypoplastic Syndromes. Hematological Oncology 2020 Jun.
Diamantopoulos PT, Pappa V, Symeonidis A, Kotsianidis I, Galanopoulos A, Papadaki H, Anagnostopoulos A, Vassilopoulos G, Zikos P, Hatzimichael E, Papaioannou M, Megalakaki A, Kotsopoulou M, Repousis P, Dimou M, Solomou E, Pontikoglou C, Kyriakakis G, Tsokanas D, Papoutselis MK, Papageorgiou S, Kourakli A, Panayiotidis P, Viniou NA. Characteristics of Long-Term Survival in Patients with Myelodysplastic Syndrome Treated With 5-Azacyditine: Results From the Hellenic 5-Azacytidine Registry. Clin Lymphoma Myeloma Leuk. 2020 Feb;20(2):114-121.
Makis A, Georgiou I, Traeger-Synodinos J, Storino MR, Giuliano M, Andolfo I, Hatzimichael E, Chaliasos N, Giapros V, Izzo P, Iolascon A, Grosso M. A Novel εγδβ-Thalassemia Deletion Associated with Severe Anemia at Birth and a β-Thalassemia Intermedia Phenotype Later in Life in Three Generations of a Greek Family. Hemoglobin. 2019 Dec 12:1-4.
Papageorgiou SG, Kontos CK, Kotsianidis I, Karousi P, Symeonidis A, Galanopoulos A, Bouchla A, Hatzimichael E, Repousis P, Zikos P, Viniou NA, Poulakidas E, Vassilakopoulos TP, Diamantopoulos P, Mparmparousi D, Bouronikou E, Papadaki H, Panayiotidis P, Pappa V. Effectiveness of 5-Azacytidine in older patients with high-risk myelodysplastic syndromes and oligoblastic acute myeloid leukemia: A retrospective analysis of the Hellenic (Greek) MDS Study Group. J Geriatr Oncol. 2020 Jan;11(1):121-124
Diamantopoulos P, Koumbi D, Kotsianidis I, Pappa V, Symeonidis A, Galanopoulos A, Zikos P, Papadaki HA, Panayiotidis P, Dimou M, Hatzimichael E, Vassilopoulos G, Delimpasis S, Mparmparousi D, Papageorgiou S, Variami E, Kyrtsonis MC, Megalakaki A, Kotsopoulou M, Repousis P, Adamopoulos I, Kontopidou F, Christoulas D, Kourakli A, Tsokanas D, Konstantinos Papoutselis M, Kyriakakis G, Viniou NA; Hellenic MDS study group. The prognostic significance of chromosome 17 abnormalities in patients with myelodysplastic syndrome treated with 5-azacytidine: Results from the Hellenic 5-azacytidine registry. Cancer Med. 2019 May;8(5):2056-2063.
Tsolkas G, Komninou D, Briasoulis E, Hatzimichael E, Papanikolaou NA. A Novel Therapeutic Approach in Acute Promyelocytic Leukemia with All-trans retinoic Acid and Cyclin-dependent Kinase Inhibitors. Clin Cancer Drugs 2018;5: 50-59
Diamantopoulos PT, Kotsianidis I, Symeonidis A, Pappa V, Galanopoulos A, Gogos D, Karakatsanis S, Papadaki H, Palla A, Hatzimichael E, Dimou M, Papageorgiou S, Delimpasis S, Papaioannou M, Papoutselis M, Kourakli A, Tsokanas D, Anagnostopoulos A, Kontos CK, Panayiotidis P, Viniou NA; Hellenic MDS study group. Chronic myelomonocytic leukemia treated with 5-azacytidine - results from the Hellenic 5-Azacytidine Registry: proposal of a new risk stratification system. Leuk Lymphoma. 2018 Nov 14:1-10. [Epub ahead of print]
Papageorgiou SG, Kontos CK, Kotsianidis I, Vasilatou D, Symeonidis A, Galanopoulos A, Bouchla A, Hatzimichael E, Repousis P, Zikos P, Viniou NA, Poulakidas E, Vassilakopoulos TP, Diamantopoulos P, Diamantopoulos MA, Mparmparousi D, Bouronikou E, Papadaki H, Panayiotidis P, Pappa V. The outcome of patients with high-risk MDS achieving stable disease after treatment with 5-azacytidine: A retrospective analysis of the Hellenic (Greek) MDS Study Group. Hematol Oncol. 2018 Aug 20. doi: 10.1002/hon.2551. [Epub ahead of print]
Papageorgiou SG, Kotsianidis I, Kontos CK, Symeonidis A, Galanopoulos A, Hatzimichael E, Poulakidas E, Diamantopoulos P, Vassilakopoulos TP, Zikos P, Papadaki H, Bouronikou E, Panayiotidis P, Viniou NA, Pappa V. Body mass index and relative dose intensity does not affect the response and outcome of high-risk MDS patients treated with azacytidine. Results from the Hellenic (Greek) MDS study group. Leuk Res. 2018 Jul 7;71:55-59. doi: 10.1016/j.leukres.2018.07.004.
Katodritou E, Kyrtsonis MC, Delimpasi S, Kyriakou D, Symeonidis A, Spanoudakis E, Vasilopoulos G, Anagnostopoulos A, Kioumi A, Zikos P, Aktypi A, Briasoulis E, Megalakaki A, Repousis P, Adamopoulos I, Gogos D, Kotsopoulou M, Pappa V, Papadaki E, Fotiou D, Nikolaou E, Giannopoulou E, Hatzimichael E, Giannakoulas N, Douka V, Kokoviadou K, Timotheatou D, Terpos E. Real-world data on Len/Dex combination at second-line therapy of multiple myeloma: treatment at biochemical relapse is a significant prognostic factor for progression-free survival. Ann Hematol. 2018 Jun 26.
Tsirigotis P, Vassilakopoulos T, Batsis I, Bousiou Z, Gkirkas K, Sakellari I, Kaloyannidis P, Roussou P, Pangalis GA, Moschogiannis M, Vassilopoulos G, Repousis P, Megalakaki A, Michalis E, Kalpadakis C, Papadaki HA, Kotsianidis I, Hatzimichael E, Spyridonidis A, Anargyrou K, Poulakidas E, Giannoullia P, Apostolidis I, Stamouli M, Konstantopoulos K, Pappa V, Panayiotidis P, Harhalakis N, Anagnostopoulos A, Angelopoulou M. Positive impact of brentuximab vedotin on overall survival of patients with classical Hodgkin lymphoma who relapse or progress after autologous stem cell transplantation: A nationwide analysis. Hematol Oncol. 2018 Jun 8. doi: 10.1002/hon.2521.
Papageorgiou SG, Vasilatou D, Kontos CK, Kotsianidis I, Symeonidis A, Galanopoulos AG, Hatzimichael E, Megalakaki A, Poulakidas E, Diamantopoulos P, Vassilakopoulos TP, Zikos P, Papadaki H, Mparmparousi D, Bouronikou E, Panayiotidis P, Viniou NA, Pappa V. The prognostic value of monosomal karyotype (MK) in higher-risk patients with myelodysplastic syndromes treated with 5-Azacitidine: A retrospective analysis of the Hellenic (Greek) Myelodysplastic syndromes Study Group. Am J Hematol. 2018 Jul;93(7):895-901. doi: 10.1002/ajh.25111. Epub 2018 May 16.
Makis A, Gkoutsias A, Palianopoulos T, Pappa E, Papapetrou E, Tsaousi C, Hatzimichael E, Chaliasos N. Prognostic Factors for Immune Thrombocytopenia Outcome in Greek Children: A Retrospective Single-Centered Analysis. Adv Hematol. 2017:7878605
E. Hatzimichael, K. Papathanasiou, I. Zerdes, S. Flindris, A. Papoudou-Bai, E. Kapsali. Plasmablastic lymphoma with coexistence of chronic lymphocytic leukemia in an immunocompetent patient: A case report and mini-review. Case Rep Hematol 2017: 2861956
Zagouri F, Kastritis E, Zomas A, Terpos E, Katodritou E, Symeonidis A, Delimpasi S, Pouli A, Vassilakopoulos TP, Michalis E, Giannouli S, Kartasis Z, Christoforidou A, Kokoviadou K, Hatzimichael E, Gika D, Megalakaki C, Papaioannou M, Kyrtsonis MC, Konstantopoulos K, Dimopoulos MA; Greek Myeloma Study Group. Hypercalcemia remains an adverse prognostic factor for newly diagnosed multiple myeloma patients in the era of novel antimyeloma therapies. Eur J Haematol. 2017 Nov;99(5):409-414. doi: 10.1111/ejh.12923. Epub 2017 Sep 26.PMID: 2867576
-----elected Assistant Professor of Haematology
Tzavella E, Hatzimichael E, Kostara C, Bairaktari E, Elisaf M, Tsimihodimos V. Sitosterolemia: A multifaceted metabolic disorder with important clinical consequences. J Clin Lipidol. 2017 [Epub ahead of print]
Lambri E, Sainis I, Kounnis I, Mistelou A, Ioachim E, Hatzimichael E, Galani V, Briasoulis E. SLCO1B3 screening in colorectal cancer patients using High-Resolution Melting Analysis method and immunohistochemistry. Tumour Biol. 2017 Mar;39(3) DOI 10.1177/1010428317691176
Angelopoulou MK, Vassilakopoulos TP, Batsis I, Sakellari I, Gkirkas K, Pappa V, Giannoulia P, Apostolidis I, Apostolopoulos C, Roussou P, Panayiotidis P, Dimou M, Kyrtsonis MC, Palassopoulou M, Vassilopoulos G, Moschogiannis M, Kalpadakis C, Margaritis D, Spyridonidis A, Michalis E, Anargyrou K, Repousis P, Hatzimichael E, Bousiou Z, Poulakidas E, Grentzelias D, Harhalakis N, Pangalis GA, Anagnostopoulos A, Tsirigotis P. Brentuximab vedotin in relapsed/refractory Hodgkin lymphoma. The Hellenic experience. Hematol Oncol. 2017 Feb 20. doi: 10.1002/hon.2383. [Epub ahead of print]
Biziota E, Mavroiedis L, Hatzimichael E, Pappas P. Metronomic chemotherapy: A potent macerator of cancer by inducing angiogenesis suppression and antitumor immune activation. Cancer Lett 2016 (epub ahead of print).
Makis A, Hatzimichael E, Papassotiriou I, Voskaridou E. 2017 Clinical trials update in new treatments of β-thalassemia. Am J Hematol 2016 Nov;91(11):1135-1145
Papoudou-Bai A, Hatzimichael E, Barbouti A, Kanavaros P. Expression patterns of the activator protein-1 (AP-1) family members in lymphoid neoplasms. Clin Exp Med. 2016 Sep 6. [Epub ahead of print]
Hatzimichael E, Lagos K, Vassou A, Gougopoulou D, Papoudou-Bai A, Briasoulis E. Durable hematologic response to lenalidomide in a patient with isolated del(5q) MDS and JAK2V617F mutation despite discontinuation of treatment. Mol Clin Oncol, 2016; 5: 23-26
Hatzimichael E, Briasoulis E. Megaloblastic anemia presenting with skin hyperpigmentation. International Journal of Hematology, 2016; 103(5):479-80
Papoudou-Bai A, Hatzimichael E, Kyriazopoulou L, Briasoulis E, Kanavaros P. Rare variants in the spectrum of human herpesvirus 8/Epstein-Barr virus-copositive lymphoproliferations. Hum Pathol. 2015 Oct;46(10):1566-71.
Londin E, Loher P, Telonis AG, Quann K, Clark P, Jing Y, Hatzimichael E, Kirino Y, Honda S, Lally M, Ramratnam B, Comstock CE, Knudsen KE, Gomella L, Spaeth GL, Hark L, Katz LJ, Witkiewicz A, Rostami A, Jimenez SA, Hollingsworth MA, Yeh JJ, Shaw CA, McKenzie SE, Bray P, Nelson PT, Zupo S, Van Roosbroeck K, Keating MJ, Calin GA, Yeo C, Jimbo M, Cozzitorto J, Brody JR, Delgrosso K, Mattick JS, Fortina P, Rigoutsos I. Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAs. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1106-15
Hatzimichael E, Lagos K, Sim VR, Briasoulis E, Crook T. Epigenetics in diagnosis, prognostic assessment and treatment of cancer: an update. EXCLI Journal 2014;13:954-976
Primikyri A, Chatziathanasiadou MV, Karali E, Kostaras E, Mantzaris MD, Hatzimichael E, Shin JS, Chi SW, Briasoulis E, Kolettas E, Gerothanassis IP, Tzakos AG. Direct binding of bcl-2 family proteins by quercetin triggers its pro-apoptotic activity. ACS Chem Biol. 2014 Dec 19;9(12):2737-41.
Hatzimichael E, Tsolas E, Briasoulis E. Profile of pacritinib and its potential in the treatment of hematologic disorders. J Blood Med. 2014 Aug 19;5:143-52.
Benetatos L, Vartholomatos G, Hatzimichael E. DLK1-DIO3 imprinted cluster in induced pluripotency: landscape in the mist. Cell Mol Life Sci. 2014 Nov;71(22):4421-30.
Benetatos L, Hatzimichael E. Delta-Like Homologue 1 and Its Role in the Bone Marrow Niche and Hematologic Malignancies. Clin Lymphoma Myeloma Leuk. 2014 Dec;14(6):451-455.
Hatzimichael E, Syed N, Lo Nigro C, Rao B, Crook T. How detection of epigenetic alterations of blood-borne DNA could improve melanoma diagnosis. Expert Rev Mol Diagn. 2014 Jul;14(6):639-42.
Hatzimichael E, Syed N., Lo Nigro C, Crook T. A blood test to identify when melanoma metastasizes: a reality for melanoma management? Melanoma Management (2014) 1(1), 11–14
Kastritis E, Zagouri F, Symeonidis A, Roussou M, Sioni A, Pouli A, Delimpasi S, Katodritou E, Michalis E, Michael M, Hatzimichael E, Vassou A, Repousis P, Christophoridou A, Kartasis Z, Stefanoudaki E, Megalakaki C, Giannouli S, Kyrtsonis MC, Konstantopoulos K, Spyroupoulou-Vlachou M, Terpos E, Dimopoulos MA; Greek Myeloma Study Group. Preserved levels of uninvolved immunoglobulins are independently associated with favorable outcome in patients with symptomatic multiple myeloma. Leukemia. 2014 Oct;28(10):2075-9.
Londin ER, Hatzimichael E, Loher P, Edelstein L, Shaw C, Delgrosso K, Fortina P, Bray PF, McKenzie SE, Rigoutsos I. The human platelet: strong transcriptome correlations among individuals associate weakly with the platelet proteome. Biol Direct. 2014 Feb 14;9:3
Hatzimichael E, Briasoulis E. Metronomic chemotherapy beyond misconceptions. Haematologica. 2013 Nov;98(11):e145.
Benetatos L, Vartholomatos G, Hatzimichael E. Polycomb group proteins and MYC: the cancer connection. Cell Mol Life Sci. 2014 Jan;71(2):257-69.
Katodritou E, Vadikolia C, Lalagianni C, Kotsopoulou M, Papageorgiou G, Kyrtsonis MC, Matsouka P, Giannakoulas N, Kyriakou D, Karras G, Anagnostopoulos N, Michali E, Briasoulis E, Hatzimichael E, Spanoudakis E, Zikos P, Tsakiridou A, Tsionos K, Anargyrou K, Symeonidis A, Maniatis A, Terpos E. "Real-world" data on the efficacy and safety of lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma who were treated according to the standard clinical practice: a study of the Greek Myeloma Study Group. Ann Hematol. 2014 Jan;93(1):129-39
Makis A, Challa A, Hatzimichael E, Briasoulis E, Siamopoulou A, Chaliasos N. Adipocytokines are related to haemolytic and inflammatory biomarkers in sickle cell beta thalassaemia. Br J Haematol. 2013 Oct;163(1):142-4.
Hatzimichael E, Murray S, Briasoulis E. Absence of BRAF exon 15 mutations in multiple myeloma and Waldenström's macroglobulinemia questions its validity as a therapeutic target in plasma cell neoplasias. Am J Blood Res. 2013
Hatzimichael E, Crook T. Cancer epigenetics: new therapies and new challenges. J Drug Deliv. 2013;2013:529312
Lo Nigro C, Wang H, McHugh A, Lattanzio L, Matin R, Harwood C, Syed N, Hatzimichael E, Briasoulis E, Merlano M, Evans A, Thompson A, Leigh I, Fleming C, Inman GJ, Proby C, Crook T. Methylated tissue factor pathway inhibitor 2 (TFPI2) DNA in serum is a biomarker of metastatic melanoma. J Invest Dermatol. 2013 May;133(5):1278-85
Hatzimichael E, Georgiou G, Benetatos L, Briasoulis E. Gene mutations and molecularly targeted therapies in acute myeloid leukemia. Am J Blood Res. 2013;3(1):29-51
Syed N, Langer J, Janczar K, Singh P, Lo Nigro C, Lattanzio L, Coley HM, Hatzimichael E, Bomalaski J, Szlosarek P, Awad M, O'Neil K, Roncaroli F, Crook T. Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma. Cell Death Dis. 2013 Jan 17;4:e458
Froudarakis M*, Hatzimichael E*, Kyriazopoulou L, Lagos K, Pappas P, Tzakos AG, Karavasilis V, Daliani D, Papandreou C, Briasoulis E. Revisiting bleomycin from pathophysiology to safe clinical use. Crit Rev Oncol Hematol. 2013 Jul;87(1):90-100
*equal contribution
Dranitsaris G, Dorward K, Hatzimichael E, Amir E Clinical trial design in biosimilar drug development. Invest New Drugs. 2013 Apr;31(2):479-87.
Benetatos L, Voulgaris E, Vartholomatos G, Hatzimichael E. Non-coding RNAs and EZH2 interactions in cancer: long and short tales from the transcriptome. Int J Cancer. 2013 Jul 15;133(2):267-74
Hatzimichael E, Lo Nigro C, Lattanzio L, Syed N, Shah R, Dasoula A, Janczar K, Vivenza D, Monteverde M, Merlano M, Papoudou-Bai A, Bai M, Schmid P, Stebbing J, Bower M, Dyer MJ, Karran LE, ElguetaKarstegl C, Farrell PJ, Thompson A, Briasoulis E, Crook T. The collagen prolyl hydroxylases are novel transcriptionally silenced genes in lymphoma. Br J Cancer. 2012 Oct 9;107(8):1423-32.
Benetatos L, Hatzimichael E, Londin E, Vartholomatos G, Loher P, Rigoutsos I, Briasoulis E. The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis. Cell Mol Life Sci. 2013 Mar;70(5):795-814
Delage B, Luong P, Maharaj L, O'Riain C, Syed N, Crook T, Hatzimichael E, Papoudou-Bai A, Mitchell TJ, Whittaker SJ, Cerio R, Gribben J, Lemoine N, Bomalaski J, Li CF, Joel S, Fitzgibbon J, Chen LT, Szlosarek PW. Promoter methylation of arginosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autopahagy and caspase-dependent apoptosis. Cell Death Dis 2012: 5:e342
Wang H, Lee S, Nigro CL, Lattanzio L, Merlano M, Monteverde M, Matin R, Purdie K, Mladkova N, Bergamaschi D, Harwood C, Syed N, Szlosarek P, Briasoulis E, McHugh A, Thompson A, Evans A, Leigh I, Fleming C, Inman GJ, Hatzimichael E, Proby C, Crook T. NT5E (CD73) is epigenetically regulated in malignant melanoma and associated with metastatic site specificity. Br J Cancer 2012;106:1446-1452.
Lo Nigro C, Monteverde M, Lee S, Lattanzio L, Vivenza D, Comino A, Syed N, McHugh A, Wang H, Proby C, Garrone O, Merlano M, Hatzimichael E, Briasoulis E, Gojis O, Palmieri C, Jordan L, Quinlan P, Thompson A, Crook T. NT5E CpG island methylation is a favourable breast cancer biomarker. Br J Cancer 2012;107:75-83.
Hatzimichael E, Dasoula A, Kounnis V, Benetatos L, Nigro CL, Lattanzio L, Papoudou-Bai A, Dranitsaris G, Briasoulis E, Crook T. Bcl2-interacting killer CpG methylation in multiple myeloma: a potential predictor of relapsed/refractory disease with therapeutic implications. Leuk Lymphoma 2012.
Dranitsaris G, Hatzimichael E. Interpreting results from oncology clinical trials: a comparison of denosumab to zoledronic acid for the prevention of skeletal-related events in cancer patients. Support Care Cancer 2012;20:1353-1360.
Dimopoulos MA, Kastritis E, Delimpasi S, Katodritou E, Hatzimichael E, Kyrtsonis MC, Repousis P, Tsirogianni M, Kartasis Z, Parcharidou A, Michael M, Michalis E, Tsatalas C, Stefanoudaki E, Hatjiharissi E, Gika D, Symeonidis A, Terpos E, Zervas K. Multiple myeloma in octogenarians: Clinical features and outcome in the novel agent era. Eur J Haematol 2012;89:10-15.
Coley HM, Hatzimichael E, Blagden S, McNeish I, Thompson A, Crook T, Syed N. Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in ovarian cancer. Oncotarget 2012;3:78-83.
Tzakos AG, Fokas D, Johannes C, Moussis V, Hatzimichael E, Briasoulis E. Targeting oncogenic protein-protein interactions by diversity oriented synthesis and combinatorial chemistry approaches. Molecules 2011;16:4408-4427.
Syed N, Coley HM, Sehouli J, Koensgen D, Mustea A, Szlosarek P, McNeish I, Blagden SP, Schmid P, Lovell DP, Hatzimichael E, Crook T. Polo-like kinase Plk2 is an epigenetic determinant of chemosensitivity and clinical outcomes in ovarian cancer. Cancer Res 2011;71:3317-3327.
Hatzimichael E, Kapsali, E. Crook, T. Tuthill, M. The role of Plerixafor in the management of Non-Hodgkin’s Lymphoma. Clin Med Rev Oncol 2011;3.
Hatzimichael E, Briasoulis, E. Attitudes of people, authorities and doctors towards clinical cancer research: high expectations, neglected responsibilities and minimal involvement outline a hazy picture. Can we do any better? Mediterranean Oncol J 2011;1:9-13.
Benetatos L, Vartholomatos G, Hatzimichael E. MEG3 imprinted gene contribution in tumorigenesis. Int J Cancer 2011;129:773-779.
Benetatos L, Dasoula A, Hatzimichael E, Syed N, Voukelatou M, Dranitsaris G, Bourantas KL, Crook T. Polo-like kinase 2 (SNK/PLK2) is a novel epigenetically regulated gene in acute myeloid leukemia and myelodysplastic syndromes: genetic and epigenetic interactions. Ann Hematol 2011;90:1037-1045.
Ximeri M, Galanopoulos A, Klaus M, Parcharidou A, Giannikou K, Psyllaki M, Symeonidis A, Pappa V, Kartasis Z, Liapi D, Hatzimichael E, Kokoris S, Korkolopoulou P, Sambani C, Pontikoglou C, Papadaki HA. Effect of lenalidomide therapy on hematopoiesis of patients with myelodysplastic syndrome associated with chromosome 5q deletion. Haematologica 2010;95:406-414.
Makis A, Shipway D, Hatzimichael E, Galanakis E, Pshezhetskiy D, Chaliasos N, Stebbing J, Siamopoulou A. Cytokine and adhesion molecule expression evolves between the neutrophilic and lymphocytic phases of viral meningitis. J Interferon Cytokine Res 2010;30:661-665.
Lee S, Syed N, Taylor J, Smith P, Griffin B, Baens M, Bai M, Bourantas K, Stebbing J, Naresh K, Nelson M, Tuthill M, Bower M, Hatzimichael E, Crook T. DUSP16 is an epigenetically regulated determinant of JNK signalling in Burkitt's lymphoma. Br J Cancer 2010;103:265-274.
Hatzimichael E, Tuthill, M. Hematopoietic stem cell transplantation. Stem Cells Cloning 2010:105-117.
Hatzimichael E, Dasoula A, Shah R, Syed N, Papoudou-Bai A, Coley HM, Dranitsaris G, Bourantas KL, Stebbing J, Crook T. The prolyl-hydroxylase EGLN3 and not EGLN1 is inactivated by methylation in plasma cell neoplasia. Eur J Haematol 2010;84:47-51.
Hatzimichael E, Dasoula A, Benetatos L, Syed N, Dranitsaris G, Crook T, Bourantas K. Study of specific genetic and epigenetic variables in multiple myeloma. Leuk Lymphoma 2010;51:2270-2274.
Chaliasos N, Challa A, Hatzimichael E, Koutsouka F, Bourantas DK, Vlahos AP, Siamopoulou A, Bourantas KL, Makis A. Serum adipocytokine and vascular inflammation marker levels in Beta-thalassaemia major patients. Acta Haematol 2010;124:191-196.
Benetatos L, Hatzimichael E, Dasoula A, Dranitsaris G, Tsiara S, Syrrou M, Georgiou I, Bourantas KL. CpG methylation analysis of the MEG3 and SNRPN imprinted genes in acute myeloid leukemia and myelodysplastic syndromes. Leuk Res 2010;34:148-153.
*equal contribution
Powles T, Stebbing J, Bazeos A, Hatzimichael E, Mandalia S, Nelson M, Gazzard B, Bower M. The role of immune suppression and HHV-8 in the increasing incidence of HIV-associated multicentric Castleman's disease. Ann Oncol 2009;20:775-779.
Hatzimichael E, Dranitsaris G, Dasoula A, Benetatos L, Stebbing J, Crook T, Bourantas KL. Von Hippel-Lindau methylation status in patients with multiple myeloma: a potential predictive factor for the development of bone disease. Clin Lymphoma Myeloma 2009;9:239-242.
Hatzimichael E, Benetatos L, Dasoula A, Dranitsaris G, Tsiara S, Georgiou I, Syrrou M, Stebbing J, Coley HM, Crook T, Bourantas KL. Absence of methylation-dependent transcriptional silencing in TP73 irrespective of the methylation status of the CDKN2A CpG island in plasma cell neoplasia. Leuk Res 2009;33:1272-1275.
Hatzimichael E, Dasoula A, Benetatos L, Makis A, Stebbing J, Crook T, Syrrou M, Bourantas KL. The absence of CDKN1C (p57KIP2) promoter methylation in myeloid malignancies also characterizes plasma cell neoplasms. Br J Haematol 2008;141:557-558.
Descamps M, Hatzimichael E, Bhuva N, Stebbing J. Radiological imaging in the context of HIV infection: size of the lesion is not everything. J HIV Ther 2008;13:47-48.
Benetatos L, Dasoula A, Syed N, Hatzimichael E, Crook T, Bourantas KL. Methylation analysis of the von Hippel-Lindau gene in acute myeloid leukaemia and myelodysplastic syndromes. Leukemia 2008;22:1293-1295
Benetatos L, Dasoula A, Hatzimichael E, Georgiou I, Syrrou M, Bourantas KL. Promoter hypermethylation of the MEG3 (DLK1/MEG3) imprinted gene in multiple myeloma. Clin Lymphoma Myeloma 2008;8:171-175.
Panteli K, Bai M, Hatzimichael E, Zagorianakou N, Agnantis NJ, Bourantas K. Serum levels, and bone marrow immunohistochemical expression of, vascular endothelial growth factor in patients with chronic myeloproliferative diseases. Hematology 2007;12:481-486.
Benetatos L, Hatzimichael E, Vassou A, Bourantas KL. Cryptococcus lung infection complicating fludarabine treatment in a chronic lymphocytic leukemia patient. Leuk Res 2007;31:119-120.
Winston A, Hatzimichael E, Marvin V, Stebbing J, Bower M. Host pharmacogenetics in the treatment of HIV and cancer. Curr Drug Saf 2006;1:107-116.
Stebbing J, Mazhar D, Lewis R, Palmieri C, Hatzimichael E, Nelson M, Gazzard B, Bower M. The presentation and survival of patients with non-cutaneous AIDS-associated Kaposi's sarcoma. Ann Oncol 2006;17:503-506.
Makis AC, Hatzimichael E, Stebbing J, Bourantas KL. C-reactive protein and vascular cell adhesion molecule-1 as markers of severity in sickle cell disease. Arch Intern Med 2006;166:366-368.
Makis AC, Hatzimichael E, Stebbing J. The genomics of new drugs in sickle cell disease. Pharmacogenomics 2006;7:909-917.
Hatzimichael E, Benetatos L, Stebbing J, Kapsali E, Panayiotopoulou S, Bourantas KL. Spontaneous splenic haematoma in a multiple myeloma patient receiving pegfilgrastim support. Clin Lab Haematol 2006;28:416-418.
Stebbing J, Hatzimichael E, Bower M, Winston A. The rationale and development of new drugs to treat HIV infection. Med Chem 2005;1:635-642.
Sfagos C, Makis AC, Chaidos A, Hatzimichael EC, Dalamaga A, Kosma K, Bourantas KL. Serum ferritin, transferrin and soluble transferrin receptor levels in multiple sclerosis patients. Mult Scler 2005;11:272-275.
Panteli KE, Hatzimichael E, Bouranta PK, Katsaraki A, Seferiadis K, Stebbing J, Bourantas KL. Serum interleukin (IL)-1, IL-2, sIL-2Ra, IL-6 and thrombopoietin levels in patients with chronic myeloproliferative diseases. Br J Haematol 2005;130:709-715.
Makis AC, Galanakis E, Hatzimichael E, Papadopoulou ZL, Siamopoulou A, Bourantas KL. Serum levels of soluble interleukin-2 receptor alpha (sIL-2Ralpha) as a predictor of outcome in brucellosis. J Infect 2005;51:206-210.
Makis AC, Hatzimichael E, Kolios G, Bourantas KL. Circulating endothelin-3 levels in patients with sickle cell disease during hydroxyurea treatment. Haematologica 2004;89:360-361.
Chaidos A, Makis A, Hatzimichael E, Tsiara S, Gouva M, Tzouvara E, Bourantas KL. Treatment of beta-thalassemia patients with recombinant human erythropoietin: effect on transfusion requirements and soluble adhesion molecules. Acta Haematologica 2004;111:189-195.
Voulgari PV, Hatzimichael E, Tsiara S, Tzallas C, Drosos AA, Bourantas KL. Investigation for the presence of anti-erythropoietin antibodies in patients with myelodysplastic syndromes. Eur J Haematol 2001;66:31-36.
Makis AC, Chaliasos N, Hatzimichael E, Bourantas KL. Recombinant human erythropoietin therapy in a transfusion-dependent beta-thalassemia major patient. Ann Hematol 2001;80:492-495.
Hatzimichael E, Christou L, Bai M, Kolios G, Kefala L, Bourantas KL. Serum levels of IL-6 and its soluble receptor (sIL-6R) in Waldenstrom's macroglobulinemia. Eur J Haematol 2001;66:1-6.
Christou L, Hatzimichael E, Chaidos A, Tsiara S, Bourantas KL. Treatment of plasma cell leukemia with vincristine, liposomal doxorubicin and dexamethasone. Eur J Haematol 2001;67:51-53.
Makis AC, Hatzimichael E, Mavridis A, Bourantas KL. Alpha-2-macroglobulin and interleukin-6 levels in steady-state sickle cell disease patients. Acta Haematologica 2000;104:164-168.
Makis AC, Hatzimichael E, Bourantas KL. The role of cytokines in sickle cell disease. Ann Hematol 2000;79:407-413.
Bourantas KL, Xenakis TA, Hatzimichael E, Kontogeorgakos V, Beris AE. Peri-operative use of recombinant human erythropoietin in Jehovah's Witnesses. Haematologica 2000;85:444-445.
Bourantas KL, Hatzimichael E, Makis AC, Kapsali E, Tsiara S, Christou L, Seferiadis K. Prolonged interferon-alpha-2b treatment of hairy cell leukemia patients. Eur J Haematol 2000;64:350-351.
Bourantas KL, Hatzimichael E, Tsiara, S. Elisaf, M. Konstantinidou, E. Xefteri, E. A patient with Down's syndrome and acute lymphoblastic leukemia who relapsed 20 years after first remission. Haema 2000;3.
Hatzimichael E, Bourantas K. L. Combination therapy with interferon-alpha-2b and hydroxyurea in patients with chronic myelogenous leukemia. Eur J Intern Med 1999;10:27-31.
Christou L, Hatzimichael E, Sotsiou-Candila F, Siamopoulos K, Bourantas KL. A patient with multiple myeloma, amyloidosis and light-chain deposition disease in kidneys with a long survival. Acta Haematol 1999;101:202-205.
Bourantas KL, Hatzimichael E, Makis AC, Chaidos A, Kapsali ED, Tsiara S, Mavridis A. Serum beta-2-microglobulin, TNF-alpha and interleukins in myeloproliferative disorders. Eur J Haematol 1999;63:19-25.
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h-index 32
Clinical Trials
As Primary Investigator
- Phase 3 Randomized, Controlled Study of Blinatumomab Alternating with Low-intensity Chemotherapy Versus Standard of Care for Older Adults With Newly Diagnosed Philadelphia-negative B-cell Precursor Acute Lymphoblastic Leukemia With Safety Run-in (Golden Gate Study)
- A Phase 2 study of Isatuximab in combination with Pomalidomide and Dexamethasone in MM patients who received one prior line of therapy containing Lenalidomide and a Proteasome Inhibitor, EAE-115, Sponsor Hellenic Society of Haematology
- A Phase 2 Study of Isatuximab in combination with Bortezomib, Cyclophosphamide, and Dexamethasone, followed by Isatuximab and Lenalidomide maintenance in Newly Diagnosed Patients with Multiple Myeloma and severe Renal Impairment, EAE-116, Sponsor Hellenic Society of Haematology
- An open-label, 3-arm, multicenter, randomized phase 3 study to evaluate the efficacy and safety of Elranatamab (pf-06863135) monotherapy and Elranatamab + Daratumumab versus Daratumumab + Pomalidomide + Dexamethasone in participants with Relapsed/Refractory Multiple Myeloma who have received at least 1 prior line of therapy including Lenalidomide and a proteasome inhibitor, MagnetisMM 05 / C1071005, Sponsor Pfizer
- An open-label, 2-arm, multicenter, randomized phase 3 study to evaluate the efficacy and safety of elranatamab (pf-06863135) + daratumumab + lenalidomide versus daratumumab + lenalidomide + dexamethasone in transplant-ineligible participants with newly-diagnosed multiple myeloma, C1071006, MagnetisMM-6, Sponsor Amgen
- A randomized, 2-arm, phase 3 study of Elranatamab (PF-06863135) versus Lenalidomide in patients with newly diagnosed Multiple Myeloma who are minimal residual disease-positive after undergoing autologous stem-cell transplantation, MagnetisMM 07 / C1071007, Sponsor Pfizer
- A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Navtemadlin Plus Ruxolitinib Versus Placebo Plus Ruxolitinib in Patients with Primary Myelofibrosis (PMF), Post Polycythemia Vera MF (Post-PV-MF), Or Post-Essential Thrombocythemia MF (Post-ET-MF) Following a Suboptimal Response to Ruxolitinib” (BOREAS-2)
- A phase 1/3 study to evaluate the efficacy and safety of selinexor, a selective inhibitor of nuclear export, in combination with ruxolitinib in treatment-naïve patients with myelofibrosis, XPORT-MF-034, Sponsor Karyopharm
- A Phase 2/3 Randomized, Controlled, Open-Label Study of KRT-232 in Subjects with Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (Post-PV-MF), Or Post-Essential Thrombocythemia MF (Post-ET-MF) who are Relapsed or Refractory to Janus Kinase (JAK) Inhibitor Treatment, Sponsor Kartos Therapeuticals
- A Phase 3, Randomized, Double-blind, Active-Control Study of Pelabresib (CPI-0610) and Ruxolitinib vs. Placebo and Ruxolitinib in JAKi Treatment Naive MF Patients (CPI 0610-04, MANIFEST-2)
- Double-Blind, Randomized, Placebo-Controlled, Prospective Phase III Study Evaluating Efficacy and Safety of Panzyga in Primary Infection Prophylaxis in Patients with Chronic Lymphocytic Leukemia, Sponsor Octapharma
- A Randomized, Controlled, Open-label, Multicenter, Inferentially Seamless Phase 2/Phase 3 Study of the Bruton’s Tyrosine Kinase (BTK) Inhibitor Ibrutinib in Combination with Rituximab Versus Physician’s Choice of Lenalidomide Plus Rituximab or Bortezomib Plus Rituximab in Participants with Relapsed or Refractory Mantle Cell Lymphoma who are BTK inhibitor-naïve, Sponsor: Janssen Pharmaceuticals
- A Multi-Country, Real-World Study to Explore Treatment Patterns, Effectiveness and Healthcare Resource Utilization for Patients Diagnosed with Myelofibrosis through Chart Review, the METER study, Sponsor Abbvie
- 16. Προοπτική μη παρεμβατική μελέτη για την περιγραφή της αποτελεσματικότητας και της ασφάλειας του ως θεραπεία πρώτης γραμμής σε ασθενείς με οξεία μυελοειδή λευχαιμία (ΟΜΛ) οι οποίοι δεν είναι κατάλληλοι για εντατική χημειοθεραπεία στη συνήθη κλινική πρακτική στην Ελλάδα», Μελέτη SURVIVE, Sponsor: AbbVie
- A Randomized, Open-Label Study of the Efficacy and Safety of Galinpepimut-S (GPS) Maintenance Monotherapy Compared to Investigator’s Choice of Best Available Therapy in Subjects with Acute Myeloid Leukemia Who Have Achieved Complete Remission After Second-Line Salvage Therapy
- Μια πολυκεντρική, ανοιχτής ετικέτας, τυχαιοποιημένη μελέτη Φάσης III για την αξιολόγηση της αποτελεσματικότητας και της ασφάλειας του Belantamab Mafodotin σε συνδυασμό με πομαλιδομίδη και δεξαμεθαζόνη (B-Pd) έναντι του συνδυασμού με πομαλιδομίδη, βορτεζομίμπη και δεξαμεθαζόνη (PVd) σε συμμετέχοντες με υποτροπιάζον/ανθεκτικό πολλαπλό μυέλωμα (DREAMM 8), Sponsor GlaxoSmithKline
- An Open-label, Phase 2 Study Treating Subjects with First or Second Relapse of MM with Carfilzomib, Pomalidomide, and Dexamethasone (KPd), Sponsor Amgen
- Μελέτη MiraCLLe: Μια Eπιδημιολογική, Προοπτική μελέτη κοόρτης, διετούς διάρκειας για να Καταγράψει την Πραγματική Στρατηγική Αντιμετώπισης Πρώτης και Δεύτερης Γραμμής θεραπεία, στην Καθ’ Ημέρα Κλινική Πράξη, Αποτελέσματα Θεραπείας, Ποιότητα Ζωής και Χρήση Πόρων σε Ασθενείς με Χρόνια Λεμφοκυτταρική Λευχαιμία στην Ελλάδα, Sponsor Astra Zeneca
- A Phase 3 Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of IMP in Adult Study Participants with Persistent or Chronic Primary Immune Thrombocytopenia (ITP), Sponsor: UCB Biopharma SRL
- Study M20-638: A Phase 3, Multicenter, Randomized, Open-Label Trial of Epcoritamab in Combination with Rituximab and Lenalidomide (R2) compared to Rituximab and Lenalidomide (R2) alone in Subjects with Relapsed or Refractory Follicular Lymphoma, Sponsor: AbbVie
- Study M20-621: A Phase 3, Multicenter, Randomized, Open-Label Trial to Evaluate the Safety and Efficacy of Epcoritamab in Combination with R-CHOP compared to R-CHOP in Subjects with High-Risk Diffuse Large B-Cell Lymphoma Version Number: 1.0, Sponsor: AbbVie
- PCYC-1143-CA: A Phase 3 Study of Ibrutinib in Combination with Venetoclax in Subjects with Mantle Cell Lymphoma, Sponsor: Pharmacyclics
- P19-568/Concrete: Κλινικές Εκβάσεις ασθενών με υποτροπιάζουσα/ανθεκτική Χρόνια Λεμφοκυτταρική Λευχαιμία (Υ/Α ΧΛΛ) οι οποίοι υποβάλλονται σε θεραπεία με Venetoclax σε συνθήκες καθημερινής κλινικής πρακτικής στην Ελλάδα, (Clinical outcomes of relapse/refractory Chronic Lymphocytic Leukemia (R/R CLL) patients treated with venetoclax in routine clinical settings in Greece) Sponsor: AbbVie Φαρμακευτική ΑΕ
- ΑSPER-III-19-1: Μία φάσης 3, διπλή-τυφλή, πολυκεντρική, τυχαιοποιημένη, ελεγχόμενη με εικονικό φάρμακο μελέτη για την αξιολόγηση της αποτελεσματικότητας, της ασφάλειας και της ανεκτικότητας της εισπνεόμενης Ιτρακοναζόλης σε μορφή ξηράς κόνεως για την πρόληψη της διηθητικής μυκητιασικής λοίμωξης σε ασθενείς με Οξεία Λευχαιμία και Ουδετεροπενία, (A phase 3, double-blind, multicentric, randomized, placebo-controlled study to assess the efficacy, safety and tolerability of Itraconazole dry powder for inhalation for the prevention of invasive mould disease in patients with Acute Leukaemia and Neutropaenia) Sponsor: Laboratoires SMB S.A
- Αναδρομική ανάλυση κλινικών εκβάσεων ασθενών με υποτροπιάζουσα/ανθεκτική Χρόνια Λεμφοκυτταρική Λευχαιμία (Υ/Α ΧΛΛ) που υποβλήθηκαν σε θεραπεία με venetoclax: Αναδρομική ανάλυση από την Ελλάδα, Sponsor: AbbVie Φαρμακευτική ΑΕ
- Α phase III, randomized, openlabel, active-controlled, multicenter study evaluating the efficacy and safety of Crovalimab versus Eculizumab in adult and adolescent patients with paroxysmal nocturnal hemoglobinuria not previously treated with complement inhibitors, Sponsor Hoffmann-La Roche
- An Open-label, Phase 2 Study Treating Subjects with First or Second Relapse of Multiple Myeloma with Carfilzomib, Pomalidomide, and Dexamethasone (KPd), Sponsor: Amgen
- Τυχαιοποιημένη, διπλά-τυφλή, ελεγχόμενη με εικονικό φάρμακο πολυκεντρική μελέτη φάσης ΙΙΙ της αζακιτιδίνης με ή χωρίς MBG453 για τη θεραπεία ασθενών με ενδιάμεσου, υψηλού ή πολύ υψηλού κινδύνου μυελοδυσπλαστικό σύνδρομο (ΜΔΣ) σύμφωνα με τα κριτήρια IPSS-R, ή με χρόνια μυελομονοκυτταρική λευχαιμία-2 (CMML-2), Sponsor: Novartis