We welcome people from all around the world! 

PostDoc Positions in Prof. Giuseppe Giannini’s Lab, Dept. Molecular Medicine, University La Sapienza, Rome

We are seeking for highly motivated and talented postdoctoral scientists (or pre-Docs with at least a couple of years of lab experience) to join our research group.

Research topic 1: Mechanisms of immune suppression by MYC(N)

MYC(N) oncogenic activation drives a severe immune suppression and a cold cancer phenotype, at least partially by impairing type-I Interferon responses. Focusing on cytosolic nucleic acid sensing pathways, our laboratory is investigating on the molecular mechanisms driving the cold phenotype of MYC(N)-driven tumors, searching for strategies to convert them into hot and more immunogenic tumors.

Who we're looking for:

·  PhD holders or predocs with lab experience in molecular and cellular cancer biology, or immunology

·  A genuine passion for discovery, analytical thinking, and a collaborative mindset

·  A robust interest on the research topic

What we offer:

·     The possibility to participate to a pluriannual research activity

·     A dynamic and intellectually stimulating environment within a leading research institute

·     A fully equipped laboratory with advanced facilities for molecular biology and confocal microscopy

·     A supportive, inclusive team that values innovation, integrity, and scientific curiosity

If interested, please send your CV and a brief motivation note to giuseppe.giannini@uniroma1.it 

Research topic 2: TP53 inactivation mechanisms in cancer stem cells and host cells (position available within FIS 3 project)

The oncosuppressor TP53 (p53) is the most frequently mutated gene in human cancers (>50%). In many tumors, including colorectal cancer, p53 can be functionally inactivated when not directly mutated. However, the mechanisms of p53 functional inactivation in cancer and host cells infiltrating the tumor microenvironment, particularly immune cells such as macrophages, along with their contribution to tumor progression, have not yet been elucidated. Unveiling further mechanisms of functional p53 inactivation and deepening our comprehension of the anticancer effects resulting from restored p53 activity is crucial in both cancer and host cells, for optimizing the application of this strategy in therapeutic contexts within clinical settings.

Who we're looking for:

·  PhD holders or predocs with lab experience in molecular and cellular cancer biology, or immunology

·  A genuine passion for discovery, analytical thinking, and a collaborative mindset

·  A robust interest on the research topic

What we offer:

·     The possibility to participate to a pluriannual research activity

·     A dynamic and intellectually stimulating environment within a leading research institute

·     A fully equipped laboratory with advanced facilities for molecular biology and confocal microscopy

·     A supportive, inclusive team that values innovation, integrity, and scientific curiosity

If interested, please send your CV and a brief motivation note to veronica.veschi@uniroma1.it