Our research group investigates the microbiota-gut-brain axis, aging, and neurodegeneration using Drosophila models. Through molecular, proteomic, behavioral, and longevity studies, we explore how nutraceuticals and natural compounds influence inflammation and oxidative stress. Our publications contribute to understanding dietary interventions for neurodegeneration and healthy aging, according to the sex.
• Cirilli, I., Patrick, O., Hrelia, S., Marcheggiani, F., Tiano, L., Beghelli, D.*, Angeloni, C. Endogenous coenzyme Q content and exogenous bioavailability in D. melanogaster. Heliyon, 2024, 10,18, e37854
doi:0.1016/j.heliyon. 2024.e37854 ISSN: 2405-8440
• Beghelli, D., Giusti, L., Zallocco, L., Ronci, M., Cappelli, A., Pontifex, M.G., Muller, M., Damiani, C., Cirilli, I., Hrelia, S., Vauzour, D., Vittadini, E., Favia, G., Angeloni, C*. Dietary fiber supplementation increases Drosophila melanogaster lifespan and gut microbiota diversity. Food and Function, 2024, 15, 14, pp. 7468 – 7477.
doi: 10.1039/d4fo00879k ISSN: 2042-6496
• Diab, F.*, Beghelli, D.*, Nuccitelli, A., Lupidi, G., Khalil, M., Portincasa, P., Vergani, L.+ Supplementation with Thymbra spicata extract ameliorates lifespan, body-weight gain and Paraquat-induced oxidative stress in Drosophila melanogaster: An age-and sex-related study. Journal of Functional Foods, 2024, 114,106078. doi.org/10.1016/j.jff.2024.106078 ISSN: 1756-4646
• Tripodi, F., Falletta, E., Leri, M., Angeloni, C., Beghelli, D., Giusti, L., Milanesi, R., Sampaio-Marques, B., Ludovico, P., Goppa, L., Rossi, P., Savino, E., Bucciantini, M., Coccetti, P.* Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts. Nutrients, 2022, 14 (20), art. no. 4368.
ISSN: 2072-6643.
• Beghelli, D., Zallocco, L., Barbalace, M.C., Paglia, S., Strocchi, S., Cirilli, I., Marzano, V., Putignani, L., Lupidi, G., Hrelia, S., Giusti, L., Angeloni, C.* Pterostilbene Promotes Mean Lifespan in Both Male and Female Drosophila Melanogaster Modulating Different Proteins in the Two Sexes. Oxidative Medicine and Cellular Longevity, 2022, art. no. 1744408.
ISSN: 1942-0900.
• Tripodi, F., Lombardi, L., Guzzetti, L., Panzeri, D., Milanesi, R., Leri, M., Bucciantini, M., Angeloni, C., Beghelli, D., Hrelia, S., Onorato, G., Di Schiavi, E., Falletta, E., Nonnis, S., Tedeschi, G., Labra, M., Coccetti, P. * Protective effect of Vigna unguiculata extract against aging and neurodegeneration. Aging 2020, 12(19), pp. 19785–19803.
doi: 10.18632/aging.104069 ISSN. 2152-5250
Proceedings
“Drosophila melanogaster as an in vivo model to study the effects of a dietary supplementation with acorn in healthy longevity”. Beghelli, D., Bresciani, L., Nuccitelli, A., Caprioli, G., Mannozzi, C., Marti, A., Del Rio, D., Laterza, A., Vittadini, E. IUFOST 22nd WORLD Congress of Food Science and Technology, 8th-12th September 2024, Rimini, Italy.
“Characterization of the brain proteome in Drosophila melanogaster as a function of sex and age”. Beghelli, D., Angeloni, C., Zallocco, L., Ronci, M., Giusti, L. 27th European Drosophila Research Conference, Lione 2023
“Endogenous Coenzyme Q content and exogenous Coenzyme Q bioavailability in D. melanogaster”. 1. Beghelli, D., Orlando, P., Silvestri, S., Marcheggiani, F., Hrelia, S., Tiano, L., Angeloni, C. SIB Membrane-Nutrizione e Ambiente (SIB), Ancona 2022
Angeloni, C., Caprioli, G., Giusti, L., Nkuimi Wandjou, J.G., Lupidi, G., Maggi, F., Beghelli, D. “Biological activities of the Italian ancient apple ‘Mela Rosa dei Monti Sibillini’ in a Drosophila melanogaster model”. Angeloni, C., Caprioli, G., Giusti, L., Nkuimi Wandjou, J.G., Lupidi, G., Maggi, F., Beghelli, D. 10th International Conference on Polyphenols and Health-ICPH, London 2022
“In vivo study of a high fiber cereal-legume derived syrup on Drosophila “. 7th Cereals & Europe Spring Meeting. 2022, Thessaloniki, Greece.
“In vivo study of a high fiber syrup on Drosophila melanogaster life span, gut microbiota and brain proteome”. Congresso Interregionale TUM 2022, Italian Society of Biochemistry and Molecular Biology, Perugia, Italia.
“Pterostilbene effects on longevity and oxidative stress in Drosophila melanogaster”. Beghelli, D., Hrelia, S., Lupidi, G., Angeloni, C. 60° Congress of the Italian Society of Biochemistry and Molecular Biology, 2019, Lecce, Italy.