Fear, anxiety, and panic are complex emotional states that are rooted in the intricate workings of the brain and its neurobiology. Unraveling the mysteries of the brain's dance of neurotransmitters and neural pathways is crucial for understanding human behavior and mental health.

The Endocannabinoid System (ECS) plays an important role in multiple aspects of neural functions, including controlling movement and motor coordination, learning and memory, emotion and motivation, addictive-like behavior, and pain modulation, among others. It interacts with a variety of neurotransmitters, such as glutamate, GABA, orexin, acetylcholine, dopamine, histamine, serotonin, norepinephrine, prostaglandins, and opioid peptides, with these interrelations being responsible for most of the neuronal effects of cannabinoids. The expression of the endocannabinoid system in the limbic system and prefrontal cortical areas explains its pivotal role in the regulation of emotions such as anxiety and fear.