Laboratory of Neurobiology and Neurobiotechnology
Almada Lab
São Paulo State University (Unesp), Assis, Department of Biological Sciences
São Paulo State University (Unesp), Assis, Department of Biological Sciences
The research conducted at the Laboratory of Neurobiology and Neurobiotechnology (LNN) aims to advance the understanding of the neural basis of anxiety, fear, and panic while also providing evidence to support the development of novel drugs for related mental disorders, such as generalized anxiety disorder, panic disorder, phobia, and post-traumatic stress disorder.
Our laboratory employs a multidisciplinary approach, including animal models, such as open field, fear conditioning, elevated plus maze, and beetle mania task. These models are applied using optogenetic, pharmacological, and morphological tools. Beyond demonstrating scientific excellence, ethics, and integrity, LNN emphasizes mentorship, innovation, collaboration, and a positive mental attitude.
The BrainON extension project aims to serve as a tool for disseminating knowledge from brain science to the general community. The upcoming edition, scheduled for March 2025, aligns with Brain Awareness Week.
13 March 2025 - 18h - YouTube
6th edition - Brain rhythms
Prof. Dr. Rafael Naime Ruggiero
Federal University of São Paulo (Unifesp)
Department of Psychobiology
Suzuki, H.H. et al., Neuroscience applied, 2025.
Dorsal hippocampus orexin 1 receptors modulate the organisation and expression of contextual conditioned fear.
Oliveira, G.V.M. et al., Psychopharmacology, 2024.
Orexin mechanisms in the prelimbic cortex modulate the expression of contextual conditioned fear.
Ville-Costa, H.H. et al., European Journal of Neuroscience, 2024.
Neonatal limited bedding and nesting experience may lead to a sex‐dependent increase in panic‐like defensive behaviours in adult mice.
doi: 10.1111/ejn.16532
Coimbra, N.C. et al., Methods in Molecular Biology, 2024.
In Vivo Neural Tract Tracing Procedures: Unravelling Neural Hodology Using Fluorescent and Non-fluorescent Neural Tract Tracers, Optogenetic Approach, and Diffusion Tensor Neurotractography Protocols