Network Publications

2024 Publications

1. Asghar Ali, Kemter, Elisabeth and Eckhard Wolf. Advances in Organ and TissueXenotransplantation. Annu Rev Anim Biosci. 2024a Feb 15;12:369-390. Go to article >

2. Asghar Ali, Kurome, Mayuko, Barbara Kessler, Elisabeth Kemter, and Eckhard Wolf. What Genetic Modifications of Source Pigs Are Essential and Sufficient for Cell, Tissue, and OrganXenotransplantation? Transpl Int. 2024b Dec 4;37:13681. doi: 10.3389/ti.2024.13681. Go to article >

3. Martin Bender, Jan-Michael Abicht, Bruno Reichart, Leuschen M, Wall F, Radan J, NeumannE, Mokelke M, Buttgereit I, Michel S, Ellgass R, Gieseke K, Steen S, Paskevicius A, Denner J,Godehardt AW, Tönjes RR, Hagl C, Ayares D, Wolf E, Schmoeckel M, Brenner P, Müller MB, andLängin M. The Endothelial Glycocalyx in Pig-to-Baboon Cardiac Xenotransplantation-First Insights. Biomedicines. 2024a Jun 16;12(6):1336. Go to article >

4. Martin Bender, Jan-Michael Abicht, Bruno Reichart, Elisabeth Neumann, Julia Radan, MarenMokelke, Ines Buttgereit, Maria Leuschen, Felicia Wall, Sebastian Michel, Reinhard Ellgass, StigSteen, Audrius Paskevicius, Andreas Lange, Barbara Kessler, Elisabeth Kemter, Nikolai Klymiuk,Joachim Denner, Antonia W. Godehardt, Ralf R. Tönjes, Jonathan M. Burgmann, ConstançaFigueiredo, Anastasia Milusev, Valentina Zollet, Neda Salimi-Afjani, Alain Despont, Robert Rieben,Stephan Ledderose, Christoph Walz, Christian Hagl, David Ayares, Eckhard Wolf, MichaelSchmoeckel, Paolo Brenner, Uli Binder, Michaela Gebauer, Arne Skerra, and Matthias Längin. Combination of Anti-CD40 and Anti-CD40L Antibodies as Co-Stimulation Blockade in PreclinicalCardiac Xenotransplantation. Biomedicines. 2024b Aug 22;12(8):1927. Go to article >

5. Martin Bender, Alessandro Panelli, Bruno Reichart, Julia Radan, Maren Mokelke, ElisabethNeumann, Ines Buttgereit, Sebastian Michel, Andreas Bauer, Ann Kathrin Fresch, Tanja Mayr, FabianWerner, Stefanie Egerer, Andrea Bähr, Barbara Kessler, Nikolai Klymiuk, David Ayares, Eckhard Wolf, Christian Hagl, Paolo Brenner, Matthias Längin, and Jan-Michael Abicht. Hemodynamics in pigto-baboon heterotopic thoracic cardiac xenotransplantation: Recovery from perioperative cardiacxenograft dysfunction and impairment by cardiac overgrowth. Xenotransplantation. 2024c Jan-Feb;31(1):e12841. Go to article >

6. Martin Bender, Julia Radan, Bruno Reichart, Maria Leuschen, Felicia Wall, Maren Mokelke,Elisabeth Neumann, Ines Buttgereit, David Ayares, Eckhard Wolf, Paolo Brenner, Jan-MichaelAbicht, and Matthias Längin. Ultrasound Assessment of Pleural Effusions After Orthotopic Pig-to-Baboon Cardiac Xenotransplantation. Xenotransplantation. 2024d Nov-Dec;31(6):e70006. Go to article > 

7. Martin Bender, Bruno Reichart, Constanca Figueiredo, Jonathan M. Burgmann, Maria Leuschen, Felicia Wall, Julia Radan, Elisabeth Neumann, Maren Mokelke, Ines Buttgereit, SebastianMichel, Reinhard Ellgass, Stefanie Egerer, Andreas Lange, Andrea Baehr, Barbara Kessler, Elisabeth Kemter, Nikolai Klymiuk, Joachim Denner, Antonia W. Godehardt, Ralf R. Tönjes, ChristianHagl, Michaela Gebauer, Uli Binder, Arne Skerra, David Ayares, Eckhard Wolf, Michael Schmoeckel,Paolo Brenner, Matthias Längin, and Jan-Michael Abicht. An Approach to Controlling Inflammationand Coagulation in Pig-to-Baboon Cardiac Xenotransplantation. Xenotransplantation. 2024e Jul-Aug;31(4):e12877. Go to article > 

8. Sarah Grimus, Victoria Sarangova, Petra B. Welzel, Barbara Ludwig, Jochen Seissler, Elisabeth Kemter, Eckhard Wolf, and Asghar Ali. Immunoprotection Strategies in β-CellReplacement Therapy: A Closer Look at Porcine Islet Xenotransplantation. Adv Sci (Weinh). 2024Aug;11(31):e2401385. Go to article >

9. Andreas Lange, Ivica Medugorac, Asghar Ali, Barbara Kessler, Mayuko Kurome, Valeri Zakhartchenko, Sabine E. Hammer, Andreas Hauser, Joachim Denner, Britta Dobenecker, GerhardWess, Paul L. J. Tan, Olga Garkavenko, Bruno Reichart, Eckhard Wolf, and Elisabeth Kemter. Genetic diversity, growth and heart function of Auckland Island pigs, a potential source for organxenotransplantation. Xenotransplantation. 2024 Mar-Apr;31(2):e12858. Go to article >

10. Sarah Merl, Bryan Chen, M. Esad Gunes, Hussein Atta, Kryscilla Yang, Dilrushki Ekanayake-Alper, Dominik Hajosi, Fei Huang, Brittany Bhola, Satyajit Patwardhan, Phil Jordache, Greg Nowak, Mercedes Martinez, Tomoaki Kato, Megan Sykes, Kazuhiko Yamada, and Joshua Weiner. Development of a large animal orthotopic intestinal transplantation model with long-term survival for 28 study of immunologic outcomes. Front Transplant. 2024 May 2;3:1367486. PMC11235311 Go to article >

11. Maren Mokelke, Martin Bender, Bruno Reichart, Elisabeth Neumann, Julia Radan, InesButtgereit, David Ayares, Eckhard Wolf, Paolo Brenner, Jan-Michael Abicht, and Matthias Längin. Transthoracic echocardiography is a simple tool for size matching in cardiac xenotransplantation. Xenotransplantation. 2024 May-Jun;31(3):e12861. Go to article >

12. Alessandra Moretti, Christian Kupatt, and Eckhard Wolf. Cellular pathophysiology ofDuchenne muscular dystrophy: insights from a novel rhesus macaque model. Signal Transduct TargetTher. 2024 Dec 7;9(1):357. Go to article > 

13. Hisato Nagano, Naoaki Mizuno, Hideyuki Sato, Eiji Mizutani, Ayaka Yanagida, Mayuko Kano, Mariko Kasai, Hiromo Yamamoto, Motoo Watanabe, Fabian Suchy, Hideki Masaki, and Hiromitsu Nakauchi. Skin graft with dermis and appendages generated in vivo by cell competition. Nature Communications 2024 29;15(1):3366 Go to article >

14. Satyajit Patwardhan, Muhammed E Gunes, Elin Manell, Julie Hong, Philip Jordache, IshitChauhan, Ahmed Almesallmy, Harko Mulder, Dilrukshi Ekanayake-Alper, Dominik Hajosi, Huaibin MKo, Kumaran Shanmugarajah, Curtis L Cetrulo, Greg Nowak, David H Sachs, Megan Sykes, and Joshua Weiner. Durable mixed chimerism may permit subsequent immunosuppression-freeintestinal transplantation-A proof-of-principle study. Am J Transplant. 2024 Oct 22:S1600-6135(24)00674-9. Go to article >

15. Satyajit Patwardhan, Julie Hong, and Joshua Weiner. Update on MaintenanceImmunosuppression in Intestinal Transplantation. Gastroenterol Clin North Am. 2024 Sep;53(3):493-507. PMC11284276. Go to article > 

16. Daniel Reichart, Gisella Puga Yung, and Eckhard Wolf. Multimodal Deep PhenotypingProvides Insights into Early Human Anti-porcine Xeno-organ Responses. Transplantation. 2024 Nov1;108(11):2157-2158. Go to article > 

17. Michael Schmoeckel, Matthias Längin, Bruno Reichart, Jan-Michael Abicht, Martin Bender,Joachim Denner, Georg Marckmann, Paolo Brenner, Eckhard Wolf, and Christian Hagl. Xenotransplantation von Organen [Xenotransplantation of solid organs]. Chirurgie (Heidelb). 2024Aug;95(8):603-609. Go to article >

18. Michael Stirm, Nikolai Klymiuk, Hiroshi Nagashima, Christian Kupatt, and Eckhard Wolf. Pig models for translational Duchenne muscular dystrophy research. Trends Mol Med. 2024 Oct;30(10):950-964. Go to article > 

19. Eckhard Wolf, and Bruno Reichart. Kidney xenotransplantation edges closer to the clinic. NatRev Nephrol. 2024 Apr;20(4):204-205. Go to article >

2025 Publications

1. Ishit Chauhan, Llors, N, Atsushi Hirakata, Yoshinori Ishikawa, Prashanth Vallabhajosyula, Joshua Weiner, Kazuhiko Yamada, David H. Sachs, Adam D. Griesemer. Progressive Hyperglycemia in Tolerant Miniature Swine Recipients of Composite Islet-kidney Grafts is Not Due to Islet Loss but Rather to Increased Insulin Demand with Growth. Transplantation (accepted).

2. *Daniel J. Garry, and Eckhard Wolf. Leducq-funded program: Engineering pig hearts for transplantation. 2025. Eur Heart J, In Press.

3. *Daniel J. Garry, Mary G. Garry, Hiromistu Nakauchi, Hideki Masaki, David H. Sachs, Joshua I. Weiner, Daniel Reichart, and Eckhard Wolf. Allogeneic, xenogeneic and exogenic hearts for transplantation. Methodist Debakey Cardiovascular Journal, In Press.

4. Tao Huang, Arthur Radley, Ayaka Yanagida, Zhili Ren, Francesca Carlisle, Somayyeh Tahajjodi, Dongwan Kim, Paul O'Neill, James Clarke, Madeline Lancaster, Zoe Heckhausen, Jingran Zhuo, Joao de Sousa, Petra Hajkova, Ferdinand von Meyenn, Hiroo Imai, Hiromitsu Nakauchi, Ge Guo, Austin Smith, and Hideki Masaki. Inhibition of PRC2 enables self-renewal of blastoid-competent naive pluripotent stem cells from chimpanzee. Cell Stem Cell. 2025. PMID: 40015279 Go to article >

5. Wayne J. Hawthorne, Richard N. Pierson III, Leo Buhler, Peter J. Cowan, Jay Fishman, Rita Bottino, Raphael P. H. Meier, Paolo Brenner, Eckhard Wolf, Emanuele Cozzi, and Muhammad M. Mohiuddin. International Xenotransplantation Association (IXA) Position Paper on the History, Current Status, and Regulation of Xenotransplantation. Xenotransplantation. 2025;32:e70002. Go to article > 

6. Raphael P. H. Meier, Richard N. Pierson III, Jay A. Fishman, Leo H. Buhler, Rita Bottino, Joseph M. Ladowski, Burcin Ekser, Eckhard Wolf, Paolo Brenner, Francesco Ierino, Muhammad Mohiuddin, David K. C. Cooper, and Wayne J. Hawthorne. International XenotransplantationAssociation (IXA) Position Paper on Kidney Xenotransplantation. Xenotransplantation. 2025 Mar-Apr;32(2):e70003. Go to article > 

7. Marlies E. Oomen, Diego Rodriguez-Terrones, Mayuko Kurome, Valeri Zakhartchenko, Lorenza Mottes, Kilian Simmet, Camille Noll, Tsunetoshi Nakatani, Carlos Michel Mourra-Diaz, Irene Aksoy, Pierre Savatier, Jonathan Goeke, Eckhard Wolf, Henrik Kaessmann, and Maria-Elena Torres-Padilla. An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development. Cell. 2025 Feb 20;188(4):1156-1174.e20. Go to article >

8. Satyabrata Das, Xiao Ma, Kidus Hailemariam, Javier E. Sierra-Pagan, Thijs Larson, Young Geun Choi, Anh Quynh Le, Riley J. Leonard, Austin Cho, Heasham A. Sadek, Jianyi Zhang, Mary G. Garry, Xiao Dong, Wuming Gong, Daniel J. Garry. The pioneer factor, ETV2, regulates networks to specify the embryonic endothelial lineage. Cardiovascular Res. In revision.

9. *Yong-ho Choe, Mayuko Kurome, Chan-Hee Jo, Hyeonjeong Lee, Hiromitsu Nakauchi, Hideki Masaki, David H. Sachs, Joshua I. Weiner, Daniel Reichart,  Daniel J. Garry, Eckhard Wolf, Mary G. Garry. Generation of interspecies chimeras using SCNT and blastocyst complementation. In preparation.

10. *Chan-Hee Jo, Mayuko Kurome, Yong-ho Choe, Hyeonjeong Lee, Hiromitsu Nakauchi,Hideki Masaki, David H. Sachs, Joshua I. Weiner, Daniel Reichart, Daniel J. Garry, Eckhard Wolf, Mary G. Garry. Parthenogenesis and embryo aggregation. In preparation.