Members | Co-Principal Investigators
Mary G. Garry, PhD

About Dr. Garry

Dr. Garry is a Professor in the Lillehei Heart Institute at the University of Minnesota. She is the Director of the Porcine Cloning Laboratory at the University of Minnesota where her laboratory is focused on gene editing and somatic cell nuclear technologies to generate large animal research models. Specifically, her laboratory focuses on the engineering of humanized skeletal muscle in the pig. These initiatives are focused on the generation of an unlimited source of human muscle and resident stem cell populations for therapeutic initiatives in patients with volumetric muscle loss in which vascularized whole and mature muscle is needed for reconstruction following injury or trauma. Her laboratory also focuses on the production of human hearts and vasculature for transplantation.  In addition, Dr. Garry’s lab is working to generate novel large animal research models. This approach will allow for the production of in vivo models to allow the testing of novel therapeutics and individualized patient responsiveness to established therapeutics.

Publications:

Choe YH, Das S, Ma X, Lee H, Sorensen JR, Hoffman DB, Jo CH, Johnson CP, Cassel N, Garry DJ, Greising SM, Garry MG. Porcine myogenesis in cloned wildtype and MYF5/MYOD/MYF6-null porcine embryo. Commun Biol. 2025 Feb 11;8(1):217. doi: 10.1038/s42003-025-07648-1. PMID: 39934347; PMCID: PMC11814088. go to article

Garry, D. J., Weiner, J. I., Greising, S. M., Sachs, D. H., Garry, M. G. (2023). Xenotransplantation and exotransplantation: Strategies to expand the number of donor organs. Xenotransplantation, 30(1), e12786. PMID: 36367201 doi: 10.1111/xen.12786. go to article

Greising, S., Weiner, A., Garry, D., Sachs, D., Garry, M. (2022). Human muscle in gene edited pigs for treatment of volumetric muscle loss. Front Genet., 13(948496). PMID: 35957684  doi: 10.3389/fgene.2022.948496. go to article

Choe YH, Sorensen J, Garry DJ, Garry MG. Blastocyst complementation and interspecies chimeras in gene edited pigs. Front Cell Dev Biol. 2022 Dec 8;10:1065536. doi: 10.3389/fcell.2022.1065536. PMID: 36568986; PMCID: PMC9773398. go to article

Garry MG, Caplan AL, Garry DJ. Emerging technologies and ethics-exogenic chimeric humanized organs. Am J Transplant. 2022 Dec;22(12):2786-2790. doi: 10.1111/ajt.17188. Epub 2022 Sep 12. PMID: 36052557; PMCID: PMC10087366. go to article

Garry DJ, Weiner JI, Greising SM, Garry MG, Sachs DH. Mechanisms and strategies to promote cardiac xenotransplantation. J Mol Cell Cardiol. 2022 Nov;172:109-119. doi: 10.1016/j.yjmcc.2022.07.013. Epub 2022 Aug 27. PMID: 36030840. go to article

Maeng G, Das S, Greising SM, Gong W, Singh BN, Kren S, Mickelson D, Skie E, Gafni O, Sorensen JR, Weaver CV, Garry DJ, Garry MG. Humanized skeletal muscle in MYF5/MYOD/MYF6-null pig embryos. Nat Biomed Eng. 2021 Aug;5(8):805-814. doi: 10.1038/s41551-021-00693-1. Epub 2021 Mar 29. PMID: 33782573. go to article

Das S, Koyano-Nakagawa N, Gafni O, Maeng G, Singh BN, Rasmussen T, Pan X, Choi KD, Mickelson D, Gong W, Pota P, Weaver CV, Kren S, Hanna JH, Yannopoulos D, Garry MG, Garry DJ. Generation of human endothelium in pig embryos deficient in ETV2. Nat Biotechnol. 2020 Mar;38(3):297-302. doi: 10.1038/s41587-019-0373-y. Epub 2020 Feb 24.PMID: 32094659. go to article

Singh BN, Sierra-Pagan JE, Gong W, Das S, Theisen JWM, Skie E, Garry MG, Garry DJ. ETV2 (Ets Variant Transcription Factor 2)-Rhoj Cascade Regulates Endothelial Progenitor Cell Migration During Embryogenesis. Arterioscler Thromb Vasc Biol. 2020 Dec;40(12):2875-2890. doi: 10.1161/ATVBAHA.120.314488. Epub 2020 Oct 29. PMID: 33115267. go to article

Garry DJ, Caplan AL, Garry MG. Chimeric Humanized Vasculature and Blood: The Intersection of Science and Ethics. Stem Cell Reports. 2020 Apr 14;14(4):538-540. doi: 10.1016/j.stemcr.2020.03.016. PMID: 32294412; PMCID: PMC7160389. go to article

Maeng G, Gong W, Das S, Yannopoulos D, Garry DJ, Garry MG. ETV2-null porcine embryos survive to post-implantation following incomplete enucleation. Reproduction. 2020 May;159(5):539-547. doi: 10.1530/REP-19-0382. PMID: 31990674; PMCID: PMC7409374. go to article