Members | Co-Principal Investigators
Hideki Masaki, PhD

Hideki Masaki, PhD is a Specially appointed Assistant Professor at the Institute of Science Tokyo. He earned his Ph.D. in Developmental Biology from Tohoku University and began his professional career in the pharmaceutical industry, working at Schering AG and Bayer Schering Pharma. During this time, he involved in developing human stem cell-based drug screening platforms, including establishment of human iPSCs. He later became a founding member of the U.S.-based biotech startup "iZumiBio," where he focused on applying human iPSCs for drug discovery. Transitioning from industry to academia, he joined Prof. Nakauchi’s lab at the University of Tokyo, contributing to research on generating transplantable organs from human PSCs in chimeric animals. His research interests include Organ Regeneration, Developmental Biology, and Stem Cell Biology.

Publications:

Huang T, Radley A, Yanagida A, Ren Z, Carlisle F, Tahajjodi S, Kim D, O'Neill P, Clarke J, Lancaster MA, Heckhausen Z, Zhuo J, de Sousa JPA, Hajkova P, von Meyenn F, Imai H, Nakauchi H, Guo G, Smith A, Masaki H. Inhibition of PRC2 enables self-renewal of blastoid-competent naive pluripotent stem cells from chimpanzee. Cell Stem Cell. 2025 Feb 26:S1934-5909(25)00041-4. doi: 10.1016/j.stem.2025.02.002. Online ahead of print. PMID: 40015279. go to article

Nagano H, Mizuno N, Sato H, Mizutani E, Yanagida A, Kano M, Kasai M, Yamamoto H, Watanabe M, Suchy F, Masaki H, Nakauchi H. Skin graft with dermis and appendages generated in vivo by cell competition. Nat Commun. 2024 Apr 29;15(1):3366. doi: 10.1038/s41467-024-47527-7. PMID: 38684678. go to article

Kano M, Mizuno N, Sato H, Kimura T, Hirochika R, Iwasaki Y, Inoshita N, Nagano H, Kasai M, Yamamoto H, Yamaguchi T, Suga H, Masaki H, Mizutani E, Nakauchi H. Functional calcium-responsive parathyroid glands generated using single-step blastocyst complementation. Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2216564120. doi: 10.1073/pnas.2216564120. Epub 2023 Jun 28. PMID: 37379351. go to article

Xenotransplantation and interspecies organogenesis: current status and issues.Kano M, Mizutani E, Homma S, Masaki H, Nakauchi H. Front Endocrinol (Lausanne). 2022 Aug 5;13:963282. doi: 10.3389/fendo.2022.963282. eCollection 2022.PMID: 35992127. go to article

Yamazaki K, Kubara K, Ishii S, Li P, Dairiki R, Hihara T, Ishizuka Y, Izumi Y, Kumai M, Kamisako T, Ishizaki H, Sato H, Masaki H, Mizuno N, Mitsuhashi K, Ito M, Hamanaka S, Yamaguchi T, Watanabe M, Sugiyama F, Nakauchi H. In vitro and in vivo functions of T cells produced in complemented thymi of chimeric mice generated by blastocyst complementation. Sci Rep. 2022 Feb 25;12(1):3242. doi: 10.1038/s41598-022-07159-7.PMID: 35217706. go to article

Kinoshita M, Kobayashi T, Planells B, Klisch D, Spindlow D, Masaki H, Bornelöv S, Stirparo GG, Matsunari H, Uchikura A, Lamas-Toranzo I, Nichols J, Nakauchi H, Nagashima H, Alberio R, Smith A. Pluripotent stem cells related to embryonic disc exhibit common self-renewal requirements in diverse livestock species. Development. 2021 Dec 1;148(23):dev199901. doi: 10.1242/dev.199901. Epub 2021 Dec 7.PMID: 34874452. go to article

Yamaguchi T, Sato H, Kobayashi T, Kato-Itoh M, Goto T, Hara H, Mizuno N, Yanagida A, Umino A, Hamanaka S, Suchy F, Masaki H, Ota Y, Hirabayashi M, Nakauchi H. An interspecies barrier to tetraploid complementation and chimera formation. Sci Rep. 2018 Oct 16;8(1):15289. doi: 10.1038/s41598-018-33690-7.PMID: 30327488. go to article

Goto T, Hara H, Sanbo M, Masaki H, Sato H, Yamaguchi T, Hochi S, Kobayashi T, Nakauchi H, Hirabayashi M. Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats. Nat Commun. 2019 Feb 5;10(1):451. doi: 10.1038/s41467-019-08394-9.PMID: 30723213. go to article