Members | Leducq Fellows
Yuya Monoe, PhD

Yuya Monoe, Ph.D., recently started his professional career in the Nakauchi Lab at the Institute of Science Tokyo. During his PhD course, he studied how chemical modifications on RNA — molecules that carry genetic instructions within cells — drive cancer progression. Using a highly sensitive mass spectrometry system, he identified cancer-specific RNA modification patterns in both tumor tissues and extracellular vesicles, the tiny particles that cancer cells release to communicate with their surroundings and promote tumor growth. In the Nakauchi Lab, he will bring this expertise in molecular analysis to new challenges in stem cell biology and regenerative medicine.

Representative publications include: 

Monoe, Y., Jingushi, K., Taniguchi, K., Hirosuna, K., Arima, J., Inomata, Y., Takano, Y., Hamamoto, H., Komura, K., Tanaka, T., et al. (2025). Cancer-specific RNA modifications in tumour-derived extracellular vesicles promote tumour growth. J. Extracell. Vesicles 14, e70083. go to article 

Monoe, Y., Miyamoto, S., Jingushi, K., Tanimoto, M., Tanaka, T., Taniguchi, K., Komura, K., Ohmichi, M., and Tsujikawa, K. (2023). Hypoxia regulates tumour characteristic RNA modifications in ovarian cancers. FEBS J. 290, 2085–2096. go to article