Members | Leducq Fellows
Mayuko Kurome, PhD

Mayuko Kurome, PhD is a Staff Scientist in Eckhard Wolf’s lab at the Ludwig Maximilian University of Munich. She has expertise as a reproductive engineering, especially in pig. Her primary focus as Leducq Fellow is to identify developmental barriers that limit the formation of interspecies chimeras between pigs and humans, especially at early embryonic stages. For this aim, she employs the approaches of intra- and interspecies chimerism with gene-edited host embryos. In addition, human haematopoietic stem cells (hHSCs) will be injected into gene-edited porcine fetuses to attempt the expansion of hHSCs in pigs.

Representative publications include:

Lange A, Medugorac I, Ali A, Kessler B, Kurome M, Zakhartchenko V, Hammer SE, Hauser A, Denner J, Dobenecker B, Wess G, Tan PLJ, Garkavenko O, Reichart B,Wolf E, Kemter E. Genetic diversity, growth and heart function of Auckland Island pigs, a potential source for organ xenotransplantation. Xenotransplantation. 2024 Mar-Apr;31(2):e12858. doi: 10.1111/xen.12858. PMID: 38646921. go to article

Simmet K, Kurome M, Zakhartchenko V, Reichenbach HD, Springer C, Bähr A, Blum H, Philippou-Massier J, Wolf E. OCT4/POU5F1 is indispensable for the lineage differentiation of the inner cell mass in bovine embryos. FASEB J. 2022 Jun;36(6):e22337. doi: 10.1096/fj.202101713RRR. PMID: 35486003. go to article