Members | Leducq Fellows
Arne Hinrichs, Dr.med.vet, DVM

Arne Hinrichs, Dr.med.vet, DVM is a postdoctoral researcher in Eckhard Wolf`s lab at the Ludwig-Maximilians-University in Munich, Germany. As a trained veterinarian, he is working on the generation and characterization of genetically modified pig models.  His primary work as a Leducq Fellow focuses on investigating growth hormone insensitivity in pigs to reduce the size of donor organs for xenotransplantation. Specifically, he uses histomorphological analysis, OMICS, and in vivo metabolic studies to elucidate the effects of growth hormone insensitivity on longitudinal growth and metabolism.

Representative publications include:

Hinrichs A, Riedel EO, Klymiuk N, Blutke A, Kemter E, Längin M, Dahlhoff M, Keßler B, Kurome M, Zakhartchenko V, Jemiller E-M, Ayares D, Bidlingmaier M, Flenkenthaler F, Hrabe de Angelis M, Arnold GJ, Reichart B, Fröhlich T, Wolf E. (2021) Growth hormone receptor knockout to reduce the size of donor pigs for preclinical xenotransplantation studies. Xenotransplantation, Mar;28(2):e12664. DOI: 10.1111/xen.12664. PMID:33241624. go to article

Hinrichs A, Keßler B, Kurome M, Blutke A, Kemter E, Bernau M, Scholz AM, Rathkolb B, Renner S, Bultmann S, Leonhardt H, Hrabe de Angelis M, Nagashima H, Hoeflich A, Blum WF, Bidlingmaier M, Wanke R, Dahlhoff M, Wolf E. (2018) Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver. Molecular Metabolism, May;11:113-128. DOI: 10.1016/j.molmet.2018.03.006. PMID:29678421. go to article