Members | Principal Investigators
Eckhard Wolf, DVM

Eckhard Wolf is Head of the Institute for Molecular Animal Breeding and Biotechnology and of the Center for Innovative Medical Models (CiMM; www.lmu.de/cimm/), LMU Munich. His lab is specialized in the generation, characterization and implementation of genetically engineered pigs as disease models (diabetes mellitus, rare monogenic diseases) and as organ donors for xenotransplantation. He leads the large animal platform in the German Center for Diabetes Research and is Spokesperson of the DFG CRC-TR 127 “Biology of xenogeneic cell, tissue and organ transplantation – from bench to bedside”. E.W. is Member of the German National Academy of Sciences – Leopoldina, Corresponding Member of the Austrian Academy of Sciences, and Diplomate of the European College of Laboratory Animal Medicine. 

Publications:

Schmoeckel DM, Längin M, Reichart B, Abicht JM, Bender M, Michel S, Kamla CE, Denner J, Tönjes RR, Schwinzer R, Marckmann G, Wolf E, Brenner P, Hagl C. Current status of cardiac xenotransplantation. Thorac Cardiovasc Surg. 2023 Dec 28. doi: 10.1055/a-2235-8854. Epub ahead of print. PMID: 38154473. go to article

Wolf E, Reichart B. Kidney xenotransplantation edges closer to the clinic. Nat Rev Nephrol. 2023 Nov 16. doi: 10.1038/s41581-023-00790-1. Epub ahead of print. PMID: 37973840. go to article

Ali A, Kemter E, Wolf E. Advances in Organ and Tissue Xenotransplantation. Annu Rev Anim Biosci. 2023 Oct 31. doi: 10.1146/annurev-animal-021122-102606. Epub ahead of print. PMID: 37906838. go to article

Milusev A, Ren J, Despont A, Shaw J, Längin M, Bender M, Abicht JM, Mokelke M, Radan J, Neumann E, Kemter E, Klymiuk N, Ayares D, Wolf E, Reichart B, Sorvillo N, Rieben R. Glycocalyx dynamics and the inflammatory response of genetically modified porcine endothelial cells. Xenotransplantation. 2023 Sep-Oct;30(5):e12820. doi: 10.1111/xen.12820. PMID: 37735958. go to article

Längin M, Buttgereit I, Reichart B, Panelli A, Radan J, Mokelke M, Neumann E, Bender M, Michel S, Ellgass R, Ying J, Fresch AK, Mayr T, Steen S, Paskevicius A, Egerer S, Bähr A, Kessler B, Klymiuk N, Binder U, Skerra A, Ledderose S, Müller S, Walz C, Hagl C, Wolf E, Ayares D, Brenner P, Abicht JM. Xenografts Show Signs of Concentric Hypertrophy and Dynamic Left Ventricular Outflow Tract Obstruction After Orthotopic Pig-to-baboon Heart Transplantation. Transplantation. 2023 Dec 1;107(12):e328-e338. doi: 10.1097/TP.0000000000004765. Epub 2023 Aug 29. PMID: 37643028. go to article

Watanabe M, Miyamoto H, Okamoto K, Nakano K, Matsunari H, Kazuki K, Hasegawa K, Uchikura A, Takayanagi S, Umeyama K, Hiramuki Y, Kemter E, Klymuik N, Kurome M, Kessler B, Wolf E, Kazuki Y, Nagashima H. Phenotypic features of dystrophin gene knockout pigs harboring a human artificial chromosome containing the entire dystrophin gene. Mol Ther Nucleic Acids. 2023 Jul 23;33:444-453. doi: 10.1016/j.omtn.2023.07.021. PMID: 37588685; PMCID: PMC10425850.
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Stirm M, Shashikadze B, Blutke A, Kemter E, Lange A, Stöckl JB, Jaudas F, Laane L, Kurome M, Keßler B, Zakhartchenko V, Bähr A, Klymiuk N, Nagashima H, Walter MC, Wurst W, Kupatt C, Fröhlich T, Wolf E. Systemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52. Proc Natl Acad Sci U S A. 2023 Jul 18;120(29):e2301250120. doi: 10.1073/pnas.2301250120. Epub 2023 Jul 10. PMID: 37428903; PMCID: PMC10629550.
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von Bibra C, Shibamiya A, Bähr A, Geertz B, Köhne M, Stuedemann T, Starbatty J, Horneffer-van der Sluis V, Klostermeier UC, Hornaschewitz N, Li X, Wolf E, Klymiuk N, Krane M, Kupatt C, Hiebl B, Eschenhagen T, Weinberger F. Immature human engineered heart tissues engraft in a guinea pig chronic injury model. Dis Model Mech. 2023 May 1;16(5):dmm049834. doi: 10.1242/dmm.049834. Epub 2023 Jun 5. PMID: 37272385; PMCID: PMC10259837. go to article

Wolf E, Reichart B, Moretti A, Laugwitz KL. Designer pigs for xenogeneic heart transplantation and beyond. Dis Model Mech. 2023 May 1;16(5):dmm050177. doi: 10.1242/dmm.050177. Epub 2023 May 30. PMID: 37249503; PMCID: PMC10245136. go to article

Fischer N, Gulich B, Keßler B, Längin M, Fishman JA, Wolf E, Boller K, Tönjes RR, Godehardt AW. PCR and peptide based PCMV detection in pig - development and application of a combined testing procedure differentiating newly from latent infected pigs. Xenotransplantation. 2023 Jul-Aug;30(4):e12803. doi: 10.1111/xen.12803. Epub 2023 Apr 30. PMID: 37120823. go to article

Reichart B, Cooper DKC, Längin M, Tönjes RR, Pierson RN, Wolf E. Cardiac xenotransplantation: from concept to clinic. Cardiovasc Res. 2023 Feb 3;118(18):3499-3516. doi: 10.1093/cvr/cvac180. PMID: 36461918; PMCID: PMC9897693. go to article