Members | Co-Principal Investigators
Daniel Reichart, MD

Dr. Daniel Reichart is a medical doctor at University of Munich Hospital and recently became head of a research group at the Gene Center Munich. For his research on aging processes in the heart, he has now been awarded by the German Research Foundation (DFG) through its Emmy Noether Programme.

Life expectancy has been continuously rising worldwide for decades. At the same time, age presents a significant risk of chronic conditions, particularly cardiovascular diseases.  Dr. Reichart wants to investigate the aging process of the heart and the incremental loss of cellular resilience at the molecular level. “Using single-cell sequencing, we can measure the RNA and epigenetic patterns of each individual heart cell. This will allow us to characterize the heterogeneity of cell types of the aging heart with high sensitivity,” says Reichart. These insights should deepen our understanding of people’s increased vulnerability to cardiac diseases as they age. Moreover, the findings should help to discover new treatment options and answer the question why people age at different rates.

Publications:

Maatz H, Lindberg EL, Adami E, López-Anguita N, Perdomo-Sabogal A, Cocera Ortega L, Patone G, Reichart D, Myronova A, Schmidt S, Elsanhoury A, Klein O, Kühl U, Wyler E, Landthaler M, Yousefian S, Haas S, Kurth F, Teichmann SA, Oudit GY, Milting H, Noseda M, Seidman JG, Seidman CE, Heidecker B, Sander LE, Sawitzki B, Klingel K, Doeblin P, Kelle S, Van Linthout S, Hubner N, Tschöpe C. The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination. Nat Cardiovasc Res. 2025 Mar;4(3):330-345.  Epub 2025 Feb 24. go to article

Reichart D, Puga Yung G, Wolf E. Multimodal Deep Phenotyping Provides Insights Into Early Human Anti-porcine Xeno-organ Responses. Transplantation. 2024 Nov 1;108(11):2157-2158. doi: 10.1097/TP.0000000000005137. Epub 2024 Aug 27. PMID: 39187932. go to article

Reichart D*, Newby GA*, Wakimoto H*, Lun M, Gorham JM, Curran JJ, Raguram A, DeLaughter DM, Conner DA, Marsiglia JDC, Kohli S, Chmatal L, Page DC, Zabaleta N, Vandenberghe L, Liu DR, Seidman JG, Seidman C. Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice. Nat Med. 2023 Feb;29(2):412-421. doi: 10.1038/s41591-022-02190-7. PMID:36797483. go to article

Reichart D*, Lindberg EL*, Maatz H*, Miranda AMA, Viveiros A, Shvetsov N, Gärtner A, Nadelmann ER, Lee M, Kanemaru K, Ruiz-Orera J, Strohmenger V, DeLaughter DM, Patone G, Zhang H, Woehler A, Lippert C, Kim Y, Adami E, Gorham JM, Barnett SN, Brown K, Buchan RJ, Chowdhury RA, Constantinou C, Cranley J, Felkin LE, Fox H, Ghauri A, Gummert J, Kanda M, Li R, Mach L, McDonough B, Samari S, Shahriaran F, Yapp C, Stanasiuk C, Theotokis PI, Theis FJ, van den Bogaerdt A, Wakimoto H, Ware JS, Worth CL, Barton PJR, Lee YA, Teichmann SA, Milting H#, Noseda M#, Oudit GY#, Heinig M#, Seidman JG#, Hubner N#, Seidman CE#. Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies. Science. 2022 Aug 5;377(6606):eabo1984. doi: 10.1126/science.abo1984. PMID:35926050. go to article

Litviňuková M*, Talavera-López C*, Maatz H*, Reichart D*, Worth CL, Lindberg EL, Kanda M, Polanski K, Heinig M, Lee M, Nadelmann ER, Roberts K, Tuck L, Fasouli ES, DeLaughter DM, McDonough B, Wakimoto H, Gorham JM, Samari S, Mahbubani KT, Saeb-Parsy K, Patone G, Boyle JJ, Zhang H, Zhang H, Viveiros A, Oudit GY, Bayraktar OA, Seidman JG, Seidman CE, Noseda M, Hubner N, Teichmann SA. Cells of the adult human heart. Nature. 2020 Dec;588(7838):466-472. doi: 10.1038/s41586-020-2797-4. PMID:32971526. go to article