Pubmed link to Carol A. Lange publications
1. Defining MAPK Modules
Lange-Carter CA, Pleiman CM, Gardner AM, Blumer KJ, Johnson GL. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science. 1993 Apr 16;260(5106):315-9.
Lange-Carter CA, Johnson GL. Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science. 1994 Sep 2;265(5177):1458-61.
Blumer KJ, Johnson GL, and Lange-Carter CA. Mammalian MEK Kinase Can Function Downstream of Protein Kinase C in a Yeast MAP Kinase Signaling Pathway. Proc. Natl. Acad. Sci. USA. 91: 4925-4929, 1994.
Winston BW, Lange-Carter CA, Gardner AM, Johnson GL, and Riches DWH. TNF-alpha Rapidly Activates the MEK/MAP Kinase Cascade in an MEK Kinase-Dependent, Raf-1-Independent Fashion in Mouse Macrophages. Proc. Natl. Acad. Sci. USA. 92: 1614-1618, 1995.
2. MAPK inputs to steroid receptor actions
Lange CA, Shen T, Horwitz KB. Phosphorylation of human progesterone receptors at Serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1032-7.
Shen T, Horwitz KB, Lange CA. Transcriptional hyperactivity of human progesterone receptors is coupled to their ligand-dependent down-regulation by mitogen activated protein kinase-dependent phosphorylation of serine 294. Mol Cell Biol. 2001 Sep;21(18):6122-31.
Pierson-Mullany L and Lange CA. Phosphorylation of Progesterone Receptor Serine 400 Mediates Ligand-Independent Transcriptional Activity in Response to Activation of Cyclin-Dependent Kinase-2 (CDK2). Mol. Cell. Biol. 24 (24): 10542-10557, 2004.
Faivre E and Lange CA. Progesterone Receptors Upregulate Wnt-1 to Induce EGFR Transactivation and c-Src-depedenent Sustained Activation of ERK1/2 Mitogen-Activated Protein Kinase in Breast Cancer Cells. Mol. Cell. Biol. 27(2); 466-480, 2007.
3. Context-dependent progesterone receptor actions and cell fate transitions
Daniel AR and Lange CA. Protein Kinases Mediate Ligand-Independent Derepression of Sumoylated Progesterone Receptors in Breast Cancer Cells. Proc. Natl. Acad. Sci. USA. 106(34): 14287-14292, 2009.
Diep CH, Charles NJ, Gilks CB, Kalloger SE, Argenta PA, Lange CA. Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells. Cell Cycle. 12(9):1433-49 (2013).
Diep CH, Knutson TP, Lange CA. Active FOXO1 is a Key Determinant of Isoform-Specific Progesterone Receptor Transactivation and Senescence Programming. Mol Cancer Res. 2016 Feb;14(2):141-62.
Knutson TP, Truong TH, Ma S, Brady NJ, Sullivan ME, Raj G, Schwertfeger KL, Lange CA. Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs. J Hematol Oncol. 2017 Apr 17;10(1):89.
Truong TH*, Dwyer AR*, Diep CH, Hu H, Hagen KM, Lange CA. Phosphorylated progesterone receptor isoforms mediate opposing stem cell and proliferative breast cancer cell fates. Endocrinology. 2018 Dec 28. doi: 10.1210/en.2018-00990. *These authors contributed equally.
4. Novel progesterone receptor actions
Hagan CR, Knutson TP, Lange CA. A Common Docking Domain in Progesterone Receptor-B links DUSP6 and CK2 signaling to proliferative transcriptional programs in breast cancer cells. Nucleic Acids Res. 41(19):8926-42, 2013.
Daniel AR, Gaviglio AL, Knutson TP, Ostrander JH, D’Assoro AB, Ravindranathan P, Peng Y, Raj GV, Yee D, Lange CA. Progesterone Receptor-B Enhances Estrogen Responsiveness of Breast Cancer Cells via Scaffolding PELP-1- and Estrogen Receptor-Containing Transcriptional Complexes. Oncogene. 34(4):506-15 (2015).
Truong TH, Hu H, Temiz NA, Hagen K, Girard BJ, Brady NJ, Schwertfeger KL, Lange CA, Ostrander JH. Cancer Stem Cell Phenotypes in ER+ Breast Cancer Models are Promoted by PELP1/AIB1 Complexes. Mol. Cancer Res. 2018 Jan 18.
Dwyer AR, Truong TH, Kerkvliet CP, Paul KV, Kabos P, Sartorius CA, Lange CA. Insulin receptor substrate-1 (IRS-1) mediates progesterone receptor-driven stemness and endocrine resistance in oestrogen receptor+ breast cancer. Br J Cancer. 2021 Jan; 124(1):217-227 .
5. BRK/PTK6 and HIF/phospho-GR Stress Signaling
Regan Anderson TM, Peacock DL, Daniel AR, Hubbard GK, Lofgren KA, Girard BJ, Schorg A, Hoogwijs D, Wenger RH, Seagroves TN, Lange CA. Breast Tumor Kinase (Brk/PTK6) is a Mediator of Hypoxia-Associated Breast Cancer Progression. Cancer Res. 73(18):5810-20, 2013.
Regan Anderson TM, Ma S, Raj GV, Cidlowski JA, Helle TM, Knutson TP, Krutilina RI, Seagroves TN, Lange CA. Breast Tumor Kinase (Brk/PTK6) is Induced by HIF, Glucocorticoid Receptor and PELP1 Mediated Stress Signaling in Triple-Negative Breast Cancer”. Cancer Research. Mar 15;76(6):1653-63, 2016.
Perez Kerkvliet C, Dwyer AR, Diep CH, Oakley RH, Liddle C, Cidlowski JA, Lange CA. Glucocorticoid receptors are required effectors of TGFβ1-induced p38 MAPK signaling to advanced cancer phenotypes in triple-negative breast cancer. Breast Cancer Res. 2020 May 1;22(1):39.
Dwyer AR, Kerkvliet CP, Krutilina RI, Playa HC, Parke DN, Thomas WA, Smeester BA, Moriarity BS, Seagroves TN, Lange CA. Breast Tumor Kinase (Brk/PTK6) Mediates Advanced Cancer Phenotypes via SH2-Domain Dependent Activation of RhoA and Aryl Hydrocarbon Receptor (AhR) Signaling. Mol Cancer Res. 2021 Feb;19(2):329-345. Epub 2020 Nov 10.
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