Research Interests:

Signal Transduction in Breast and Ovarian Cancer

Dr. Lange's laboratory is focused on the integrated actions of growth factor- or stress-activated protein kinases and steroid hormone receptors (SRs) in breast and ovarian cancers. The ovarian steroid hormones, estrogen and progesterone, as well as growth factor receptor tyrosine kinase-initiated signaling pathways, are required for normal breast development. These pathways also interact to influence breast tumorigenesis and breast cancer progression. Ongoing research projects in the laboratory include the study of the role of protein tyrosine kinases and mitogen activated protein kinase (MAPK) cascades in human breast cancer cell proliferation and survival and their contribution to mechanisms of steroid hormone resistance in human breast cancer. Identifying the essential pathways and partners will enable the targeting of multiple signaling molecules in addition to SRs, which is predicted to halt cancer progression, prevent recurrence, and increase patient survival. In order to study problems in breast cancer cell biology, techniques in signal transduction, endocrinology, protein biochemistry and molecular biology are employed. 

Pubmed link to Carol A. Lange publications

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