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The valve-in-stent device addresses the gaps in the IP landscape by providing a secure, long-term solution that mimics a healthy ET without relying on native muscle function.
The valve-in-stent device addresses the gaps in the IP landscape by providing a secure, long-term solution that mimics a healthy ET without relying on native muscle function.
Devices that plug or reduce the cross-sectional area of the pET fail to mimic the opening and closing function of a healthy ET.
Devices that plug or reduce the cross-sectional area of the pET fail to mimic the opening and closing function of a healthy ET.
Porous Shim
Porous Shim
The porous shim plugs the ET while allowing air pressure to equalize through the pores in the material. Although shims and plugs are currently used in the clinic, these devices often migrate and provide only a short-term solution.
Reverse-action Stent
Reverse-action Stent
The reverse action-stent reduces the cross-sectional area of the ET by hooking into tissue of the ET lumen and exerting radial force inwards. Although the stent decreases its diameter, the ET is constantly open which could cause turbulent airflow and potentially intensify symptoms of autophony.
One-way valve devices do not account for the bidirectional pressure gradients that occur in the ET.
One-way valve devices do not account for the bidirectional pressure gradients that occur in the ET.
Cone Stent with Valve
Cone Stent with Valve
The cone stent with valve consists of a unidirectional flap valve with two cone-shaped stents extending from either side. The valve-in-stent device is differentiated from this patent because it uses a flexure-based valve system, allows for bidirectional pressure equalization, and is secured within a self-expanding stent.
Devices that rely on muscle-control or nerve stimulation require that patients have viable tissue surrounding their pET.
Devices that rely on muscle-control or nerve stimulation require that patients have viable tissue surrounding their pET.
Muscle-controlled Valve
Muscle-controlled Valve
The muscle-controlled valve is tethered to muscles surrounding the ET and is actuated by muscle contractions near the distended region. This design relies on functional muscle contractions to operate, which may not be observed in many patients.
Neurostimulator
Neurostimulator
The neurostimulation approach requires that patients have functional musculature and tissue at the distended region.
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