Publications
Publications:
Melissa A. Solem, Ross G. Pelzel, Nicholas B. Rozema, Taylor G. Brown, Emma Reid, Rachel H. Mansky and Rocio Gomez-Pastor. Absence of hippocampal pathology persists in the Q175DN mouse model of Huntington's disease despite elevated HTT aggregation. Journal of Huntington's disease (2025). https://journals.sagepub.com/doi/10.1177/18796397251316762
Deepti Mudaliar, Rachel H. Mansky, Angel White, Grace Baudhuin, Jon Hawkinson, Henry Wong, Michael A. Walters and Rocio Gomez-Pastor. Discovery of a CK2α′-Biased ATP-Competitive Inhibitor from a High-Throughput Screen of an Allosteric-Inhibitor-Like Compound. ACS Chemical Neuroscience (2024). https://pubs.acs.org/doi/10.1021/acschemneuro.4c00062
Ivan Tkáč, Tiankai Xie, Nitya Shah, Sarah Larson, Janet M Dubinsky, Rocio Gomez-Pastor, Hayley S McLoughlin, Harry T Orr, Lynn E Eberly, Gülin Öz. Regional sex differences in neurochemical profiles of healthy mice measured by magnetic resonance spectroscopy at 9.4 tesla. Frontiers in Neuroscience (2023). https://pubmed.ncbi.nlm.nih.gov/37954878/
Brown TG, Thayer MN, VannTreeck JG, Zarate N, Hart DW, Heilbronner S, Gomez-Pastor R. Striatal spatial heterogeneity, clustering, and white matter association of GFAP+ astrocytes in a mouse model of Huntington’s disease. Frontiers in Cellular Neuroscience (2023). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10175581/
Mansky RH, Greguske EA, Yu D, Zarate N, Intihar TA, Tsai W, Brown TG, Thayer MN, Kumar K, Gomez-Pastor R. Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease. Cell Reports (2023). www.sciencedirect.com/science/article/pii/S2211124723002097
Zarate, N., Gundry, K., Yu, D., Casby, J., Eberly LE., Oz, G., and Gomez-Pastor, R. Neurochemical correlates of synapse density in a Huntington's disease mouse model. Journal of Neurochemistry (2022). https://onlinelibrary.wiley.com/doi/full/10.1111/jnc.15714
White A., McGlone A., Gomez-Pastor R. Protein Kinase CK2 and its potential role as a therapeutic target in Huntington’s disease. Biomedicines (2022). https://pubmed.ncbi.nlm.nih.gov/36009526/
Yu D*, Zarate N*, White A*, Coates D, Tsai W, Nanclares C, Cuccu F, Yue JS, Brown TG, Mansky R, Jiang K, Kim H, Nichols-Meade T, Larson SN, Gundry K, Zhang Y, Tomas-Zapico C, Lucas JJ, Benneyworth M, Öz G, Cvetanovic M, Araque A and Gomez-Pastor R. CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington’s disease. Acta Neuropathol Commun (2022). https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-022-01379-8
Nicole Zarate,Taylor A. Intihar, Dahyun Yu, Jacob Sawyer, Wei Tsai, Maha Syed, Luke Carlson and Rocio Gomez-Pastor. Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic Density. Int. J. Mol. Sci. (2021). https://www.mdpi.com/1422-0067/22/23/13113
Burchfiel ET, Vihervaara A, Guertin MJ, Gomez-Pastor R, Thiele DJ. Comparative interactomes of HSF1 in stress and disease reveal a role for CTCF in HSF1-mediated gene regulation. J Biol Chem. 2020;Nov 18;jbc.RA120.015452 . https://www.sciencedirect.com/science/article/pii/S0021925820000873?via%3Dihub
Zarate N, Gomez-Pastor R. Excitatory synapse impairment and mitochondrial dysfunction in Huntington's disease: Heat shock factor 1 (HSF1) converging mechanisms. Neural Regen Res 2020;15:69-70. http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=1;spage=69;epage=70;aulast=Zarate
Liu P, Smith BR, Huang ES, Mahesh A, Vonsattel JPG, Petersen AJ, Gomez-Pastor R, Ashe KH. A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington's disease patients. Acta Neuropathol Commun. 2019 Jul 30;7(1):111. doi: 10.1186/s40478-019-0764-9. https://www.ncbi.nlm.nih.gov/pubmed/31358058
Intihar TA, Martinez EA, Gomez-Pastor R. Mitochondrial Dysfunction in Huntington's Disease: Interplay between HSF1, p53 and PGC-1 transcription factors. Front. Cell. Neurosci., 19 March 2019. doi:org/10.3389/fncel.2019.00103. https://www.frontiersin.org/articles/10.3389/fncel.2019.00103/full
Gomez-Pastor R, Burchfiel E, Thiele DJ. Regulation of heat shock transcription factors and their roles in physiology and disease. Nat Rev Mol Cell Biol. 2017 Aug 30. doi: 10.1038/nrm.2017.73 https://www.ncbi.nlm.nih.gov/pubmed/28852220
Gomez-Pastor R, Burchfiel ET, Neef DW, Jaeger AM, Cabiscol E, McKinstry SU, Doss A, Aballay A, Lo DC, Akimov SS, Ross CA, Eroglu C, Thiele DJ. Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease. Nat Commun. 2017 Feb 13;8:14405 https://www.ncbi.nlm.nih.gov/pubmed/28194040
Neef DW, Jaeger AM, Gomez-Pastor R, Willmund F, Frydman J, Thiele DJ. A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1. Cell Rep. 2014 Nov 6;9(3):955-66. doi: 10.1016/j.celrep.2014.09.056 https://www.ncbi.nlm.nih.gov/pubmed/25437552
Casani S, Gómez-Pastor R, Matallana E, Paricio N. Antioxidant compound supplementation prevents oxidative damage in a Drosophila model of Parkinson's disease. Free Radic Biol Med. 2013 Aug;61:151-60. doi: 10.1016/j.freeradbiomed.2013.03.021 https://www.ncbi.nlm.nih.gov/pubmed/23548634
Lavara-Culebras E, Muñoz-Soriano V, Gómez-Pastor R, Matallana E, Paricio N. Effects of pharmacological agents on the lifespan phenotype of Drosophila DJ-1beta mutants. Gene. 2010 Aug 15;462(1-2):26-33. doi: 10.1016/j.gene.2010.04.009. https://www.ncbi.nlm.nih.gov/pubmed/20423725
List of all publications can be found in:
