Our Research
In the Binstadt lab, we are interested in understanding the mechanistic links between systemic autoimmune and/or inflammatory diseases and the increased risk of cardiovascular disease associated with these diseases. We also investigate fundamental mechanisms of autoimmune disease pathogenesis. Scroll down for our published work in this area (Bryce Binstadt's full publication list can be found here). If you are interested in learning more about our work or joining our team, please contact us.
Profibrotic VEGFR3-Dependent Lymphatic Vessel Growth in Autoimmune Valvular Carditis
Osinski V, Yellamilli A, Firulyova MM, Zhang MJ, Peck AL, Auger JL, Faragher JL, Marath A, Voeller RK, O'Connell TD, Zaitsev K, Binstadt BA. Arterioscler Thromb Vasc Biol. 2024 Jan 25. doi: 10.1161/ATVBAHA.123.320326
Autoimmune Valvular Carditis Requires Endothelial Cell TNFR1 Expression
Faragher JL, Auger JL, Osinski V, Meier LA, Engelson BJ, Firulyova MM, Gonzalez-Torres MI, Brombacher F, Zaitsev K, Marath A, Binstadt BA. Arterioscler Thromb Vasc Biol. 2023 Apr 6. doi: 10.1161/ATVBAHA.122.319025.
CD47 promotes autoimmune valvular carditis by impairing macrophage efferocytosis and enhancing cytokine production
Meier LA*, Faragher JL*, Osinski V, Auger JL, Voeller R, Marath A, Binstadt BA. J Immunol. 2022, June;ji2100903. doi: 10.4049/jimmunol.2100903. *Co-first authors
Noninvasive ultrasound stimulation of the spleen to treat inflammatory arthritis
Zachs DP, Offutt SJ, Graham RS, Kim Y, Mueller J, Auger JL, Schuldt NJ, Kaiser CRW, Heiller AP, Dutta R, Guo H, Alford JK, Binstadt BA*, Lim HH*. Nat Commun. 2019 Mar 12;10(1):951. doi: 10.1038/s41467-019-08721-0. PMID: 30862842. *Co-senior authors
A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance
Dutta R, Lunzer MM, Auger JL, Akgün E, Portoghese PS, Binstadt BA. Arthritis Res Ther. 2018 Jul 27;20(1):154. doi: 10.1186/s13075-018-1661-5. PMID: 30053832.
CD301b/MGL2+ Mononuclear Phagocytes Orchestrate Autoimmune Cardiac Valve Inflammation and Fibrosis
Meier LA, Auger JL, Engelson BJ, Cowan HM, Breed ER, Gonzalez-Torres MI, Boyer JD, Verma M, Marath A, Binstadt BA. Circulation. 2018 Jun 5;137(23):2478-2493. doi: 10.1161/CIRCULATIONAHA.117.033144. Epub 2018 Jan 31. PMID: 29386201.
Cutting Edge: Dual TCRα Expression Poses an Autoimmune Hazard by Limiting Regulatory T Cell Generation
Schuldt NJ, Auger JL, Spanier JA, Martinov T, Breed ER, Fife BT, Hogquist KA, Binstadt BA. J Immunol. 2017 Jul 1;199(1):33-38. doi: 10.4049/jimmunol.1700406. Epub 2017 May 24. PMID: 28539428.
Brief Report: Arthritis in KRN T Cell Receptor-Transgenic Mice Does Not Require Interleukin-17 or Th17 Cells
Auger JL, Cowan HM, Engelson BJ, Kashem SW, Prinz I, Binstadt BA. Arthritis Rheumatol. 2016 Aug;68(8):1849-55. doi: 10.1002/art.39646. PMID: 26882006.
Bi-Allelic TCRα or β Recombination Enhances T Cell Development but Is Dispensable for Antigen Responses and Experimental Autoimmune Encephalomyelitis
Schuldt NJ, Auger JL, Hogquist KA, Binstadt BA. PLoS One. 2015 Dec 22;10(12):e0145762. doi: 10.1371/journal.pone.0145762. PMID: 26693713.
Fcγ receptor III and Fcγ receptor IV on macrophages drive autoimmune valvular carditis in mice
Hobday PM, Auger JL, Schuneman GR, Haasken S, Verbeek JS, Binstadt BA. Arthritis Rheumatol. 2014 Apr;66(4):852-62. doi: 10.1002/art.38311. PMID: 24757138.
Macrophage scavenger receptor 1 (Msr1, SR-A) influences B cell autoimmunity by regulating soluble autoantigen concentration
Haasken S, Auger JL, Taylor JJ, Hobday PM, Goudy BD, Titcombe PJ, Mueller DL, Binstadt BA. J Immunol. 2013 Aug 1;191(3):1055-62. doi: 10.4049/jimmunol.1201680. Epub 2013 Jun 21. PMID: 23794629.
Autoantibody-mediated arthritis in the absence of C3 and activating Fcγ receptors: C5 is activated by the coagulation cascade
Auger JL, Haasken S, Binstadt BA. Arthritis Res Ther. 2012 Dec 13;14(6):R269. doi: 10.1186/ar4117. PMID: 23237573.
Incomplete TCR-β allelic exclusion accelerates spontaneous autoimmune arthritis in K/BxN TCR transgenic mice
Auger JL, Haasken S, Steinert EM, Binstadt BA. Eur J Immunol. 2012 Sep;42(9):2354-62. doi: 10.1002/eji.201242520. Epub 2012 Jul 16. PMID: 22706882.
Absence of β2 integrins impairs regulatory T cells and exacerbates CD4+ T cell-dependent autoimmune carditis
Haasken S, Auger JL, Binstadt BA. J Immunol. 2011 Sep 1;187(5):2702-10. doi: 10.4049/jimmunol.1000967. Epub 2011 Jul 27. PMID: 21795599.
The neuropeptide neuromedin U promotes autoantibody-mediated arthritis
Rao SM, Auger JL, Gaillard P, Weissleder R, Wada E, Torres R, Kojima M, Benoist C, Mathis D, Binstadt BA. Arthritis Res Ther. 2012 Feb 7;14(1):R29. doi: 10.1186/ar3732. PMID: 22314006.
The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms
Binstadt BA, Hebert JL, Ortiz-Lopez A, Bronson R, Benoist C, Mathis D. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16758-63. doi: 10.1073/pnas.0909132106. Epub 2009 Sep 15. PMID: 19805369.