Publications
2023
Guidolin, Valeria, et al. "Liquid Chromatography–Mass Spectrometry Screening of Cyclophosphamide DNA Damage In Vitro and in Patients Undergoing Chemotherapy Treatment." Chemical Research in Toxicology 2023. link
Guidolin, Valeria, et al. "Characterization and quantitation of busulfan DNA adducts in the blood of patients receiving busulfan therapy." Molecular Therapy-Oncolytics 2023. link
2022
Dator, Romel P., et al. "Identification of Formaldehyde-Induced DNA–RNA Cross-Links in the A/J Mouse Lung Tumorigenesis Model." Chemical Research in Toxicology 2022. link
Solivio, Morwena J., et al. "In vivo identification of adducts from the new hypoxia-activated prodrug CP-506 using DNA adductomics." Chemical research in toxicology 35.2 2022. link
Volpe, Matthew R., et al. "A small molecule inhibitor prevents gut bacterial genotoxin production." Nature Chemical Biology 2022. link
2021
Peterson, Lisa A., et al. "Coexposure to Inhaled Aldehydes or Carbon Dioxide Enhances the Carcinogenic Properties of the Tobacco-Specific Nitrosamine 4-Methylnitrosamino-1-(3-pyridyl)-1-butanone in the A/J Mouse Lung." Chemical research in toxicology 2021. link
Walters, Kristine, et al. "Identification of New Candidate Biomarkers to Support Doxorubicin Treatments in Canine Cancer Patients." 2021.
Guidolin, Valeria, et al. "Identification of New Markers of Alcohol-Derived DNA Damage in Humans." Biomolecules 11.3 2021. link
Murray, Kevin J., et al. "Extension of Diagnostic Fragmentation Filtering for Automated Discovery in DNA Adductomics." Analytical Chemistry 93.14 (2021): 5754-5762 2021. link
2020
Viviana Paiano, Laura Maertens, Valeria Guidolin, Jing Yang, Silvia Balbo, and Stephen S. Hecht. Quantitative Liquid Chromatography–Nanoelectrospray Ionization–High-Resolution Tandem Mass Spectrometry Analysis of Acrolein-DNA Adducts and Etheno-DNA Adducts in Oral Cells from Cigarette Smokers and Nonsmokers. Chem Res Toxicol, 2020. link
Evan M. Alexander, Dale F. Kreitler, Valeria Guidolin, Alexander K Hurben, Eric J Drake, Peter W. Villalta, Silvia Balbo, Andrew M. Gulick, and Courtney C. Aldrich. Biosynthesis, Mechanism of Action, and Inhibition of the Enterotoxin Tilimycin Produced by the Opportunistic Pathogen Klebsiella oxytoca. ACS Infect. Dis., 2020. link
Romel Dator, Peter W. Villalta, Nicole Thomson, Joni Jensen, Dorothy K. Hatsukami, Irina Stepanov, Benedikt Warth, and Silvia Balbo. Metabolomics Profiles of Smokers from Two Ethnic Groups with Differing Lung Cancer Risk. Chem Res Toxicol, 2020. link.
Lisa A Peterson, Silvia Balbo, Naomi Fujioka, Dorothy K. Hatsukami, Stephen S. Hecht, Sharon E. Murphy, Irina Stepanov, Natalia Tretyakova, Robert J. Turesky and Peter W Villalta. Applying tobacco, environmental and dietary-related biomarkers to understand cancer etiology and evaluate prevention strategies.Cancer Epidemiol Biomarkers Prev, 2020. link.
2019
Andrea Carrà, Valeria Guidolin, Romel Dator, Pramod Upadhyaya, Fekadu Kassie, Peter W. Villalta and Silvia Balbo. Targeted High Resolution LC/MS3 Adductomics Method for the Characterization of Endogenous DNA Damage. Front Chem, 2019, link.
Andrea Carrà, Veronica Macaluso, Peter W. Villalta, Riccardo Spezia, Silvia Balbo. Fragmentation Spectra Prediction and DNA Adducts Structural Determination. J Am Soc Mass Spectrom., 2019, link.
Yindi Jiang, Alessia Stornetta, Peter W. Villalta, Matthew R. Wilson, Paul D. Boudreau, Li Zha, Silvia Balbo, and Emily P. Balskus. Reactivity of an Unusual Amidase May Explain Colibactin’s DNA Cross-Linking Activity. JACS, 2019, link.
Faraz Bishehsari, Lijuan Zhang, Robin M. Voigt, Natalie Maltby, Bita Semsarieh, Eyas Zorub, Maliha Shaikh, Sherry Wilber, Andrew R. Armstrong, Seyed Sina Mirbagheri, Nailliw Z. Preite, Peter Song, Alessia Stornetta, Silvia Balbo, Christopher B. Forsyth, Ali Keshavarzian. Alcohol Effects on Colon Epithelium are Time‐Dependent. Alcohol Clin Exp Res, 2019, link.
Romel Dator, Morwena J. Solivio, Peter W. Villalta, Silvia Balbo. Bioanalytical and Mass Spectrometric Methods for Profiling Aldehydes in Biological Fluids. Review. Toxics, 2019, link.
Amin Sobh, Alex Loguinov, Alessia Stornetta, Silvia Balbo, Abderrahmane Tagmount, Luoping Zhang, Chris D Vulpe. Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde. Tox. Sci., 2019, link.
Matthew R. Wilson, Yindi Jiang, Peter W. Villalta, Alessia Stornetta, Paul D. Boudreau, Andrea Carrá, Caitlin A. Brennan, Eunyoung Chun, Lizzie Ngo, Leona D. Samson, Bevin P. Engelward, Wendy S. Garrett, Silvia Balbo, Emily P. Balskus. The human gut bacterial genotoxin colibactin alkylates DNA. Science, 2019, link.
Yupeng Li, Bin Ma, Qing Cao, Silvia Balbo, Lijiao Zhao, Pramod Upadhyaya, and Stephen S. Hecht. Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N′‑Nitrosonornicotine. Chem Res Toxicol, 2019, link.
Jing Yang, Silvia Balbo, Peter W. Villalta, and Stephen S. Hecht. Analysis of Acrolein-Derived 1,N2 ‑Propanodeoxyguanosine Adducts in Human Lung DNA from Smokers and Nonsmokers. Chem Res Toxicol, 2019, link.
2018
Silvia Balbo, Irina Stepanov. The Wild West of E-Cigarettes, Chem Res Toxicol, 2018, link
Sharon E. Murphy, Sungshim Lani Park, Silvia Balbo, Christopher A. Haiman, Dorothy K. Hatsukami, Yesha Patel, Lisa A. Peterson, Irina Stepanov, Daniel O. Stram, Natalia Tretyakova, Stephen S. Hecht and Loïc Le Marchand. Tobacco biomarkers and genetic/epigenetic analysis to investigate ethnic/racial differences in lung cancer risk among smokers. NPJ Precis Oncol., 2018, link.
Romel Dator, Linda von Weymarn, Peter W. Villalta, Cory J. Hooyman, Laura A. Maertens, Pramod Upadhyaya, Sharon E. Murphy, Silvia Balbo. In vivo stable isotope labeling and mass spectrometry-based metabolic profiling of a potent tobacco-specific carcinogen in rats. Anal Chem, 2018, link
Alessia Stornetta , Valeria Guidolin and Silvia Balbo. Alcohol-Derived Acetaldehyde Exposure in the Oral Cavity. Cancers, 2018, link
2017
Guang Cheng, Adam T. Zarth, Pramod Upadhyaya, Peter W. Villalta, Silvia Balbo, and Stephen S. Hecht. Investigation of the Presence in Human Urine of Mercapturic Acids Derived from Phenanthrene, a Representative Polycyclic Aromatic Hydrocarbon. Chem Biol Interact., 2017, link.
Alessia Stornetta, Peter W. Villalta, Frederike Gossner, William R. Wilson, Silvia Balbo, and Shana J. Sturla. DNA Adduct Profiles Predict in Vitro Cell Viability after Treatment with the Experimental Anticancer Prodrug PR104A. Chem Res Toxicol, 2017, link.
Romel Dator, Andrea Carra’, Laura Maertens, Valeria Guidolin, Peter W. Villalta, Silvia Balbo. A High Resolution/Accurate Mass (HRAM) Data-Dependent MS3 Neutral Loss Screening, Classification, and Relative Quantitation Methodology for Carbonyl Compounds in Saliva. J Am Soc Mass Spectrom, 2017, link.
2016
Carol J. Díaz-Díaz, Sean M. Ronnekleiv-Kelly, Manabu Nukaya, Peter G. Geiger, Silvia Balbo, Romel Dator, Bryant W. Megna, Patrick R. Carney, Christopher A. Bradfield, Gregory D. Kennedy. The Aryl Hydrocarbon Receptor is a Repressor of Inflammation-associated Colorectal Tumorigenesis in Mouse. Annals of Surgery, 2016, link.
Silvia Balbo, Rita Cervera Juanes, Samir Khariwala, Erich J. Baker, James B. Daunais and Kathleen A. Grant. Increased levels of the acetaldehyde-derived DNA adduct N2 -ethyldeoxyguanosine in oral mucosa DNA from Rhesus monkeys exposed to alcohol. Mutagenesis, 2016, link.
Ali Khammanivong, Arunkumar Anandharaj, Xuemin Qian, Jung Min Song, Pramod Upadhyaya, Silvia Balbo, Dipankar Bandyopadhyay, Erin B. Dickerson, Stephen S Hecht, and Fekadu Kassie. Transcriptome profiling in oral cavity and esophagus tissues from (S)-N′-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis. Mol Carcinog, 2016, link.
2015
Alessia Stornetta, Peter W. Villalta, Stephen S. Hecht, Shana J. Sturla, Silvia Balbo. Screening for DNA Alkylation Mono and Cross-Linked Adducts with a Comprehensive LC-MS3 Adductomic Approach. Anal Chem, 2015, link.
Valerie Zabala, Ming Tong, Rosa Yu, Teresa Ramirez, Emine B. Yalcin, Silvia Balbo, Elizabeth Silbermann, Chetram Deochand, Kavin Nunez, Stephen Hecht and Suzanne M. de la Monte. Potential Contributions of the Tobacco Nicotine-Derived Nitrosamine Ketone (NNK) in the Pathogenesis of Steatohepatitis in a Chronic Plus Binge Rat Model of Alcoholic Liver Disease. Alcohol and Alcoholism, 2015, link.
Silvia Balbo, Philip J. Brooks. Implications of Acetaldehyde-Derived DNA Adducts for Understanding Alcohol-Related Carcinogenesis. Biological Basis of Alcohol-Induced Cancer, 2015, link.
