Publications

High-Throughput Screening of Isomeric Reaction Products by Droplet Microfluidics Coupled to Cyclic Ion Mobility-Mass Spectrometry
Penabad, L. I., Diehl, R.C., Olman, A., Unger, M. J., Somerville, T.D., López, J. C. V., Cain, C. N.,  Chakrabarty, S., Murray, L. A. M., Armbruster, M. R., Figueroa, A. V., Xu, Z., Ruotolo, B. T., Narayan, A. R. H., Kennedy, R. T. (2026). Analytical Chemistry, 98(27), 20442–20452.

Phenotyping and selection of cells using mass spectrometry and a microfluidic droplet printer
Mavrakis, E., Knecht, G. T., Unger, M. J., Narayan, A. R. H., & Kennedy, R. T. (2025). Analytical Chemistry, 97(48), 26607–26615.

Engineering the reaction pathway of a non-heme iron oxygenase using ancestral sequence reconstruction

Yang, D., Chiang, C.-H., Wititsuwannakul, T., Brooks, C. L., 3rd, Zimmerman, P. M., & Narayan, A. R. H. (2024). Journal of the American Chemical Society, 146(50), 34352–34363.

Ancestral sequence reconstruction to enable biocatalytic synthesis of azaphilones

Chiang, C.-H., Wang, Y., Hussain, A., Brooks, C. L., 3rd, & Narayan, A. R. H. (2024). Journal of the American Chemical Society, 146(44), 30194–30203. 

Biocatalytic stereoselective oxidation of 2-arylindoles

Champagne, S. E., Chiang, C.-H., Gemmel, P. M., Brooks, C. L., 3rd, & Narayan, A. R. H. (2024). Journal of the American Chemical Society, 146(4), 2728–2735. 

High-throughput liquid chromatographic analysis using a segmented flow injector with a 1 s cycle time

Makey, D. M., Diehl, R. C., Xin, Y., Murray, B. E., Stoll, D. R., Ruotolo, B. T., Grinias, J. P., Narayan, A. R. H., Lopez-Carillo, V., Stark, M., Johnen, P., & Kennedy, R. T. (2023). Analytical Chemistry, 95(46), 17028–17036. 

TMPRSS2 inhibitor discovery facilitated through an in silico and biochemical screening platform

Peiffer, A. L., Garlick, J. M., Wu, Y., Wotring, J. W., Arora, S., Harmata, A. S., Bochar, D. A., Stephenson, C. J., Soellner, M. B., Sexton, J. Z., Brooks, C. L., 3rd, & Mapp, A. K. (2023). ACS Medicinal Chemistry Letters, 14(6), 860–866.

Deciphering the evolution of flavin-dependent monooxygenase stereoselectivity using ancestral sequence reconstruction

Chiang, C.-H., Wymore, T., Rodríguez Benítez, A., Hussain, A., Smith, J. L., Brooks, C. L., 3rd, & Narayan, A. R. H. (2023). Proceedings of the National Academy of Sciences of the United States of America, 120(15), e2218248120. 

Structural basis for control of methylation extent in polyketide synthase metal-dependent C-methyltransferases

Lao, Y., Skiba, M. A., Chun, S. W., Narayan, A. R. H., & Smith, J. L. (2022). ACS Chemical Biology, 17(8), 2088–2098. 

Allostery in the dynamic coactivator domain KIX occurs through minor conformational micro-states

Peiffer, A. L., Garlick, J. M., Joy, S. T., Mapp, A. K., & Brooks, C. L., 3rd. (2022). PLoS Computational Biology, 18(4), e1009977.