Publications

Singer Lab related publications below

1. Kasa-Vubu JZ, Lee CC, Rosenthal A, Singer K, Halter JB. Cardiovascular fitness and exercise as determinants of insulin resistance in postpubertal adolescent females. J Clin Endocrinol Metab. 2005 Feb;90(2):849-54.

2. Singer K, Rosenthal A, and Kasa-Vubu JZ. Elevated testosterone and hypergonadotropism in active adolescents of normal weight with oligomenorrhea. J Pediatr Adol Gynecol. October 2009: 323-327.

3. Westcott D, DelProposto J, Geletka L, Wang T, Singer K, Saltiel A, Lumeng CN. MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. J Exp Med, December 2009. 21; 206 (13); 3143-56.

4. Singer K, Pietropaolo M, and Menon RK. Improving type 1 diabetes control with leptin – Is this a game change? Pediatr Diabetes, Vol 11, Issue 4, 2010.

5. Singer K, Subbaiah P, Odetola F, Hutchinson R, and Shanley T. Clinical course of sepsis in children with acute leukemia admitted to the pediatric intensive care unit. Pediatr Crit Care Med April 2011. Nov;12(6):649-54.

6. Morris DL, Singer K, Lumeng CN. Adipose tissue macrophages: Phenotypic plasticity and diversity in lean and obese states. Curr Opin Clin Nutr Metab Care. July 2011; 14(4); 341-6.

7. Singer K, Menon RK., Lesperance MM, McHugh JB, Gebarski SS, and Avram A Residual thyroid tissue after thyroidectomy in a patient with TSH receptor-activating mutation presenting as a neck mass. Journal of Clinical Endocrinology and Metabolism. 2013 Feb; 98 (2):448-52.

8. Singer K, Morris DL, Oatmen KE, Wang T, Delproposto J, Mergian T, Cho K, Lumeng CN. Neuropeptide Y is Produced by Adipose Tissue Macrophages and Regulates Obesity-Induced Inflammation. PLOS One, 2013; 8(3):e47929.

9. Morris DL, Cho KW, Delproposto J, Oatmen KE, Geletka L, Martinez-Santibanez G, Singer K, Lumeng CN. Adipose Tissue Macrophages Function as Antigen Presenting Cells and Regulate Adipose Tissue CD4+ T cells in Mice. Diabetes. Aug 2013. 62 (8); 2763-72.

10. Singer K, Eng D, Lumeng CN, Gebremariam, A., Lee J. The Relationship between Body Fat Mass Percentiles and Inflammation in Children. Obesity. May 2014. 22 (5) 1332-1336.

11. Singer K, Heiniger N., Thomas, IH, Worden, FP, Menon RK, and Chen M. Ectopic Cushing Syndrome Secondary to Metastatic Medullary Thyroid Cancer in a Child with Multiple Endocrine Neoplasia Type 2B: Clues to early diagnosis of the paraneoplastic syndrome. Journal of Pediatric Endocrinology and Metabolism. Epub May 2014.

12. Singer K, DelProposto J, Morris DL, Zamarron B, Mergian T, Maley N, Cho KW, Geletka L, Subbaiah P, Muir L, Martinez-Santibanez G, Lumeng CN. Diet-Induced Obesity Promotes Myelopoiesis in Hematopoietic Stem Cells. Molecular Metabolism. September 2014. 3 (6) 664-675.

13. Cho, K.W., Morris, D.L, DelProposto, J.L, Geletka, L, Zamaroon, B., Martinez-Santibanez, G., Meyer, K.A., Singer, K., O’Rourke, R.W., Lumeng, C.N. An MHC Class II Dependent Activation Loop Between Adipose Tissue Macrophages and CD4+ T cells Controls Obesity-Induced Inflammation, Cell Reports, Oct 23;9 (2):605-17. 2014

14. Martinez-Santibanez G, Singer K, Cho KW, Delproposto J, Mergian T, Lumeng CN. Obesity-Induced Remodeling of the Adipose Tissue Elastin Network is Independent of Metalloelastase MMP-12. Adipocyte. In press 2015.

15. Singer K, Maley N, Mergian T, DelProposto J, Cho KW, Zamarron B, Martinez-Santibanez G, Geletka L, Wachowiak P, Demirjian C, and Lumeng CN. Differences in Hematopoietic Stem Cells Contribute to Sexually Dimorphic Inflammatory Responses to High Fat Diet-induced Obesity. Journal of Biological Chemistry. May 2015.

16. Morris DL, Oatmen KE, Mergian TA, Cho KW, DelProposto J, Singer K, Evans-Molina C, O’Rourke RW, Lumeng CN. CD40 Promotes MHC Class II Expression on Adipose Tissue Macrophages and Regulates Adipose Tissue CD4+ T Cells with Obesity. Journal of Leukocyte Biology. December 2015. PMID: 26658005.

17. Veiga-Lopez A, Moeller J, Sreedharan R, Singer K, Lumeng CN, Ye W, Pease A,Padmanabhan V. Developmental Programming: interaction between prenatal BPA exposure and postnatal adiposity on metabolic variables in female sheep. American Journal of Physiology - Endocrinology and Metabolism. Epub Dec 2015. PMID: 26646100.

18. Maley N, Gebremariam A, Odetola F, and Singer K. Influence of obesity diagnosis with organ dysfunction, mortality, and resource use among children hospitalized with infection in the United States. Journal of Intensive Care Medicine. February 2016. PMID: 26880005.

19. Singer BH, Newstead MW, Zeng X, Cooke CL, Thompson RC, Singer K, Ghantasala R, Parent JM, Murphy GG, Iwashyna TJ, Standiford TJ. Cecal ligation and puncture results in long-term central nervous system myeloid inflammation. PLOS One. February 2016 PMID: 26862765.

20. Griffin C, Lanzetta N, Eter L, and Singer K. Sexually dimorphic myeloid inflammatory and metabolic responses to diet-induced obesity. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. Epub June 2016. PMID: 27252473.

21. Scheller EL, Khoury B, Moller KL, Wee NK, Khandaker S, Kozloff KM, Abrishami SH, Zamarron BF, Singer K. Changes in skeletal integrity and marrow adiposity during high-fat diet and after weight-loss. Front Endocrinol. Jul 2016. PMID: 27512386.

22. Cho KW, Zamarron B, DelProposto JL, Geletka L, Muir L, Meyer KA, Singer K, O’Rourke RW, and Lumeng CN. Adipose Tissue Dendritic Cells Are Independent Contributors to Obesity-Induced Inflammation and Insulin Resistance. Journal of Immunology. September 2016. PMID: 27683748.

23. Singer K and Lumeng CN. The Initiation of Metabolic Inflammation During Childhood. Journal of Clinical Investigation. 1/2017 PMID: 28045405.

24. Zamarron BF, Mergian T, Cho KW, Martinez-Santibanez G, Luan D, Singer K, DelProposto JL, Geletka L, Muir L, Lumeng CN. Macrophage Proliferation Sustains Adipose Tissue Inflammation in Formerly Obese Mice. Diabetes. 2/2017. PMID: 28108608.

25. Wang SY, Andrews CA, Gardner TW, Wood M, Singer K, and Stein JD. Ophthalmic Screening Patterns Among Youth with Type 1 and Type 2 Diabetes Enrolled in a Large U.S. Managed Care Network. JAMA Ophthalmology. Accepted 1/2017. PMID: 28334336.

26. Muir LA, Baker NA, Washabaugh AR, Neeley CK, Flesher CG, DelProposto JB, Geletka L, Ghaferi AA, Finks JF, Singer K, Varban OA, Lumeng CN, O’Rourke RW. Adipocyte hypertrophy-hyperplasia balance contributes to weight loss after bariatric surgery. Adipocyte. January 2017. PMID: 28425841.

27. Gállego Suárez C, Singer BH, Gebremariam A, Lee JM, Singer K. The relationship between adiposity and bone density in U.S. children and adolescents. PLoS ONE. July 2017, 12(7): e0181587. PMID: 28723934.

28. Molloy CT, Adkins LJ, Griffin C, Singer K, Weinberg JB. Mouse Adenovirus Type 1 Infection of Adipose Tissue. Virus Res. November 2017. [Epub ahead of print: pii: S0168-1702(17)30639-1. doi: 10.1016/j.virusres.2017.11.014]. PMID: 29141203.

29. Varghese M, Griffin C, Singer K. The role of sex and sex hormones in regulating obesity-induced inflammation (Chapter). Sex and gender factors affecting metabolic homeostasis, diabetes and obesity. Advances in Experimental Medicine and Biology book series. PMID: 29224091.

30. Peterson LS, Gállego Suárez C, Segaloff HE, Griffin C, Martin ET, Odetola FO, Singer K. Outcomes and Resource Use Among Overweight and Obese Children With Sepsis in the Pediatric Intensive Care Unit. J Intensive Care Med. February 2018 [Epub ahead of print doi: 10.1177/0885066618760541] PMID: 29471722.

31. Griffin C, Eter L, Lanzetta N, Abrishami S, Varghese M, McKernan K, Muir L, Lane J, Lumeng CN, Singer K. TLR4, TRIF, and MyD88 are essential for myelopoiesis and CD11c+ adipose tissue macrophage production in obese mice. J Biol Chem. 2018 Apr 10. [Epub ahead of print: pii: jbc.RA117.001526. doi: 10.1074/jbc.RA117.001526] PMID:29636416.

32. Gállego Suárez C, Gregg BE, Watson ME Jr, Sturza J, Bermick JR, Singer K. Preserving Future Generations of Pediatric Researchers. J Pediatr. 2018 May;196:4-6. doi: 10.1016/j.jpeds.2018.01.061. PMID: 29703371.

33. Stojanovska J, Lumeng CN, Griffin C, Hernando D, Hoffman O, Haft J, Kim K, Burant CF, Singer K, Tsodikov A, Long B, Romano M, Tang P, Yang B, and Chenevert T. Water-fat magnetic resonance imaging quantifies relative proportions of brown and while adipose tissues: ex-vivo experiments. Journal of Medical Imaging. Accepted June 2018.

34. Chang E, Varghese M, and Singer K. Gender and Sex Differences in Adipose Tissue. Current Diabetes Reports. July 2018. PMID 30058013.

35. Varghese M, Griffin C, McKernan K, Eter L, Lanzetta N, Agarwal D, Abrishami S, and Singer K. Sex differences in inflammatory responses to adipose tissue lipolysis in diet-induced obesity. Endocrinology. February 2019. PMID 30544158.

36. Li Z, Hardji J, Evers S, Hutch CR, Choi SM, Shao Y, Learman BS, Lewis KT, Schill RL, Mori H, Bagchi DP, Romanelli SM, Kim K, Bowers E, Griffin C, Seeley R, Singer K, Sandoval D, Rosen C, and MacDougald O. G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche. Journal of Clinical Investigation. May 2019. PMID 31063988.

37. Griffin C, Hutch CR, Abrishami S, Stelmak D, Eter L, Li Z, Chang E, Agarwal D, Zamarron B, Varghese M, Subbaiah P, MacDougald OA, Sandoval DA, and Singer K. Inflammatory responses to dietary and surgical weight loss in male and female mice. Biology of Sex Differences. April 2019. PMID 30944030.

38. Hafner H, Chang E, Carlson Z, Zhu A, Varghese M, Clemente J, Abrishami S, Bagchi DP, MacDougald OA, Singer K, and Gregg B. Lactational high fat diet exposure programs metabolic inflammation and bone marrow adiposity in male offspring. Nutrients. June 2019. PMID 31234301.

39. Chang E, Hafner H, Varghese M, Griffin C, Islam M, Carlson Z, Zhu A, Hak L, Abrishami S, Gregg B, and Singer K. Programming effects of maternal and gestational obesity on offspring metabolism and metabolic inflammation. Scientific Reports. November 2019. PMID 31690792.

40. Puttabyatappa M, Ciarelli J, Chatoff A, Singer K, and Padmanabhan V. Developmental Programming: Adipose Depot-Specific Changes and Thermogenic Adipocyte Distribution in the Female Sheep. Molecular and Cellular Endocrinology. December 2019. PMID 31863810.

41. Varghese M, Griffin C, McKernan K, Eter L, Abrishami S, and Singer K. Female adipose tissue has improved adaptability and metabolic health compared to males in aged obesity. Aging. January 2020. PMID 31983693.

42. Zamarron BF, Luan D, Lucas HR, Mergian TA, Porsche CE, Martinez-Santibanez G, Singer K, Cho KW, DelProposto JL, Geletka LM, Muir LA, Lumeng CN. Weight Regain in Formerly Obese Mice Hastens the Development of Hepatic Steatosis and Reveals Impaired Adipose Tissue Function. Obesity. April 2020. PMID 32281747.

43. Davis FM, denDekker A, Kimball A, Joshi AD, El Azzoungy M, Wolf SJ, Obi AT, Lipinski J, Gudjonsson JE, Xing X, Plazyo O, Audu C, Melvin WJ, Singer K, Henke PK, Moore BB, Burant C, Kunkel SL, Gallagher KA. Epigenetic Regulation of TLR4 in Diabetic Macrophages Modulates Immunometabolism and Wound Repair. J Immunolology. March 2020. PMID 32205424.

44. McKernan K, Varghese M, Patel R, and Singer K. Role of TLR4 in the induction of inflammatory change in adipocytes and macrophages. Adipocyte. April 2020. PMID 32403975.

45. Gállego-Suárez C*, Bulan A*, Hirschfeld, Wachowiak P, Abrishami S, Griffin C, Sturza J, Tzau A, Hayes T, Woolford S, Lumeng CN, Lee J, Singer K. Enhanced Myeloid Leukocytes in Obese Children and Adolescents at risk for Metabolic Impairment. Frontiers Endocrinology. May 2020. PMID 32528415 * Co-first authors

46. Ludzki AC, Krueger EM, Baldwin TC, Schleh MW, Porsche CE, Ryan BJ, Muir LA, Singer K, Lumeng CN and Horowitz JF. Acute Aerobic Exercise Remodels the Adipose Tissue Progenitor Cell Phenotype in Obese Adults. Frontiers in Physiology. July 2020. PMID 32848853.

47. Huizinga GP, Singer BH, and Singer K. The Collision of Meta-Inflammation and SARS-CoV-2 Pandemic Infection. Endocrinology. Accepted August 2020.

48. Safari H, Kaczorowski N, Felder ML, Brannon ER, Varghese M, Singer K, and Eniola-Adefso, O. Biodegradable, Bile Salt Microparticles for Localized Fat Dissolution. Science Advances. December 2020. PMID 33277261.

49. Bowers E and Singer K. Obesity-induced Inflammation: The impact of the hematopoietic stem cell niche. JCI Insight. February 2021.PMID 33554957.

50. Nandedkar-Kularni N*, Esakov E*, Gregg B, Atkinson MA, Kusmartseva I, Rogers DG, Horner JD, Singer K, Lundy SK, Sims EK, Felton JL, Al-Huniti T, Kalinoski AN, Morran MP, Gupta NK, Bretz JD, Balaji S, Chen T and McInerney MF. Insulin receptor expressing T cells appear in individuals at risk for type 1 diabetes and can move into the pancreas in C57BL/6 transgenic mice. Journal of Immunology. March 2021. PMID 33658296.

51. Hutch CR, Stelmak D, Kanke M, Koch-Laskowski K, Cummings B, Griffin C, Leix K, Sethupathy P, Singer K, and Sandoval D. Diet-Dependent Sex Differences in the Response to Vertical Sleeve Gastrectomy. American Journal of Physiology Endocrinology and Metabolism. May 2021. PMID 33998293.

52. Islam MR, Schultz K, Varghese M, Abrishami S, Villano J* and Singer K*. * Co-senior authors. Weight gain, glucose tolerance, and the gut microbiome of male C57Bl/6j mice given corncob or paper bedding. Journal of the American Association for Laboratory Animal Science. June 2021. PMID 34183093.

53. LaBarre JL, Singer K and Burant CF. Advantages of studying the metabolome in response to mixed-macronutrient challenges and suggestions for future research designs. The Journal of Nutrition. July 2021. PMID 34255076.

54. Varghese M, Song J, and Singer K. Age and Sex: impact on adipose tissue metabolism and inflammation. Mechanisms of Ageing and Development. August 2021. PMID 34474078.

55. Varghese M, Griffin C, Abrishami S, Eter L, Lanzetta N, Hak L, Clemente J, Agarwal D, Lerner A, Westerhoff M, Patel R, Bowers E, Islam M, Perla S and Singer K. Sex hormones regulate meta-inflammation in diet-induced obesity in mice. Journal of Biological Chemistry. Accepted September 2021. PMID 34599964.

56. Mancuso P, Curtis JL, Weitzel A, Griffin C, Bouchard B, Freeman CM, Bridges D, and Singer K. Diet-Induced Obesity in Mice Impairs Host Defense against Klebsiella Pneumonia in vivo and Glucose Transport and Bactericidal Functions in neutrophils in vitro. AJP Lung. December 2021. PMID 34850640.

57. Akhaphong B, Gregg B, Kumusoglu D, Scheys J, Singer K, Delproposto J, Lumeng CN, Bernal-Mizrachi E, Alejandro E. Maternal high-fat diet during pre-conception and gestation predisposes adult female offspring to metabolic dysfunction in mice. Frontiers in Endocrinology, section Obesity. January 2022. PMID 35111136.

58. Varghese M, Clemente J, Lerner A, Abrishami S, Islam M, and Subbaiah P, and Singer K. Monocyte trafficking and polarization contribute to sex differences in meta-inflammation. Frontiers in Endocrinology, March 2022. PMID 35422759.

59. Li Z, Bowers E, Zhu J, Yu H, Hardij J, Bagchi DP, Mori H, Lewis KT, Granger K, Schill RL, Romanelli SM, Abrishami S, Hankenson KD, Singer K, Rosen CJ, and MacDougald OA. Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits. PMID 35731039. eLife. June 2022.

60. Li Z, Bagchi DP, Zhu J, Bowers E, Yu H, Hardij J, Mori H, Granger K, Skjaerlund JD, Mandair GS, Abrishami S, Singer K, Hankenson KD, Rosen CJ, MacDougald OA. Constitutive bone marrow adipocytes suppress local bone formation. JCI Insight. Accepted August 2022. PMID 36048537.

61. Song J, Farris D, Ariza P, Moorjani S, Blin M, Chen J, Tyrell D, Zhang M, Varghese M, Singer K, Salmon M, and Goldstein DR. Age-associated adipose tissue inflammation promotes monocyte chemotaxis and enhances atherosclerosis. Aging Cell. Jan 2023. PMID 36683460.

62. Kumar AJ, Parthasarathy C, Prescott HC, Denstaedt S, Newstead M, Bridges D, Bustamante A, Singer K*, and Singer BH*. Pneumosepsis survival in the setting of obesity leads to persistent steatohepatitis and metabolic dysfunction. Hepatology Communications. Accepted May 2023. PMID 37556193

* Co-senior authors

63. Kim K, Varghese M, Sun H, Abrishami S, Bowers E, Bridges D, Meijer JL, Singer K* and Gregg B*. The influence of maternal high fat diet during lactation on offspring hematopoietic priming. Endocrinology. Accepted November 2023. PMID 38048597.

*Co-senior authors