Our current research explores the use of decellularized lung tissue as a platform for developing advanced 3D cell culture matrices. By leveraging the unique extracellular matrix composition of lung tissue, we aim to create physiologically relevant environments for studying cellular behavior, disease modeling, and tissue regeneration. 

Our lab investigates sex as a biological variable by utilizing porcine pulmonary fibroblasts to study lung diseases and uncover sex-based differences in cellular behaviors. This research aims to enhance our understanding of how sex influences disease progression and cellular responses, ultimately contributing to more personalized approaches in medicine. 

Our lab employs 3D bioreactor systems to study the effects of physiological mechanical stimuli on cells within 3D microenvironments. By simulating conditions such as shear stress, stretch, and pressure, we aim to better understand how mechanical cues influence cellular behavior, tissue function, and disease mechanisms, paving the way for advancements in regenerative medicine and mechanobiology. 

Our research focuses on immune cell mechanotransduction, specifically examining how macrophages respond to 3D microenvironmental cues. By studying the interplay between mechanical signals and immune cell behavior, we aim to uncover mechanisms that regulate macrophage function in health and disease. This work has significant implications for understanding inflammation, tissue repair, and immune-related pathologies.