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Key Personnel
Sung Kyun Park, Principal Investigator
Kelly Bakulski, Principal Investigator
Bhramar Mukherjee, Co-Investigator
Henry Paulson, Co-Investigator
Roger Albin, Co-Investigator
Hiroko Dodge, Consultant
Mary Amburgey, Research Process Manager
Xin Wang, Research Investigator
Habyeong Kang, Postdoctoral Research Fellow
AD and Dementia are a major current and future public health challenge. Research on environmental risk factors for AD and dementia is critically needed to prevent future cases.
AD and Dementia are a major current and future public health challenge. Research on environmental risk factors for AD and dementia is critically needed to prevent future cases.
Transport of lead (Pb) and cadmium (Cd) to the brain.
The goal of this project is to understand the environment’s role in the development of Alzheimer’s Disease and related dementias (ADRD). Specifically, we aim to (1) conduct a biologic hypothesis-based approach to test the associations of chronic exposure to lead and cadmium with incident ADRD; (2) conduct a data-driven environment-wide association study to systematically evaluate a wide-range of environmental toxicants with incident ADRD; and (3) develop and validate an exposome-based risk prediction model for ADRD using machine learning methods. This project is funded by the National Institute on Aging (NIA, R01 AG070897).
PUBLICATIONS
Park SK, Ding N, Han D. Perfluoroalkyl Substances and Cognitive Function in Older Adults: Should We Consider Non-Monotonic Dose-Responses and Chronic Kidney Disease? Environ Res 2021;192:110346.
Bakulski KM, Seo YA, Hickman RC, Brandt D, Vadari HS, Hu H, Park SK. Heavy metals exposure and Alzheimer’s disease and related dementias. J Alzheimers Dis 2020;76(4):1215-1242.
Bakulski KM, Hu H, Park SK. Chapter 51. Lead, cadmium and Alzheimer’s disease. In: Genetics, Neurology, Behavior, and Diet in Dementia. The Neuroscience of Dementia, Volume 2. (edited by Martin CR, Preedy VR). Academic Press, Elsevier. London, United Kingdom. 2020. ISBN: 978-0-12-815868-5.
Peng Q, Bakulski K, Nan B, Park SK. Cadmium and Alzheimer’s disease mortality in U.S. adults: Updated evidence with a urinary biomarker and extended follow-up time. Environ Res 2017;157:44-51.
Farooqui Z, Bakulski KM, Power MC, Weisskopf MG, Sparrow D, Spiro III A, Vokonas PS, Nie H, Hu H, Park SK. Associations of cumulative Pb exposure and longitudinal changes in Mini-Mental Status Exam scores, global cognition and domains of cognition: The VA Normative Aging Study. Environ Res 2017;152:102-108.
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