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Biomechanics of aqueous veins and perilimbal sclera in intraocular pressure regulation
Biomechanics of aqueous veins and perilimbal sclera in intraocular pressure regulation
The hypothesis of this project is that the deformed shape of aqueous veins is influenced by the biomechanical properties of the surrounding perilimbal scleral tissue, and that overly stiff sclera undermines the passive and adaptive mechanisms of the aqueous outflow pathway in regulating IOP.
Collaborators:
Dr. Sayoko E. Moroi,
Dr. Amanda Bicket,
Dr. Alan Argento,
Dr. Wonsuk Kim,
Ni L, Riesterer J, Wang H, Berry L, Blackburn K, Chuang J, Kim W, Xu G, Moroi SE, Argento A: Method for the biomechanical analysis of aqueous veins and perilimbal sclera by three-dimensional photoacoustic imaging and strain field calculation. Sci Rep 11(1): 22108, 01/2021. PM34764362/PMC8585983
Funding support: The Glaucoma Foundation, Kellogg Eye Center startup fund
Hemodynamic responses to retinal photostimulation in transgenic mouse brain
Hemodynamic responses to retinal photostimulation in transgenic mouse brain
The central hypothesis of this study is that photoacoustic tomography can detect subtle photoresponse changes in several key nuclei of the mouse visual system, making it useful for in vivo studies of various disease models.
Collaborators:
Dr. Kwoon Wong,
Dr. Xueding Wang,
Chang KW, Zhu Y, Wang X, Wong KY, Xu G: Label-free photoacoustic computed tomography of mouse cortical responses to retinal photostimulation using a pair-wise correlation map. Biomed Opt Express 13 (2): 1017-1025, 01/2022. PM35284169/PMC8884203
Funding Supports: Mcubed, Kellogg Eye Center startup fund
The central hypothesis of this research is that, by assessing the molecular markers reflecting pathophysiology information and the mechanical markers reflecting tissue stiffness, PA-US endoscopy, which fits seamlessly into standard ileocolonoscopy procedures, can facilitate accurate diagnosis of the pathology of Crohn's Disease strictures.
Collaborators:
Dr. Peter Higgins
Dr. Katheryn Eaton
Dr. Xueding Wang
Funding Supports: R01DK125687, Crohn's and Colitis Foundation, R21AI122098, American Gastroenterology Association
Real time fine needle assessment of architectural heterogeneity in prostate cancer
Real time fine needle assessment of architectural heterogeneity in prostate cancer
The central hypothesis of this research is that the PA pre-biopsy can guide prostate biopsy, improve the core yield, and decrease false negative rates.
Collaborators:
Dr. Aaron Udager
Dr. Todd Morgan
Dr. Wei John
Dr. Matthew Davenport
Dr. Brian Fowlkes
Dr. Paul Carson
Dr. Xueding Wang
Funding Supports: R37CA222829, MICHR
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