Selected Publications

Gregg B, Ellsworth L, Pavela G, Shah K, Berger PK, Isganaitis E, VanOmen S, Demerath EW, Fields DA. Bioactive compounds in mothers milk affecting offspring outcomes: A narrative review. Pediatr Obes. 2022 Jan 20;:e12892. doi: 10.1111/ijpo.12892. [Epub ahead of print] Review. PubMed PMID: 35060344. 

Hafner H, Mulcahy MC, Carlson Z, Hartley P, Sun H, Westerhoff M, Qi N, Bridges D, Gregg B. Lactational High Fat Diet in Mice Causes Insulin Resistance and NAFLD in Male Offspring Which Is Partially Rescued by Maternal Metformin Treatment. Front Nutr. 2021;8:759690. doi: 10.3389/fnut.2021.759690. eCollection 2021. PubMed PMID: 34977118; PubMed Central PMCID: PMC8714922. 

Nagel EM, Jacobs D, Johnson KE, Foster L, Duncan K, Kharbanda EO, Gregg B, Harnack L, Fields DA, Demerath EW.Maternal Dietary Intake of Total Fat, Saturated Fat, and Added Sugar Is Associated with Infant Adiposity and Weight Status at 6 mo of Age. J Nutr. 2021 Aug 7;151(8):2353-2360. doi: 10.1093/jn/nxab101. PubMed PMID: 33982119; PubMed Central PMCID: PMC8435996. 

Ellsworth L, McCaffery H, Chernyak S, Lam S, Sargis RM, Padmanabhan V, Gregg B. Lactational exposure to polychlorinated biphenyls is higher in overweight /obese women and associated with altered infant growth trajectory: A pilot study. Curr Res Toxicol. 2020 Jun 10;1:133-140. doi: 10.1016/j.crtox.2020.10.002. eCollection 2020 Jun 10. PubMed PMID: 34345842; PubMed Central PMCID: PMC8320629. 

Alejandro EU, Jo S, Akhaphong B, Llacer PR, Gianchandani M, Gregg B, Parlee SD, MacDougald OA, Bernal-Mizrachi E. Maternal low-protein diet on the last week of pregnancy contributes to insulin resistance and β-cell dysfunction in the mouse offspring. Am J Physiol Regul Integr Comp Physiol. 2020 Oct 1;319(4):R485-R496. doi: 10.1152/ajpregu.00284.2019. Epub 2020 Sep 2. PubMed PMID: 32877242; PubMed Central PMCID: PMC7717124. 

Jackson BA, Gregg BE, Tutor SD, Bermick JR, Stanley KP. Human Milk Retains Important Immunologic Properties After Defatting. JPEN J Parenter Enteral Nutr. 2020 Jul;44(5):904-911. doi: 10.1002/jpen.1722. Epub 2019 Oct 9. PubMed PMID: 31599047. 

Ellsworth L, Perng W, Harman E, Das A, Pennathur S, Gregg B. Impact of maternal overweight and obesity on milk composition and infant growth. Matern Child Nutr. 2020 Jul;16(3):e12979. doi: 10.1111/mcn.12979. Epub 2020 Feb 19. PubMed PMID: 32074402; PubMed Central PMCID: PMC7296794. 

Carlson Z, Hafner H, Mulcahy M, Bullock K, Zhu A, Bridges D, Bernal-Mizrachi E, Gregg B. Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner. Am J Physiol Endocrinol Metab. 2020 May 1;318(5):E600-E612. doi: 10.1152/ajpendo.00473.2019. Epub 2020 Mar 10. PubMed PMID: 32154743; PubMed Central PMCID: PMC7272730. 

Ellsworth L, McCaffery H, Harman E, Abbott J, Gregg B. Breast Milk Iodine Concentration Is Associated with Infant Growth, Independent of Maternal Weight. Nutrients. 2020 Jan 30;12(2). doi: 10.3390/nu12020358. PubMed PMID: 32019065; PubMed Central PMCID: PMC7071233. 

Chang E, Hafner H, Varghese M, Griffin C, Clemente J, Islam M, Carlson Z, Zhu A, Hak L, Abrishami S, Gregg B, Singer K.Programming effects of maternal and gestational obesity on offspring metabolism and metabolic inflammation. Sci Rep. 2019 Nov 5;9(1):16027. doi: 10.1038/s41598-019-52583-x. PubMed PMID: 31690792; PubMed Central PMCID: PMC6831633. 

Hafner H, Chang E, Carlson Z, Zhu A, Varghese M, Clemente J, Abrishami S, Bagchi DP, MacDougald OA, Singer K, Gregg B. Lactational High-Fat Diet Exposure Programs Metabolic Inflammation and Bone Marrow Adiposity in Male Offspring.Nutrients. 2019 Jun 21;11(6). doi: 10.3390/nu11061393. PubMed PMID: 31234301; PubMed Central PMCID: PMC6628038. 

Ellsworth L, Harman E, Padmanabhan V, Gregg B. Lactational programming of glucose homeostasis: a window of opportunity. Reproduction. 2018 Aug;156(2):R23-R42. doi: 10.1530/REP-17-0780. Epub 2018 May 11. Review. PubMed PMID: 29752297; PubMed Central PMCID: PMC6668618. 

Gregg BE, Botezatu N, Brill JD, Hafner H, Vadrevu S, Satin LS, Alejandro EU, Bernal-Mizrachi E. Gestational exposure to metformin programs improved glucose tolerance and insulin secretion in adult male mouse offspring. Sci Rep. 2018 Apr 10;8(1):5745. doi: 10.1038/s41598-018-23965-4. PubMed PMID: 29636523; PubMed Central PMCID: PMC5893596. 

Thomas I, Gregg B. Metformin; a review of its history and future: from lilac to longevity. Pediatr Diabetes. 2017 Feb;18(1):10-16. doi:

Booms S, Hill E, Kulhanek L, Vredeveld J, Gregg B. Iodine Deficiency and Hypothyroidism From Voluntary Diet Restrictions in the US: Case Reports. Pediatrics. 2016 Jun;137(6). doi: 10.1542/peds.2015-4003. Epub 2016 May 10. PubMed PMID: 27244854. 

Gregg B, Connor CG, Ruedy KJ, Beck RW, Kollman C, Schatz D, Cengiz E, Harris B, Tamborlane WV, Klingensmith GJ, Lee JM. Body mass index changes in youth in the first year after type 1 diabetes diagnosis. J Pediatr. 2015 May;166(5):1265-1269.e1. doi: 10.1016/j.jpeds.2015.02.036. PubMed PMID: 25919735. 

Alejandro EU, Gregg B, Blandino-Rosano M, Cras-Méneur C, Bernal-Mizrachi E. Natural history of β-cell adaptation and failure in type 2 diabetes. Mol Aspects Med. 2015 Apr;42:19-41. doi: 10.1016/j.mam.2014.12.002. Epub 2014 Dec 24. Review. PubMed PMID: 25542976; PubMed Central PMCID: PMC4404183. 

Gregg B, Elghazi L, Alejandro EU, Smith MR, Blandino-Rosano M, El-Gabri D, Cras-Méneur C, Bernal-Mizrachi E.Exposure of mouse embryonic pancreas to metformin enhances the number of pancreatic progenitors. Diabetologia.2014 Dec;57(12):2566-75. doi: 10.1007/s00125-014-3379-5. Epub 2014 Sep 24. PubMed PMID: 25249235; PubMed Central PMCID: PMC4417192. 

Alejandro EU, Gregg B, Wallen T, Kumusoglu D, Meister D, Chen A, Merrins MJ, Satin LS, Liu M, Arvan P, Bernal-Mizrachi E. Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring. J Clin Invest. 2014 Oct;124(10):4395-410. doi: 10.1172/JCI74237. Epub 2014 Sep 2. PubMed PMID: 25180600; PubMed Central PMCID: PMC4191023. 

Gregg BE, Moore PC, Demozay D, Hall BA, Li M, Husain A, Wright AJ, Atkinson MA, Rhodes CJ. Formation of a human β-cell population within pancreatic islets is set early in life. J Clin Endocrinol Metab. 2012 Sep;97(9):3197-206. doi: 10.1210/jc.2012-1206. Epub 2012 Jun 28. PubMed PMID: 22745242; PubMed Central PMCID: PMC3431572. 

Blandino-Rosano M, Alejandro EU, Sathyamurthy A, Scheys JO, Gregg B, Chen AY, Rachdi L, Weiss A, Barker DJ, Gould AP, Elghazi L, Bernal-Mizrachi E. Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21Cip. Diabetologia. 2012 May;55(5):1380-9. doi: 10.1007/s00125-012-2465-9. Epub 2012 Feb 12. PubMed PMID: 22327314; PubMed Central PMCID: PMC3646796.