The objective of this project is to support the findings and hypotheses of the different arrhythmia mechanisms by applying new advanced techniques of spatio-temporal signal processing, visualization and machine learning technics over a wide set of signals (ECG, EGM, electrophysiological signals, mechanical signals) obtained from both simulated models and real clinical cases.
For the validation of detailed models of cardiac simulation in patients, the approach followed in this project gravitates around the development of iteratively improved models of atrial arrhythmias. We hypothesize that an electromechanical atrial model personalized on a given patient can provide different biomarkers to help doctors make an optimal patient selection for ablation procedures and guide ablation to increase efficiency and to maximize the overall atrial mechanical function after ablation. We also hypothesize that subtle and precise changes in the P wave from the ECG can be used as a predictor of AF recurrence when reconnecting the isolation of the PV.
Using electromechanical atrial models and patient-specific torso models, together with clinically recorded signals, new biomarkers of reconnection of the PV will be proposed.
URJC University
H. Virgen Arrixaca
H. Virgen Arrixaca
UMH University
UPCC University
H. Virgen Arrixaca
URJC University
URJC University
URJC University
Paul Bernal
Vinicio Carrera
Alba Vadillo
Jacobo Chaquet
2020
García-García, A and Prieto-Egido, I and Guerrero-Curieses, A and Feijoo-Martínez, J and Muñoz-Romero, S and Manzano Fernández S and Flores-Blanco, P and Rojo-Álvarez, J and Martínez-Fernández, A. Data Science Analysis and Profile Representation Applied to Secondary Prevention of Acute Coronary Syndrome. IEEE Access 9. 78607-78620, 2021.F.I.:4.098 (61/266, Q1 Engineering, Electrical and Electronic).
[coord] Pérez-Gutiérrez MF, JJ Sánchez-Muñoz, M Erazo-Rodas, A Guerrero-Curieses, E Everss, A Quesada, R Ruiz-Granell, A Ibánez, A Bellver, JL Rojo-Álvarez, A García-Alberola. Spectral Analysis and Mutual Information Estimation of Left and Right Intracardiac Electrograms During Ventricular Fibrillation. Sensors 2020. F.II.: 3.275 (16/61, Q1 Instruments and Instrumentation)
[coord] Caulier R, Sanroman M, S Muñoz-Romero, M Blanco, R Goya, A García-Alberola, JL Rojo-Álvarez. Spatial-temporal Signals and Clinical Indices in Electrocardiographic Imaging (I): Preprocessing and Bipolar Potentials. Sensors 2020. F.I: 3.275 (16/61, Q1 Instruments and Instrumentation)
[coord] Caulier R, Blanco M, R Goya, S Muñoz-Romero, Sanroman M, A García-Alberola, JL Rojo-Álvarez. Spatial-temporal Signals and Clinical Indices in Electrocardiographic Imaging (II): Electrogram Clustering and T-wave Alternans. Sensors 2020. F.I:3.275 (16/61, Q1 Instruments and Instrumentation)
González L, P Talón, S Muñoz-Romero, C Soguero, JL Rojo-Álvarez. A Big Data Approach to Customer Relationship Management Strategy in Hospitality using Multiple Correspondence Domain Description. Applied Sciences 10(15):5334, 2020. FI: 2.474 (67/148, Q2 Applied Physics)
Venegas P, Perez N, Zapata S, Mosquera J, Augot D, JL Rojo-Álvarez, Benitez D. An Approach to Automatic Classification of CulicoidesSpecies by Learning the Wing Morphology. Plos ONE 934-941, 2020. F. I: 2.74 (27/71, Q2 Multidisciplinary sciences).
El Yaagoubi M, Mora I, Jabrane Y, S Muñoz-Romero, JL Rojo-Álvarez, Pareja JA. Quantitative Cluster Headache Analysis for Neurological Diagnosis Support using Statistical Classification. Information and Communications Technology. Information 11(8):393, 2020.
Vayas G, Soguero C, JL Rojo-Álvarez, Gimeno-Blanes FJ. On the Differential Analysis of Enterprise Valuation Methods as a Guideline for Unlisted Companies Assessment (I): Empowering Discounted Cash Flow Valuation. Applied Sciences 10(17)5875, 2020. FI.: 2.474 (67/148, Q2 Applied Physics)
L Serna Jara, JJ Pastor Pérez, JA Flores Yepes. Study of compressive strength of gypsum with graphene addition. Cement Wapno Beton 25:232-241, 2020.
S Muñoz-Romero, A Gorostiaga, Soguero, I Mora-Jiménez, JL Rojo-Álvarez. Informative Variable Identifier: Expanding Interpretability in Feature Selection. Pattern Recognition 98 (107077), 2020. FI: 5.898, (14/134, Q1 Computer Science, Artificial Intelligence).
Vayas G, Soguero C, Rodriguez M, JL Rojo-Álvarez, Gimeno-Blanes J. On the Differential Analysis of Enterprise Valuation Methods as a Guideline for Unlisted Companies Assessment (II): Applying Machine Learning Techniques for Unbiased Enterprise Value Assessment. Applied Sciences (10(15)): 5334, 2020. F.I: 2.474 (67/148, Q2 Applied Physics)
Aguilar Palacios C, S Muñoz-Romero, JL Rojo-Álvarez. Cold-Start Promotional Sales Forecasting through Gradient Boosted-based Contrastive Explanations. IEEE Access 8: 137574-86, 2020. F.I.:4.098 (61/266, Q1 Engineering, Electrical and Electronic).
Rodriguez-Ibañez M, FJ Gimeno-Blanes, Cuenca P, S Muñoz-Romero, Soguero C, JL Rojo-Álvarez. On the Statistical and Temporal Dynamics of Sentiment Analysis. IEEE Access 8:7994, 2020. F.I: 4.098, (52/265, Q1 Engineering, Electrical and Electronic).
Pérez-Gutiérrez MF, JJ Sánchez-Muñoz, M Erazo-Rodas, A Guerrero-Curieses, E Everss, A Quesada, R Ruiz-Granell, A Ibáñez, A Bellver, JL Rojo-Álvarez, A García-Alberola. Spectral Analysis and Mutual Information Estimation of Left and Right Intracardiac Electrograms During Ventricular Fibrillation. Sensors 2020. F.II.: 3.275 (16/61, Q1 Instruments and Instrumentation).
Caulier-Cisterna R, Sanroman M, S Muñoz-Romero, M Blanco, R Goya, A García-Alberola, JL Rojo-Álvarez. Spatial-temporal Signals and Clinical Indices in Electrocardiographic Imaging (I): Preprocessing and Bipolar Potentials. Sensors 2020. F.I: 3.275 (16/61, Q1 Instruments and Instrumentation).
Caulier-Cisterna R, Blanco M, R Goya, S Muñoz-Romero, Sanroman M, A García-Alberola, JL Rojo-Álvarez. Spatial-temporal Signals and Clinical Indices in Electrocardiographic Imaging (II): Electrogram Clustering and T-wave Alternans. Sensors 2020. F.I:3.275 (16/61, Q1 Instruments and Instrumentation).
Henriksson M, García-Alberola A, Sörnmo L. Short-term reproducibility of parameters characterizing atrial fibrillatory waves. Comput Biol Med. 2020 Feb;117:103613.
Dallaglio PD, di Marco A, Moreno Weidmann Z, Perez L, Alzueta J, García-Alberola A, Fernandez-Lozano I, Díaz-Infante E, Rodriguez A, Basterra N, Calvo D, Rodriguez Garcia M, Aceña M, Anguera I. Antitachycardia pacing for shock prevention in patients with hypertrophic cardiomyopathy and ventricular tachycardia. Heart Rhythm. 2020 Jul;17(7):1084-1091.
Ganapathi M, Argyriou L, Martínez-Azorín F, Morlot S, Yigit G, Lee TM, Auber B, von Gise A, Petrey DS, Thiele H, Cyganek L, Sabater-Molina M, Ahimaz P, Cabezas-Herrera J, Sorlí-García M, Zibat A, Siegelin MD, Burfeind P, Buchovecky CM, Hasenfuss G, Honig B, Li Y, Iglesias AD, Wollnik B. Bi-allelic missense disease-causing variants in RPL3L associate neonatal dilated cardiomyopathy with muscle-specific ribosome biogenesis.Human Genetics. 139-11:1443-1454, 2020.
Lillo-Castellano J, J González-Ferrer, M Marina-Breysse, J Martínez-Ferrer, Luisa Pérez-Álvarez, Javier Alzueta, J Martínez, A Rodríguez, JC Rodríguez-Pérez, I Anguera, X Viñolas, A García-Alberola, JG Quintanilla, J Alfonso-Almazán, J García, L Borrego, V Cañadas-Godoy, N Pérez-Castellano, J Pérez-Villacastín, J Jiménez-Díaz, J Jalife, D Filgueiras-Rama, Personalized monitoring of electrical remodelling during atrial fibrillation progression via remote transmissions from implantable devices, EP Europace 22,5: 704–715, 2020.
C Hall, P Gurha, M Sabater-Molina, A Asimaki, M Futema, RC. Lovering, M Suárez, B Aguilera, P Molina, Esther Zorio, C Coarfa, MJ. Robertson, SM. Cheedipudi, Keat-eng Ng, P Delaney, J Hernández, F Pastor, JR. Gimeno, William J. McKenna, AJ. Marian, P Syrris. RNA sequencing-based transcriptome profiling of cardiac tissue implicates novel putative disease mechanisms in FLNC-associated arrhythmogenic cardiomyopathy. International Journal of Cardiology 302:124-130, 2020.
Sabater-Molina, M.; Navarro-Peñalver, M.; Muñoz-Esparza, C.; Esteban-Gil, Á.; Santos-Mateo, J.J.; Gimeno, J.R. Genetic Factors Involved in Cardiomyopathies and in Cancer. J. Clin. Med. 9, 1702, 2020.
C. Hall, Mohammed M. Akhtar, M Sabater-Molina, Marta Futema, Angeliki Asimaki, A Protonotarios, Chrysoula Dalageorgou, A Pittman, Mari Paz Suarez, B Aguilera, P Molina, E Zorio, J Hernández, F Pastor, JR. Gimeno, P Syrris, WJ. McKenna. Filamin C variants are associated with a distinctive clinical and immunohistochemical arrhythmogenic cardiomyopathy phenotype. International Journal of Cardiology 307:101-108, 2020.
de la Morena-Barrio ME, Sabater M, de la Morena-Barrio B, Ruhaak RL, Miñano A, Padilla J, Toderici M, Roldán V, Gimeno JR, Vicente V, Corral J. ALG12-CDG: An unusual patient without intellectual disability and facial dysmorphism, and with a novel variant. Mol Genet Genomic Med. (8):e1304, 2020.
2021
M Piles, J Muñoz-Mari, A Guerrero, G Camps-Valls, JL Rojo-Álvarez. Autocorrelation Metrics to Estimate Persistence from Satellite Soil Moisture Time. Series: Application to Semi-Arid Regions. Ref revista/libro: IEEE Transactions on Geoscience and Remote Sensing (TGRS). Clave: A Volumen: 60 Páginas, inicial: 4401417final: Fecha: 2021. Impacto: 8.125 (29/276, Q1 Engineering, Electrical and Electronic)
Salinet J, Molero R, Schlindwein FS, Karel J, Rodrigo M, Rojo-Álvarez JL, Berenfeld O, Climent AM, Zenger B, Vanheusden F, Paredes JGS, MacLeod R, Atienza F, Guillem MS, Cluitmans M, Bonizzi P. Electrocardiographic Imaging for Atrial Fibrillation: A Perspective From Computer Models and Animal Experiments to Clinical Value. Front Physiol 30:653013, 2021.
Bote-Curiel, L, Ruiz-Llorente, S, Muñoz-Romero, S., Yagüe M, Barquín, A, García-Donas J, Rojo-Álvarez JL. A resampling univariate analysis approach to ovarian cancer from clinical and genetic data. IEEE Access, 9, 25959-25972, 2021. F.I.:4.098 (61/266, Q1 Engineering, Electrical and Electronic).
Serna Jara LM; Flores Yepes, J; Pastor-Perez, J. Analysis of the Resistance to Bending of Gypsum with Added Graphene. Coatings 11(6):1-10, 2021
Flores Yepes J, Jara L, Gabarrón A, Alcaraz A, J Pérez. Analysis of Additives in Gypsum Coatings Based on Melamine, Polycarbonate Salts, Polycarboxylate, and Polycarboxylic Acids. Coatings 11(10):1-23, 2021.
Bleijendaal H, Ramos LA, Lopes RR, Verstraelen TE, Baalman SWE, Oudkerk Pool MD, Tjong FVY, Melgarejo-Meseguer FM, Gimeno-Blanes FJ, Gimeno-Blanes JR, Amin AS, Winter MM, Marquering HA, Kok WEM, Zwinderman AH, Wilde AAM, Pinto YM. Computer versus cardiologist: Is a machine learning algorithm able to outperform an expert in diagnosing a phospholamban p.Arg14del mutation on the electrocardiogram? Heart Rhythm 18(1):79-87, 2021.
L Ferrero; M ortiz; V Quiles; E Iáñez; JA Flores; JM. Azorín. Análisis de Simetría Cerebral durante el Uso de un BCI Basado en Imágenes Motoras para el Control de un Exoesqueleto de Miembro Inferior. Symmetry 13 (9), 1746, 2021.
Martínez-Ramón, A Gupta, JL Rojo-Álvarez, C Christodoulou. Machine Learning Applications in Electromagnetics and Antenna Array Processing, 1-436, 2021. Artech House Publishers, ISBN 1630817759.
Cantero López F, Elvira Ruiz G, Peñafiel Verdú P, Martínez Sánchez J, Sánchez Muñoz JJ, Muñoz Esparza C, Vázquez Andrés DJ, Martínez Herrera M, García Almagro FJ, García Alberola A. Emergency department attendance and reasons for consultation after cryoballoon ablation for pulmonary vein isolation of atrial fibrillation. Rev Esp Cardiol 74(3):233-237, 2021.
Briongos-Figuero S, García-Alberola A, Rubio J, Segura JM, Rodríguez A, Peinado R, Alzueta J, Martínez-Ferrer JB, Viñolas X, Fernández de la Concha J, Anguera I, Martín M, Cerdá L, Pérez L; Long-Term Outcomes Among a Nationwide Cohort of Patients Using an Implantable Cardioverter-Defibrillator: UMBRELLA Study Final Results. J Am Heart Assoc 10(1):e018108, 2021.
Briongos-Figuero S, García-Alberola A, et al. Long-Term Outcomes Among a Nationwide Cohort of Patients Using an Implantable Cardioverter-Defibrillator: UMBRELLA Study Final Results. J Am Heart Assoc 10(1):e018108, 2021.
Ruiz E, P Penafiel-Verdu, C Munoz-Esparza, J Martinez, JJ Sanchez-Munoz, F Garcia, M Salar-Alcaraz, FJ Pastor, N Fernandez-Villa, M Veas, M Martinez-Herrera, D Vazquez-Andres, A Jimenez, DA Pascual A Garcia-Alberola. Efficacy of left bundle branch area pacing in patients with indication for cardiac resynchronization therapy. European Heart Journal 42:S1, 2021.
Martínez-Solé J, Sabater-Molina M, et al. Facts and Gaps in Exercise Influence on Arrhythmogenic Cardiomyopathy: New Insights From a Meta-Analysis Approach. Front Cardiovasc Med. 8:702560, 2021.
Escobar-Lopez L, (…) Sabater Molina M, et al. Association of Genetic Variants With Outcomes in Patients With Nonischemic Dilated Cardiomyopathy. J Am Coll Cardiol 78(17):1682-1699, 2021.
Walsh R, (…) Sabater-Molina M, et al. Enhancing rare variant interpretation in inherited arrhythmias through quantitative analysis of consortium disease cohorts and population controls. Genet Med. 23(1):47-58, 2021.
Sánchez Muñoz JJ, Muñoz-Esparza C, Peñafiel-Verdú P, Sánchez JM, Almagro FG, Ruiz GE, Gimeno Blanes JR, Alberola García A. Catheter ablation of ventricular arrhythmias in left ventricular noncompaction cardiomyopathy. Heart Rhythm 18(4):545-552, 2021.
Salar Alcaraz ME, Buendía F, Flores Blanco PJ, García Alberola A, Pascual Figal DA, Manzano Fernández S. Usefulness of a smartphone-based event recorder for ambulatory patients with palpitations. Rev Esp Cardiol 74(12):1114-6, 2021.
Ferrero-De-Loma-Osorio Á, Cózar R, García-Alberola A, Valles E, Barrera A, Toquero J, Ormaetxe JM, Sánchez JM, Ruiz-Granell R, Amador PB, Rubio JM, Martí-Amor J, Pascual P, Molina I, Martínez-Alday JD; RECABA Investigators. Primary results of the Spanish Cryoballoon Ablation Registry: acute and long-term outcomes of the RECABA study. Nature Sci Rep. 26;11(1):17268, 2021
G Elvira Ruiz, P Penafiel-Verdu, C Munoz-Esparza, J Martinez-Sanchez, JJ Sanchez-Munoz, F Garcia-Almagro, M Salar-Alcaraz, FJ Pastor-Perez, N Fernandez-Villa, M Veas, M Martinez-Herrera, D Vazquez-Andres, A Jimenez, DA Pascual-Figal, A Garcia-Alberola. Efficacy of left bundle branch area pacing in patients with indication for cardiac resynchronization therapy. European Heart Journal 42:S1, ehab724.0400, 2021.
Álvarez-Ortega CA, Ruiz MA, Solórzano-Guillén C, Barrera A, Toquero-Ramos J, Martínez-Alday JD, Grande C, Segura JM, García-Alberola A, Moriña-Vázquez P, Ferrero-de-Loma-Osorio Á, Villuendas R, Rocío C, Arcocha MF, Ibañez A, Peinado R. Time to -30°C as a predictor of acute success during cryoablation in patients with atrial fibrillation. Cardiol J. 2021.10.5603/CJ.a2021.0135, 2021.
Hernández Del Rincón JP, (…) Sabater-Molina M, Gimeno Blanes JR, Pastor Quirante F. Prevented Sudden Cardiac Death and Neurologic Recovery in Inherited Heart Diseases. Front Cardiovasc Med.8: 634300, 2021.
Bayonas-Ruiz A, Muñoz-Franco FM, Ferrer V, Pérez-Caballero C, Sabater-Molina M, Tomé MT, Bonacasa B. Cardiopulmonary Exercise Test in Patients with Hypertrophic Cardiomyopathy: A Systematic Review and Meta-Analysis. J Clin Med. 25;10(11), 2021.
Akhtar MM, (…) Sabater-Molina M et al. European Genetic Cardiomyopathies Initiative Investigators. Association of Left Ventricular Systolic Dysfunction Among Carriers of Truncating Variants in Filamin C With Frequent Ventricular Arrhythmia and End-stage Heart Failure. JAMA Cardiol. 2021 Aug 1;6(8):891-901.
Suay-Corredera C, (…), Sabater Molina M, et al. Protein haploinsufficiency drivers identify MYBPC3 variants that cause hypertrophic cardiomyopathy. J Biol Chem. 297(1):100854, 2021
Ferrero-De-Loma-Osorio Á, Cózar R, García-Alberola A, et al. RECABA Investigators. Primary results of the Spanish Cryoballoon Ablation Registry: acute and long-term outcomes of the RECABA study. Nature Sci Rep. 26;11(1):17268, 2021.
López Cuenca D, Orenes M, Olmo Conesa MC, Pastor Moreno A, Santos Mateo JJ, Muñoz C, Navarro M, Castro FJ, Sabater Molina M, Gimeno Blanes JR. Reasons for refusing diagnostic tests and therapeutic recommendations and associated complications in inherited heart diseases. The RELUCTANT study. Rev Esp Cardiol 74(6):526-532, 2021.
2022
Vadillo, A, Goya-Esteban, R, Caulier-Cisterna, R., García-Alberola, A, JL Rojo-Álvarez. Differential Beat Accuracy for ECG Family Classification Using Machine Learning. Ref revista/libro: IEEE Access
10:129362 final: 81, 2022. Impacto: 3.367 (94/273, Q2 Engineering, Electrical and Electronic)
Chaquet J, Gimeno-Blanes J, Moral-Rubio S, S Muñoz-Romero, JL Rojo-Álvarez. On the Black-box Challenge for Fraud Detection using Machine Learning (II):Non-Linear Analysis through Interpretable Autoencoders. Ref revista/libro: Applied Sciences 12(8) Páginas, inicial: 3568 , 2022. Impacto: 2.474 (67/148, Q2 Applied Physics)
Chaquet J, Gimeno-Blanes J, Moral-Rubio S, S Muñoz-Romero, JL Rojo-Álvarez. On the Black-box Challenge for Fraud Detection using Machine Learning (I):Linear Models and Informative Feature Selection. Applied Sciences 12(7) Páginas, inicial: 3328, 2022. Impacto: 2.474 (67/148, Q2 Applied Physics)
[coord] Melgarejo-Meseguer FM, E Everss, M Gutiérrez-Fernández, S Muñoz-Romero, FJ Gimeno-Blanes, A García-Alberola, JL Rojo-Álvarez. Generalization and Regularization for Inverse Cardiac Estimators. IEEE Trans. Biomed. Eng 69(10) Páginas, inicial: 3029 final: 3038, 2022. Impacto: 4.756 (37/98 Q2 Biomedical Engineering)
Bote L, S Ruiz-Llorente, S Muñoz, M Yagüe-Fernández, A Barquin, I Garcia-Donas, JL Rojo-Álvarez. Multivariate Feature Selection and Autoencoder Embeddings of Ovarian Cancer Clinical and Genetic Data. Expert Systems with Applications(ESW) 206: 117865, 2022. Impacto: 8.665 (23/276, Q1 Engineering, Electrical and Electronic)
Gazquez A, Sabater-Molina M, et al. Milk fat globule membrane plus milk fat increase docosahexaenoic acid availability in infant formulas. Eur J Nutr. 2022.
Barc J, (…) Sabater-Molina M, Gimeno JR, (…). Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. Nat Genet. 2022 10.1038/s41588-021-01007-6.
Rouhi L, Fan S, Cheedipudi SM, Braza-Boïls A, Sabater-Molina M, Yao Y, Robertson MJ, Coarfa C, Gimeno JR, et al. The EP300/TP53 pathway, a suppressor of the Hippo and canonical WNT pathways, is activated in human hearts with arrhythmogenic cardiomyopathy in the absence of overt heart failure. Cardiovasc Res. 118(6):1466-1478, 2022.
Guler MN, Tscheiller NM, Sabater-Molina M, Gimeno JR, Nebigil CG. Evidence for reciprocal network interactions between injured hearts and cancer. Front Cardiovasc Med. 9:929259, 2022.
Siguero M, (…), Felipe-Medina N, Torroja C, José Gómez M, Sabater-Molina M et al. Human Hereditary Cardiomyopathy Shares a Genetic Substrate With Bicuspid Aortic Valve. Circulation. 2022
Sánchez-Campillo M, Pastor-Fajardo MT, Sabater-Molina M, López-Andreo MJ, Larqué E. Critical Steps for Human Gut Exfoliome RNA Profiling Analysis Using Non-Invasive Stool Samples. Ann Nutr Metab. 78(2):80-90, 2022.
Escobar-Lopez L, Ochoa JP, Royuela A, Verdonschot JAJ, Dal Ferro M, Espinosa MA, Sabater-Molina M, et al. Clinical Risk Score to Predict Pathogenic Genotypes in Patients With Dilated Cardiomyopathy. J Am Coll Cardiol. 80(12):1115-1126, 2022.
Martinez-Mateu L, J Saiz, O Berenfeld. Rotors Drift Toward and Stabilize in Low Power Regions in Heterogeneous Models of Atrial Fibrillation. Computing in Cardiology 2022; 49. ISSN: 2325-887X
de Frutos F, (…), Sabater-Molina M, Elliot PM, Garcia-Pavia P. European Genetic Cardiomyopathies Initiative Investigators. Natural History of MYH7-Related Dilated Cardiomyopathy. J Am Coll Cardiol. 2022 11;80(15):1447-1461.
Bayonas-Ruiz A, Munoz FM, Sabater-Molina M, Oliva-Sandoval MJ, Gimeno JR, Bonacasa B. Current therapies for hypertrophic cardiomyopathy: a systematic review and meta-analysis of the literature. ESC Heart Fail. 2022
Vallès E, Jiménez J, Marti J, Toquero J, Ormaetxe JM, Barrera A, García-Alberola A, et al. Cryoballoon Ablation for Persistent and Paroxysmal Atrial Fibrillation: Procedural Differences and Results from the Spanish RECABA. J Clin Med. 2022 22;11(5):1166.
Martínez-Campelo L, Cruz R, Blanco-Verea A, Moscoso I, Ramos-Luis E, Lage R, Álvarez-Barredo M, Sabater-Molina M, Peñafiel-Verdú P, Jiménez-Jáimez J, Rodríguez-Mañero M, Brion M. Searching for genetic modulators of the phenotypic heterogeneity in Brugada syndrome. PLoS One 17(3):e0263469, 2022.
Sabater Molina M, et al. Polymorphisms in ACE, ACE2, AGTR1 genes and severity of COVID-19 disease. PLoS One 17(2):e0263140, 2022.
2023
[coord] Bernal Oñate, Enrique V. Carrera, FM Melgarejo, Gordillo R, A García Alberola, JL Rojo-Álvarez. Atrial Fibrillation Detection with Spectral Manifolds in Low-dimensional Latent Spaces. IEEE Access (11):103364-103376, 2023. Impacto: 3.367 (94/273, Q2 Engineering, Electrical and Electronic)
Rodriguez M, Soguero C, Gimeno J, JL Rojo-Álvarez. Opening the 21st Century Technologies to Industries: On the Special Issue Machine Learning for Society. Special Issue Machine Learning and Deep Learning Applications for Society. Ref revista/libro: Applied Sciences-Basel 13(13): 7371, 2023. Impacto: 2.838 (73/160, Q2 Applied Physics)
[coord] Bernal Oñate, FM Melgarejo, EV. Carrera, JJ Sánchez Muñoz, A García Alberola, JL Rojo-Álvarez. Different Ventricular Fibrillation Types in Low-dimensional Latent Spaces. Sensors 23(5): 2527, 2023. Impacto: 3.275 (15/64, Q1 Instruments and Instrumentation)
Martinez-Mateu L; F Melgarejo; S Muñoz-Romero; FJ Gimeno-Blanes; A García-Alberola; S Rocher Ventura; J Saiz, JL Rojo-Álvarez. Manifold analysis of the P-wave changes induced by pulmonary vein isolation during cryoballoon procedure. Ref revista/libro: Computers in Biology and Medicine 155:106655, 2023. Impacto: 13/94 (Q1, Biology)
Álvarez CA, Solórzano Guillén CR, Barrera Cordero A, Toquero JE, Martínez JD, Grande Morales CE, Rodríguez González A, García Alberola A et al. Repeat cryoablation as a redo procedure for atrial fibrillation ablation: Is it a good choice? Cardiol J. 2023.
[coord] Martinez-Mateu L, Melgarejo-Meseguer F, Muñoz-Romero S et al. Manifold analysis of the P-wave changes induced by pulmonary vein isolation during cryoballoon procedure. Com. Biol. Med. 155: 106655, 2023.
Álvarez-Ortega CA, Ruiz MA, Solórzano-Guillén C, Barrera A, Toquero-Ramos J, Martínez-Alday JD, Grande C, Segura JM, García-Alberola A, et al. Time to -30°C as a predictor of acute success during cryoablation in patients with atrial fibrillation. Cardiol J 2023;30(4):534-542.
2024
Vadillo A Chaquet J, Goya R, Caulier R, Sánchez-Muñoz JJ and García-Alberola, A, JL Rojo-Álvarez. Exploring Cardiac Rhythms and Improving ECG Beat Classification Through Latent Spaces. IEEE Access (12): 27501 final: 27517, 2024. Impacto: 3.367 (94/273, Q2 Engineering, Electrical and Electronic)
Bernal P, Carrera E, FM Melgarejo, R Gordillo, JL Rojo-Álvarez, R Lara. Volcanic Micro-Earthquake Classification with Spectral Manifolds in Low-Dimensional Latent Spaces. Ref revista/libro: IEEE Access (12): 20624-36, 2024. Impacto: 3.367 (94/273, Q2 Engineering, Electrical and Electronic)
Rodríguez Muñoz D, Ramos Jiménez J, Marco Á, Lozano Granero C, García Alberola A, et al. Symptom burden guiding invasive electrophysiological study in paroxismal supraventricular tachycardia: The believe SVT registry. Am Heart J. 2024 269:15-24.
Zapata Martínez M, Pardo Ríos M, García Alberola A, et al. Screening de cardiopatías en niños y adolescentes (Prevencar Program). Atenc Primaria. 2024;56(2):102782.
Sabater Molina M, Gimeno Blanes JR. In recognition of the Spanish origin of CRISPR/Cas9. Implications for the treatment of familial heart disease. Rev Esp Cardiol 19:S1885-5857, 2024.
2020
Caulier Cisterna, R, Gonzales L Phd, González Appelgren, JP, Esteban Oyarzún, JE Phd, Uribe S. Phd, Eblen Zajjur, A. Md-Phd. Spinal Cord Neurovascular Response Using Non-Invasive Near Infrared Spectroscopy in Humans. LXXV Congreso Chileno de Neurología, Psiquiatría y Neurocirugía 2020 (SONEPSYN 2020)
Esteban Oyarzún, JE Phd, González Appelgren, JP, Caulier Cisterna, R. Gonzales L Phd, Trujillo O. Md, Uribe S. Phd, Eblen Zajjur, A. Md-Phd. Non-invasive near-infrared spectroscopy assessment of the spinal neurovascular response in a patient with acute transverse myelitis. LXXV Congreso Chileno de Neurología, Psiquiatría y Neurocirugía 2020 (SONEPSYN 2020)
González Appelgren, JP, Esteban Oyarzún, JE Phd, Caulier Cisterna, R, Gonzales L Phd, Uribe S. Phd, Eblen Zajjur, A. Md-Phd. Assessment of the spinal cord neurovascular response using non-invasive near infrared spectroscopy in three patients with complete traumatic spinal cord. LXXV Congreso Chileno de Neurología, Psiquiatría y Neurocirugía 2020 (SONEPSYN 2020)
C Soguero, N Alonso, Sergio Muñoz, JL Rojo-Álvarez, M Rubio, I Caballero, I Mora. Finding Associations among Chronic Conditions by Bootstrap and Multiple Correspondence Analysis. 2020 IEEE International Conference on Bioinformatics. S12205. Montreal, Canadá, 5-10 July 2020.
A Gupta, C Christodoulou, M Martínez-Ramón, JL Rojo-Álvarez. Deep Neural Nets for DOA Estimation with Random Arrays. 2020 IEEE International Symposium on Antennas and Propagation Radio Science Meeting. Montreal, Canadá 5-10 July 2020.
Carrillo LM, M Fernández, F Lacunza Ruiz, P Peñafiel Verdú, C Muñoz Esparza, I Gil Ortega, D López, E Cabrera Romero, M Sabater Molina, JR Gimeno Blanes. Aplicación del nuevo score de riesgo de muerte súbita de Sieira en una población con síndrome de Brugada. eCongreso SEC 2020 de la Salud Cardiovascular. Comunicación Mini Oral. 28-31 octubre 2020.
Gimeno Blanes J, M. Sabater Molina, I. San Roman, L. Polo, I. Garrido, C. Salas, F. Lopez Andreu. European Human Genetics Virtual Conference 2020. Non-amyloidotic transthyretin cardiomyopathy, 6-9 Junio, 2020.
2021
JL Rojo-Álvarez. Avances en intervencionismo cardiovascular: Sistemas para la reconstrucción espacio-temporal y la inversión de los potenciales cardíacos. Track de Ingeniería Biomédica en Cardiología. Sociedad Española de Cardiología y Sociedad Española de Ingeniería Biomédica, SEC 2021, Zaragoza 27-29 oct 2021.
JL Rojo-Álvarez. Medidas no lineales en el latido cardiaco. Aplicaciones para el deporte. XVIII Congreso Internacional de la Sociedad Española de Medicina del Deporte. Universidad Católica San Antonio de Murcia (UCAM) 25-27 de noviembre de 2021, Murcia.
B Gil-Casares, J Portoles, P Lopez, F Tornero JL Rojo-Álvarez. Analyzing Transitions In The Integrated Model Of Renal Replacement Therapy In A Regional Health System. 2021 58th ERA-EDTA Congress. German Society of Nephrology. Oral MO813, Berlín, Alemania, 5-8 June 2021.
González-Appelgren J, R. Caulier-Cisterna, JE. Oyarzún, A. Eblen-Zajjur, S. Uribe. Peri-spinal neurovascular response triggered by a painless peripheral stimulus in patients with chronic high blood pressure. 24th Meeting of the European Council for Cardiovascular Research (2021 ECCR Virtual Meeting).
Oyarzún J, R Caulier-Cisterna, Juan Pablo González-Appelgren, Antonio Eblen-Zajjur A; Sergio Uribe. Recording of the spinal neurovascular response triggered by a non-noxious peripheral nerve stimulation in patients with diabetes mellitus. 19th Annual World Congress Insulin Resistance, Diabetes & Cardiovascular Disease (WCIRDC2021).
C Plaza Seco, M Blanco Velasco, JL Rojo Álvarez y S Muñoz Romero, “P-wave detection using latent spaces from Autoencoders and Domain Description Classifiers,” CASEIB 2021, pp. 91-94, 25-26 Nov 2021.
García-Alberola A. Codirección “XVIII Curso de Ablación y Sistemas de Navegación en Electrofisiología Cardíaca”. Hospital Gregorio Marañón – Hospital Virgen de la Arrixaca. Madrid, 25-26 Noviembre de 2021.
Gimeno Blanes JR, M. Sabater-Molina, I. San Roman, L. Polo, I. Garrido, C. Salas, F. Lopez Andreu. Abnormal TTR associated with unclassified cardiomyopathy. IV Florence International Symposium on advances in Cardiomyopathies. Florencia, 9-10 septiembre, 2021.
M. Sabater Molina, E. Nicolas Rocamora, A. Iborra Bendicho, E. García Vázquez, F. Dominguez Rodriguez, R. Barriales Villa, E. Zorio, C. Gil Ortuño, C. Muñoz Esparza, A. Rodríguez, R. Jara Rubio, A. Moreno, P. Marcos Rodriguez, P. García Pavía, J. Gimeno Blanes. Renin-angiotensin system polymorphisms as potential modifier in COVID-19 outcome with the presentation number P25.001.D. European Human Genetics Virtual Conference, Online, August 28-31, 2021.
JJ Sánchez, Muñoz. Penn Medicine. Live Activity. The Mark E. Josephson Twenty-Eighth Annual State of the Art Arrhythmia Symposium, 11 sept 2021.
M Sabater Molina. X JORNADA DE CARDIOGENÉTICA Unidad: Laboratorio de Cardiogenética, Cardiopatías hereditarias, Cardiología Experimental del Hospital Universitario Virgen de La Arrixaca, 27/11/2021.
JJ Sánchez, Muñoz. Curso Comunicación internacional en las profesiones sanitarias (Spanish Doctors) 2ed. 1oct 2020 - 31 oct 2021.
JJ Sánchez, Muñoz. Working Group on Myocardial and Pericardial Diseases Webinar: Hypertrophic cardiomyopathy - from the gene to the heart and from the patient to their family. ESC Working Group. 22/10/2021.
JJ Sánchez, Muñoz. EHRA Webinar: Reducing inappropriate and unnecessary ICD shocks. European Accreditation Council for Continuing Medical Education. 25/10/2021.
García García, A; Leithold, Gunnar; Sabater Molina, M; Burillo Milla, E; Fernández Villa, ; Veas Porlán, Ml; Nieto López, A; Gimeno Blanes, JR. Ectasia coronaria severa familiar, una nueva entidad. XV Congreso Regional de la Sociedad Murciana de Cardiología, 28 y 29 de Mayo de 2021, Murcia.
Ruiz, G; Peñafiel Verdú, P; Muñoz Esparza, C; Martínez Sánchez, J; Sánchez Muñoz, JJ; García Almagro, F; Salar Alcaraz, M; García Alberola, A. Eficacia de la estimulación en el área de la rama izquierda en pacientes con indicación de terapia de resincronización cardiaca. Comunicación oral. XV Congreso Regional de la Sociedad Murciana de Cardiología, 28 y 29 de Mayo de 2021, Murcia.1er premio VIFOR a la mejor comunicación.
JJ Sánchez, Muñoz. Penn Medicine. Live Activity. 16th Annual International Symposium on Ventricular Arrhythmias: Pathophysiology and Therapy 15 oct 2021.
JJ Sánchez, Muñoz. Together VT Congress. 20 Nov 2021, Bordeaux, Francia.
JJ Sánchez, Muñoz. Cardiomyopathy 2021. The Cardiomyopathy Mindset Conference. GR I CARDIAC NET. 1-3 oct 2021.
JJ Sánchez, Muñoz. Diagnosis of hypertrophic cardiomyopathy from the stethoscope to tissue characterisation. European Accreditation Council for Continuing Medical Education (EACCME). ESC Working groups
JJ Sánchez, Muñoz. X Jornada de Cardiogenética. Unidad CSUR-ERN de Cardiopatías Familiares. 26 noviembre 2021, Murcia(12h).
Sánchez Muñoz, JJ. Curso de Patologías musculoesquelético, sistema nervioso, endocrino y otras actividades asistenciales en inglés (II). Comunicación internacional en las profesiones sanitarias (Spanish Doctors) 2ed. Fundación para la Formación de la OMC (FFOMC). 1 de abril al 31 de octubre de 2021
2022
Fernández-Vázquez; M.J. Fernández; …; FM Melgarejo-Meseguer; … FJ Gimeno-Blanes. Relación del nivel de actividad física y el curso evolutivo de la enfermedad en pacientes con síndrome de Brugada. SEC Zaragoza (Spain) 28-30 oct 2021.
Sánchez-Muñoz JJ. Role of Purkinje in the initiation and maintenance of ventricular fibrillation induced by programmed ventricular pacing. About two cases with Brugada síndrome. 16th edition Venice Arrhythmias 2022.
Sánchez-Muñoz JJ. The activation pattern of induced ventricular fibrillation in one case of Brugada Syndrome. Hypothesis based on 12-lead ECG and right ventricular EGM. 16th edition Venice Arrhythmias 2022.
Sánchez-Muñoz et al. Phenotypic characteristics of patients with arrhythmogenic left ventricular cardiomyopathy and sustained ventricular tachycardias. EHRA 2022. Copenhague. 2022.
Sabater Molina, M.; Gil Ortuño, C.; Muñoz Esparza, C. Gimeno Blanes, JR. Distribution And Cardiac Outcomes Of Neuromuscular Disorders Referred To An Inherited Cardiac Disease Unit. Annual Congress ESC. Barcelona. 2022.
Sánchez-Muñoz JJ et al. Purkinje-myocardium: a relationship beyond triggers in ventricular fibrillation. 16th Venice Arrhythmias 2022.
Gil Ortuño, C.; Nicolas, M; Olmo, C.; Muñoz C; Navarro M, JR Gimeno, Sabater Molina, M. ¿Does The Phenomenon Of Genetic Anticipation Exist In Hypertrophic Cardiomyopathy? Annual Congress Of The Working Group On Myocardial And Pericardial Diseases. European Society Of Cardiology. Turín Italia. 2022.
Sabater Molina, M. Navarro, M.; Gil, C.; Muñoz C.; Gimeno Blanes, JR. ¿Distribution And Cardiac Outcomes Of Neuromuscular Disorders Referred To An Inherited Cardiac Disease Unit? Annual Congress Of The Working Group On Myocardial And Pericardial Diseases. European Society Of Cardiology. Turín Italia. 2022.
Sabater Molina, M.; Gimeno Blanes, J. R. Tendencias En La Prevención De Muerte Súbita En Miocardiopatía Hipertrófica. Congreso SEC. Palma De Mallorca. 2022.
Muñoz Esparza, C.; Gil, C.; Sabater Molina, M.; Gimeno Blanes, JR. Análisis De Una Población Con Miocardiopatía Arritmogénica Según Su Forma De Debut. Congreso SEC. Palma De Mallorca. 2022.
Gazquez Garcia, A.; Sabater Molina, M.; et al. La Membrana Del Glóbulo Graso Y La Grasa Láctea Incrementan La Biodisponibilidad De Ácido Docosahexaenoico En Fórmulas Infantiles. Conferencia Finut 2022. Ciudad De México. 2022.
Sanchez Muñoz, J. J.; Sabater Molina, M. Miocardiopatía No Compactada Y Bradicardia Sinusal, Una Rara Combinación Asociada A La Mutación Del Gen Hcn4. Jornada De Cardiogenética. Murcia. 2022.
Sabater Molina, M.; Navarro Peñalver, M.; Gil Ortuño, C; Muñoz, C.; Gimeno Blanes, J. R. Distribution And Cardiac Outcomes Of Neuromuscular Disorders Referred To An Inherited Cardiac Disease Unit. Jornada De Cardiogenética, Murcia. 2022.
2023
Sánchez-Muñoz JJ et al. Regional patterns of activation during induced ventricular fibrillation in Brugada Syndrome. EHRA 2023 European Heart Rhythm Association, Barcelona 2023.
[coord] Melgarejo FM; L. Martinez; S Muñoz; FJ Gimeno-Blanes; A García-Alberola; JL Rojo (2023). A Convex Optimized Estimator of the Laplacian Operator for Bioelectric Simulations. XXXVth URSI GASS. Sapporo (Japan) 19-26 Aug 2023.
[coord] Melgarejo FM; A. Román-Román; FJ Gimeno-Blanes; S Muñoz-Romero; A García-Alberola; JJ Sánchez-Muñoz; O. Berenfeld; JL Rojo-Álvarez (2023). Multicomponent Organization Analysis in Spatial Domains of Atrial Fibrillation. Computing in Cardiology Conference (CinC). Atlanta (USA) 1-4 Oct 2023.
[coord] Kazemi-Diaz A, Bote-Curiel L, Sabater-Molina M, Gimeno-Blanes JR, Sala-Pla S, Gimeno-Blanes FJ, S Muñoz-Romero y JL Rojo. An Embedding Approach for Biomarker Identification in Hypertrophic Cardiomyopathy. En: Computing in Cardiology. IEEE Computer Society; 2023.
[coord] E. Feito; FM Melgarejo-Meseguer; A García-Alberola, JL Rojo-Álvarez . Improved Machine Learning Strategies and Algorithms for Transmembrane Potential. Atlanta (USA) 1-4 Oct 2023.
2024
[coord] Sánchez-Muñoz JJ, Lozano D, FM Melgarejo-Meseguer, Gimeno J, Gil A, JL Rojo-Álvarez. Novel analysis in surgical ventricular fibrillation with manifold learning techniques Congress EHRA 2024. Berlin 2024.
Time-Frequency Analysis, Audio-Based Features, And Low-Dimensional Manifold Latent Spaces In Cardiac And Seismographic Signals. Doctorando: P Bernal, 2024. Directores: JL Rojo-Álvarez, FM Melgarejo. Calificación: Sobresaliente Cum Laude. URJC.
Machine Learning Interpretable para la detección del fraude crediticio. Doctorando: J Chaquet-Ulldemolins. Directores: JL Rojo, FJ Gimeno. Mayo 2022 Calificación: Sobresaliente Cum Laude. URJC.
Interpretable machine learning for promotional sales forecasting. Doctorando: C Aguilar Palacios. Director: JL Rojo-Álvarez, S Muñoz-Romero. Sept 2021 Calificación: Sobresaliente Cum Laude. URJC.
Interpretable data science methods for Knowledge discovery from ovarian cancer data. Doctorando: L Bote Curiel. Director: JL Rojo, S Muñoz. Julio 2021 Calificación: Sobresaliente Cum Laude. URJC.
Estudio de biomarcadores predictores de miocardiopatías en pacientes portadores de variantes génicas patogénicas. Doctorando: JA Diaz Muñoz. Directores: JR Gimeno Blanes, M Sabater Molina. 2021. Calificación: Sobresaliente Cum Laude. HUVA
Modelos de Valoración de empresas no cotizadas en bolsa. Doctorando: G Vayas Ortega. Tutor: JL Rojo-Álvarez. Director: C Soguero, FJ Gimeno. Diciembre 2020 Calificación: Sobresaliente. URJC.
Desarrollo de Algorítmia para Dispositivos de Monitorización Cardiaca de Nueva Generación. Doctorando: FM Melgarejo. Directores: JL Rojo, FJ Gimeno. Octubre 2019 Calificación: Sobresaliente Cum Laude.
Desarrollo de técnicas de inteligencia artificial y análisis masivo de datos para la detección de eventos y ruido en señales electrocardiográficas de monitorización prolongada. Doctorando: C Plaza Seco. Directores: JL Rojo-Álvarez, M Blanco.
Métodos de Machine Learning en Nefrología. Doctorando: B Gil-Casares Casanova. Directores: FM Melgarejo, JL Rojo-Álvarez. En desarrollo.
Manifold Learning como herramienta para la interpretabilidad de variables latentes en biomedicina. Doctorando Estela Sánchez Gómez. Directores: FM Melgarejo, JL Rojo-Álvarez. En desarrollo
This work was supported by research Grant PID2019-104356RB-C42, and PID2019-104356RB-C43 funded by MCIN / AEI /10.13039/501100011033.