By Fatoumata Doumbia, Grace Hartman, Hannah Wallace, and Nathan Zekarias
Specimen from Nathan Zekarias' collection (may not be Anopheles)
Changes in the geographic range of Anopheles mosquitoes and the transmission season of Plasmodium due to anthropogenic climate change may result in an increased risk of malaria, worldwide.
Climate: long-term patterns of weather, including temperature and precipitation, in a region
Climate change refers to changes in those long-term patterns of weather, temperature, precipitation, etc.
Natural cycles of climate change have occurred throughout Earth's history.
For example, there have been periods, known as Ice Ages, interspersed with periods of warming.
Human activities have accelerated climate change to unprecedented rates.
Natural processes that contribute to changes in climate include:
El Nino-Southern Oscillation
Volcanic or meteor activity
Changes in Earth's orbit and tilt on its axis
Anthropogenic (human-caused) contributions to climate change include:
Burning of fossil fuels
Clearing and burning of vegetation
Especially, large areas of ancient forests
Greenhouse effect: The surface of the Earth is heated by the Sun, and the surface also emits heat. The greenhouse effect occurs when heat from the Earth's surface is reflected by "greenhouse gases" in the atmosphere. When heat is reflected back to the surface, it does not escape the atmosphere, and the planet warms.
The greenhouse effect is a natural process that makes the Earth warm enough for life.
However, the excess burning of fossil fuels and deforestation amplify the greenhouse effect to unnatural levels.
Increased global average temperatures and precipitation*
Increased frequency and severity of extreme weather events
Droughts
Wildfires
Hurricanes*
Heat waves
Changes in seasonal effects
Growing season in agriculture
Breeding seasons for various organisms*
Melting glaciers and ice sheets
Sea level rise
Increased flooding*
"Massive redistribution of global biodiversity” (Carlson et al. 2023)*
*These factors contribute to a potential increase in the spread of vector-borne diseases, including malaria.
Figure 1, Anopheles gambiae illustration
What are Anopheles?
Anopheles are a genus known as "marsh mosquitoes" (USFWS)
This genus is in the mosquito family--Culicidae--which is in the order Diptera.
Diptera are the flies, which means that mosquitoes are flies!
There are more than 450 species of Anopheles, and they are found all over the world (Afrane et al. 2012).
Many species are malaria vectors
Vector: A living agent that transmits parasites/pathogens to other living organisms
They are the sole vectors of malaria
Like all arthropods, mosquitoes are poikilotherms, or cold-blooded.
This means that they do not regulate their body temperature.
Many aspects of the biology and ecology of mosquitoes depend on the temperature of the environment.
Mosquitoes thrive in warm weather, especially in tropical countries.
How does malaria transmission occur?
Malaria is transmitted to humans from the protazoa genus Plasmodium
Five species in Plasmodium can transfer malaria
Most notorious are P. falciparum and P. vivax
Female mosquitoes ingest pre-larval stages of Plasmodium from humans
Plasmodium mature in the female's body and are transferred out when they feed on another human (Bray et al.)
Globally, African countries have the highest rate of malaria spread due to the climate and environmental conditions
Figure 4, This map shows the geographic ranges of the many different species of Anopheles. Currently, colder regions are not subject to malaria, but malaria can be reintroduced.
Predictions
Figure 5: The life cycle of Anopheles. Increasing temperatures will likely speed up the development of mosquitoes.
Climate factors, including temperature and precipitation, affect where pathogens, vectors, and hosts can survive.
Changes in climate factors change the geographic range of pathogen vulnerability.
"Climate limits the spatial range, timing, and magnitude of malaria" (Colón-González et al. 2021)
Increasing temperatures will "exponentially" increase (Colón-González et al. 2021):
Biting
Development and maturation
Incubation
"Capacity to produce more offspring” (Afrane et al. 2012)
Increasing precipitation will increase:
"Creation of mosquito breeding sites" (Colón-González et al. 2021)
Increasing drought conditions may also increase the availability of mosquito breeding sites
Efforts to increase water storage may inadvertently supply mosquitoes with standing water, perfect for laying eggs
The effects of climate change on the life cycle of Anopheles "translat[es] to an increased disease transmission efficiency” (Afrane et al. 2012)
The effects of climate change on the environment predict that the geographic range of Anopheles will expand, both in latitude and altitude.
Temperate regions of North America, Central Europe, and Northern Asia
Highland regions of Africa
This map shows the length of time that Plasmodium can be transmitted during a year. In dark red areas, Plasmodium can be transmitted during 12 months of the year. In dark blue areas, Plasmodium can be transmitted during 1 month of the year. In grey ares, it is too cold for Plasmodium to survive.
[Projection maps courtesy of Ryan et al. 2023]
This map shows the length of time that Plasmodium will be able to be transmitted during the year in 2050, based on current predictions of climate change. Many areas will have a longer transmission season, including some areas that currently do not have one. Other areas--that now have a long transmission season--may have a shorter transmission season because it will be too hot for Plasmodium transmission during part of the year.
Case Studies
There is “clear evidence that Anopheles mosquitoes have undergone rapid range shifts over the twentieth century” (Carlson et al. 2023)
In the past, the majority of malaria infections in Africa were via Anopheles gambiae vectors. Recently, foreign Anopheles species have been expanding their ranges, particularly into the East African Highlands. These new species are "major potential threat[s] to malaria control in the region” (Ryan et al. 2021).
An. stephensi--which is native to South Asia and the Middle East--now has "established populations in Djibouti, Ethiopia, and Sudan" (Ryan et al. 2021).
This species is known to be "resilient to habitat extremes” and may significantly increase malaria risk in urban areas (Ryan et al. 2021).
An. arabiensis has been observed "breeding in the central Kenyan highlands...for the first time" (Afrane et al. 2012).
Anopheles mosquitoes had not been reported in this high elevation region before. The appearance of An. arabiensis suggests that climate change has made the area "conducive to the proliferation of malaria vector species” (Afrane et al. 2012).
In 2023, a case of locally-acquired malaria was reported in Maryland for the first time in 40 years. That summer, at least eight other cases were reported in Florida and Texas (Dillinger).
Malaria cases in northwest Pakistan tripled from 2022 to 2023. Researchers blame this sharp increase on "climate-induced disasters, in the shape of devastating floods and excessive rains" (Saeed 2024)
There is a lot of concern regarding climate change and malaria
Climate change is considered to be making malaria worse by producing conditions that favor the spread of malaria-carrying mosquitoes
Increasing rates of malaria infection are increasing burdens on local healthcare systems.
This will disproportionately impact underdeveloped countries and regions with under-resourced healthcare systems.
Primary Literature:
Afrane, Y. A., Githeko, A. K., & Yan, G. (2012). The ecology of anopheles mosquitoes under climate change: Case studies from the effects of deforestation in East African Highlands. Annals of the New York Academy of Sciences, 1249(1), 204–210. https://doi.org/10.1111/j.1749-6632.2011.06432.x
Bray, R. S., & Garnham, P. C. C. (1982). The life-cycle of primate malaria parasites. British Medical Bulletin, 38(2), 117-122. 10.1093/oxfordjournals.bmb.a071746
Carlson, C. J., Bannon, E., Mendenhall, E., Newfield, T., & Bansal, S. (2023). Rapid range shifts in African anopheles mosquitoes over the last century. Biology Letters, 19(2). https://doi.org/10.1098/rsbl.2022.0365
Colón-González, F. J., Sewe, M. O., Tompkins, A. M., Sjödin, H., Casallas, A., Rocklöv, J., Caminade, C., & Lowe, R. (2021). Projecting the risk of mosquito-borne diseases in a warmer and more populated world: A multi-model, Multi-scenario Intercomparison Modelling Study. The Lancet Planetary Health, 5(7). https://doi.org/10.1016/s2542-5196(21)00132-7
Ryan, S. J., Lippi, C. A., Villena, O. C., Singh, A., Murdock, C. C., & Johnson, L. R. (2023). Mapping current and future thermal limits to suitability for malaria transmission by the invasive mosquito anopheles stephensi. Malaria Journal, 22(1). https://doi.org/10.1186/s12936-023-04531-4
General Sources:
Dillinger, K. (2023, August 21). Case of locally acquired malaria reported in Maryland. CNN. https://www.cnn.com/2023/08/18/health/malaria-maryland/index.html
Mason, J., Burt, J., Muller, P., & Blij, H. D. (2018). Physical Geography: The Global Environment (5th ed.). Oxford University Press Academic US. https://umbc-bookshelf.vitalsource.com/books/9780190929084
"Nail Mosquito". United States Fish and Wildlife Service. Retrieved 16 December 2023. Common Name: Nail Mosquito, marsh mosquitoes
NASA. (n.d.). Effects - NASA science. NASA. https://science.nasa.gov/climate-change/effects/
Norris, L. (2023, October 1). Is the threat of malaria increasing?. Bill & Melinda Gates Foundation. https://www.gatesfoundation.org/ideas/articles/malaria-threat-climate-change
Saeed, A. (2024, May 30). Climate change causes malaria cases to triple in northwest Pakistan. Gavi, the Vaccine Alliance.
Images/Graphics:
Header Image: Encyclopaedia Britannica. (2013). Why do mosquito bites itch? Mosquito. Retrieved November 17, 2024, from https://www.britannica.com/animal/mosquito-insect/images-videos.
Figure 1: Anopheles gambiae African Malaria mosquito unfed female - Lizzie Harper. (2023, April 20). Lizzie Harper. https://lizzieharper.co.uk/image/anopheles-gambiae-african-malaria-mosquito-unfed-female/
Figure 2: Malaria – Biogents USA. (2022, September 22). Biogents USA. https://us.biogents.com/malaria/
Figure 3: Figure 2: Public Library of Science. (n.d.). PLOS Biology Issue Image: Vol. 3(6) June 2005. PLOS Biology. https://doi.org/10.1371/image.pbio.v03.i06.g001
Figure 4: Wikipedia contributors. (3 C.E.). File:Anopheles-Range-map.png - Wikipedia. https://en.m.wikipedia.org/wiki/File:Anopheles-range-map.png
Figure 5: Hawkes FM, Hopkins RJ. The mosquito: An introduction. In: Hall M, Tamïr D, editors. Mosquitopia: The Place of Pests in a Healthy World [Internet]. New York: Routledge; 2022. Figure 2.1, [The mosquito life cycle.]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK585164/figure/F2.1/ doi: 10.4324/9781003056034-3