Publications

Hartley VL, Qaqish AM, Wood MJ, Studnicka BT, Iwai K, Liu TC, MacDuff DA. HOIL1 regulates group 3 innate lymphoid cell numbers in the colon and protects against systemic dissemination, colonic ulceration, and lethality from Citrobacter rodentium infection. The Journal of Immunology 2023 Oct 30:ji2300351. Online ahead of print.

Wood MJ, Marshall JN, Hartley VL, Liu TC, Iwai K, Stappenbeck TS, MacDuff DA. HOIL1 regulates group 2 innate lymphoid cell numbers and type 2 inflammation in the small intestine. Mucosal Immunology 2022; 15(4):642-655.

Tan JMJ, Mellouk N, Osborne SE, Ammendolia DA, Dyer DN, Li R, Brunen D, van Rijn JM, Huang J, Czuczman MA, Cemma MA, Won AM, Yip CM, Xavier RJ, MacDuff DA, Reggiori F, Debnath J, Yoshimori T, Kim PK, Fairn GD, Coyaud E, Raught B, Muise AM, Higgins DE, Brumell JH. An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytognese cell-to-cell spread. Nature Microbiology 2018 Dec;3(12):1472-1485.

MacDuff DA, Baldridge MT, Qaqish AM, Nice TJ, Darbandi AD, Hartley VL, Peterson ST, Miner JJ, Iwai K, Virgin HW. HOIL1 is essential for the induction of type I and III interferons by MDA5 and regulates persistent murine norovirus infection. Journal of Virology 2018; Sept 12. JVI.01368-18. 

Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL Jr, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Wang YT, MacDuff DA, Kreamalmayer D, Howitt MR, Neil JA, Cadwell K, Allen PM, Handley SA, van Lookeren Campagne M, Baldridge MT, and Virgin HW. Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science 2018; 360(6385):204-208.

Watson RO, Bell SL, MacDuff DA, Kimmey JM, Diner EJ, Olivas J, Vance RE, Stallings CL, Virgin HW, and Cox JS. The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy. Cell Host Microbe 2015; 17(6):811-9.

West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A and Shadel GS. Mitochondrial DNA stress primes the antiviral innate immune response. Nature 2015; 520(7548):553-7.

MacDuff DA, Reese TA, Kimmey JM, Weiss LA, Song C, Zhang X, Kambal A, Duan E, Carrero JA, Boisson B, Laplantine E, Israël A, Picard C, Colonna C, Edelson BT, Sibley LD, Stallings CL, Casanova JL, Iwai K, and Virgin HW. Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection. Elife 2015;4:e04494.

Schoggins JW, Macduff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy B, Aitchison JD, Aderem A, Elliott RM, García-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM. Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature 2014; 505(7485):691-5.

Ali S, Karki N, Bhattacharya C, Zhu R, MacDuff DA, Stenglein MD, Schumacher AJ, Demorest ZL, Harris RS, Matin A, Aggarwal S. APOBEC3 inhibits DEAD-END function to regulate microRNA activity. BMC Mol Biol. 2013; 14:16.

Shoji-Kawata S, Sumpter R, Leveno M, Campbell GR, Zou Z, Kinch L, Wilkins AD, Sun Q, Pallauf K, MacDuff D, Huerta C, Virgin HW, Helms JB, Eerland R, Tooze SA, Xavier R, Lenschow DJ, Yamamoto A, King D, Lichtarge O, Grishin NV, Spector SA, Kaloyanova DV, Levine B. Identification of a candidate therapeutic autophagy-inducing peptide. Nature 2013; 494(7436):201-6.

Boisson B, Laplantine E, Prando C, Giliani S, Israelsson E, Xu Z, Abhyankar A, Israël L, Trevejo-Nunez G, Bogunovic D, Cepika AM, MacDuff D, Chrabieh M, Hubeau M, Bajolle F, Debré M, Mazzolari E, Vairo D, Agou F, Virgin HW, Bossuyt X, Rambaud C, Facchetti F, Bonnet D, Quartier P, Fournet JC, Pascual V, Chaussabel D, Notarangelo LD, Puel A, Israël A, Casanova JL, Picard C. Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. Nature Immunology 2012; 13(12):1178-86.

Demorest ZL, MacDuff DA, Brown WL, Morham SG, Parise LV, Harris RS; The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination. PLoS One 2010; 5(7):e11660.

MacDuff DA, Demorest ZL, Harris RS; AID can restrict L1 retrotransposition suggesting a dual role in innate and adaptive immunity. Nucleic Acids Research 2009; 37(6):1854-67.

MacDuff DA, Offer SM, Demorest ZL & Harris RS. (2008) Antibody Gene Diversification by Aid-Catalyzed DNA Editing, in RNA and DNA Editing: Molecular Mechanisms and Their Integration into Biological Systems (ed H. C. Smith), John Wiley & Sons, Inc., Hoboken, NJ, USA. 

Schumacher AJ, Haché G, Macduff DA, Brown WL, Harris RS. The DNA deaminase activity of human APOBEC3G is required for Ty1, MusD, and human immunodeficiency virus type 1 restriction. Journal of Virology 2008; 82(6):2652-60.

MacDuff DA, Neuberger MS and Harris RS; MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells. Molecular Immunology 2006; 43:1099-1108.

MacDuff DA and Harris RS; Directed DNA deamination by AID/APOBEC3 in immunity. Current Biology 2006; 16:R186-9.

Full publication list: http://www.ncbi.nlm.nih.gov/pubmed/?term=macduff+d