Topical view of old intestinal villi with reduced mucin and infiltrated by pancreatic trypsin. Frank A DeLano
Autodigestion in Shock
Clinical Evidence for Autodigestion
Enhanced intestinal permeability and intestinal co-morbidities in heat strain: A review and case for autodigestion. Temperature,
Association of Serum Amylase Levels With Mortality in Critically Ill Patients With Coronavirus Disease . more
Plasma enzymatic activity, proteomics and peptidomics in COVID-19-induced sepsis: A novel approach for the analysis of hemostasis. more
Autodigestion in Heart Failure
Digestive enzyme activity and protein degradation in plasma of heart failure patients. more.
Enteral Blockade of Digestive Enzymes in Shock
Enteral administration of the serine protease inhibitor gabexate mesylate FOY) preserves vascular function in experimental trauma/hemorrhagic shock. more
The serine protease inhibitor (gabexate mesylate, Foy) administered into the lumen of the small intestine (enteral) improves volume requirements and autonomic cardiovascular function after experimental trauma/hemorrhagic shock in the absence of blood reperfusion. more
Efficacy of Tranexamic Acid in Blood Versus Crystalloid-Resuscitated Trauma/Hemorrhagic Shock. more
Comorbities in Shock Due to Autodigestion
Pancreatic Trysin Activates
Proenzymes (e.g. MMP9)
In Vivo.
Pancreatic Trypsin Increases
Matrix Metalloproteinase-9 Accumulation and Activation during Acute Intestinal Ischemia-Reperfusion. more
Proteolytic Leptin Receptor Cleavage with High Fat Diet and Obesity
Loss of Satiety and Desire to Eat During High Fat Diet is due to Proteolytic Cleavage of the Leptin Receptor in the Brain. More