Intestinal villi stained with alcian blue and MoAb against trypsin (brown) before (left) and after hemorrhagic (right) shock.
Frank A. Delano
Shock and multiorgan failure is the main cause of death in hospitals.
The autodigestion hypothesis for shock and multiorgan failure. Review
The mucosal barrier breakdown and pancreatic digestive enzyme leak. Article
Blockade of Digestive Proteases in the Lumen of the Small Intestine
For the first time, the life of a severely injured septic patient could be saved by deliberate enteral blockade of the digestive enzymes. A Case Report.
Peptidomics as an Independent Test of the
Autodigestion Hypothesis
Digestive enzymes degrade plasma proteins and generate numerous peptides that can be detected in blood plasma. They are independent predictors of mortality in Septic Patients.
Peptidomic analysis of rat plasma: Proteolysis in hemorrhagic shock.
Autodigestion: Proteolytic degradation and multiple organ failure in shock.