Li S, Ni A, Feng GS. Bridging cell surface receptor with nuclear receptors in control of bile acid homeostasis. (Review) Acta Pharmacol Sin. 36, 113-118, 2015.
Li J, Kang Y, Wei L, Liu W, Tian Y, Chen B, Lin X, Li Y, Feng GS, Lu Z. Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor. PLoS One 9, e102847, 2014.
Liu CY, Feng GS. NCOA5, a molecular link between type 2 diabetes and liver cancer. Hepatobiliary Surg Nutr. 3, 106-8, 2014.
Li S, Hsu DD, Li B, Luo X, Alderson N, Qiao L, Ma L, Zhu HH, He Z, Suino-Powell K, Ji K, Li J, Shao J, Xu HE, Li T, Feng GS. Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell Metab. 20, 320-32, 2014.
Sun L, Chen C, Jiang B, Li Y, Deng Q, Sun M, An X, Yang X, Yang Y, Zhang R, Lu Y, Zhu DS, Huo Y, Feng GS, Zhang Y, Luo J. Grb2-associated binder 1 is essential for cardioprotection against ischemia/reperfusion injury. Basic Res Cardiol. 109, 420, 2014.
Lee B, Qiao L, Kinney B, Feng GS, Shao J. Macrophage depletion disrupts immune balance and energy homeostasis. PLoS One 9, e99575, 2014.
Luo X, Feng GS. VEGFA genomic amplification tailors treatment of HCCs with sorafenib. Cancer Discov. 4, 640-1, 2014.
Yoo HS, Qiao L, Bosco C, Leong LH, Lytle N, Feng GS, Chi NW, Shao J. Intermittent cold exposure enhances fat accumulation in mice. PLoS One 9, e96432, 2014.
Lajiness JD, Snider P, Wang J, Feng GS, Krenz M, Conway SJ. SHP-2 deletion in postmigratory neural crest cells results in impaired cardiac sympathetic innervation. Proc Natl Acad Sci USA 111, E1374-82, 2014.
Lee B, Qiao L, Lu M, Yoo HS, Cheung W, Mak R, Schaack J, Feng GS, Chi NW, Olefsky JM, Shao J. C/EBPα regulates macrophage activation and systemic metabolism. Am J Physiol Endocrinol Metab. 306, E1144-54, 2014.
Qiao L, Yoo Hs, Bosco C, Lee B, Feng GS, Schaack J, Chi NW, Shao J. Adiponectin reduces thermogenesis by inhibiting brown adipose tissue activation in mice. Diabetologia 57, 1027-36, 2014.
Wang Z, Dela Cruz R, Ji F, Guo S, Zhang J, Wang Y, Feng GS, Birnbaumer L, Jiang M, Chu WM. G(i)α proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells. Cell Commun. Signal. 12, 10, 2014.
Chen E, Swift RV, Alderson N, Feher VA, Feng GS, Amaro RE. Computation-guided discovery of influenza endonuclease inhibitors. ACS Med Chem Lett. 5, 61-64, 2014.
Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng GS, Gotoh N, Zhang X. Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J Cell Sci. 127, 571-82, 2014.
Puri P, Phillips BT, Suzuki H, Orwig KE, Rajkovic A, Lapinski PE, King PD, Feng GS, Walker WH. The transition from stem cell to progenitor spermatogonia and male fertility requires the SHP2 protein tyrosine phosphatase. Stem Cells 32, 741-53, 2014.
Kim HK, Feng GS, Chen D, King PD, Kamiya N. Targeted disruption of Shp2 in chondrocytes leads to metachondromatosis with multiple cartilaginous protrusions. J Bone Miner Res 28, 761-9, 2014.
Ng GY, Yeh LK, Zhang Y, Liu H, Feng GS, Kao WW, Liu CY. Role of SH2-containing tyrosine phosphatase Shp2 in mouse corneal epithelial stratification. Invest Ophthalmol Vis Sci. 54, 7933-42, 2013.
He Z, Feng GS. Control of body weight versus tumorigenesis by concerted action of leptin and estrogen. Rev Endocr Metab Disord. 14, 339-45, 2013.
Lapinski PE, Meyer MF, Feng GS, Kamiya N, King PD. Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice. Dis Model Mech 6, 1448-58, 2013.
Kim HK, Aruwajoye O, Sucato D, Richards BS, Feng GS, Chen D, King PD, Kamiya N. Induction of SHP2 deficiency in chondrocytes causes severe scoliosis and kyphosis in mice. Spine (Phila Pa 1976) 38, E1307-12, 2013.
Wen W, Han T, Chen C, Huang L, Sun W, Wang X, Chen SZ, Xiang DM, Tang L, Cao D, Feng GS, Wu MC, Ding J, Wang HY. Cyclin G1 expands liver tumor-initiating cells by Sox2 induction via Akt/mTOR signaling. Mol Cancer Ther. 12, 1796-804, 2013.
Cai Z, Tao C, Li H, Ladher R, Gotoh N, Feng GS, Wang F, Zhang X. Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Development 140, 2711-23, 2013.
Coulombe G, Leblanc C, Cagnol S, Maloum F, Lemieux E, Perreault N, Feng GS, Boudreau F, Rivard N. Epithelial tyrosine phosphatase SHP-2 protects against intestinal inflammation in mice. Mol. Cell Biol. 33, 2275-84, 2013.
Shi ZQ, Sunico CR, McKercher SR, Cui J, Feng GS, Nakamura T, Lipton SA. S-nitrosylated SHP-2 contributes to NMDA receptor-mediated excitotoxicity in acute ischemic stroke. Proc Natl Acad Sci USA 110, 3137-42, 2013.
Yu J, Deng R, Zhu HH, Zhang SS, Zhu C, Montminy M, Davis R, Feng GS. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2. J Biol Chem 288, 3823-30, 2013.
He Z, Zhu HH, Bauler TJ, Wang J, Ciaraldi T, Alderson N, Li S, Raquil MA, Ji K, Wang S, Shao J, Henry RR, King PD, Feng GS. Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase. Proc Natl Acad Sci USA 110, E79-88, 2013.
Broxmeyer HE, Etienne-Julan M, Gotoh A, Braun SE, Lu L, Cooper S, Feng GS, Li XJ, Chan RJ. Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase function. Stem Cells Dev. 22, 998-1006, 2013.
Haglund E, Sułkowska JI, He Z, Feng GS, Jennings PA, Onuchic JN. The unique cysteine knot regulates the pleotropic hormone leptin. PLoS One 7, e45654, 2012.
Wu K, Ding J, Chen C, Sun W, Ning BF, Wen W, Huang L, Han T, Yang W, Wang C, Li Z, Wu MC, Feng GS, Xie WF, Wang HY. Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development. Hepatology 56, 2255-67, 2012.
Li S, Hsu DD, Wang H, Feng GS. Dual faces of SH2-containing protein-tyrosine phosphatase Shp2/PTPN11 in tumorigenesis. Front Med. 6, 275-9, 2012.
Mali RS, Ma P, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Nabinger S, Ghosh J, Sharma N, Munugalavadla V, Chatterjee A, Li S, Sandusky G, Craig AW, Bunting KD, Feng GS, Chan RJ, Zhang ZY, Kapur R. Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood 120, 2669-78, 2012.
Huang H, Woo AJ, Waldon Z, Schindler Y, Moran TB, Zhu HH, Feng GS, Steen H, Cantor AB. A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation. Genes Dev. 26, 1587-601, 2012.
Huang J, Yan J, Zhang J, Zhu S, Wang Y, Shi T, Zhu C, Chen C, Liu X, Cheng J, Mustelin T, Feng GS, Chen G, Yu J. SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane. Nat. Commun. 3, 911, 2012.
Yang W, Wang C, Lin Y, Liu Q, Yu LX, Tang L, Yan HX, Fu J, Chen Y, Zhang HL, Tang L, Zheng LY, He YQ, Li YQ, Wu FQ, Zou SS, Li Z, Wu MC, Feng GS, Wang HY. OV6⁺ tumor-initiating cells contribute to tumor progression and invasion in human hepatocellular carcinoma. J Hepatol. 57, 613-20, 2012.
Sharma N, Kumar V, Everingham S, Mali RS, Kapur R, Zeng LF, Zhang ZY, Feng GS, Hartmann K, Roers A, Craig AW. SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice. Mol. Cell Biol. 32, 2653-63, 2012.
He Z, Zhang SS, Meng Q, Li S, Zhu HH, Raquil MA, Alderson N, Zhang H, Wu J, Rui L, Cai D, Feng GS. Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals. Mol. Cell Biol. 32, 1867-78, 2012.
Qian YW, Chen Y, Yang W, Fu J, Cao J, Ren YB, Zhu JJ, Su B, Luo T, Zhao XF, Dai RY, Li JJ, Sun W, Wu MC, Feng GS, Wang HY. p28(GANK) prevents degradation of Oct4 and promotes expansion of tumor-initiating cells in hepatocarcinogenesis. Gastroenterology 142, 1547-58, 2012.
Zhang X, Zhang Y, Tao B, Teng L, Li Y, Cao R, Gui Q, Ye M, Mou X, Cheng H, Hu H, Zhou R, Wu X, Xie Q, Ning W, Lai M, Shen H, Feng GS, Ke Y. Loss of Shp2 in alveoli epithelia induces deregulated surfactant homeostasis, resulting in spontaneous pulmonary fibrosis. FASEB J. 26, 2338-50, 2012.
Feng GS. Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox. (Review) Cancer Cell 21, 150-4, 2012.
Matsuura S, Yan M, Lo MC, Ahn EY, Weng S, Dangoor D, Matin M, Higashi T, Feng GS, Zhang DE. Negative effects of GM-CSF signaling in a murine model of t(8;21)-induced leukemia. Blood 119, 3155-63, 2012.
Li L, Chen L, Hu L, Liu Y, Sun HY, Tang J, Hou YJ, Chang YX, Tu QQ, Feng GS, Shen F, Wu MC, Wang HY. Nuclear factor high-mobility group box1 mediating the activation of Toll-like receptor 4 signaling in hepatocytes in the early stage of nonalcoholic fatty liver disease in mice. Hepatology 54, 1620-30, 2011.
Sun W, Ding J, Wu K, Ning BF, Wen W, Sun HY, Han T, Huang L, Dong LW, Yang W, Deng X, Li Z, Wu MC, Feng GS, Xie WF, Wang HY. Gankyrin-mediated dedifferentiation facilitates the tumorigenicity of rat hepatocytes and hepatoma cells. Hepatology 54, 1259-72, 2011.
Zhu HH, Feng GS. The dynamic interplay between a PTK (Kit) and a PTP (Shp2) in hematopoietic stem and progenitor cells. Cell Cycle 10, 2241-2, 2011.
Futami M, Zhu QS, Whichard ZL, Xia L, Ke Y, Neel BG, Feng GS, Corey SJ. G-CSF receptor activation of the Src kinase Lyn is mediated by Gab2 recruitment of the Shp2 phosphatase. Blood 118, 1077-86, 2011.
Cai Z, Simons DL, Fu XY, Feng GS, Wu SM, Zhang X. Loss of Shp2-mediated mitogen-activated protein kinase signaling in Muller glial cells results in retinal degeneration. Mol. Cell Biol. 14, 2973-83, 2011.
Bard-Chapeau EA, Li S, Ding J, Zhang SS, Zhu HH, Princen F, Fang DD, Han T, Bailly-Maitre B, Poli V, Varki NM, Wang H, Feng GS. PTPN11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell 19, 629-639, 2011.
Zhu HH, Ji K, Alderson N, He Z, Li S, Liu W, Zhang DE, Li L, Feng GS. Kit-Shp2-Kit signaling axis regulates a functional hematopoietic stem and progenitor cell pool. Blood 117, 5350-5361, 2011.
Zhao J, Wang W, Ha CH, Kim JY, Wong C, Redmond EM, Hamik A, Jain MK, Feng GS, Jin ZG. Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis. Arterioscler Thromb Vasc Biol. 31, 1016-23, 2011.
Lu Y, Xiong Y, Huo Y, Han J, Yang X, Zhang R, Zhu DS, Klein-Hessling S, Li J, Zhang X, Han X, Li Y, Shen B, He Y, Shibuya M, Feng GS, Luo J. Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway. Proc Natl Acad Sci USA 108, 2957-62, 2011.
Fu J, Chen Y, Cao J, Luo T, Qian YW, Yang W, Ren YB, Su B, Cao GW, Yang Y, Yan YQ, Shen F, Wu MC, Feng GS, Wang HY. p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways. Hepatology 53, 181-92, 2011.
Bauler TJ, Kamiya N, Lapinski PE, Langewisch E, Mishina Y, Wilkinson JE, Feng GS, King PD. Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations. Dis Model Mech 4, 228-39, 2011.
Ruan X, Li Z, Zhang Y, Yang L, Pan Y, Wang Z, Feng GS, Chen Y. Apolipoprotein A-I possesses an anti-obesity effect associated with increase of energy expenditure and up-regulation of UCP1 in brown fat. J Cell Mol Med. 15, 763-72, 2011.
Zhu Y, Park J, Hu X, Zheng K, Li H, Cao Q, Feng GS, Qiu M. Control of oligodendrocyte generation and proliferation by Shp2 protein tyrosine phosphatase. Glia 58, 1407-14, 2010.
Cai Z, Feng GS, Zhang X. Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development. J Neurosci. 30, 4110-9, 2010.
Pan Y, Carbe C, Powers A, Feng GS, Zhang X. Sprouty2-modulated Kras signaling rescues Shp2 deficiency during lens and lacrimal gland development. Development 137, 1085-93, 2010.
Weng T, Mao F, Wang Y, Sun Q, Li R, Yang G, Zhang X, Luo J, Feng GS, Yang X. Osteoblastic molecular scaffold Gab1 is required for maintaining bone homeostasis. J Cell Sci. 123, 682-9, 2010.
2001 - 2009
McPherson VA, Sharma N, Everingham S, Smith J, Zhu HH, Feng GS, Craig AW. SH2 domain-containing phosphatase-2 protein-tyrosine phosphatase promotes Fc epsilon RI-induced activation of Fyn and Erk pathways leading to TNF alpha release from bone marrow-derived mast cells. J Immunol. 183, 4940-7, 2009.
Hagihara K, Zhang EE, Ke YH, Liu G, Liu JJ, Rao Y, Feng GS. Shp2 acts downstream of SDF-1alpha/CXCR4 in guiding granule cell migration during cerebellar development. Dev Biol. 334, 276-84, 2009.
Zhang, SS, E. Hao, J. Yu, W. Liu, J. Wang, F. Levine, and G.S. Feng. Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic beta-cells. Proc. Natl. Acad. SciUSA 106, 7531-7536, 2009.
Wu D, Pang Y, Ke Y, He Z, Tautz L, Mustelin T and Feng GS. A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase. PLoS ONE, 4(3): e4914, 2009.
Yu J, Zhang SS, Saito K, Williams S, Arimura Y, Ma Y, Ke Y, Baron V, Mercola D, Feng GS, Adamson E, Mustelin T. PTEN regulation by Akt-EGR1-ARF-PTEN axis. EMBO 28, 21-33, 2009.
Princen F, Bard E, Sheikh F, Zhang SS, Wang J, Zago WM, Wu D, Trelles RD, Bailly-Maitre B, Kahn CR, Chen Y, Reed JC, Tong GG, Mercola M, Chen J, Feng GS. Deletion of Shp2 tyrosine phosphatase in muscle leads to dilated cardiomyopathy, insulin resistance, and premature death. Mol. Cell Biol. 29, 378-88, 2009.
Mitra S, Beach C, Feng GS, Plattner R. SHP-2 is a novel target of Abl kinases during cell proliferation. J Cell Sci. 121, 3335-46, 2008.
Dawson MI, Xia Z, Jiang T, Ye M, Fontana JA, Farhana L, Patel B, Xue LP, Bhuiyan M, Pellicciari R, Macchiarulo A, Nuti R, Zhang XK, Han YH, Tautz L, Hobbs PD, Jong L, Waleh N, Chao WR, Feng GS, Pang Y, Su Y. Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity. J Med Chem 51, 5650-62. 2008.
Luo X, Feng L, Jiang X, Xiao F, Wang Z, Feng GS, Chen Y. Characterization of the topology and functional domains of RKTG. Biochem J 414, 339-406, 2008.
Krajewska M, Banares S, Zhang EE, Huang X, Scadeng M, Jhala US, Feng GS, Krajewski S. Development of diabesity in mice with neuronal deletion of Shp2 tyrosine phosphatase. Am J Pathol 172, 1312-24, 2008.
Pan Y, Carbe C, Powers A, Esko JD, Grobe K, Feng GS, Zhang X. Bud specific modification of heparan sulfate regulates Shp2 dependent FGF signaling during lacrimal gland induction. Development 135, 301-310, 2008.
Ruhul Amin AR, Uddin Biswas MH, Senga T, Feng GS, Kannagi R, Agarwal ML, Hamaguchi M. A role for SHPS-1/SIRPalpha in Concanavalin A-dependent production of MMP-9. Genes Cells 9, 1023-33, 2007.
Ke K, Zhang EE, Hagihara K, Wu D, Pang YH, Klein R, Curran T, Ranscht B, Feng GS. Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality. Mol. Cell Biol. 27, 6706-6717, 2007.
Amin AR, Thakur VS, Paul RK, Feng GS, Qu CK, Mukhtar H, Agarwal ML. SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG. Proc Natl Acad Sci USA 104, 5419-24, 2007.
Ni S, Zhao C, Feng GS, Paulson RF, Correll PH. A novel Stat3 binding motif in Gab2 mediates transformation of primary hematopoietic cells by the Stk/Ron receptor tyrosine kinase in response to Friend virus infection. Mol. Cell Biol. 10, 3708-15, 2007.
Feng GS. Shp2-mediated molecular signaling in control of embryonic stem cell self-renewal and differentiation. (Review) Cell Res 1, 37-41, 2007.
Chan RJ and Feng GS. PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase (Invited review). Blood 109, 862-867, 2007.
Ke Y, Wu D, Princen F, Nguyen T, Pang Y, Lesperance J, Muller WJ, Oshima RG, Feng GS. Role of Gab2 in mammary tumorigenesis and metastasis. Oncogene 26, 4951-4960, 2007.
Dong XP, Li XM, Gao TM, Zhang EE, Feng GS, Xiong WC, Mei L. Shp2 is dispensable in the formation and maintenance of the neuromuscular junction. Neurosignals 15, 53-63, 2006-2007.
Nguyen TV, Ke Y, Zhang EE, Feng GS. Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals. J Immunol. 177, 5990-6, 2006.
An H, Zhao W, Hou J, Zhang Y, Xie Y, Xu H, Qian C, Feng T, Zhou J, Liu S, Yu Y, Wang J, Feng GS, Cao XT. SHP-2 negatively regulates TLR4/TLR3-mediated type I interferon production in macrophages by inhibiting TRIF- and TBK1-dependent signals. Immunity 25, 919-928, 2006.
Bard-Chapeau EA, Yuan J, Droin N, Long S, Zhang EE, Nguyen TV, Feng GS. Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection. Mol. Cell Biol. 26, 4664-74, 2006.
Feng GS. Shp2 as a therapeutic target for leptin resistance and obesity. (Review) Expert Opin Ther Targets 10, 135-42, 2006.
Bard-Chapeau EA, Hevener AL, Long S, Zhang EE, Olefsky JM, Feng GS. Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nature Medicine 11, 567-571, 2005.
Wang FM, Liu HQ, Liu SR, Tang SP, Yang L, Feng GS. SHP-2 promoting migration and metastasis of MCF-7 with loss of E-cadherin, dephosphorylation of FAK and section of MMP-9 induced by IL-1beta in vivo and in vitro. Breast Cancer Res Treat 89, 5-14, 2005.
Zhang EE, Chapeau E, Hagihara K, Feng GS. Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci USA 101(45), 16064-9, 2004.
Sun Y, Yuan J, Liu H, Shi Z, Baker K, Vuori K, Wu J, Feng GS. Role of Gab1 in UV-induced c-Jun NH2-terminal kinase activation and cell apoptosis. Mol. Cell Biol. 24(4), 1531-9, 2004.
Chan RJ, You M, Feng GS. Identification of trans-acting factors by electrophoretic mobility shift assay. Methods Mol Biol. 249, 7-20, 2004.
Chan RJ, Johnson SA, Li Y, Yoder MC, Feng GS. A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis. Methods Mol Biol. 249, 7-20, 2004.
Ruhul Amin AR, Oo ML, Senga T, Suzuki N, Feng GS, Hamaguchi M. SH2 domain containing protein tyrosine phosphatase 2 regulates concanavalin A-dependent secretion and activation of matrix metalloproteinase 2 via the extracellular signal-regulated kinase and p38 pathways. Cancer Res. 63(19), 6334-9, 2003.
von Wichert G, Haimovich B, Feng GS, Sheetz MP. Force-dependent integrin-cytoskeleton linkage formation requires downregulation of focal complex dynamics by Shp2. EMBO J. 22(19), 5023-35, 2003.
Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS. GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2. J Biol Chem, 278(36), 34641-53, 2003.
MacGillivray M, Herrera-Abreu MT, Chow CW, Shek C, Wang Q, Vachon E, Feng GS, Siminovitch KA, McCulloch CA, Downey GP. The protein tyrosine phosphatase SHP-2 regulates interleukin-1-induced ERK activation in fibroblasts. J Biol Chem, 278(29), 27190-8, 2003.
Chen Y, Wen R, Yang S, Schuman J, Zhang EE, Yi T, Feng GS, Wang D. Identification of Shp-2 as a Stat5A phosphatase. J Biol Chem, 278(19), 16520-7, 2003.
Wu TR, Hong YK, Wang XD, Ling MY, Dragoi AM, Chung AS, Campbell AG, Han ZY, Feng GS, Chin YE. SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei. J Biol Chem, 277(49), 47572-80, 2002.
Mustelin T, GS Feng, N Bottini, A Alonso, N Kholod, D Birle, J Merlo and H Huynh. Protein tyrosine phosphatases (invited review article). Frontiers in Bioscience 7:D85-D142, 2002.
Shen R, Ouyang YB, Qu CK, Alonso A, Sperzel L, Mustelin T, Kaplan MH, Feng GS. Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. Mol. Cell Biol. 22(10), 3230-6, 2002.
Wu CJ, DM O’Rourke, GS Feng, GR Johnson, Q Wang, and MI Greene. The tyrosine phosphatase Shp-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors. Oncogene 20, 6018-25, 2001.
Qu CK, S Nguyen, J Chen, and GS Feng. Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development. Blood 97, 911-914, 2001.
You M, LM Flick, DH Yu, and GS Feng. Modulation of the nuclear factor-kappaB pathway by Shp-2 tyrosine phosphatase in interleukin (IL)-6 induction by IL-1 or tumor necrosis factor. J Exp Med193, 101-109, 2001.
1995 - 2000
Shi ZQ, DH Yu, M Park, M Marshall, and GS Feng. Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity. Mol Cell Biol 20, 1526-36, 2000.
Schoenwaelder SM, LA Petch, R Shen, GS Feng and K Burridge. The protein-tyrosine phosphatase Shp-2 regulates RhoA activity. Curr Biol 10, 1523-26, 2000.
Tanowitz MJ. J Si, DH Yu, GS Feng and L Mei. Regulation of neuregulin-mediated AchR synthesis by protein tyrosine phosphatase SHP2. J Neuroscience 19, 9426-35, 1999.
Kim CH, CK Qu, G Hangoc, S Cooper, N Anzai, GS Feng, and HE Broxmeyer. Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicates the protein tyrosine phosphatase SHP-1 in chemokine responses. J Exp Med 190, 681-690, 1999.
Qu CK, WM Yu, B Azzarelli, and GS Feng. Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals. Proc Natl Acad Sci USA 96, 8528-33, 1999.
Feng GS. Shp-2 tyrosine phosphatase: Signaling one cell or many (invited review article). Exp Cell Res 253, 47-54, 1999.
Zhao C, DH Yu, R Shen and GS Feng. Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1. J Biol Chem 274, 19649-54, 1999.
You M, DH Yu and GS Feng. Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. Mol Cell Biol 19, 2416-24, 1999.
Oehrl W, C Kardinal, S Ruf, K Adermann, J Groffen, GS Feng, J Blenis, TH Tan and SM Feller. The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins. Oncogene 17, 1893–1901, 1998.
Qu CK, WM Yu, B Azzarelli, S Cooper, HE Broxmeyer and GS Feng. Biased suppression of hematopoiesis and multiple developmental defects in chimeric mice containing Shp-2 mutant cells. Mol Cell Biol 18, 6075-82, 1998.
Yu DH, CK Qu, O Henegariu, XL Lu, and GS Feng. Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration and focal adhesion. J Biol Chem 273, 21125-31, 1998.
Lu XL, CK Qu, ZQ Shi, and GS Feng. Downregulation of platelet-derived growth factor receptor-beta in Shp-2 mutant fibroblast cells. Oncogene. 17, 441-448, 1998.
Qu CK, and GS Feng. Shp-2 has a positive regulatory role in ES cell differentiation and proliferation. Oncogene. 17, 433-440, 1998.
Kim SO, J Jiang, W Yi, GS Feng, and SJ Frank. Involvement of the src homology 2-containing tyrosine phosphatase SHP-2 in growth hormone signaling. J Biol Chem 273, 2344-54, 1998.
Shi ZQ, W Lu, and GS Feng. The Shp-2 tyrosine phosphatase has opposite effects in mediating the activation of extracellular signal-regulated and c-Jun NH2-terminal mitogen-activated protein kinases. J Biol Chem 273, 4904-08, 1998.
Tang J, GS Feng, and W Li. Induced direct binding of the adaptor protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor. Oncogene 15, 1823-32, 1997.
Qu CK, ZQ Shi, R Shen, FY Tsai, SH Orkin, and GS Feng. A deletion mutation in the SH2-N domain of Shp-2 severely suppresses hematopoietic cell development. Mol Cell Biol 17, 5499-07, 1997.
Saxton TM, M Henkemeyer, S Gasca, R Shen, F Shalaby, GS Feng, and T Pawson. Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J 16, 2352-64, 1997.
Yin T, R Shen, GS Feng, and YC Yang. Molecular characterization of domains required for the specific interactions between Shp-2 phosphatase and JAK tyrosine kinases. J Biol Chem 272, 1032-37, 1997.
Tauchi T, K Miyazawa, GS Feng, HE Broxmeyer, and K Toyama. A coiled-coil tetramerization domain of Bcr-Abl is essential for the interactions of SH2-containing signal transduction molecules. J Biol Chem 272, 1389-94, 1997.
Marengere LEM, P Waterhouse, GS Duncan, HW Mittrucker, GS Feng, and TW Mak. Regulation of T cell receptor signaling by tyrosine phosphatase Syp association with CTLA-4. Science 272, 1170-73, 1996.
Feng GS, YB Ouyang, DP Hu, ZQ Shi, R Gentz, and J Ni. Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. J Biol Chem 271, 12129-32, 1996.
Tauchi T, JE Damen, K Toyama, GS Feng, HE Broxmeyer, and G Krystal. Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis. Blood 87, 4495-01, 1996.
Zhang-Sun G, CR Yang, J Viallet. GS Feng, JJM Bergeron, and BI Posner. A 60 Kilodalton protein in rat hepatoma cells overexpressing insulin receptor was tyrosine phosphorylated and associated with Syp, phosphatidylinositol 3-kinase, and Grb2 in an insulin-dependent manner. Endocrinology 137, 2649-58, 1996.
1988 - 1994
Tauchi T, GS Feng, R Shen, M Hoatlin, GC Bagby Jr, L Lu, and HE Broxmeyer. Involvement of SH2-containing phosphotyrosine phosphatase Syp in erythropoietin receptor signal transduction pathways. J Biol Chem 270, 5631-35, 1995.
Fuhrer DK, GS Feng, and YC Yang. Syp associates with gp130 and JAK2 in response to IL-11 in 3T3-L1 mouse preadipocytes. J Biol Chem270, 24826-30, 1995.
Tauchi T, GS Feng, MS Marshall, R Shen, C Mantel, and HE Broxmeyer. The ubiquitously expressed Syp phosphatase interacts with c-kit and Grb2 in hematopoietic cells. J Biol Chem 269, 25206-11, 1994.
Feng GS, and T Pawson. Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction (review article). Trends in Genetics10, 54-58, 1994.
Tauchi T, GS Feng, R Shen, HY Song, D Donner, T Pawson, and HE Broxmeyer. SH2-containing phosphotyrosine phosphatase Syp is a target of p210bcr-abl tyrosine kinase. J Biol Chem 269, 15381-87, 1994.
Feng GS, R Shen, HHQ Heng, LC Tsui, A Kazlauskas, and T Pawson. Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp. Oncogene9, 1545-50, 1994.
Kozlowski M, I Mlinaric-Rascan, GS Feng, R Shen, FWL Tsui, T Pawson, and KA Siminovitch. Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J Exp Med178, 2157-63, 1993.
Kuhne MR, T Pawson, GE Lienhard, and GS Feng. The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J Biol Chem268, 11479-81, 1993.
Kazlauskas A, GS Feng, T Pawson, and M Valius. The 64 Kd protein that associates with the PDGF receptor beta-subunit via tyrosine 1009 is the SH2-containing phosphotyrosine phosphatase Syp. Proc Natl Acad Sci USA90, 6939-43, 1993.
Feng GS, CC Hui, and T Pawson. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science259, 1607-11, 1993.
Thomas SM, LF Garrity, CR Brandt, CS Schobert, GS Feng, MW Taylor, JM Carlin, and GI Byrne. The gamma interferon-mediated antimicrobial response: Indoleamine 2,3-dioxygenase-deficient mutant host cells no longer inhibit intracellular Chlamydia spp. or Toxoplasma growth. J Immunol150, 5529-34, 1993.
Feng GS, K Chong, A Kumar, and BRG Williams. Identification of dsRNA-binding domains of the interferon-induced, dsRNA-activated protein kinase. Proc Natl Acad Sci USA89, 5447-51, 1992.
Taylor MW, and GS Feng. Relationship between interferon-gamma, indoleamine 2,3-dioxygenase, and tryptophan catabolism (review). FASEB J5, 2516-2522, 1991.
Feng GS, W Dai, SL Gupta, G Werner-Felmayer, H Wachter, O Takikawa, and MW Taylor. Analysis of interferon-gamma resistant mutants that are possibly defective in their signaling mechanism. Mol Gen Genet230, 91-96, 1991.
Shen RN, L Lu, GS Feng, MW Taylor, and HE Broxmeyer. Cure with low dose total body irradiation of the hematological disorder induced in mice with the friend leukemia virus: possible mechanism involving interferon and interleukin-2. Lymphokine Res 10, 83-87, 1991.
Feng GS, and MW Taylor. Interferon-gamma resistant mutants are defective in the induction of indoleamine 2,3-dioxygenase. Proc Natl Acad Sci USA86, 7144-48, 1989.
Feng GS, PW Gray, HM Shepard, and MW Taylor. Antiproliferative activity of a hybrid protein between interferon-gamma and tumor necrosis factor-beta. Science241, 1501-03, 1988.