Representative Publications
Liang,Y., Kaneko, K., Xin, B., Lee, J., Sun, X., Zhang, K., and Feng, G.S. Temporal Analyses of Postnatal Liver Development and Maturation by Single Cell Transcriptomics (2021) bioRxiv. doi: https://doi.org/10.1101/2021.07.14.451852
Feng, G. S., Hanley, K. L., Liang, Y., & Lin, X. Improving the Efficacy of Liver Cancer Immunotherapy: the Power of Combined Preclinical and Clinical Studies (2020) Hepatology. doi:10.1002/hep.31479
Wang, G., Luo, X., Liang, Y., Kaneko, K., Li, H., Fu, X.D., Feng, G.s., A Tumorigenic Index for Quantitative Analysis of Liver Cancer Initiation and Progression (2019) Proc Natl Acad Sci USA, doi:10.1073/pnas.1911193116
Wen, L., Xin, B., Wu, P., Lin, C.H., Peng, C., Wang, G., Lee, Jin., Lu, L.F., Feng, G.S., An Efficient Combination Immunotherapy for Primary Liver Cancer hy Harmonized Activation of Innate and Adaptive Immunity in Mice (2019) Hepatology, doi:10.1002/hep.30528
Liu, J.J., Li, Y., Chen, W.S., Liang, Y., Wang, G., Zong, M., Kaneko, K., Xu, R., Karin, M., Feng, G-S., Shp2 Deletion in Hepatocytes Suppresses Hepatocarcinogenesis Driven by Oncogenic β-Catenin, PIK3CA and MET (2018) Journal of Hepatology, doi:10.1016/j.jhep.2018.02.014
Liang, Y., Feng, Y., Zong, M., Wei, X.F., Lee, J., Feng, Y., Li, H., Yang, G.S., Wu, Z.J., Fu, X.D., and Feng, G.S. (2018) β -Catenin Deficiency in Hepatocytes Aggravates Hepatocarcinogenesis Driven by Oncogenic β -Catenin and MET. Hepatology, 67: 1807-1822 doi:10.1002/hep.29661
Lee J, Liao R, Wang G, Yang BH, Luo X, Varki N, Qiu SJ, Ren B, Fu W, Feng GS (2017). Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions. Cell Reports 21, 1870-1882
Luo X, Liao R, Hanley K, Zhu HH, Malo KN, Hernandez C, Wei X, Varki NM, Alderson N, Chu C, Li S, Fan J, Loomba R, Qiu SJ, Feng GS (2016). Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells. Cell Reports 17, 2979–2993
Zhu HH, X Luo, K Zhang, J Cui, H Zhao, Z Ji, Z Zhou, J Yao, L Zeng, K Ji, WQ Gao, ZY Zhang, and GS Feng (2015). Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals. Proc Natl Acad Sci USA 112, 13342-7.
Deng Z, S Ma, H Zhou, Aiping Zang, Y Fang, T Li, H Shi, M Liu, M Du, PR Taylor, HH Zhu, J Chen, G Meng, F Li, C Chen, Y Zhang, X Zhang, E Pearlman, X Li, GS Feng and H Xiao (2015). Tyrosine phosphatase SHP2 mediates Dectin-induced SYK activation and anti-fungal TH17 response. Nature Immunol. 16, 642-52.
He Z, HH Zhu, TJ Bauler, J Wang, T Ciaraldi, N Alderson, S Li, MA Raquil, K Ji, S Wang, J Shao, R Henry, PD King, and GS Feng (2013). Non-receptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase. Proc Natl Acad Sci USA. 110, E79-88.
Li S, DDF Hsu, B Li, X Luo, N Alderson, L Qiao, L Ma, HH Zhu, Z He, K Suino-Powell, K Ji, J Li, J Shao, HE Xu, T Li, and GS Feng. Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell Metabolism 20, 320-32, 2014.
He Z, SS Zhang, Q Meng, S Li, HH Zhu, MA Raquil, N Alderson, H Zhang, J Wu, L Rui, D Cai, and GS Feng (2012). Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals. Mol Cell Biol 32, 1867-1878, 2012. PMCID 3347413
Feng GS. Conflicting roles of molecules in hepatocarcinogenesis: paradigm or paradox (Invited Review). Cancer Cell 21, 150-154, 2012. PMCID 3285429
Bard-Chapeau, EA, S Li, J Ding, SS Zhang, HH Zhu, F Princen, DD Fang, T Han, B Bailly-Maitre, V Poli, H Wang and GS Feng. PTPN11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell 19, 629-639, 2011. PMCID 3098128
Bard-Chapeau, EA, J Yuan, N Droin, S Long, EE Zhang, TV Nguyen, and GS Feng. Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection. Mol Cell Biol 26, 4664-4674, 2006.
Bard-Chapeau E, AL Hevener, S Long, EE Zhang, JM Olefsky and GS Feng. Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action. Nature Medicine 11, 567-571, 2005.
Feng GS, CC Hui, and T Pawson. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 259, 1607-1611, 1993.
For a comprehensive list of publications, please see Here.