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Discuss: In-Lab #1
Draw the arrow-pushing mechanism for the synthesis of aspirin from salicylic acid.
(You may abbreviate the aromatic ring (“Ar”) in the intermediates)
Step 1. Heat water bath until boiling
Step 1. Heat water bath until boiling
reflux apparatus
Fill a small crystallizing dish half-way with water
Place on a hotplate (medium setting) and bring to a gentle boil
Step 2. Add reagents to 15-mL RBF:
Step 2. Add reagents to 15-mL RBF:
2.1 Salicyclic acid (200 mg)
2.1 Salicyclic acid (200 mg)
setup_SA.mp42.2 Acetic anhydride (2 mL)
2.2 Acetic anhydride (2 mL)
setup_AA.mp4
2.3 Phosphoric acid (2 drops)
2.3 Phosphoric acid (2 drops)
setup_H3PO4.mp4
Discuss: Part of In-Lab #3
Report the mass of salicylic acid given.
Re-calculate the theoretical yield of aspirin in mmol and mg (show your work).
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