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Aqueous layer removal and water washes
Aqueous layer removal and water washes
rxn_workup_1.mp4- Remove AQ layer
a. Use a pipet to remove the water – save the layer that contains the alkyl halide!
2. Wash with water
2. Wash with water
a. Add 1 mL of water, mix, and vent often!
b. Allow layers to separate, and then remove the water
Quench with weak base and water washes
Quench with weak base and water washes
rxn_workup_2.mp43. Quench with weak base
3. Quench with weak base
a. Add 1 mL of 5% NaHCO3 solution
b. Carefully agitate and vent
What gas is formed at this step?
What gets left behind in the conical vial?
4. Wash with water
4. Wash with water
a. Add 1 mL of water, mix, then remove as much water as possible on the last wash
we don't want water mass to contribute to % yield!
PRODUCT LOSS:
PRODUCT LOSS:
QUENCHING WITH WEAK BASE – 50 mg lost at this step
FINAL WASH WITH WATER – 25 mg lost at this step
Discuss:
Discuss:
Why is the reaction quenched? How does quenching contribute to product loss?
Why might you lose a little product after the final wash with water?
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