Publications

TAN Lab publications

R. van Bruggen, Z.H. Patel, M. Wang, T.R. Suk, M.W.C. Rousseaux, Q. Tan (2023) A Versatile Strategy for Genetic Manipulation of Cajal-Retzius Cells in the Adult Mouse Hippocampus. eNeuro. doi:10.1523/ENEURO.0054-23.2023


Check out our new paper! We devised a strategy that combines neonatal intracerebroventricular injections of viral vectors into the Cajal-Retzius neuron-targeting Cre mouse line. Our method will facilitate the study of Cajal-Retzius neurons in the postnatal and adult hippocampus.

S. Sharma, B. Hourigan, Z. Patel, J. A. Rosenfeld, K. M. Chan, M. F. Wangler, J. S. Yi, A. Lehman, the CAUSES Study, G. Horvath, P. A. Cloos, Q. Tan. Novel CIC variants identified in individuals with neurodevelopmental phenotypes. Human Mutation, (2022) 1– 11. 

https://onlinelibrary.wiley.com/doi/abs/10.1002/humu.24346 (Request of full-text article can be sent to qiumin@ualberta.ca).

Check out our paper! We describe the genetics and phenotypes of four individuals with CIC pathogenic variants and performed functional studies of some of the variants. Importantly, we identify the first case of a pathogenic variant specific to an isoform of CIC and a second case of pediatric leukemia linked to germline CIC variants.

H. Hong, J. Lee, G.Y. Park, S. Kim, J. Park, J.S. Park, Y. Song, S. Lee, T.J. Kim, Y.J. Lee, T.Y. Roh, S.K. Kwok, S.W. Kim, Q. Tan, Y. Lee, Postnatal regulation of B-1a cell development and survival by the CIC-PER2-BHLHE41 axis, Cell Reports, 38 (2022) 110386.

https://www.sciencedirect.com/science/article/pii/S2211124722001073

From our collaborator! A new role of CIC in B cell development.



B. Hourigan, S.D. Balay, G. Yee, S. Sharma, Q. Tan, Capicua regulates the development of adult-born neurons in the hippocampus, Scientific Reports, 11 (2021) 11725. 

https://rdcu.be/clQSa  (https://www.nature.com/articles/s41598-021-91168-5)

Our lab's first paper! New neurons are being born everyday in the adult brain (how cool is that!) and capicua plays an important role in this process.

Our paper is also featured in the Guest Editor's Collection "Adult neurogenesis and aging mechanisms". Check it out here.



C.S. Kao, R. van Bruggen, J.R. Kim, X.X.L. Chen, C. Chan, J. Lee, W.I. Cho, M. Zhao, C. Arndt, K. Maksimovic, M. Khan, Q. Tan, M.D. Wilson, J. Park, Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS, Nat Commun, 11 (2020) 5304. 

https://www.nature.com/articles/s41467-020-18949-w

From our collaborator! A new genetic mouse model for amyotrophic lateral sclerosis, aka Lou Gehrig's disease.


A. Didonna, E. Canto Puig, Q. Ma, A. Matsunaga, B. Ho, S.J. Caillier, H. Shams, N. Lee, S.L. Hauser, Q. Tan, S.S. Zamvil, J.R. Oksenberg, Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis, Proc Natl Acad Sci U S A, 117 (2020) 23742-23750.

https://www.pnas.org/content/117/38/23742

From our collaborator! The ataxin 1-capicua protein complex may play a role in Multiple Sclerosis.


Publications before the tan LAB

Q Tan*, HY Zoghbi*. (2019) Mouse models as a tool for discovering new neurological diseases. Neurobiology of Learning and Memory (*Co-corresponding authors)

VV Bondar, CJ Adamski, TS Onur, Q Tan, L Wang, J Diaz-Garcia, J Park, HT Orr, J Botas, HY Zoghbi. (2018) PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in Spinocerebellar ataxia type 1. Human Molecular Genetics 27 (15): 2863-2873.

Q Tan*, LM Brunetti, MWC Rousseaux, H-C Lu, Y-W Wan, JP Revelli, Z Liu, MA Goodell, HY Zoghbi*. (2018) Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma. Proceedings of the National Academy of Sciences U S A 115 (7) E1511-E1519 (*Co-corresponding authors)

MWC Rousseaux, T Tschumperlin, H-C Lu, EP Lackey, VV Bondar, Y-W Wan, Q Tan, CJ Adamski, J Friedrich, K Twaroski, W Chen, J Tolar, C Henzler, A Sharma, A Bajić, T Lin, L Duvick, RV Sillitoe, HY Zoghbi, HT Orr. (2018) Gain of function of the ATXN1-CIC complex drives cerebellar pathology in Spinocerebellar ataxia type 1. Neuron 97 (6):1235-1243

H-C Lu*, Q Tan*, MWC Rousseaux, J-Y Kim, Y-W Wan, S-Y Yeh, JM Patel, X Liu, Y Lee, JD Fryer, J Han, M Chahrour, RH Finnell, Y Lei, EZ Zurita-Jimenez, P Ahimaz, K Anyane-Yeboa, D Lehalle, N Jean-Marcais, A-L Mosca-Boidron, J Thevenon, MA Cousin, DE Bro, BC Lanpher, EW Klee, N Alexander, MN Bainbridge, HT Orr, Z Liu, CP Schaaf, HY Zoghbi. (2017) Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans. Nature Genetics 49: 527-536. (*co-first authors)

Q Tan, H Krishna Yalamanchili, J Park, A De Maio, H-C Lu, Y-W Wan, JJ White, VV Bondar, LS Sayegh, X Liu, Y Gao, RV Sillitoe, HT Orr, Z Liu, HY Zoghbi. (2016) Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegeneration models. Human Molecular Genetics 25, 5083-5093. Issue cover image.

J Park, I Al-Ramahi, Q Tan, N Mollema, JR Diaz-Garcia, T Gallego-Flores, H-C Lu, S Lagalwar, L Duvick, H Kang, Y Lee, P Jafar-Nejad, LS Sayegh, R Richman, X Liu, Y Gao, CA Shaw, JSC Arthur., HT Orr, TF Westbrook, J Botas, HY Zoghbi. (2013) RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1. Nature 498, 325-331.