2025
Amoah DP, Hussein SK, Johnson JL, LaPointe P. (2025) Ordered ATP hydrolysis in the Hsp90 chaperone is regulated by Aha1 and a conserved post-translational modification. Protein Sci. Jan;34(1):e5255. doi: 10.1002/pro.5255.
2024
Hussein S, Amoah D, LaPointe P (2024) Recruitment of Ahsa1 to Hsp90 is regulated by a conserved peptide that inhibits ATPase stimulation. EMBO Rep. Jun 27. doi: 10.1038/s44319-024-00193-8.
Wickenberg M, Mercier R, Yap M, Walker J, Baker K, LaPointe P (2024) Hsp90 inhibition leads to an increase in surface expression of multiple immunological receptors in cancer cells. Front Mol Biosci. Apr 5:11:1334876
2023
Mercier R, Yama D, LaPointe P, Johnson JL (2022) The Hsp90 conformational cycle dictates sensitivity to Hsp90 inhibitors and alterations in cochaperone levels. PLOS Genetics 19(5): e1010772
2022
Mercier R, LaPointe P. (2022) The role of cellular proteostasis in antitumor immunity. J Biol Chem. 298(5): 101930
Bording-Jorgensen M, Armstrong H, Wickenberg M, LaPointe P, Wine E. (2022). Macrophages and Epithelial Cells Mutually Interact through NLRP3 to Clear Infection and Enhance the Gastrointestinal Barrier. Immuno. 2(1), 13-25.
2021
Banerjee H, LaPointe P, Eitzen G, Rachubinski RA. (2021). A Small Molecule Inhibitor of Pex-Pex19 Interaction Disrupts Glycosome Biogenesis and Causes Lethality in Trypanosoma brucei. Front Cell Dev Biol. Jul 19;9:703603
2020
LaPointe P, Mercier R, Wolmarans A. (2020) Aha-type co-chaperones: the alpha or the omega of the Hsp90 ATPase cycle? Biol Chem 401(4): 423-434
Gutiérrez T, Qi H, Yap MC, Tahbaz N, Milburn LA, Lucchinetti E, Lou PH, Zaugg M, LaPointe PG, Mercier P, Overduin M, Bischof H, Burgstaller S, Malli R, Ballanyi K, Shuai J, Simmen T. (2020). The ER chaperone calnexin controls mitochondrial positioning and respiration. Sci Signal. Jun 30;13(638)
2019
Mercier, R., Wolmarans, A., Schubert, J., Neuweiler, H., Johnson, J. L., LaPointe, P. (2019). The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation. Nat. Commun. 10(1), 1273
Lee, B. L., Rashid, S., Wajda, B., Wolmarans, A., LaPointe, P., Spyracopoulos, L. (2019). The Hsp90 Chaperone: 1H and 19F Dynamic Nuclear Magnetic Resonance Sprectroscopy Reveals a Perfect Enzyme. Biochemistry. 58(15), 1869-1877
2018
Wolmarans, A., Kwantes, A., & LaPointe P. (2018). A novel method for site-specific chemical SUMOylation:SUMOylation of Hsp90 modulates co-chaperone binding in vitro. Biol. Chem. doi: 10.1515/hsz-2018-0251
2017
Zuehlke, A. D., Reidy, M, Lin, C., LaPointe, P, Alsomairy, S, Lee, D. J., Rivera-Marquez, G. M., Beebe, K., Prince, T., Lee, S., Trepel, J. B., Xu, W., Johnson, J., Masison, D., Neckers, L. (2017). An Hsp90 co-chaperone protein in yeast is functionality replaced by replaced by site-specific posttranslational modification. Nat Commun. 8, 15328
Pimmett, V. L., Deng, H., Haskins, J.A., Mercier, R. J., LaPointe, P., & Simmonds, A. J. (2017). The activity of the Drosophila Vestigial protein is modified by Scalloped-dependent phosphoryaltion. Dev. Biol. 6, 33179
2016
Wolmarans, A., Lee, B., Spyracopoulos, L. & LaPointe, P. (2016). The Mechanisn of Hsp90 Stimulation by Aha1. Sci. Rep. 6, 33179
2014
Horvat, N. K., Armstrong, H., Lee, B. L., Mercier, R., Wolmarans, A., Knowles, J., Spyracopoulos, L. & LaPointe, P. (2014). A mutation in the catalytic loop of Hsp90 specifically
impairs ATPase stimulation by Aha1p, but not Hch1p. J Mol Biol. 426(12), 2379-92
2013
Wang, Y., Mercier, R., Hobman, T. C. & LaPointe, P. (2013). Regulation of RNA interference by Hsp90 is an evolutionarily conserved process. Biochim Biophys Acta 1833, 2673-2681.
Schellenberg, M. J., Wu, T., Ritchie, D. B., Fica, S., Staley, J. P., Atta, K. A., LaPointe, P. & MacMillan, A. M. (2013). A conformational switch in PRP8 mediates metal ion
coordination that promotes pre-mRNA exon ligation. Nat Struct Mol Biol 20, 728-34.
Pare, J. M., LaPointe, P. & Hobman, T. C. (2013). Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNA interference-mediated silencing in
mammalian cells. Mol Biol Cell 24, 2303-10.
Mok, S. A., Lund, K., LaPointe, P. & Campenot, R. B. (2013). A HaloTag(R) method for assessing the retrograde axonal transport of the p75 neurotrophin receptor and other
proteins in compartmented cultures of rat sympathetic neurons. J Neurosci Methods 214, 91-104.
2012
Wuest, F., Bouvet, V., Mai, B. & LaPointe, P. (2012). Fluorine- and rhenium-containing geldanamycin derivatives as leads for the development of molecular probes for imaging
Hsp90. Org Biomol Chem 10, 6724-31.
Armstrong, H., Wolmarans, A., Mercier, R., Mai, B. & LaPointe, P. (2012). The co-chaperone Hch1 regulates Hsp90 function differently than its homologue Aha1 and confers
sensitivity to yeast to the Hsp90 inhibitor NVP-AUY922. PLoS One 7, e49322.